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Punicalagin

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In Silico Prediction of Inhibitory Potential of a Punicalagin β-anomer Against SARS-COV-2 Main Protease (Mpro)

Norberto Monteiro, Vitória Monteiro, Lorena Lima, Anna Karolline, Richele Machado,

The pandemic caused by the new coronavirus has resulted in a global health emergency and has prompted an urgent need for new treatment strategies. No target-specific drugs are currently available for SARS-CoV-2, but new drug candidates targeting the viral replication cycle are being explored. A prime target of drug-discovery efforts ... Read more >>

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Punicalagin in Cancer Prevention-Via Signaling Pathways Targeting.

Izabela Berdowska, Małgorzata Matusiewicz, Izabela Fecka,

The extract of pomegranate (<i>Punica granatum</i>) has been applied in medicine since ancient times due to its broad-spectrum health-beneficial properties. It is a rich source of hydrolyzable tannins and anthocyanins, exhibiting strong antioxidative, anti-inflammatory, and antineoplastic properties. Anticancer activities of pomegranate with reference to modulated signaling pathways in various cancer ... Read more >>

Nutrients (Nutrients)
[2021, 13(8):]

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Punicalagin and ellagic acid containing Punica granatum L. fruit rind extract prevents vincristine-induced neuropathic pain in rats: an in silico and in vivo evidence of GABAergic action and cytokine inhibition.

Vivek Jain, Ashutosh Pareek, Yashumati Ratan Bhardwaj, Saurabh Kumar Sinha, Madan Mohan Gupta, Nirmal Singh,

<b>Objectives:</b> We aimed to investigate the protective potential of Punica granatum L. fruit rind extract (PFE) containing punicalagin (10.3% W/W), ellagic acid (EA) (2.7%W/W) in vincristine (75 µg/kg i.p.)- induced neuropathic pain in Wistar rats.<b>Methods:</b> Docking simulation studies were done on the three-dimensional (3D) structure of the GABA<sub>A</sub> and PPAR ... Read more >>

Nutr Neurosci (Nutritional neuroscience)
[2021, :1-18]

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The Whitening Properties of the Mixture Composed of Pomegranate, Osmanthus and Olive and the Protective Effects Against Ultraviolet Deleterious Effects.

Xiaoling Wang, Sandrine Heraud, Amelie Thepot, Morgan Dos Santos, Zhen Luo,

<h4>Background</h4>Ultraviolet (UV) rays are the major environmental factor that damage skin physiology causing deleterious effects such as oxidation, photoaging and pigmentation. There has been considerable interest in using botanicals to prevent skin damages caused by UV irradiation.<h4>Aim</h4>In this study, three plant extracts were tested either individually or combined together (mixture) ... Read more >>

Clin Cosmet Investig Dermatol (Clinical, cosmetic and investigational dermatology)
[2021, 14:561-573]

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Punicalagin Inhibited Inflammation and Migration of Fibroblast-Like Synoviocytes Through NF-κB Pathway in the Experimental Study of Rheumatoid Arthritis.

Mingcheng Huang, Keping Wu, Shan Zeng, Wenfen Liu, Tianjiao Cui, Zhiqing Chen, Lian Lin, Dongying Chen, Hui Ouyang,

<h4>Background</h4>The aggressive phenotype of fibroblast-like synoviocytes (FLSs) is essential in the synovitis and bone destruction in rheumatoid arthritis (RA). Punicalagin is a natural polyphenol extracted in pomegranate juice, which possesses antioxidant, anti-inflammatory and anti-tumor properties suggesting it may be a potent drug for RA therapy. However, there is paucity of ... Read more >>

J Inflamm Res (Journal of inflammation research)
[2021, 14:1901-1913]

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Dual-tautomerism separation method based on asymmetric transformation: Gram-scale preparation of high-purity punicalagin from pomegranate peel wastes.

Guangying Sun, Munire Abuduaini, Guliqire Adili, Yongxin Zhao, Haji Akber Aisa,

In this study, a special orthogonal separation method, named as dual-tautomerism separation (DTS), was developed for the purification of tautomeric compounds from complex matrixes. In DTS, isomers of these compounds are individually collected and asymmetrically transformed to the mixtures of isomers. After separating the mixture with an identical method, high-purity ... Read more >>

J Chromatogr A (Journal of chromatography. A)
[2021, 1651:462281]

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Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis.

FeiFei Liu, Hao Yang, DongZhe Li, XueJian Wu, QiCai Han,

<h4>Background</h4>Punicalagin (PUN) is a common anti-inflammatory polyphenol. However, the function and mechanism of PUN in osteoarthritis remains unknown.<h4>Methods</h4>Chondrocytes were isolated from rats, and confirmed by toluidine blue staining and immunofluorescence. Chondrocytes were challenged by lipopolysaccharide (LPS), and rat osteoarthritis model was established by Hulth method. The secretion of inflammatory factors, ... Read more >>

Bone (Bone)
[2021, 152:116070]

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Punicalagin and zinc (II) ions inhibit the activity of SARS-CoV-2 3CL-protease in vitro.

M J Saadh, A M Almaaytah, M Alaraj, M F Dababneh, I Sa'adeh, S M Aldalaen, A M Kharshid, A Alboghdadly, M Hailat, A Khaleel, K D Al-Hamaideh, W Abu Dayyih,

<h4>Objective</h4>Coronavirus 2019 (COVID-19) has now been declared as a worldwide pandemic. Currently, no drugs have been endorsed for its treatment; in this manner, a pressing need has been developed for any antiviral drugs that will treat COVID-19. Coronaviruses require the SARS-CoV-2 3CL-Protease (3CL-protease) for cleavage of its polyprotein to yield ... Read more >>

Eur Rev Med Pharmacol Sci (European review for medical and pharmacological sciences)
[2021, 25(10):3908-3913]

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Isolation and structure elucidation of cistusin: A new ellagitannin from Cistus × incanus L. leaves

Izabela Fecka, Maciej Włodarczyk, Aneta Starzec,

The leaves of Cistus × incanus L. (pink rock-rose) are used as plant material rich in antioxidants by the pharmaceutical and food industry. The main components which occur in pink rock-rose are polyphenols, especially flavonoids (glycosides of flavonols) and tannins (proanthocyanidins and ellagitannins). Derivatives of flavonols and flavan-3-ols as bioactive ... Read more >>

(Industrial crops and products.)
[2021, 158:Not Available]

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Synergistic In Vitro Antimicrobial Activity of Pomegranate Rind Extract and Zinc (II) against Micrococcus luteus under Planktonic and Biofilm Conditions.

Vildan Celiksoy, Rachael L Moses, Alastair J Sloan, Ryan Moseley, Charles M Heard,

Infectious diseases caused by microbial biofilms are a major clinical problem, and new antimicrobial agents that can inhibit biofilm formation and eradicate pre-formed biofilms are urgently needed. Pomegranate extracts are a well-established folkloric medicine and have been used in the treatment of infectious diseases since ancient times, whilst the addition ... Read more >>

Pharmaceutics (Pharmaceutics)
[2021, 13(6):]

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Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.

Feng Fu, Chaoyang Liu, Rui Shi, Man Li, Min Zhang, Yanyan Du, Qiaojuan Wang, Jun Li, Guoen Wang, Jianming Pei, Mingge Ding,

<b><i>Aims:</i></b> This study aims to explore the efficacy of punicalagin (PG) on diabetic cardiomyopathy (DCM), with a specific focus on the mechanisms underlying the effects of PG on mitochondrial fusion/fission dynamics. <b><i>Results:</i></b> Cardiac structural and functional abnormalities were ameliorated in diabetic rats receiving PG administration as evidenced by increased ejection ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2021, 35(8):618-641]

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Analysis of chemical compounds of pomegranate peel polyphenols and their antibacterial action against Ralstonia solanacearum

Xinxin Chen, Hengkai Zhang, Jianke Li, Li Chen,

The antibacterial action of pomegranate peel against plant pathogen Ralstonia solanacearum has been focused in this study. We identified the chemical composition of pomegranate peel polyphenols (PPPs) and expanded their antibacterial spectrum by adding a new member R. solanacearum. PPPs were consisting of punicalagin, ellagic acid, catechin, gallic acid, epicatechin, ... Read more >>

S Afr J Bot (South African journal of botany : official journal of the South African Association of Botanists = Suid-Afrikaanse tydskrif vir plantkunde : amptelike tydskrif van die Suid-Afrikaanse Genootskap van Plantkundiges)
[2021, 140:4-10]

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Polyphenol Diversity and Antioxidant Activity of European Cistus creticus L. (Cistaceae) Compared to Six Further, Partly Sympatric Cistus Species.

Brigitte Lukas, Laura Bragagna, Katharina Starzyk, Klaudia Labedz, Klaus Stolze, Johannes Novak,

This investigation focused on the qualitative and quantitative composition of polyphenolic compounds of Mediterranean northern shore <i>Cistus creticus</i> and six further, partly sympatric <i>Cistus</i> species (<i>C. albidus</i>, <i>C. crispus, C. ladanifer</i>, <i>C. monspeliensis</i>, <i>C. parviflorus</i>, <i>C. salviifolius</i>). Aqueous extracts of 1153 individual plants from 13 countries were analyzed via high ... Read more >>

Plants (Basel) (Plants (Basel, Switzerland))
[2021, 10(4):]

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Enhanced Skin Permeation of Punicalagin after Topical Application of Pluronic Micelles or Vesicles Loaded with Lafoensia pacari Extract.

Sandra Alves de Sousa Garcia, Priscila Bianca Rodrigues da Rocha, Bruno Dos Santos Souza, Andressa Tuane Santana Paz, Ana Luiza Caetano Negris, Ricardo Neves Marreto, Edemilson Cardoso da Conceição, Maria Teresa Freitas Bara, Stephânia Fleury Taveira,

Punicalagin, the principal ellagitannin of <i>Lafoensia pacari</i> leaves, has proven antioxidant activity, and standardized extracts of <i>L. pacari</i> can be topically used for skin aging management. We hypothesized that Pluronic nanomicelles or vesicles could solubilize sufficiently large amounts of the standardized extracts of <i>L. pacari</i> and provide chemical stability to punicalagin. The ... Read more >>

Planta Med (Planta medica)
[2021, :]

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Effects of Green Tea Powder, Pomegranate Peel Powder, Epicatechin and Punicalagin Additives on Antimicrobial, Antioxidant Potential and Quality Properties of Raw Meatballs.

Tuğba Demir,

Alternative technologies, which have been developed in order to meet the consumers' demand for nourishing and healthy meat and meat products, are followed by the food industry. In the present study, it was determined, using the HPLC method, that green tea contains a high level of epicatechin (EP) under optimal ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(13):]

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Punicalagin induces ROS-mediated apoptotic cell death through inhibiting STAT3 translocation in lung cancer A549 cells.

Le Fang, Hong Wang, Jie Zhang, Xiaolei Fang,

Lung cancer is a noxious disease with substandard overall survival. Despite this, there are several treatment strategies for lung cancer include chemotherapy, radiotherapy, surgery; however, the overall survival remains poor. Punicalagin has been documented as a potential phytomedicine to selectively inhibit the progression and expansion of numerous cancers. In the present study, we evaluated ... Read more >>

J Biochem Mol Toxicol (Journal of biochemical and molecular toxicology)
[2021, 35(6):1-10]

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An Insight into Anticancer Bioactives from Punica granatum (Pomegranate).

Kanika Sharma, Payal Kesharwani, Shiv Kumar Prajapati, Ankit Jain, Dolly Jain, Nishi Mody, Swapnil Sharma,

Cancer is one of the major reasons for mortality across the globe. Side effects that are observed with the pharmacological medications present in the market majorly affect the quality of life of patients. This has caused the researchers to find an alternative source of medications such as herbal medicine which ... Read more >>

Anticancer Agents Med Chem (Anti-cancer agents in medicinal chemistry)
[2021, :]

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The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro.

Nina A Hering, Julia Luettig, Britta Jebautzke, Jörg D Schulzke, Rita Rosenthal,

<b>Scope:</b> Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical application such as in intestinal diseases. The present study characterizes effects of punicalagin, ellagic acid and ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:610164]

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Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway.

Gaoran Ge, Jiaxiang Bai, Qing Wang, Xiaolong Liang, Huaqiang Tao, Hao Chen, Minggang Wei, Junjie Niu, Huilin Yang, Yaozeng Xu, Yuefeng Hao, Yi Xue, Dechun Geng,

Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the main clinical symptoms. In this study, we established a collagen-induced arthritis (CIA) model and found a large number of M1 macrophages and pyroptosis, which are ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2021, :]

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Metabolic changes in pomegranate fruit skin following cold storage promote chilling injury of the peel.

Ravi Singh Baghel, Alexandra Keren-Keiserman, Idit Ginzberg,

Pomegranate cv. 'Wonderful' fruit are susceptible to chilling injuries of the peel (CIp) when stored at 7 °C in modified-atmosphere bags for more than 3 months. The damage, manifested as superficial browning, is restricted to the fruit skin, i.e., the outer colored layer of the peel. To characterize possible causes of CIp ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):9141]

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Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications.

Shiyao Zhang, Mengyi Xu, Wenxiang Zhang, Chang Liu, Siyu Chen,

Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(11):]

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Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats.

Mohammad Nasehi, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Mohammad-Reza Zarrindast, Shahram Zarrabian,

Sleep deprivation has deteriorating effects on cognitive functions and activation of brain inflammation mechanisms has been reported by some studies following total sleep deprivation. Some studies have reported the health benefits of punicalagin, a main abstract from <i>Punica granatum</i> L., including those for the treatment of Alzheimer's disease. The antioxidant ... Read more >>

J Integr Neurosci (Journal of integrative neuroscience)
[2021, 20(1):87-93]

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Phytochemical Analysis Using UPLC-MSn Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of Phyllanthus emblica L. Habitat in Nepal.

Lingfang Wu, Qiunan Zhang, Wenyi Liang, Yongben Ma, Liying Niu, Lanzhen Zhang,

<i>Phyllanthus emblica</i> L. is widely used in traditional Tibetan medicine for its therapeutic effects on treating liver, kidney, and bladder problems. We have reported that the tannin fraction has a good anti-hepatocellular carcinoma effect, but its active ingredients are not clear. This study was to find the active ingredients of ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2021, 2021:6623791]

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Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro.

Ruikun Du, Laura Cooper, Zinuo Chen, Hyun Lee, Lijun Rong, Qinghua Cui,

The emerging SARS-CoV-2 infection is the cause of the global COVID-19 pandemic. To date, there are limited therapeutic options available to fight this disease. Here we examined the inhibitory abilities of two broad-spectrum antiviral natural products chebulagic acid (CHLA) and punicalagin (PUG) against SARS-CoV-2 viral replication. Both CHLA and PUG ... Read more >>

Antiviral Res (Antiviral research)
[2021, 190:105075]

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Recovery of Bioactive Compounds from Pomegranate (Punica granatum L.) Peel Using Pressurized Liquid Extraction.

Paula García, Carolina Fredes, Inés Cea, Jesús Lozano-Sánchez, Francisco Javier Leyva-Jiménez, Paz Robert, Cristina Vergara, Paula Jimenez,

Pressurized liquid extraction (PLE) is a clean and environmentally friendly alternative for the recovery of bioactive compounds from fruit by-products. Herein we focused on PLE for the extraction of bioactive compounds from pomegranate peel using a combination of pressurized water and ethanol. The main aim was to determine the optimal ... Read more >>

Foods (Foods (Basel, Switzerland))
[2021, 10(2):]

Cited: 2 times

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