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Psychiatric Disorders Associated With Epilepsy

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Prevalence and associated factors of depression among people with epilepsy in Mekelle, Tigray, Ethiopia, 2019.

Jemal Seid, Kalayu Mebrahtu,

<title>Abstract</title> <p> Background - Epilepsy is the world’s most common neurological disorder, affecting approximately 50 million people worldwide and contributed to different psychiatric illness. Depression is one of the most frequent co morbid psychiatric disorders that affects the life of the patients. This comorbidity in people with epilepsy ... Read more >>

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Psychiatric Comorbidities and Psychiatric Medication Use Are Highly Prevalent in Patients With Eosinophilic Esophagitis and Associate With Clinical Presentation.

Craig C Reed, S Ryanne Corder, Erin Kim, Emily Sanders, Manaswita Tappata, Swathi Eluri, Evan S Dellon,

OBJECTIVES:The prevalence of psychiatric disease in patients with eosinophilic esophagitis (EoE) is not fully characterized. We aimed to determine the prevalence of psychiatric disease and centrally acting medication use in a cohort of children and adults with EoE and evaluated whether psychiatric disease affects the EoE clinical presentation. METHODS:We conducted ... Read more >>

Am. J. Gastroenterol. (The American journal of gastroenterology)
[2020, :]

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Mental and somatic comorbidity of depression: a comprehensive cross-sectional analysis of 202 diagnosis groups using German nationwide ambulatory claims data.

Annika Steffen, Julia Nübel, Frank Jacobi, Jörg Bätzing, Jakob Holstiege,

BackgroundDepression is frequently accompanied by other mental disorders and various somatic diseases; however, previous comorbidity studies often relied on self-reported data and have not simultaneously assessed the entire spectrum of mental and somatic diagnoses. The aim is to provide a complete picture of mental and somatic comorbidity of depression in ... Read more >>

BMC Psychiatry (BMC Psychiatry)
[2020, 20:]

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Deviations in early hippocampus development contribute to visual hallucinations in schizophrenia.

Arnaud Cachia, Claire Cury, Jérôme Brunelin, Marion Plaze, Christine Delmaire, Catherine Oppenheim, François Medjkane, Pierre Thomas, Renaud Jardri,

Auditory hallucinations (AHs) are certainly the most emblematic experiences in schizophrenia, but visual hallucinations (VHs) are also commonly observed in this developmental psychiatric disorder. Notably, several studies have suggested a possible relationship between the clinical variability in hallucinations' phenomenology and differences in brain development/maturation. In schizophrenia, impairments of the hippocampus, ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):102]

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Prevalence of depression and associated factors among epileptic patients at Ilu Ababore zone hospitals, South West Ethiopia, 2017: a cross‑sectional study.

Nigus Alemnew Engidaw, Lemi Bacha, Adamu Kenea,

Background:Depression is one of the most common and overwhelming mental disorder in patients with epilepsy. Despite its high prevalence, depression continues to be under-recognized and undertreated. This study aimed to assess the prevalence of depression and its associated factors among epileptic patients attending the outpatient department of Ilu Ababore zone ... Read more >>

Ann Gen Psychiatry (Annals of general psychiatry)
[2020, 19:19]

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Depressive symptoms and its associated factors among prisoners in Debre Berhan prison, Ethiopia.

Yared Reta, Ruth Getachew, Melese Bahiru, Betelhem Kale, Keralem Workie, Yohannes Gebreegziabhere,

BACKGROUND:Depression is a common mental disorder among prisoners characterized by a mood change involving a feeling of sadness, lack of interest, or hopelessness that lasts for weeks, months, or even longer. Besides imprisonment, depression is the primary factor leading to suicidal attempts. However, little is known about the depressive status ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0220267]

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Lowered Paraoxonase 1 Activities May Explain the Comorbidities Between Temporal Lobe Epilepsy or Mesial Temporal Sclerosis and Comorbid Depression, Anxiety and Psychosis

Ana Paula Michelin, Mchael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania Gastaldello Moreira, Buranee Kanchanatwan, Décio Sabbatini Barbosa,

Background: Temporal lobe epilepsy (TLE) is the most common focal epilepsy subtype in adults and is frequently accompanied by depression, anxiety and psychosis. Aberrations in total paraoxonase (PON)1 status may occur in TLE and those psychiatric conditions. Methods: We examined paraoxonase (PON)1 status, namely Q192R PON1 genotypes and PON1 enzymatic ... Read more >>

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Sociodemographic and Clinical Variables of Depression among Patients with Epilepsy in a Neuropsychiatric Hospital in Nigeria.

Nasir Olamide Madandola, Shehu Sale, Adebayo Sunday Adebisi, Ayodele Obembe, Auwal S Salihu, Abdulfatai Tomori Bakare, Ishak Abioda Danjuma,

Background:Depression is a major contributor to the global burden of disease. Its occurrence in patients living with epilepsy is not just common but also a serious comorbidity. Patients tend to suffer if the depressive disorder is undetected and thus untreated. The aim of this study is to estimate the prevalence ... Read more >>

Depress Res Treat (Depression research and treatment)
[2020, 2020:2953074]

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ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.

Paul M Thompson, Neda Jahanshad, Christopher R K Ching, Lauren E Salminen, Sophia I Thomopoulos, Joanna Bright, Bernhard T Baune, Sara Bertolín, Janita Bralten, Willem B Bruin, Robin Bülow, Jian Chen, Yann Chye, Udo Dannlowski, Carolien G F de Kovel, Gary Donohoe, Lisa T Eyler, Stephen V Faraone, Pauline Favre, Courtney A Filippi, Thomas Frodl, Daniel Garijo, Yolanda Gil, Hans J Grabe, Katrina L Grasby, Tomas Hajek, Laura K M Han, Sean N Hatton, Kevin Hilbert, Tiffany C Ho, Laurena Holleran, Georg Homuth, Norbert Hosten, Josselin Houenou, Iliyan Ivanov, Tianye Jia, Sinead Kelly, Marieke Klein, Jun Soo Kwon, Max A Laansma, Jeanne Leerssen, Ulrike Lueken, Abraham Nunes, Joseph O' Neill, Nils Opel, Fabrizio Piras, Federica Piras, Merel C Postema, Elena Pozzi, Natalia Shatokhina, Carles Soriano-Mas, Gianfranco Spalletta, Daqiang Sun, Alexander Teumer, Amanda K Tilot, Leonardo Tozzi, Celia van der Merwe, Eus J W Van Someren, Guido A van Wingen, Henry Völzke, Esther Walton, Lei Wang, Anderson M Winkler, Katharina Wittfeld, Margaret J Wright, Je-Yeon Yun, Guohao Zhang, Yanli Zhang-James, Bhim M Adhikari, Ingrid Agartz, Moji Aghajani, André Aleman, Robert R Althoff, Andre Altmann, Ole A Andreassen, David A Baron, Brenda L Bartnik-Olson, Janna Marie Bas-Hoogendam, Arielle R Baskin-Sommers, Carrie E Bearden, Laura A Berner, Premika S W Boedhoe, Rachel M Brouwer, Jan K Buitelaar, Karen Caeyenberghs, Charlotte A M Cecil, Ronald A Cohen, James H Cole, Patricia J Conrod, Stephane A De Brito, Sonja M C de Zwarte, Emily L Dennis, Sylvane Desrivieres, Danai Dima, Stefan Ehrlich, Carrie Esopenko, Graeme Fairchild, Simon E Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Hugh P Garavan, David C Glahn, Nynke A Groenewold, Tiril P Gurholt, Boris A Gutman, Tim Hahn, Ian H Harding, Dennis Hernaus, Derrek P Hibar, Frank G Hillary, Martine Hoogman, Hilleke E Hulshoff Pol, Maria Jalbrzikowski, George A Karkashadze, Eduard T Klapwijk, Rebecca C Knickmeyer, Peter Kochunov, Inga K Koerte, Xiang-Zhen Kong, Sook-Lei Liew, Alexander P Lin, Mark W Logue, Eileen Luders, Fabio Macciardi, Scott Mackey, Andrew R Mayer, Carrie R McDonald, Agnes B McMahon, Sarah E Medland, Gemma Modinos, Rajendra A Morey, Sven C Mueller, Pratik Mukherjee, Leyla Namazova-Baranova, Talia M Nir, Alexander Olsen, Peristera Paschou, Daniel S Pine, Fabrizio Pizzagalli, Miguel E Rentería, Jonathan D Rohrer, Philipp G Sämann, Lianne Schmaal, Gunter Schumann, Mark S Shiroishi, Sanjay M Sisodiya, Dirk J A Smit, Ida E Sønderby, Dan J Stein, Jason L Stein, Masoud Tahmasian, David F Tate, Jessica A Turner, Odile A van den Heuvel, Nic J A van der Wee, Ysbrand D van der Werf, Theo G M van Erp, Neeltje E M van Haren, Daan van Rooij, Laura S van Velzen, Ilya M Veer, Dick J Veltman, Julio E Villalon-Reina, Henrik Walter, Christopher D Whelan, Elisabeth A Wilde, Mojtaba Zarei, Vladimir Zelman, ,

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in health and disease. Building on large-scale genetic studies that discovered the first robustly replicated genetic loci associated ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):100]

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A Link between Genetic Disorders and Cellular Impairment, Using Human Induced Pluripotent Stem Cells to Reveal the Functional Consequences of Copy Number Variations in the Central Nervous System-A Close Look at Chromosome 15.

Alessia Casamassa, Daniela Ferrari, Maurizio Gelati, Massimo Carella, Angelo Luigi Vescovi, Jessica Rosati,

Recent cutting-edge human genetics technology has allowed us to identify copy number variations (CNVs) and has provided new insights for understanding causative mechanisms of human diseases. A growing number of studies show that CNVs could be associated with physiological mechanisms linked to evolutionary trigger, as well as to the pathogenesis ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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Prevalence and factors associated with suicidal behavior among adolescents with epilepsy at Mulago and Butabika national referral hospitals in Uganda.

Hillary Kuteesa, Catherine Abbo, Winstons Muhwezi,

<title>Abstract</title> <p> Background Suicide is the 3 rd leading cause of death among young people. Patients with epilepsy are 2 times more likely to have suicidal ideation and 3 times more likely to plan suicide attempt. In addition to seizures, these young people experience a variety of psychiatric ... Read more >>

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Common mental illness among epilepsy patients in Bahir Dar city, Ethiopia: A cross-sectional study.

Minale Tareke, Minychil Birehanu, Desalegne Amare, Andargie Abate,

BACKGROUND:Common mental illness has a substantial impact on seizure control and negatively affects the overall quality of life among individuals with epilepsy. However, there is a dearth of studies that examined the associated factors of common mental illness among epilepsy patients in Ethiopia, particularly in the study area. This study ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227854]

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Psychosocial and Physiologic Characteristics of Patients with Non-epileptic Events: A Retrospective Study.

Dipali Nemade, Vikram Shivkumar, Paul Ferguson, Jaysingh Singh, Sona Shah,

Background The main focus of this study is to aid early identification of psychogenic non-epileptic seizure (PNES) patients by identifying physical and psychosocial characteristics to reduce the health care burden, to reduce the unnecessary use of anti-epileptic medications and their side effects, and maximizing cost-effective use of video electroencephalography (VEEG). ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6767]

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Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic.

Heidi M Munger Clary, Rachel D Croxton, Jonathan Allan, James Lovato, Gretchen Brenes, Beverly M Snively, Mingyu Wan, James Kimball, Matthew H Wong, Cormac A O'Donovan, Kelly Conner, Victor Jones, Pamela Duncan,

OBJECTIVE:Anxiety and depression in epilepsy are prevalent, associated with poor outcomes, underrecognized, undertreated, and thus a key area of need for treatment research. The objective of this study was to assess factors associated with research participation among epilepsy clinic patients who screened positive for anxiety or depression. This was accomplished ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 104(Pt A):106907]

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Apoptotic Markers Are Increased in Epilepsy Patients: A Relation with Manganese Superoxide Dismutase Ala16Val Polymorphism and Seizure Type through IL-1β and IL-6 Pathways.

Aline Kegler, Ana Letícia Fornari Caprara, Eduardo Tanuri Pascotini, Josi Arend, Patricia Gabbi, Marta M M F Duarte, Ana Flavia Furian, Mauro Schneider Oliveira, Luiz Fernando Freire Royes, Michele Rechia Fighera,

The MnSOD Ala16Val single nucleotide polymorphism (SNP) has been associated with different diseases. However, there are scarcely studies relating this SNP in epilepsy, a neurologic disease that involves some interacting pathways, such as apoptotic and inflammatory factors. In this sense, we decided to investigate the relationship of MnSOD Ala16Val SNP ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:6250429]

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Health service costs and their association with functional impairment among adults receiving integrated mental health care in five low- and middle-income countries: the PRIME cohort study.

Dan Chisholm, Emily Garman, Erica Breuer, Abebaw Fekadu, Charlotte Hanlon, Mark Jordans, Tasneem Kathree, Fred Kigozi, Nagendra Luitel, Girmay Medhin, Vaibhav Murhar, Inge Petersen, Sujit D Rathod, Rahul Shidhaye, Joshua Ssebunnya, Vikram Patel, Crick Lund,

This study examines the level and distribution of service costs-and their association with functional impairment at baseline and over time-for persons with mental disorder receiving integrated primary mental health care. The study was conducted over a 12-month follow-up period in five low- and middle-income countries participating in the Programme for ... Read more >>

Health Policy Plan (Health policy and planning)
[2020, :]

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Understanding the relationships between mental disorders, self-reported health outcomes and positive mental health: findings from a national survey.

Janhavi Ajit Vaingankar, Siow Ann Chong, Edimansyah Abdin, Fiona Devi Siva Kumar, Boon Yiang Chua, Rajeswari Sambasivam, Saleha Shafie, Anitha Jeyagurunathan, Esmond Seow, Mythily Subramaniam,

BACKGROUND:The link between mental illness and mental health is gaining focus in research and practice. This study aimed to investigate the association of mental disorders with positive mental health (PMH), overall health and quality of life. In addition, the role of PMH in mediating the relationships between mental disorders and ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2020, 18(1):55]

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Impact of mental disorders and chronic physical conditions on quality-adjusted life years in Singapore.

Edimansyah Abdin, Siow Ann Chong, Janhavi Ajit Vaingankar, Saleha Shafie, Swapna Verma, Nan Luo, Kelvin Bryan Tan, Lyn James, Derrick Heng, Mythily Subramaniam,

The current study aims to evaluate the burden of disease in Singapore by estimating the quality-adjusted life years (QALYs) lost due to mental disorders and chronic physical conditions. The second Singapore Mental Health Study (SMHS-2016) was conducted in 2016 among 6126 respondents aged 18 years and above. The World Health ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2695]

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Does cannabidiol reduce severe behavioural problems in children with intellectual disability? Study protocol for a pilot single-site phase I/II randomised placebo controlled trial.

Daryl Efron, Kaitlyn Taylor, Jonathan M Payne, Jeremy L Freeman, Noel Cranswick, Melissa Mulraney, Chidambaram Prakash, Katherine J Lee, Katrina Williams,

INTRODUCTION:Severe behavioural problems (SBPs) are a common contributor to morbidity and reduced quality of life in children with intellectual disability (ID). Current medication treatment for SBP is associated with a high risk of side effects. Innovative and safe interventions are urgently needed. Anecdotal reports and preliminary research suggest that medicinal ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e034362]

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Medical cannibus as an alternative for opioids for chronic pain: A case report.

Franklin E Caldera,

Opioid medication-related deaths have increased to epidemic proportions in the last decade. This report describes a case of 43-year-old female with a traumatic brain injury who developed chronic pain and opioid dependence. The patient expressed concerns and wanted weaning off opioids. Recent legalization of medical marijuana in Pennsylvania allows us ... Read more >>

SAGE Open Med Case Rep (SAGE open medical case reports)
[2020, 8:2050313X20907015]

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Probable Mechanism of Antiepileptic Effect of the Vagus Nerve Stimulation in the Context of the Recent Results in Sleep Research.

Ivan N Pigarev, Marina L Pigareva, Ekaterina V Levichkina,

Front Neurosci (Frontiers in Neuroscience)
[2020, 14:160]

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Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study.

Dawn C Buse, Michael L Reed, Kristina M Fanning, Ryan Bostic, David W Dodick, Todd J Schwedt, Sagar Munjal, Preeti Singh, Richard B Lipton,

BACKGROUND:Migraine has many presumed comorbidities which have rarely been compared between samples with and without migraine. Examining the association between headache pain intensity and monthly headache day (MHD) frequency with migraine comorbidities is novel and adds to our understanding of migraine comorbidity. METHODS:The MAST Study is a prospective, web-based survey ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):23]

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A genome-wide multiphenotypic association analysis identified candidate genes and gene ontology shared by four common risky behaviors.

Jing Ye, Li Liu, Xiaoqiao Xu, Yan Wen, Ping Li, Bolun Cheng, Shiqiang Cheng, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Om Prakash Kafle, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiaomeng Chu, Lin Niu, Feng Zhang,

BACKGROUND:Risky behaviors can lead to huge economic and health losses. However, limited efforts are paid to explore the genetic mechanisms of risky behaviors. RESULT:MASH analysis identified a group of target genes for risky behaviors, such as APBB2, MAPT and DCC. For GO enrichment analysis, FUMA detected multiple risky behaviors related ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12(4):3287-3297]

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Pilomotor Seizures in a Patient With LGI1 Encephalitis.

Jinxia Yang, Qiying Sun, Guang Yang,

Limbic encephalitis (LE) with antibodies against leucine-rich glioma inactivated protein 1 (LGI1) is an autoimmune disease with variable clinical features, including seizures, cognitive disorders, psychiatric disturbances, and hyponatremia. The majority of these patients present faciobrachial dystonic seizures (FBDS), which are regarded as a characteristic symptom. A few cases have reported ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:61]

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Editorial: Ketogenic Diet in Epilepsy and Associated Comorbidities: Clinical Efficacy and Mechanisms.

Tianfu Li, Jiong Qin, Xiang-Ping Chu,

Front Neurol (Frontiers in neurology)
[2020, 11:66]

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