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Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder.

Xiao-Lie He, Li Yang, Zhao-Jie Wang, Rui-Qi Huang, Rong-Rong Zhu, Li-Ming Cheng,

Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative that exerts neuroprotective effects through anti-inflammatory and antioxidant effects. Curcumin exhibits antidepressant effects in the treatment of major depressive disorder. To investigate the antidepressant effects of solid lipid nanoparticles loaded with both curcumin and dexanabinol, and the underlying mechanisms associated with this ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):537-542]

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"The COVID-19 Pandemic and its Effect on Mental Health in USA - A Review with Some Coping Strategies".

Barnali Bhattacharjee, Tathagata Acharya,

The COVID-19 pandemic has resulted in enormous losses in terms of human lives and economy in United States. The outbreak has been continuing to heavily impact the mental health of people. Developing key strategies to prevent mental illnesses is extremely important for the well-being of people. A survey conducted during ... Read more >>

Psychiatr Q (The Psychiatric quarterly)
[2020, 91(4):1135-1145]

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Adherence to safety and self-isolation guidelines, conspiracy and paranoia-like beliefs during COVID-19 pandemic in Poland - associations and moderators.

Joachim Kowalski, Marta Marchlewska, Zuzanna Molenda, Paulina Górska, Łukasz Gawęda,

Highlights • Conspiracy beliefs concerning coronavirus are present in the population and are negatively related to adherence to epidemiological safety guidelines.• Conspiracy beliefs may originate partially from boredom and paranoia proneness.• Certain factors – trust in media outlets and internal motivation to isolation – may be potentially worthwhile to address ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, :]

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Targeting affect leads to reduced paranoia in people with psychosis: a single case series.

Daniel Silva, Tess Maguire, Pamela McSherry, Katherine Newman-Taylor,

BACKGROUND:Current psychological interventions for psychosis focus primarily on cognitive and behavioural management of delusions and hallucinations, with modest outcomes. Emotions are not usually targeted directly, despite evidence that people with psychosis have difficulty identifying, accepting and modifying affective states. AIMS:This study assessed the impact of emotion regulation skills practice on ... Read more >>

Behav Cogn Psychother (Behavioural and cognitive psychotherapy)
[2020, :1-12]

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Problems in measuring the JTC-bias in patients with psychotic disorders with the fish task: A secondary analysis of a baseline assessment of a randomized controlled trial

Nico Pytlik, Daniel Soll, Klaus Hesse, Steffen Moritz, Andreas Bechdolf, Jutta Herrlich, Tilo Kircher, Stefan Klingberg, Martin Landsberg, Bernhard Müller, Georg Wiedemann, Andreas Wittorf, Wolfgang Wölwer, Michael Wagner, Stephanie Mehl,

Abstract Background: The jumping to conclusions bias (JTC) is considered to be an important causal factor in theoretical models on the formation and maintenance of delusions. However, recent meta-analytic findings show a rather equivocal pattern of results regarding associations between JTC and delusions. Thus, the aim of the present preregistered ... Read more >>

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Countertransference in Forensic Inpatient Settings: An Empirical Examination of Therapist Responses to Patients With Psychotic Disorders.

Louis De Page, Marie Boulanger, Bénédicte De Villers, Patrizio Di Virgilio, Thierry Pham, Xavier Saloppé, Benjamin Thiry,

OBJECTIVE:Countertransference in forensic inpatient settings has received little empirical attention despite frequent emotional reactions in staff members, such as anger, disgust, or fear. In this exploratory study, we investigated countertransference in two forensic medium-secure units for patients with psychotic disorders. METHOD:We measured countertransference using the Therapist Response Questionnaire and measured ... Read more >>

J Forensic Nurs (Journal of forensic nursing)
[2020, :]

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Measuring Fidelity to Evidence-Based Practices: Psychometrics.

T Ruud, R E Drake, G R Bond,

This special section presents the psychometric properties of fidelity scales used in a national mental health services project in Norway to improve the quality of care of people with psychoses. Across Norway, 39 clinical units in six health trusts participated. The project provided education, implementation support and fidelity assessments. The ... Read more >>

Adm Policy Ment Health (Administration and policy in mental health)
[2020, 47(6):871-873]

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Reduction in social learning and increased policy uncertainty about harmful intent is associated with pre-existing paranoid beliefs: Evidence from modelling a modified serial dictator game.

Joseph M Barnby, Vaughan Bell, Mitul A Mehta, Michael Moutoussis,

Current computational models suggest that paranoia may be explained by stronger higher-order beliefs about others and increased sensitivity to environments. However, it is unclear whether this applies to social contexts, and whether it is specific to harmful intent attributions, the live expression of paranoia. We sought to fill this gap ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2020, 16(10):e1008372]

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Virtual Reality-based Interventions for Patients with Paranoia

Elham Monaghesh, Taha Samad-Soltani, Sara Farhang,

Abstract Background : Paranoia is an important psychiatric symptom with an important effect on daily life. Virtual reality (VR) based treatments are suggested as an effectual treatment for patients with paranoia, facilitating learning. To our knowledge, there is a lack of systematic reviews to evaluate VR-based treatment as a treatment ... Read more >>

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Association of cannabis use-related predictor variables and self-reported psychotic disorders: US adults, 2001-2002 and 2012-2013

Ofir Livne, Dvora Shmulewitz, Aaron Sarvet, Deborah Hasin,

Objective: To determine the association of cannabis use-related variables and self-reported psychotic disorders during two time periods (2001-2002; 2012-2013). Methods: Logistic regression was used to analyze data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC, 2001-2002; N=43,093) and NESARC-III (2012-2013; N=36,309). Among those with and without cannabis ... Read more >>

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Heart rate variability as an index of emotion (dys)regulation in psychosis?

Annika Clamor, Lea Ludwig, Tania M Lincoln,

The vagally-mediated heart rate variability (HRV), an indicator of the autonomic nervous system (ANS), has been proposed as a transdiagnostic marker for emotion regulation (ER). In people with psychotic disorders (PSY), HRV is profoundly reduced compared to healthy controls (HC). Similarly, questionnaire-based assessments of adaptive ER point to a deficit ... Read more >>

Int J Psychophysiol (International journal of psychophysiology : official journal of the International Organization of Psychophysiology)
[2020, :]

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Excess Mortality and Life-Years Lost in People With Schizophrenia and Other Non-affective Psychoses: An 11-Year Population-Based Cohort Study.

Nicholas Chak Lam Yung, Corine Sau Man Wong, Joe Kwun Nam Chan, Eric Yu Hai Chen, Wing Chung Chang,

Psychotic disorders are associated with premature mortality, but research was primarily based on Western countries and rarely examined non-affective psychoses other than schizophrenia (ONAP). This population-based cohort study investigated excess mortality in 46 896 schizophrenia and 20 651 ONAP patients between January 2006 and December 2016 in Hong Kong (HK), ... Read more >>

Schizophr Bull (Schizophrenia bulletin)
[2020, :]

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Implementation of guidelines on family involvement for persons with psychotic disorders in community mental health centres (IFIP): protocol for a cluster randomised controlled trial.

Lars Hestmark, Maria Romøren, Kristin Sverdvik Heiervang, Bente Weimand, Torleif Ruud, Reidun Norvoll, Kristiane Myckland Hansson, Irene Norheim, Eline Aas, Elisabeth Geke Marjan Landeweer, Reidar Pedersen,

BACKGROUND:Family involvement for persons with psychotic disorders is under-implemented in mental health care, despite its firm scientific, economic, legal and moral basis. This appears to be the case in Norway, despite the presence of national guidelines providing both general recommendations on family involvement and support in the health- and care ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):934]

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Dissociable mechanisms underpinning effort-cost decision-making across the psychosis spectrum.

Alexis E Whitton, Jaisal T Merchant, Kathryn E Lewandowski,

Recent theoretical models propose that abnormal effort-cost decision-making (ECDM) likely has divergent underpinnings across mood and psychotic disorders. However, whether this same model applies to individuals across the psychosis spectrum, including individuals with affective psychosis, remains unclear. This study aimed to empirically test whether two component processes - working memory ... Read more >>

Schizophr Res (Schizophrenia research)
[2020, :]

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COVID-19 telehealth challenges for patients with schizophrenia and other psychoses.

Paul A Maguire, Jeffrey Cl Looi,

Aust N Z J Psychiatry (The Australian and New Zealand journal of psychiatry)
[2020, :4867420968887]

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Paranoia, hallucinations and compulsive buying during the early phase of the COVID-19 outbreak in the United Kingdom: A preliminary experimental study.

B Lopes, C Bortolon, R Jaspal,

This study examines the impact of COVID-19 (in the early phase of the outbreak) on symptoms of psychosis, namely paranoia and hallucinations. Three hundred and sixty-one people in the United Kingdom participated in a 2 (self-isolation vs. no self-isolation) x 2 (perceived COVID-19 symptomatology vs. no perceived COVID-19 symptomatology) x ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 293:113455]

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Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study.

Noriaki Hirakawa, Hironori Kuga, Yoji Hirano, Jinya Sato, Naoya Oribe, Itta Nakamura, Shogo Hirano, Takefumi Ueno, Yuko Oda, Osamu Togao, Akio Hiwatashi, Hiroshi Honda, Shigenobu Kanba, Toshiaki Onitsuka,

There may be different neural bases between subjects with epilepsy only (EP) and interictal chronic epilepsy psychosis (EPS). However, there have been few structural MRI studies of EPS. The current study was conducted to investigate the neural substrate of EPS. T1-weighted images were analyzed in 14 patients with EPS and ... Read more >>

Brain Imaging Behav (Brain imaging and behavior)
[2020, 14(5):1382-1387]

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Causal Links between Major Depressive Disorder and Insomnia: A Mendelian Randomisation Study.

Lei Cai, Yiran Bao, Xiaoqian Fu, Hongbao Cao, Ancha Baranova, Xiangrong Zhang, Jing Sun, Fuquan Zhang,

Both Major depressive disorder (MDD) and insomnia are two common mental disorders. However, the inherent and comprehensive genetic factors causing the links between MDD and insomnia are unclear yet. Here, based on GWAS results for each disorder, we used linkage disequilibrium (LD) score regression analysis and a multi-single nucleotide polymorphism ... Read more >>

Gene (Gene)
[2020, :145271]

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An alternative approach to future diagnostic standards for major depressive disorder.

Yong-Ku Kim, Seon-Cheol Park,

During the period extending from 1780 to 1880, the conceptualization of melancholia changed from an intellectual to a mood model. The modern view of depression, based on Kraepelinian dualism, has reflected changes in opinion on psychiatric taxonomy of individual melancholia. From the point of view of an "operational revolution," the ... Read more >>

Prog Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry)
[2020, 105:110133]

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Behind the opaque curtain: A 20-year longitudinal study of dissociative and first-rank symptoms in schizophrenia-spectrum psychoses, other psychoses and non-psychotic disorders.

Clara Humpston, Martin Harrow, Cherise Rosen,

BACKGROUND:Depersonalization and derealization are currently considered diagnostically distinct from first-rank symptoms (FRS) seen in schizophrenia-spectrum psychoses. Nevertheless, the lived experiences of these symptoms can be very similar phenomenologically. AIMS:To investigate the interrelationships between depersonalization, derealization and FRS in individuals with different types of psychotic and non-psychotic diagnoses. METHODS:The Chicago Follow-up ... Read more >>

Schizophr. Res. (Schizophrenia research)
[2020, :]

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Psychiatric Disorders and Hydroxychloroquine for Coronavirus Disease 2019 (COVID-19): A VigiBase Study.

Philippe Garcia, Alexis Revet, Antoine Yrondi, Vanessa Rousseau, Yannick Degboe, François Montastruc,

INTRODUCTION:In the stressful context of the coronavirus disease 2019 (COVID-19) pandemic, some reports have raised concerns regarding psychiatric disorders with the use of hydroxychloroquine. In this study, we reviewed all psychiatric adverse effects with hydroxychloroquine in COVID-19 patients, as well as in other indications, reported in VigiBase, the World Health ... Read more >>

Drug Saf (Drug safety)
[2020, :]

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TNF-α inhibitors and psychiatric adverse drug reactions in the spectrum of bipolar (manic) or psychotic disorders: Analysis from the French pharmacovigilance database.

Cécile Marie Yelnik, Louise Gaboriau, Nadine Petitpain, Hélène Théophile, Emmanuel Delaporte, Louise Carton, Sophie Gautier, Marc Lambert,

OBJECTIVE:This study aimed to describe reports of psychiatric adverse drug reaction (ADR) in the spectrum of bipolar (manic features) or psychotic disorders that occurred under tumor necrosis factor alpha (TNF-α) inhibitors therapy. METHODS:We searched the French pharmocovigilance database for reports of psychiatric ADR in the spectrum of bipolar (manic features) ... Read more >>

Therapie (Therapie)
[2020, :]

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Link between childhood trauma and psychotic-like experiences in non-affected siblings of schizophrenia patients: A case-control study.

Feten Fekih-Romdhane, Tasnim Nsibi, Hadhami Sassi, Majda Cheour,

AIM:Prior research has consistently demonstrated a relationship between childhood trauma (CT) exposure and an increased risk of developing psychotic-like experiences (PLE) and disorders. Studying the link between CT and PLE in non-clinical populations with or without genetic risk factors could help elucidate the etiopathogeny of psychotic disorders, by removing the ... Read more >>

Early Interv Psychiatry (Early intervention in psychiatry)
[2020, :]

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A Temporal Network Approach to Paranoia: A Pilot Study.

Alba Contreras, Carmen Valiente, Alexandre Heeren, Richard Bentall,

Paranoid beliefs have been conceptualized as a central psychological process linked to schizophrenia and many mental disorders. Research on paranoia has indicated that it is pivotal to consider not only levels but also dynamic aspects of incriminated related mechanisms over time. In the present study, we conceptualized paranoia as a ... Read more >>

Front Psychol (Frontiers in psychology)
[2020, 11:544565]

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The Acceptability and Feasibility of Using Text Messaging to Support the Delivery of Physical Health Care in those Suffering from a Psychotic Disorder: a Review of the Literature.

Henry Griffiths,

Those suffering with serious mental illness (SMI), such as psychotic disorders, experience life expectancy 15 years shorter than the general population. Cardiovascular disease is the biggest cause of death in those with psychotic disease and many risk factors may be limited by healthy lifestyle choices. Text messaging interventions represent mobile health ... Read more >>

Psychiatr Q (The Psychiatric quarterly)
[2020, 91(4):1305-1316]

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