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Full Text Journal Articles about
Pulmonary Function Testing

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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation.

Dandan Wang, Jiajie Zhang, Yan Sun, Nan Lv, Jianwei Sun,

Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells.Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):498-505]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Incorporation of methotrexate into coconut oil nanoemulsion potentiates its antiproliferation activity and attenuates its oxidative stress.

Mayson H Alkhatib, Shaza A Alyamani, Faiza Abdu,

Methotrexate (MTX), a chemotherapeutic agent, has limited clinical applications due to its pulmonary and neurotoxicity. The antineoplastic activity of MTX-NE COCO, which is MTX formulated in coconut oil nanoemulsion (NE), was evaluated in A549 non-small cell lung cancer cells while its adverse side effects on the oxidative stress of the ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):422-430]

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Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury.

Iman O Sherif, Alaa A Alshaalan, Nora H Al-Shaalan,

Remote renal injury is a drastic consequence of hepatic ischemia/reperfusion (IR) injury. Vildagliptin (V) is a dipeptidyl peptidase-4 inhibitor that has a hepatorenal protective effect against models of liver and renal IR. This research was done to explore the protective role of vildagliptin against renal injury following hepatic IR injury ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):208-215]

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Clinicopathologic characteristics and outcomes of lupus nephritis with positive antineutrophil cytoplasmic antibody.

Shuai Wang, Jin Shang, Jing Xiao, Zhanzheng Zhao,

Aims: The aim was to determine whether anti-neutrophil cytoplasmic antibody (ANCA)-positive serology in patients with lupus nephritis (LN) is associated with different clinicopathologic features and outcomes.Methods: In our retrospective analysis, 283 patients were enrolled between 2013 and 2018. Thirty-six patients were ANCA-positive, and this group was compared with the remaining ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):244-254]

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Serum osteoprotegerin level is positively associated with peripheral artery disease in patients with peritoneal dialysis.

Wei-Chen Lin, Jen-Pi Tsai, Yu-Hsien Lai, Yu-Li Lin, Chiu-Huang Kuo, Chih-Hsien Wang, Bang-Gee Hsu,

Osteoprotegerin (OPG) is a potential biomarker of cardiovascular disease complications and severity. Peripheral arterial disease (PAD) is associated with an increased risk of death in patients on peritoneal dialysis (PD). Therefore, this study aimed to evaluate the relationship between serum OPG levels and PAD by measuring the ankle-brachial index (ABI) ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):131-136]

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The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19.

Liang Su, Xiang Ma, Huafeng Yu, Zhaohua Zhang, Pengfei Bian, Yuling Han, Jing Sun, Yanqin Liu, Chun Yang, Jin Geng, Zhongfa Zhang, Zhongtao Gai,

This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):707-713]

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Comparison of microwave ablation treatments in patients with renal secondary and primary hyperparathyroidism.

Haoyang Ma, Chun Ouyang, Yaoyu Huang, Changying Xing, Chen Cheng, Wei Liu, Donglan Yuan, Ming Zeng, Xiangbao Yu, Haibin Ren, Yanggang Yuan, Lina Zhang, Fangyan Xu, Ying Cui, Wenkai Ren, Hui Huang, Hanyang Qian, Boqiang Fan, Ningning Wang,

Purpose: Microwave ablation (MWA) is feasible for severe renal secondary hyperparathyroidism (SHPT) and primary hyperparathyroidism (PHPT) patients ineligible for parathyroidectomy (PTX). Here we compared the clinical manifestations and characteristics of parathyroid glands in these two groups, and summarized the techniques, safety and efficacy of MWA.Methods: Baseline clinical characteristics, ablation-related techniques, ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):66-76]

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Inhibition of SARS-CoV 3CL protease by flavonoids.

Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim,

There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):145-151]

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High-dose ulinastatin to prevent late-onset acute renal failure after orthotopic liver transplantation.

Haijin Lv, Xuxia Wei, Xiaomeng Yi, Jianrong Liu, Pinglan Lu, Mi Zhou, Yuling An, Huimin Yi,

Purpose: To compare the efficacy and safety of two distinct doses of ulinastatin on late-onset acute renal failure (LARF) following orthotopic liver transplantation (OLT).Methods: The high-risk recipients that underwent OLT were divided into two groups according to ulinastatin dose: low-dose (LD) ulinastatin group, 0.8 million U/d; high-dose (HD) ulinastatin group, ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):137-145]

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Effectively suppressed angiogenesis-mediated retinoblastoma growth using celastrol nanomicelles.

Zhanrong Li, Zhihua Guo, Dandan Chu, Huayang Feng, Junjie Zhang, Lei Zhu, Jingguo Li,

Celastrol, a Chinese herbal medicine, has already shown an inhibition effect on retinoblastoma growth activity in our previous research, but its mechanism is not well understood. Angiogenesis is a main driving force in many tumors. Here, we studied whether celastrol could inhibit angiogenesis-mediated retinoblastoma growth, if so, through what mechanism. ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):358-366]

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TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm.

Shuo Wang, Chenhong Jia,

The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is still unclear. Transient receptor ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):59-68]

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Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury.

Xin Chen, Yan Chai, Shao-Bo Wang, Jia-Chong Wang, Shu-Yuan Yue, Rong-Cai Jiang, Jian-Ning Zhang,

Hypothalamic-pituitary-adrenal axis dysfunction may lead to the occurrence of critical illness-related corticosteroid insufficiency. Critical illness-related corticosteroid insufficiency can easily occur after traumatic brain injury, but few studies have examined this occurrence. A multicenter, prospective, cohort study was performed to evaluate the function of the hypothalamic-pituitary-adrenal axis and the incidence of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1259-1265]

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control.

Xin Wang, Kaiyuan Deng, Cheng Wang, Yao Li, Tianqi Wang, Zhi Huang, Yakun Ma, Peiqing Sun, Yi Shi, Shengyong Yang, Yan Fan, Rong Xiang,

A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identification of compound X22 with a nanomolar potency against CDK4 and CDK9 and potent antiproliferative ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):414-423]

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Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.

Yuan Zhang, Xin Meng, Haikang Tang, Minghui Cheng, Fujun Yang, Wenqing Xu,

Mutation of the proto-oncogene K-Ras is one of the most common molecular mechanisms in non-small cell lung cancer. Many drugs for treating lung cancer have been developed, however, due to clinical observed K-Ras mutations, corresponding chemotherapy and targeted therapy for such mutation are not efficient enough. In this study, on ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):344-353]

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Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study.

Alaa A-M Abdel-Aziz, Adel S El-Azab, Nawaf A AlSaif, Mohammed M Alanazi, Manal A El-Gendy, Ahmad J Obaidullah, Hamad M Alkahtani, Abdulrahman A Almehizia, Ibrahim A Al-Suwaidan,

Cyclic imides containing 3-benzenesulfonamide, oxime, and β-phenylalanine derivatives were synthesised and evaluated to elucidate their in vivo anti-inflammatory and ulcerogenic activity and in vitro cytotoxic effects. Most active anti-inflammatory agents were subjected to in vitro COX-1/2 inhibition assay. 3-Benzenesulfonamides (2-4, and 9), oximes (11-13), and β-phenylalanine derivative (18) showed potential anti-inflammatory activities with ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):610-621]

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Clinical observation and management of COVID-19 patients.

Taisheng Li, Hongzhou Lu, Wenhong Zhang,

Three leading infectious disease experts in China were invited to share their bedside observations in the management of COVID-19 patients. Professor Taisheng Li was sent to Wuhan to provide frontline medical care. He depicts the clinical course of SARS-CoV-2 infection. Furthermore, he observes the significant abnormality of coagulation function and ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):687-690]

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The prevalence of viral infections in children with cystic fibrosis in a tertiary care center in Saudi Arabia.

Hanaa Banjar, Mohammad Chaballout, Kawthar Karkour, Hadeel Al-Ghamdi, Ibrahim Al-Mogarri, Sami Al-Haider, Imran Nizami, Rawia Raja, Ali AlNakhli,

IntroductionStudies have shown that pulmonary exacerbations in cystic fibrosis (CF) patients are associated with respiratory viruses. The most common agent causing viral infections in patients with CF before the age of 3 years is respiratory syncytial virus.ObjectivesTo obtain the prevalence of the different types of viral infection in CF patients ... Read more >>

Int J Pediatr Adolesc Med (International Journal of Pediatrics & Adolescent Medicine)
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The 6-min walk test in the functional evaluation of patients with lung cancer qualified for lobectomy.

Stefan Wesolowski, Tadeusz M Orlowski, Marek Kram,

OBJECTIVES:The American College of Chest Physicians guidelines recommend low-technology exercise tests in the functional evaluation of patients with lung cancer considered for resectional surgery. However, the 6-min walk test (6MWT) is not included, because the data on its clinical value are inconsistent. Our goal was to evaluate the 6MWT in ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2020, 30(4):559-564]

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Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment.

Yi Le, Yiyuan Gan, Yihong Fu, Jiamin Liu, Wen Li, Xue Zou, Zhixu Zhou, Zhenchao Wang, Guiping Ouyang, Longjia Yan,

In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) and three human cancer cell lines including A549, PC-3, and SMMC-7721. The results displayed that some of the compounds had good activities, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):555-564]

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Lung Transplantation for Bronchopulmonary Dysplasia in Adults: A Clinical and Pathologic Study of 3 Cases.

Natalia Liu, Oscar W Cummings, Amir Lagstein, Chadi A Hage, Kevin M Chan, Chen Zhang,

Bronchopulmonary dysplasia (BPD) is usually seen in premature infants who require mechanical ventilation and oxygen therapy for acute respiratory distress. Although most patients wean from oxygen therapy by the ages of 2 to 3, rehospitalization for respiratory problems is common in these patients in adulthood. There have been few studies ... Read more >>

Am. J. Surg. Pathol. (The American journal of surgical pathology)
[2020, 44(4):509-515]

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Longitudinal functional changes with clinically significant radiographic progression in idiopathic pulmonary fibrosis: are we following the right parameters?

Marco Mura, Nada Taha, Dejanira D'Amato, Karishma Hosein, Tiziana Ranalli, Gianluigi Sergiacomi, Maurizio Zompatori,

<title>Abstract</title> <p> Background . Progression of the disease in idiopathic pulmonary fibrosis (IPF) is difficult to predict, due to its variable and heterogenous course. The relationship between radiographic progression and functional decline in IPF is unclear. We sought to confirm that a simple HRCT fibrosis visual score is ... Read more >>

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