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Therapeutic sildenafil inhibits pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.

Zhouxin Ren, Jiansheng Li, Junling Shen, Haibin Yu, Xiaofeng Mei, Peng Zhao, Zhenya Xiao, Wanliu Wu,

Context: Clinical reports showed sildenafil beneficial therapy on severe chronic obstructive pulmonary disease (COPD) with pulmonary hypertension (PH) patients.Objective: The study investigated therapeutic effects of silenafil on pulmonary damage induced by cigarette smoke exposure and bacterial inhalation in rats.Materials and methods: Female Sprague-Dawley rats (200-250 g) were divided into control group ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2020, 58(1):116-123]

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TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm.

Shuo Wang, Chenhong Jia,

The natural outcome of abdominal aortic aneurysm (AAA) is that of slow progression and ultimate rupture, then a life-threatening hemorrhage consequently. Ruptured AAA is a dramatic catastrophe and constitutes one of the leading causes of acute death in elderly men. However, the mechanism of AAA is still unclear. Transient receptor ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2020, 14(1):59-68]

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The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases.

Lei Gu, Wei Liu, Meng Ru, Jing Lin, Guoqing Yu, Jia Ye, Zheng-An Zhu, Yuebin Liu, Jian Chen, Guoxiang Lai, Wen Wen,

BACKGROUND:Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. CASE PRESENTATION:This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, ... Read more >>

BMC Pulm Med (BMC Pulmonary Medicine)
[2020, 20(1):65]

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Effect of Pressure-Controlled Ventilation-Volume Guaranteed on One-Lung Ventilation in Elderly Patients Undergoing Thoracotomy.

Wenyu Yao, Mingyuan Yang, Qinghao Cheng, Shiqiang Shan, Bo Yang, Qian Han, Jun Ma,

BACKGROUND Volume-controlled ventilation (VCV) in one-lung ventilation (OLV) is most commonly used in thoracotomy, but pressure-controlled ventilation-volume guaranteed (PCV-VG) is used in elderly patients to improve arterial oxygenation, reduce inflammatory factors, and decrease acute lung injury (ALI). The purpose of this study was to investigate the effects of these 2 ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e921417]

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Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia.

Yuchao Guo, Ruifeng Liu, Lianfeng Chen, Wei Wu, Shuyang Zhang,

BACKGROUND:This study investigated neutrophil activation and neutrophil-derived extracellular traps formation in coronary artery ectasia. METHODS:We enrolled 90 patients who underwent coronary angiography, and included 30 patients with coronary artery ectasia (CAE), 30 patients with obstructive coronary artery disease (CAD) and 30 patients with normal coronary arteries (CON). Intra-neutrophil mean myeloperoxidase ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):101]

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Abdominal and pelvic radiographs of medical devices and materials-Part 1: gastrointestinal and vascular devices and materials.

Rishi Philip Mathew, Medica Sam, Timothy Alexander, Vimal Patel, Gavin Low,

When compared with chest radiographs, medical devices of the abdomen and pelvis are less frequently seen. However, with recent advances in technology the interpreting radiologists are seeing more medical objects on these radiographs. The identification of these devices and materials are crucial for not only enabling the radiologist to understand ... Read more >>

Diagn Interv Radiol (Diagnostic and interventional radiology (Ankara, Turkey))
[2020, 26(2):101-110]

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Honeycomb lung-like structures resulting from clustering of traction bronchiectasis distally in sarcoidosis.

Michiru Sawahata, Noriharu Shijubo, Takeshi Johkoh, Koichi Hagiwara, Satoshi Konno, Tetsuo Yamaguchi,

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known ... Read more >>

Respirol Case Rep (Respirology case reports)
[2020, 8(3):e00539]

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Left Ventricular Noncompaction and Congenital Heart Disease Increases the Risk of Congestive Heart Failure.

Keiichi Hirono, Yukiko Hata, Nariaki Miyao, Mako Okabe, Shinya Takarada, Hideyuki Nakaoka, Keijiro Ibuki, Sayaka Ozawa, Naoki Yoshimura, Naoki Nishida, Fukiko Ichida, Lvnc Study Collaborators,

BACKGROUND:Left ventricular noncompaction (LVNC) is a hereditary cardiomyopathy that is associated with high morbidity and mortality rates. Recently, LVNC was classified into several phenotypes including congenital heart disease (CHD). However, although LVNC and CHD are frequently observed, the role and clinical significance of genetics in these cardiomyopathies has not been ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(3):]

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Interstage management of pulmonary blood flow after the Norwood procedure with right ventricle-to-pulmonary artery conduit.

Takashi Yasukawa, Takaya Hoashi, Masataka Kitano, Masatoshi Shimada, Kenta Imai, Kenichi Kurosaki, Hajime Ichikawa,

OBJECTIVES:Our goal was to assess the efficacy of managing pulmonary blood flow from the Norwood procedure with a right ventricle-to-pulmonary artery (RV-PA) conduit until stage 2 palliation (S2P). METHODS:Among 48 consecutive patients undergoing the Norwood procedure between 2008 and 2018, 40 (83.3%) patients who survived to discharge were included in ... Read more >>

Eur J Cardiothorac Surg (European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery)
[2020, :]

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The Neutrophil Percentage-to-Albumin Ratio Is Associated with All-Cause Mortality in Critically Ill Patients with Acute Kidney Injury.

Benji Wang, Diwen Li, Bihuan Cheng, Binyu Ying, Yuqiang Gong,

Background There is no evidence to suggest the predictive power of neutrophil percentage-to-albumin ratio (NPAR) in patients with acute kidney injury (AKI). We hypothesized that NPAR would correlate with all-cause mortality in critically ill patients with AKI. Methods From the MIMIC-III V1.4 database, we extracted demographics, vital signs, comorbidities, laboratory ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:]

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Melatonin receptor agonist protects against acute lung injury induced by ventilator through up-regulation of IL-10 production.

Geng-Chin Wu, Chung-Kan Peng, Wen-I Liao, Hsin-Ping Pao, Kun-Lun Huang, Shi-Jye Chu,

BACKGROUND:It is well known that ventilation with high volume or pressure may damage healthy lungs or worsen injured lungs. Melatonin has been reported to be effective in animal models of acute lung injury. Melatonin exerts its beneficial effects by acting as a direct antioxidant and via melatonin receptor activation. However, ... Read more >>

Respir. Res. (Respiratory research)
[2020, 21(1):65]

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Depletion of CD4 and CD8 Positive T Cells Impairs Venous Thrombus Resolution in Mice.

Subhradip Mukhopadhyay, Joel Gabre, Christine Chabasse, Jonathan S Bromberg, Toni M Antalis, Rajabrata Sarkar,

Resolution of deep venous thrombosis involves coordinated inflammatory processes. T cells regulate inflammation in vivo and modulate vascular remodeling in other settings, but their role in venous thrombus resolution remains undefined. To determine the role of T cells in venous thrombus resolution in vivo, stasis induced thrombi were created by ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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A rare case of mesenteric vessel thrombosis post caesarian section-An underdiagnosed entity.

Richa Pawar, Komal Brar, Chanchal Malhotra, Sonia Chhabra, Deepshikha Rana, Anubha Gupta,

INTRODUCTION:Respiratory distress is an uncommon clinical event after caesarean section and occurs due to pulmonary thromboembolism. Various causes of pulmonary thromboembolism are thrombophlebitis, ovarian venous thrombosis and mesenteric vein thrombosis. PRESENTATION OF CASE:We report a case of 30 year old female who presented with respiratory distress after eight days of ... Read more >>

Int J Surg Case Rep (International journal of surgery case reports)
[2020, 68:170-173]

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Chemokine Receptor 5, a Double-Edged Sword in Metabolic Syndrome and Cardiovascular Disease.

Zhongwen Zhang, Qiannan Wang, Jinming Yao, Xiaojun Zhou, Junyu Zhao, Xiaoqian Zhang, Jianjun Dong, Lin Liao,

The key characteristic of cardiovascular disease (CVD) is endothelial dysfunction, which is likely the consequence of inflammation. It is well demonstrated that chemokines and their receptors play a crucial role in regulating inflammatory responses, and recently, much attention has been paid to chemokine receptor 5 (CCR5) and its ligands. For ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2020, 11:146]

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The relationship between exercise capacity and neutrophil//lymphocyte ratio in patients taken to cardiopulmonary rehabilitation program.

Okan S,

OBJECTIVES:The aim of the present study was to evaluate the relationship between exercise capacity and n/lymphocyte ratio (NLR) in patients enrolled in a cardiopulmonary rehabilitation program. BACKGROUND:NLR has recently been used as a potential marker to determine inflammation in cardiac and non-cardiac diseases. METHODS:In this retrospective study, an exercise test ... Read more >>

Bratisl Lek Listy (Bratislavske lekarske listy)
[2020, 121(3):206-210]

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Intravital Microscopy of the Beating Murine Heart to Understand Cardiac Leukocyte Dynamics.

Nathaniel H Allan-Rahill, Michael R E Lamont, William M Chilian, Nozomi Nishimura, David M Small,

Cardiovascular disease is the leading cause of worldwide mortality. Intravital microscopy has provided unprecedented insight into leukocyte biology by enabling the visualization of dynamic responses within living organ systems at the cell-scale. The heart presents a uniquely dynamic microenvironment driven by periodic, synchronous electrical conduction leading to rhythmic contractions of ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:92]

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Clinical characteristics of 25 death cases infected with COVID-19 pneumonia: a retrospective review of medical records in a single medical center, Wuhan, China

Xun Li, Luwen Wang, Shaonan Yan, Fan Yang, Longkui Xiang, Jiling Zhu, Bo Shen, Zuojiong Gong,

Summary Background The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) is a highly infectious disease, which was occurred in Wuhan, Hubei Province, China in December 2019. As of February 13, 2020, a total of 59883 cases of COVID-19 in China have been confirmed and 1368 patients have died from ... Read more >>

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Spontaneous Pulmonary Hypertension Associated With Systemic Sclerosis in P-Selectin Glycoprotein Ligand 1-Deficient Mice.

Rafael González-Tajuelo, María de la Fuente-Fernández, Daniel Morales-Cano, Antonio Muñoz-Callejas, Elena González-Sánchez, Javier Silván, Juan Manuel Serrador, Susana Cadenas, Bianca Barreira, Marina Espartero-Santos, Carlos Gamallo, Esther F Vicente-Rabaneda, Santos Castañeda, Francisco Pérez-Vizcaíno, Ángel Cogolludo, Luis Jesús Jiménez-Borreguero, Ana Urzainqui,

OBJECTIVE:Pulmonary arterial hypertension (PAH), one of the major complications of systemic sclerosis (SSc), is a rare disease with unknown etiopathogenesis and noncurative treatments. As mice deficient in P-selectin glycoprotein ligand 1 (PSGL-1) develop a spontaneous SSc-like syndrome, we undertook this study to analyze whether they develop PAH and to examine ... Read more >>

(Arthritis & rheumatology (Hoboken, N.J.))
[2020, 72(3):477-487]

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Computed Tomography Images of Fibrotic Pulmonary Sarcoidosis Leading to Chronic Respiratory Failure.

Michiru Sawahata, Takeshi Johkoh, Takeshi Kawanobe, Chiyoko Kono, Yosikazu Nakamura, Masashi Bando, Koichi Hagiwara, Tamiko Takemura, Fumikazu Sakai, Noriharu Shijubo, Satoshi Konno, Tetsuo Yamaguchi,

BACKGROUND:There is currently no consensus on the morphology of severe fibrotic pulmonary sarcoidosis, and we examined computed tomography (CT) findings and progression. METHODS:We analyzed findings in 10 consecutive patients (three men, seven women) with pulmonary sarcoidosis requiring oxygen therapy for chronic respiratory failure, who were extracted from >2500 sarcoidosis patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(1):]

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Standardized image interpretation and post-processing in cardiovascular magnetic resonance - 2020 update : Society for Cardiovascular Magnetic Resonance (SCMR): Board of Trustees Task Force on Standardized Post-Processing.

Jeanette Schulz-Menger, David A Bluemke, Jens Bremerich, Scott D Flamm, Mark A Fogel, Matthias G Friedrich, Raymond J Kim, Florian von Knobelsdorff-Brenkenhoff, Christopher M Kramer, Dudley J Pennell, Sven Plein, Eike Nagel,

With mounting data on its accuracy and prognostic value, cardiovascular magnetic resonance (CMR) is becoming an increasingly important diagnostic tool with growing utility in clinical routine. Given its versatility and wide range of quantitative parameters, however, agreement on specific standards for the interpretation and post-processing of CMR studies is required ... Read more >>

J Cardiovasc Magn Reson (Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance)
[2020, 22(1):19]

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Peripheral Blood Platelet-Lymphocyte Ratio Is Good Predictor of Chemosensitivity and Prognosis in Gastric Cancer Patients.

Yuka Ohe, Sachio Fushida, Takahisa Yamaguchi, Jun Kinoshita, Hiroto Saito, Koichi Okamoto, Keishi Nakamura, Hidehiro Tajima, Itasu Ninomiya, Tetsuo Ohta,

Introduction:Platelets are one factor promoting tumor development. Conversely, lymphocytes are one factor for immune protection. The peripheral blood platelets-lymphocyte ratio (PLR) is useful as an inflammation/immune indicator to predict postoperative recurrence and prognosis of a variety of malignancies. The peripheral blood neutrophil-lymphocyte ratio (NLR) has also been reported as a ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:1303-1311]

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P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation.

Alexandre Mansour, Christilla Bachelot-Loza, Nicolas Nesseler, Pascale Gaussem, Isabelle Gouin-Thibault,

The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted to the primary and secondary prevention of arterial thrombosis. Indeed, it has been established that platelet activation also has an essential ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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The therapeutic impact of human neonatal BMSC in a right ventricular pressure overload model in mice.

Rong Liufu, Guocheng Shi, Xiaomin He, Jingjing Lv, Wei Liu, Fang Zhu, Chen Wen, Zhongqun Zhu, Huiwen Chen,

OBJECTIVE:To determine the impact of donor age on the therapeutic effect of bone marrow-derived mesenchymal stem cells (BMSCs) in treating adverse remodeling as the result of right ventricle (RV) pressure overload. METHODS:BMSCs were isolated from neonatal (< 1 month), infant (1 month to 1 year), and young children (1 year to 5 years) and were compared ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):96]

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CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma.

Chia-Chia Chao, Chiang-Wen Lee, Tsung-Ming Chang, Po-Chun Chen, Ju-Fang Liu,

Osteosarcoma, the most common of all bone malignancies, has a high likelihood of lung metastasis. Up until now, the molecular mechanisms involved in osteosarcomas with lung metastases are not clearly understood. Recent observations have shown that the chemokine CXCL1 and its receptor CXCR2 assist with the homing of neutrophils into ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

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Ticagrelor Increases SIRT1 and HES1 mRNA Levels in Peripheral Blood Cells from Patients with Stable Coronary Artery Disease and Chronic Obstructive Pulmonary Disease.

Giorgio Aquila, Francesco Vieceli Dalla Sega, Luisa Marracino, Rita Pavasini, Laura Sofia Cardelli, Anna Piredda, Alessandra Scoccia, Valeria Martino, Francesca Fortini, Ilaria Bononi, Fernanda Martini, Marco Manfrini, Antonio Pannuti, Roberto Ferrari, Paola Rizzo, Gianluca Campo,

Ticagrelor is a powerful P2Y12 inhibitor with pleiotropic effects in the cardiovascular system. Consistently, we have reported that in patients with stable coronary artery disease (CAD) and concomitant chronic obstructive pulmonary disease (COPD) who underwent percutaneous coronary intervention (PCI), 1-month treatment with ticagrelor was superior in improving biological markers of ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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