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Pulmonary Interstitial Emphysema

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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Surgical outcomes and prognosis of non-small-cell lung cancer in patients with chronic lung diseases: a retrospective analysis.

Soohwan Choi, Jaekil Park,

OBJECTIVES:Lung cancer treatment in patients with chronic lung diseases is challenging because postoperative care is difficult and surgical outcomes are poorer than in patients with healthy lungs. This study aimed to examine postsurgical outcomes of patients with comorbid lung diseases treated for lung cancer. METHODS:This retrospective study enrolled 1526 patients ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, :]

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Pleuroparenchymal fibroelastosis in patients with idiopathic pulmonary fibrosis.

Song-I Lee, Eun Jin Chae, Joon Seon Song, Jae Ha Lee, Jin Woo Song,

BACKGROUND AND OBJECTIVE:PPFE is characterized by fibrosis in the pleura and subpleural lung parenchyma in the upper lobes, while other types of ILD, mainly UIP, can be observed in about half of the patients in their lower lobes. The aim of this study was to evaluate the clinical significance of ... Read more >>

Respirology (Respirology (Carlton, Vic.))
[2020, :]

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Usefulness of quantitative computed tomography analysis using a commercially available software program through its simple and automatic procedures in evaluation of emphysema and pulmonary fibrosis

Yoshiaki Kitaguchi, Keisaku Fujimoto, Masanori Yasuo, Yosuke Wada, Fumika Ueno, Takumi Kinjo, Satoshi Kawakami, Kiyoyasu Fukushima, Masayuki Hanaoka,

<title>Abstract</title> <p> Background The aim of this study was to investigate the usefulness of quantitative computed tomography (CT) analysis using a commercially available software program through its simple and automatic procedures. The software program, which was developed with the density mask technique using two thresholds, was used for ... Read more >>

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Low FVC/TLC in Preserved Ratio Impaired Spirometry (PRISm) is associated with features of and progression to obstructive lung disease.

Spyridon Fortis, Alejandro Comellas, Victor Kim, Richard Casaburi, John E Hokanson, James D Crapo, Edwin K Silverman, Emily S Wan,

One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from chest CT (FVC/TLCCT) among current ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5169]

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Rituximab effect in severe progressive connective tissue disease-related lung disease: preliminary data.

Alejandro Robles-Perez, Jordi Dorca, Ivan Castellví, Joan Miquel Nolla, Maria Molina-Molina, Javier Narváez,

Progressive connective tissue disease (CTD)-related lung disease is a challenging condition that requires lung transplantation in some patients. Treatment with rituximab may improve lung function. To evaluate the effect of rituximab in patients with progressive CTD-related lung disease who met criteria for inclusion in waiting list for a lung transplant. ... Read more >>

Rheumatol. Int. (Rheumatology international)
[2020, :]

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Respiratory surveillance in mineral dust-exposed workers.

Clare Wood, Deborah Yates,

Recently, there has been a worldwide resurgence in pneumoconiosis, or pulmonary fibrosis due to occupational mineral dust exposure. In Queensland, Australia, there has been a re-emergence of coal workers' pneumoconiosis and silicosis. Some coal mining communities have experienced a resurgence of progressive massive fibrosis in the USA and a worldwide ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(1):190632]

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Pulmonary Cystic Disease and Its Mimics.

Kirk D Jones,

Cystic diseases of the lung encompass a fairly broad variety of different diseases with causes including genetic abnormalities, smoking-related problems, developmental disorders, malignant neoplasms, and inflammatory processes. In addition, there are several diagnoses that closely resemble cystic lung disease, including cavitary diseases, cystic bronchiectasis, emphysema, and cystic changes in fibrosing ... Read more >>

Surg Pathol Clin (Surgical pathology clinics)
[2020, 13(1):141-163]

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Three cases of intra-abdominal free air onset associated with COPD treated conservatively.

Saki Shuto, Megumi Naka, Chisato Konishi, Koichi Maekawa,

Pneumoperitoneum is caused by respiratory disease in rare cases and can be treated conservatively. It is important to confirm physical abdominal examinations, laboratory data, and radiological findings to avoid unnecessary surgical procedures. The diagnosis of pneumoperitoneum associated with respiratory disease requires the exclusion of other fatal illnesses, especially gastrointestinal perforation. ... Read more >>

Clin Case Rep (Clinical Case Reports)
[2020, 8(3):428-432]

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Uncovering the mechanisms of exertional dyspnoea in combined pulmonary fibrosis and emphysema.

Camila M Costa, J Alberto Neder, Carlos G Verrastro, Marcelle Paula-Ribeiro, Roberta Ramos, Eloara M Ferreira, Luiz E Nery, Denis E O'Donnell, Carlos A C Pereira, Jaquelina Ota-Arakaki,

The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxaemia. However, there is little evidence to support these assumptions.We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, 55(1):]

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Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications.

Francesco Raimondi, Nadya Yousef, Fiorella Migliaro, Letizia Capasso, Daniele De Luca,

Lung ultrasound (LUS) is the latest amongst imaging techniques: it is a radiation-free, inexpensive, point-of-care tool that the clinician can use at the bedside. This review summarises the rapidly growing scientific evidence on LUS in neonatology, dividing it into descriptive and functional applications. We report the description of the main ... Read more >>

Pediatr. Res. (Pediatric research)
[0, :1-8]

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Lobe-specific outcomes of surgery for lung cancer patients with idiopathic interstitial pneumonias.

Mariko Fukui, Kazuya Takamochi, Kazuhiro Suzuki, Akihiro Hotta, Katsutoshi Ando, Takeshi Matsunaga, Shiaki Oh, Kenji Suzuki,

OBJECTIVE:Idiopathic interstitial pneumonias (IIPs) are predominantly encountered in the lower lobe, and frequently with concomitant emphysema that is predominantly in the upper lobe. However, the impact of the resection site on surgical outcomes of lung cancer with IIPs remains unclear. This study was conducted to evaluate the surgical outcome between ... Read more >>

Gen Thorac Cardiovasc Surg (General thoracic and cardiovascular surgery)
[2020, :]

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Characteristics of Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension Assessed by Echocardiography in a Three-Year Observational Cohort Study.

Shingo Nakayama, Shotaro Chubachi, Kaori Sakurai, Hidehiro Irie, Akihiro Tsutsumi, Mizuha Hashiguchi, Yuji Itabashi, Mitsushige Murata, Hidetoshi Nakamura, Koichiro Asano, Koichi Fukunaga,

Background:Pulmonary hypertension (PH) is a major comorbidity of chronic obstructive pulmonary disease (COPD). However, the association of PH detected by echocardiography and COPD-related outcome in longitudinal follow-up has not been elucidated. In this study, we aimed to investigate the relationship between clinical characteristics of COPD patients with PH detected by ... Read more >>

Int J Chron Obstruct Pulmon Dis (International Journal of Chronic Obstructive Pulmonary Disease)
[2020, 15:487-499]

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Phenotypic comparison between smoking and non-smoking chronic obstructive pulmonary disease.

Sundeep S Salvi, Bill B Brashier, Jyoti Londhe, Kanchan Pyasi, Vandana Vincent, Shilpa S Kajale, Sajid Tambe, Kuldeep Mandani, Arjun Nair, Sze Mun Mak, Sapna Madas, Sanjay Juvekar, Louise E Donnelly, Peter J Barnes,

BACKGROUND:Although COPD among non-smokers (NS-COPD) is common, little is known about this phenotype. We compared NS-COPD subjects with smoking COPD (S-COPD) patients in a rural Indian population using a variety of clinical, physiological, radiological, sputum cellular and blood biomarkers. METHODS:Two hundred ninety subjects (118 healthy, 79 S-COPD, 93 NS-COPD) performed pre- ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):50]

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Desquamative interstitial pneumonia in a non-smoker with neurofibromatosis type 1 (Von Recklinghausen syndrome).

Gustavo Ferrer, Alwiya Omar Saleh, Henry D Tazelaar, Andrea V Arrossi,

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with multiple systemic manifestations. Pulmonary involvement has been reported in the form of interstitial fibrosis, emphysema, pulmonary hypertension and thoracic neoplasm. We report a case of desquamative interstitial pneumonia in a non-smoker with NF1. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(1):]

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Follicular Bronchiolitis: Two Cases with Varying Clinical and Radiological Presentation.

Delyse Garg, Mohit Mody, Chaitanya Pal, Pratik Patel, Christina Migliore, Christine Minerowicz, Nikhil Madan,

Follicular bronchiolitis (FB) is a rare bronchiolar disorder associated with hyperplasia of the bronchial-associated lymphoid tissue (BALT). It is characterized by the development of lymphoid follicles with germinal centers in the walls of small airways. It falls under the category of lymphoproliferative pulmonary diseases (LPDs) and commonly occurs in relation ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:4564587]

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[Clinical features and prognosis of pneumocystis pneumonia in patients treated with rituximab for autoimmune diseases].

W Zhang, X Wang, Y Hu, J J Huang, Y Cheng, Z Jin, G F Wang,

Objective: To determine the clinical features and outcomes of pneumocystic pneumonia (PCP) in patients treated with rituximab for autoimmune diseases. Methods: PCP patients with autoimmune diseases as underlying diseases from January 2009 to April 2019 in Peking University First Hospital (male 67 cases, female 35 cases, age 17-79) were retrospectively ... Read more >>

Zhonghua Yi Xue Za Zhi (Zhonghua yi xue za zhi)
[2020, 100(8):614-618]

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Analysing the Clinical Features of Pneumomediastinum Associated with Diabetic Ketoacidosis in 79 Cases.

Weidong Zhang, Jingfang Chen, Xiaoming Wu, Luyu Chen, Jinxing Wei, Mingqiang Xue, Qingzheng Liang,

Objective:To analyse the clinical features of pneumomediastinum associated with DKA (diabetic ketoacidosis) to improve clinicians' understanding of the disease. Methods:A total of 78 patients with pneumomediastinum associated with DKA were identified in the literature search, and one patient treated in our hospital was included. The clinical features of the 79 ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2020, 13:405-412]

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Spontaneous Pneumomediastinum and Diffuse Subcutaneous Emphysema after Methamphetamine Inhalation.

Michael Agustin, Gabriel David, Ji Yeong Kang, Ornusa Teerasukjinda,

Methamphetamines are commonly abused drugs for their stimulant and euphoric effects. Inhaled and intravenous use may cause damage to the respiratory system. Spontaneous pneumomediastinum is a condition where changes in intrathoracic pressure leads to alveolar rupture and dissection of air along the tracheobronchial tree. Massive subcutaneous emphysema may result from ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:7538748]

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A Case Series of Vaping-Induced Lung Injury in a Community Hospital Setting.

Mohammed Ali, Kashmala Khan, Mihir Buch, Manuel Ramos-Ramirez, Munish Sharma, Seema Patel, Saiara Choudhury, Humayun Anjum, Alamgir Khan, Salim Surani,

Acute and subacute injury to the lung parenchyma can be caused by multiple products. Over the past few years, vaping (also known as E-cigarettes) has become a popular trend and has been considered "safer" alternative to smoking cigarettes, especially among young adults. The use of E-cigarettes has rapidly increased, and ... Read more >>

Case Rep Pulmonol (Case reports in pulmonology)
[2020, 2020:9631916]

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Classification of Interstitial Lung Abnormality Patterns with an Ensemble of Deep Convolutional Neural Networks.

David Bermejo-Peláez, Samuel Y Ash, George R Washko, Raúl San José Estépar, María J Ledesma-Carbayo,

Subtle interstitial changes in the lung parenchyma of smokers, known as Interstitial Lung Abnormalities (ILA), have been associated with clinical outcomes, including mortality, even in the absence of Interstitial Lung Disease (ILD). Although several methods have been proposed for the automatic identification of more advanced Interstitial Lung Disease (ILD) patterns, ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):338]

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[Pulmonary complications in cocaine users].

M Underner, G Peiffer, J Perriot, N Jaafari,

Cocaine can be responsible for many psychiatric and/or somatic disorders. The aim of this systematic literature review of data was to expose relations between cocaine use and pulmonary complications. Cocaine can be responsible for acute respiratory symptoms (cough, black sputum, hemoptysis, dyspnea, wheezing, chest pain) and for various pulmonary disorders ... Read more >>

Rev Mal Respir (Revue des maladies respiratoires)
[2020, 37(1):45-59]

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Comorbidity in idiopathic pulmonary fibrosis - what can biomarkers tell us?

Tiago M Alfaro, Carlos Robalo Cordeiro,

Idiopathic pulmonary fibrosis (IPF) is characterized by progressive parenchymal scarring, leading to dyspnoea, respiratory failure and premature death. Although IPF is confined to the lungs, the importance of IPF comorbidities such as pulmonary hypertension and ischaemic heart disease, lung cancer, emphysema/chronic obstructive pulmonary disease, gastroesophageal reflux, sleep apnoea and depression ... Read more >>

Ther Adv Respir Dis (Therapeutic advances in respiratory disease)
[2020, 14:1753466620910092]

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Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation. Mechanistic Implications for Desquamative Interstitial Pneumonitis.

Takuji Suzuki, Cormac McCarthy, Brenna C Carey, Michael Borchers, David Beck, Kathryn A Wikenheiser-Brokamp, Dianna Black, Claudia Chalk, Bruce C Trapnell,

Desquamative interstitial pneumonia (DIP) is a rare, smoking-related, diffuse parenchymal lung disease characterized by marked accumulation of alveolar macrophages (AMs) and emphysema, without extensive fibrosis or neutrophilic inflammation. Because smoking increases expression of pulmonary GM-CSF (granulocyte/macrophage-colony stimulating factor) and GM-CSF stimulates proliferation and activation of AMs, we hypothesized that chronic ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(1):87-94]

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Moraxella catarrhalis bacteremic pneumonia.

Hiroki Anezaki, Norohiko Terada, Takahisa Kawamura, Hanako Kurai,

An 81-year-old man with lung cancer with bone metastases, interstitial pneumonia, and emphysema, was hospitalized for pain control. He developed fever and chills during hospitalization. Physical examination revealed a fever of 39.1 °C, but there were no findings on history or physical examination to suggest the source of the infection. Gram-negative ... Read more >>

IDCases (IDCases)
[2020, 19:e00712]

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