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Pulmonary Eosinophilia

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Eosinophilic Pneumonia and Lymphadenopathy Associated With Vaping and Tetrahydrocannabinol Use.

Eric S Mull, Guliz Erdem, Kathleen Nicol, Brent Adler, Richard Shell,

Idiopathic acute eosinophilic pneumonia is a rare and potentially life-threatening condition that is defined by bilateral pulmonary infiltrates and fever in the presence of pulmonary eosinophilia. It often presents acutely in previously healthy individuals and can be difficult to distinguish from infectious pneumonia. Although the exact etiology of idiopathic acute ... Read more >>

Pediatrics (Pediatrics)
[2020, :]

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Tegafur/gimeracil/oteracil-induced eosinophilic pneumonia.

Toshiyuki Sumi, Hisashi Nakata, Yuji Mori, Hiroki Takahashi,

Clinicians should be aware that eosinophilic pneumonia is one of the types of drug-induced lung injury that can be caused by tegafur/gimeracil/oteracil (TS-1). ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(4):e00551]

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Relationship of Blood Eosinophils with Fractional Exhaled Nitric Oxide and Pulmonary Function Parameters in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation.

Bin Tang, Dan Huang, Jun Wang, Lin-Lin Luo, Qiu-Gen Li,

BACKGROUND The 2018 Global Initiative for Chronic Obstructive Lung Disease Report reveals that the blood eosinophil count could forecast the risk of flare-ups. This study explored the correlations of blood eosinophils with fractional exhaled nitric oxide (FeNO) and pulmonary function parameters in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921182]

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Hospitalisation patterns of patients with interstitial lung disease in the light of comorbidities and medical treatment – a German claims data analysis.

Julia Wälscher, Sabine Witt, Larissa Schwarzkopf, Michael Kreuter,

BackgroundInterstitial lung disease (ILD) is a heterogeneous group of mainly chronic lung diseases differing in disease course and prognosis. For most subtypes, evidence on relevance and outcomes of hospitalisations is lacking.MethodsUsing German claims data we investigated number of hospitalisations (zero-inflated-negative-binomial models providing rate ratios (RR)) and time to first hospitalisation ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21:]

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Exon 8 KIT mutation and pulmonary eosinophilia.

Diana Betancor, Karin Lazo Plaza, Jose Cano Eguez, Parameswaran Nair, Michael Trus,

Allergy (Allergy)
[2020, :]

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Lack of IL-1 Receptor Signaling Reduces Spontaneous Airway Eosinophilia in Juvenile Mice with Muco-Obstructive Lung Disease.

Ryan Brown, Michelle Paulsen, Simone Schmidt, Jolanthe Schatterny, Angela Frank, Stephanie Hirtz, Rebecca Delaney, Declan Doherty, Matthias Hagner, Cliff Taggart, Sinéad Weldon, Marcus A Mall,

Previous studies demonstrated spontaneous type 2 airway inflammation with eosinophilia in juvenile Scnn1b (sodium channel, non-voltage-gated 1, β-subunit)-transgenic (Scnn1b-Tg) mice with muco-obstructive lung disease. IL-1 receptor (IL-1R) signaling has been implicated in allergen-driven airway disease; however, its role in eosinophilic inflammation in muco-obstructive lung disease remains unknown. In this study, ... Read more >>

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(3):300-309]

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It Takes 1 for Type 2: IL-1 Receptor Mediates Eosinophilia in Scnn1b Transgenic Mice.

Ana M Jaramillo, Christopher M Evans,

Am. J. Respir. Cell Mol. Biol. (American journal of respiratory cell and molecular biology)
[2020, 62(3):269-270]

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Unilateral antibiotic-induced acute eosinophilic pneumonia on the operative side after surgery for primary lung cancer: a case report.

Yasufumi Goda, Tsuyoshi Shoji, Hiromichi Katakura,

BACKGROUND:Acute eosinophilic pneumonia (AEP) is a rare idiopathic lung disease characterized by pulmonary eosinophilia. The epidemiology of AEP remains understudied; however, past reports have reported that AEP can be caused by an allergic reaction to medications, such as antibiotics or inhaled antigens, such as tobacco smoke. AEP usually occurs bilaterally. ... Read more >>

Surg Case Rep (Surgical case reports)
[2020, 6(1):40]

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Severe clopidogrel-induced DRESS with eosinophilic pneumonia associated with Epstein-Barr virus reactivation.

Yuji Inagaki, Kazunobu Tachibana, Yasushi Inoue, Takahiko Kasai, Yoshikazu Inoue,

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a type of hypersensitivity drug reaction. Here, we report the case of a 78-year-old man who presented with a rash, fever, dry cough, and swollen parotid glands who had been prescribed clopidogrel for one year. Computed tomography showed consolidation and interlobular ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00541]

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Real-Life Study of Mepolizumab in Idiopathic Chronic Eosinophilic Pneumonia.

Emeline Brenard, Charles Pilette, Caroline Dahlqvist, Benoît Colinet, Florence Schleich, Florence Roufosse, Antoine Froidure,

INTRODUCTION:Idiopathic chronic eosinophilic pneumonia (ICEP) is an orphan lung disease characterized by concomitant systemic and local eosinophilia, along with bilateral lung infiltrates. Symptoms include dyspnea of subacute/chronic onset, cough, and general systemic signs. Although all patients do respond to oral corticosteroids, relapse rate is very high, which highlights the need ... Read more >>

Lung (Lung)
[2020, :]

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Three New Cases of Melioidosis, Guadeloupe, French West Indies.

Bénédicte Melot, Sylvaine Bastian, Nathalie Dournon, Eric Valade, Olivier Gorgé, Anne Le Fleche, Charlotte Idier, Mireille Vernier, Elisabeth Fernandes, Bruno Hoen, Sébastien Breurec, Michel Carles,

Melioidosis has been detected in the Caribbean, and an increasing number of cases has been reported in the past few decades, but only 2 cases were reported in Guadeloupe during the past 20 years. We describe 3 more cases that occurred during 2016-2017 and examine arguments for increasing endemicity. ... Read more >>

Emerging Infect. Dis. (Emerging infectious diseases)
[2020, 26(3):617-619]

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Strongyloides Hyperinfection Associated with Enterococcus faecalis Bacteremia, Meningitis, Ventriculitis and Gas-Forming Spondylodiscitis: A Case Report.

Liang En Wee, Su Wai Khin Hnin, Zheyu Xu, Lawrence Soon-U Lee,

An elderly Singaporean male with no travel history was hospitalized for fever and altered mental status. Blood cultures grew Enterococcus faecalis, and given a preceding history of steroid use and peripheral eosinophilia, Strongyloides hyperinfection was suspected. Stool specimens were positive for Strongyloides stercoralis larvae over four days, and larvae were ... Read more >>

Trop Med Infect Dis (Tropical medicine and infectious disease)
[2020, 5(1):]

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Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes.

G Daniel Brooks,

Uncontrolled asthma continues to be a problem for many patients with moderate-to-severe allergic asthma. Dupilumab, which blocks the receptors for interleukin-4 and interleukin-13, has been effective in reducing asthma exacerbations, improving forced expiratory volume in one second (FEV1), and reducing oral corticosteroid use. When selecting patients for dupilumab, it is ... Read more >>

Ther Clin Risk Manag (Therapeutics and Clinical Risk Management)
[2020, 16:181-187]

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Asthma and hypercapnic respiratory failure.

P K Shamil, Nitesh Gupta, Sumita Agrawal, Pranav Ish, Shibdas Chakrabarti,

Hypercapnia is an uncommon entity in asthma exacerbation. Meticulous evaluation for the underlying aetiology of hypercapnia is warranted in these patients. http://bit.ly/2sTKTk2. ... Read more >>

Breathe (Sheff) (Breathe (Sheffield, England))
[2020, 16(1):190311]

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Eosinophils, Basophils, and Type 2 Immune Microenvironments in COPD-Affected Lung Tissue.

Prajakta Jogdand, Premkumar Siddhuraj, Michiko Mori, Caroline Sanden, Jimmie Jönsson, Andrew F Walls, Jennifer Kearley, Alison A Humbles, Roland Kolbeck, Leif Bjermer, Paul Newbold, Jonas S Erjefält,

Although elevated blood or sputum eosinophils are present in many patients with chronic obstructive pulmonary disease (COPD), uncertainties remain regarding the anatomical distribution pattern of lung-infiltrating eosinophils. Basophils have remained virtually unexplored in COPD. This study mapped tissue-infiltrating eosinophils, basophils, and eosinophil-promoting immune mechanisms in COPD-affected lungs.Surgical lung tissue and ... Read more >>

Eur. Respir. J. (The European respiratory journal)
[2020, :]

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How Common is Eosinophilia in Tuberculosis? Case Report.

Hansa Haftu, Kibeten Tadese, Teklu Gebrehiwot, Hagos Gebregziabher,

Though peripheral blood eosinophilia is common due to allergic diseases, drugs, parasitic infections, and malignancies, it is rarely reported due to tuberculosis (TB). The association between eosinophilia and TB is not well known. We have a case of the 9-year-old female present with abdominal pain in the right upper quadrant which ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2020, 11:59-63]

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Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.

Axel Dietschmann, Sebastian Schruefer, Sven Krappmann, David Voehringer,

Repeated inhalation of airborne conidia derived from the fungus Aspergillus fumigatus (Af) can lead to a severe eosinophil-dominated inflammatory condition of the lung termed allergic bronchopulmonary aspergillosis (ABPA). ABPA affects about 5 million individuals worldwide and the mechanisms regulating lung pathology in ABPA are poorly understood. Here, we used a ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2020, :]

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IL-17 regulates dendritic cell migration to the peribronchial lymph nodes and allergen presentation in experimental allergic asthma.

Adan Chari Jirmo, Mandy Busse, Christine Happle, Jelena Skuljec, Kathleen Dalüge, Anika Habener, Ruth Grychtol, David S DeLuca, Oliver D Breiholz, Immo Prinz, Gesine Hansen,

IL-17 is associated with different phenotypes of asthma, however, it is not fully elucidated how it influences induction and maintenance of asthma and allergy. In order to determine the role of IL-17 in development of allergic asthma, we used IL-17A/F double knockout (IL-17A/F KO) and wild type (wt) mice with ... Read more >>

Eur. J. Immunol. (European journal of immunology)
[2020, :]

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Acute Eosinophilic Pneumonia: A Rare Complication of Daptomycin Therapy.

Michael H Storandt, Abhishek Matta,

Daptomycin is a cyclic lipopeptide antibiotic with great efficacy targeting gram-positive cocci, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococcus. Acute eosinophilic pneumonia is a rare complication of daptomycin therapy, with a poorly understood etiology thought to involve the accumulation of the drug in pulmonary surfactant inducing inflammation. We present a 56-year-old male with ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6803]

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Discordant bilateral bronchoalveolar lavage findings in a patient with acute eosinophilic pneumonia associated with counterfeit tetrahydrocannabinol oil vaping.

Daniel Puebla Neira, Sarah Tambra, Vibha Bhasin, Ranjana Nawgiri, Alexander G Duarte,

Vaping has emerged as a popular alternative form of inhalation of nicotine and marihuana derivates (including Tetrahydrocannabinol, THC) in part due to the avoidance of combustion byproducts. Unfortunately, THC oil (especially that produced by unregulated individuals) may contain dilutants such as propylene glycol, vitamin E, and flavoring ingredients that can ... Read more >>

Respir Med Case Rep (Respiratory medicine case reports)
[2020, 29:101015]

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Strongyloides stercoralis hyperinfection syndrome presenting as mechanical ileus after short-course oral steroids for chronic obstructive pulmonary disease (COPD) exacerbation.

Kathrin Rothe, Juri Katchanov, Jochen Schneider, Christoph D Spinner, Veit Phillip, Dirk H Busch, Dennis Tappe, Rickmer Braren, Roland M Schmid, Julia Slotta-Huspenina,

We report a case of a fatal Strongyloides stercoralis hyperinfection syndrome (SHS) in a migrant from Kenya, who had been living in Germany for three decades. A short-course oral steroid treatment for Chronic Obstructive Pulmonary Disease (COPD) exacerbation had been administered four weeks prior to the presentation. The initial clinical ... Read more >>

Parasitol. Int. (Parasitology international)
[2020, 76:102087]

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Vaping-Associated Respiratory Distress Syndrome: Case Classification and Clinical Guidance.

Craig M Lilly, Shahzad Khan, Kathryn Waksmundzki-Silva, Richard S Irwin,

Exposure to vaping is associated with a growing list of respiratory syndromes including an acute progressive form with life-threatening hypoxemic respiratory failure and pathologic changes of lung injury termed vaping-associated respiratory distress syndrome. Data Sources:Center from Disease Control, Departments of Public Health, MEDLINE (via PubMed), and the Cochrane Library. Study ... Read more >>

Crit Care Explor (Critical care explorations)
[2020, 2(2):e0081]

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Promising Effects of Benralizumab on Chronic Eosinophilic Pneumonia.

Kohsuke Isomoto, Tomohisa Baba, Akimasa Sekine, Naoto Aiko, Takashi Ogura,

We herein report a case of refractory chronic eosinophilic pneumonia (CEP) complicated with uncontrolled bronchial asthma, in which remission was successfully induced with single dose of benralizumab, a monoclonal antibody against the alpha-chain of the interleukin-5 receptor. Resolution of the patient's symptoms and consolidation on chest X-ray were observed at ... Read more >>

Intern. Med. (Internal medicine (Tokyo, Japan))
[2020, :]

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A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification.

Farah Zarka, Charles Veillette, Jean-Paul Makhzoum,

Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establishing the right diagnosis of a vasculitis mimic will prevent unnecessary immunosuppressive therapy. ... Read more >>

Int J Rheumatol (International journal of rheumatology)
[2020, 2020:8392542]

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Association between peripheral blood/bronchoalveolar lavage eosinophilia and significant oxygen requirements in patients with acute eosinophilic pneumonia.

Joon Young Choi, Jeong Uk Lim, Ho Jung Jeong, Ji Eun Lee, Chin Kook Rhee,

BACKGROUND:We investigated the association between a combination of two markers, peripheral (PEC) and bronchoalveolar lavage (BAL) eosinophil percentage (BEP), and oxygen requirements in patients with acute eosinophilic pneumonia (AEP). METHODS:We retrospectively reviewed the medical records of patients with AEP treated at the Armed Forces Capital Hospital between May 2012 and ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):22]

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