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Serum total prostate-specific antigen (tPSA): correlation with diagnosis and grading of prostate cancer in core needle biopsy.

Nina Čamdžić, Suada Kuskunović-Vlahovljak, Mirsad Dorić, Svjetlana Radović, Edina Lazović Salčin, Mirsad Babić,

Aim To investigate the impact of pre-treatment serum total prostate-specific antigen (PSA) level on prevalence of prostate carcinoma detection in prostate core needle biopsy, and its correlation with established prognostic factors. Methods Prostate needle biopsy samples of 115 patients with available pre-treatment serum total PSA (tPSA) level were analysed. For ... Read more >>

Med Glas (Zenica) (Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina)
[2021, 18(1):]

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Recent Advances and Current Role of Transperineal Prostate Biopsy.

Yasin Bhanji, Mathew J Allaway, Michael A Gorin,

"Approximately 1 million prostate biopsies are performed each year in the United States. This procedure has traditionally been performed using a transrectal approach, which is associated with a significant risk of infectious complications including sepsis. In recent years, transperineal prostate biopsy has been increasingly adopted due to its lower associated ... Read more >>

Urol Clin North Am (The Urologic clinics of North America)
[2021, 48(1):25-33]

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Optimizing Surgical Techniques in Robot-Assisted Radical Prostatectomy.

Camilo Arenas-Gallo, Jonathan E Shoag, Jim C Hu,

Robot-assisted radical prostatectomy (RARP) is the most common surgical treatment of localized prostate cancer. The ideal procedure would achieve maximum oncological efficacy while minimizing associated side effects, such as erectile dysfunction and urinary incontinence. Surgeon experience and surgical technique affect RARP outcomes. Here, the authors review RARP technical modifications aimed ... Read more >>

Urol Clin North Am (The Urologic clinics of North America)
[2021, 48(1):1-9]

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A prospective randomized study comparing bipolar plasmakinetic transurethral resection of the prostate and monopolar transurethral resection of the prostate for the treatment of Benign Prostatic Hyperplasia: efficacy, sexual function, Quality of Life, and complications.

Hugo Otaola-Arca, Manuel Álvarez-Ardura, Roberto Molina-Escudero, Mario I Fernández, Álvaro Páez-Borda,

OBJECTIVE:To generate high-quality data comparing the clinical efficacy and safety profile between monopolar transurethral resection of the prostate (M-TURP) and bipolar plasmakinetic resection of the prostate (PK-TURP) for benign prostatic hyperplasia (BPH). MATERIALS AND METHODS:Prospective, randomized, single-blinded study conducted in a tertiary-care public institution (Dec/2014-Aug/2016). INCLUSION CRITERIA:prostate of <80g in ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47(1):131-144]

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Health-Related Quality of Life and Its Associated Factors in Prostate Cancer Patients Who Receive Androgen Deprivation Therapy.

Ching-Hui Chien, Cheng-Keng Chuang, Kuan-Lin Liu, Chun-Te Wu, See-Tong Pang, Ying-Hsu Chang,

<b>Background:</b>Presently, few studies have examined the impact of positive thinking on the HRQoL of prostate cancer patients who receive androgen deprivation therapy (ADT).<br><br><b>Objectives:</b>We explored the factors that affect health-related quality of life (HRQoL), particularly positive thinking, of prostate cancer patients who receive ADT.<br><br><b>Methods:</b>A cross-sectional design was used. A total of ... Read more >>

Cancer Nurs (Cancer nursing)
[2021, 44(1):E34-E42]

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Prostate Cancer Spheroids: A Three-Dimensional Model for Studying Tumor Heterogeneity.

Mauricio Rodríguez-Dorantes, Carlos David Cruz-Hernandez, Sergio Alberto Cortés-Ramírez, Jenie Marian Cruz-Burgos, Juan Pablo Reyes-Grajeda, Oscar Peralta-Zaragoza, Alberto Losada-Garcia,

Prostate cancer is one of the main causes of cancer and the sixth cause of death among men worldwide. One of the major challenges in prostate cancer research is cell heterogeneity defined as the different genomic and phenotypic characteristics in each individual cell making more difficult to assess the proper ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2174:13-17]

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Urethra-sparing minimally invasive simple prostatectomy: an old technique revisited.

Andreia Cardoso, Estevao Lima,

PURPOSE OF REVIEW:The aim of this study was to review recent development in urethra and ejaculation preserving laparoscopic and robotic simple prostatectomy. RECENT FINDINGS:Since Madigan prostatectomy original description in 1990, to recent reports of robotic-assisted surgery using this urethra-sparing technique, many studies have suggested the advantages of the preservation of ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(1):18-23]

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The Role of Theranostics in Prostate Cancer.

Elisabeth O'Dwyer, Lisa Bodei, Michael J Morris,

Theranostics in men with metastatic castration-resistant prostate cancer (mCRPC) has been developed to target bone and the tumor itself. Currently, bone-directed targeted alpha therapy with radium-223 (223Ra) is the only theranostic agent proven to prolong survival in men with mCRPC who have symptomatic bone metastases and no known visceral metastases. ... Read more >>

Semin Radiat Oncol (Seminars in radiation oncology)
[2021, 31(1):71-82]

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Androgen Signaling in the Tumor Microenvironment.

Berna C Özdemir,

The key function of mesenchymal/stromal androgen receptor (AR) signaling for prostate development has been well documented by tissue recombination experiments. Some studies have addressed the expression and function of AR in stromal cells in prostate cancer, yet our understanding of the role of stromal AR in other tissues beyond prostate ... Read more >>

Adv Exp Med Biol (Advances in experimental medicine and biology)
[2021, 1270:169-183]

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Pelvic floor muscles after prostate radiation therapy: morpho-functional assessment by magnetic resonance imaging, surface electromyography and digital anal palpation.

Aline Moreira Ribeiro, Larissa Guerra Nammur, Elaine Cristine Lemes Mateus-Vasconcelos, Cristine Homsi Jorge Ferreira, Valdair Francisco Muglia, Harley Francisco de Oliveira,

AIM:To evaluate the radiotherapy (RT) effect in the pelvic floor muscles (PFM) function in men with prostate cancer (PC). MATERIALS AND METHODS:A cross-sectional study included three groups of patients with PC and RT indication: 1) Pre-RT group: evaluated before the beginning of RT; 2) Acute group: evaluated between six months ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2021, 47(1):120-130]

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Current evidence for focal therapy and partial gland ablation for organ-confined prostate cancer: systematic review of literature published in the last 2 years.

Paulo Priante Kayano, Laurence Klotz,

PURPOSE OF REVIEW:The shift in the diagnostic algorithm for prostate cancer to early imaging with mpMRI has resulted in many patients being diagnosed with small volume, apparently unilateral, clinically significant cancers. In these patients, a minimally invasive, nonmorbid intervention is appealing. The aim of this study was to review data ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(1):49-57]

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Evaluating Dimensions of Fatigue in Men With Prostate Cancer Receiving Radiation Therapy.

Kristin Dickinson, Kevin Kupzyk, Leorey Saligan,

<b>Background:</b>Cancer-related fatigue (CRF) is a complex multidimensional symptom. Identifying the fatigue dimension that may be most bothersome can guide in the development of individualized management strategies.<br><br><b>Objective:</b>The purpose of this article is to describe the multidimensional fatigue experience of men with prostate cancer.<br><br><b>Methods:</b>Data for this study were obtained from an ongoing ... Read more >>

Cancer Nurs (Cancer nursing)
[2021, 44(1):71-78]

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Cell-Internalization SELEX of RNA Aptamers as a Starting Point for Prostate Cancer Research.

Mauricio Rodríguez-Dorantes, Sergio Alberto Cortés-Ramírez, Jenie Marian Cruz-Burgos, Juan Pablo Reyes-Grajeda, Alberto Losada-García, Vanessa González-Covarrubias, Carlos David Cruz-Hernández,

In the treatment of cancer, over the last decade different drugs delivery systems have been developed to increase therapeutic specificity to improve drug's efficacy, and safety by increasing bioavailability. Among these systems, small nucleic acid molecules with a three-dimensional structure, known as aptamers, have shown several advantages. Several approaches to ... Read more >>

Methods Mol Biol (Methods in molecular biology (Clifton, N.J.))
[2021, 2174:245-254]

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Effect of acetogenin fraction of Annona muricata leaves on antioxidant status and some indices of benign prostatic hyperplasia in rats.

Patience N Ogbu, Evelyn O Ugota, Rita U Onwuka, Ikechukwu M Ogbu, Chinyere Aloke,

ABSTRACT Objectives: This work investigated the effect of acetogenin-rich fraction of Annona muricata leaves (AFAL) on antioxidant status and some markers of benign prostatic hyperplasia (BPH) in rats. Methods: BPH was experimentally induced in the rats by subcutaneous injection of testosterone propionate (TP, 3 mg/kg) for 28 consecutive days. The rats ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2020, 25(1):80-86]

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Echotexture analysis of prostate parenchyma for detection of benign prostatic hyperplasia in dogs.

Mohammad Hossein Khanbazi, Asghar Mogheiseh, Mohammad Saeed Ahrari Khafi, Saeed Nazifi, Nooshin Derakhshandeh, Kamran Golchin-Rad,

Ultrasonography is one of the most common methods for the diagnosis of prostate disorders, such as benign prostatic hyperplasia (BPH), in dogs. Changes in the echotexture are one of the indicators used to diagnose prostate disorders. The purpose of this study was to investigate the changes occurred in the dogs' ... Read more >>

Top Companion Anim Med (Topics in companion animal medicine)
[2020, :100501]

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Improving radio-chemotherapy efficacy of prostate cancer by co-deliverying docetaxel and dbait with biodegradable nanoparticles.

Nianli Liu, Jiayin Ji, Hui Qiu, Zhiying Shao, Xin Wen, Aoxing Chen, Senbang Yao, Xingying Zhang, Hong Yao, Longzhen Zhang,

Combining DNA damage repair inhibitors and chemotherapeutic agents is an emerging strategy in cancer treatment. In this study, we engineered the polycation nanoparticle (NP), which co-encapsulated DNA damage repair inhibitor Dbait and chemotherapeutic drug Docetaxel (Dtxl), using H1 nanopolymer (folate--polyethylenimine600-cyclodextrin), and the size of H1/Dbait/Dtxl was about 117 nm. We demonstrated ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):305-314]

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A shared decision: Bipolar vs. monopolar transurethral resection of the prostate for benign prostatic hyperplasia.

Naeem Bhojani, Kevin C Zorn, Dean Elterman,

Can Urol Assoc J (Canadian Urological Association journal = Journal de l'Association des urologues du Canada)
[2020, 14(12):431]

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Model-based meta-analysis of the time to first acute urinary retention or BPH-related surgery in patients with moderate or severe symptoms.

Salvatore D'Agate, Chandrashekhar Chavan, Michael Manyak, Juan Manuel Palacios-Moreno, Matthias Oelke, Martin C Michel, Claus G Roehrborn, Oscar Della Pasqua,

AIMS:Combination therapy of 5α-reductase inhibitor and α-blocker is a guideline endorsed therapeutic approach for patients with moderate-to-severe lower urinary tract symptoms or benign prostatic hyperplasia (LUTS/BPH) who are at risk of disease progression. We aimed to disentangle the contribution of clinical and demographic baseline characteristics affecting the risk of acute ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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Round table: arguments in supporting abbreviated or biparametric MRI of the prostate protocol.

Michele Scialpi, Eugenio Martorana, Pietro Scialpi, Alfredo D'Andrea, Riccardo Torre, Aldo Di Blasi, Stefano Signore,

Prostate Imaging Reporting and Data System (PI-RADS) version 2.1 update, in the attempt to improve clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) of the prostate, has clear limitations. The role of dynamic contrast-enhanced sequences is not defined, precise guidance on the clinical management (biopsy or clinical surveillance) for score ... Read more >>

Abdom Radiol (NY) (Abdominal radiology (New York))
[2020, 45(12):3974-3981]

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Visceral Metastases as Predictors of Response and Survival Outcomes in Patients of Castration-Resistant Prostate Cancer Treated With 177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy: A Systematic Review and Meta-analysis.

Swayamjeet Satapathy, Bhagwant Rai Mittal, Ashwani Sood,

BACKGROUND:The presence of visceral metastases is associated with poor prognosis in patients of metastatic castration-resistant prostate cancer (mCRPC) treated with hormonal therapy and chemotherapy. However, studies evaluating its impact on treatment outcomes with Lu-labeled prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) are currently limited and show inconsistent results. This systematic ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(12):935-942]

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Delayed 68Ga-PSMA PET/CT Image-Guided Biopsy for Low-Grade Adenocarcinoma in Benign Prostatic Hyperplasia.

Sampath Santhosh, Godwin Jeeva,

Image-guided biopsy of prostate with multiparametric MRI is being adopted in the workup of prostate adenocarcinoma (PAC). Ga-PSMA PET/CT-guided biopsy has also been shown to be equally sensitive in the evaluation of higher-grade tumors with increased PSMA expression. The sensitivity of Ga-PSMA PET/CT, however, reduces with lesser PSMA expression in ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, :]

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Race, Decisional Regret and Prostate Cancer Beliefs: Identifying Targets to Reduce Racial Disparities in Prostate Cancer.

Molly E DeWitt-Foy, Kristina Gam, Charles Modlin, Simon P Kim, Robert Abouassaly,

PURPOSE:African American men are more likely to be diagnosed with, die of and experience decisional regret about their prostate cancer than nonAfrican American men. Although clinical discrepancies may be attributed to genetic risk and/or access to care, explanations for racial discrepancies in decisional regret remain largely speculative. We aim to ... Read more >>

J Urol (The Journal of urology)
[2020, :101097JU0000000000001385]

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18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy.

Gaurav Malviya, Rachana Patel, Mark Salji, Rafael S Martinez, Peter Repiscak, Ernest Mui, Susan Champion, Agata Mrowinska, Emma Johnson, Maha AlRasheedi, Sally Pimlott, David Lewis, Hing Y Leung,

BACKGROUND:Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following ADT. There is therefore an urgent need for early detection of treatment resistance. METHODS:Isogenic androgen-responsive (CWR22Res) and castration-resistant (22Rv1) human prostate cancer cells ... Read more >>

EJNMMI Res (EJNMMI research)
[2020, 10(1):143]

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Holmium Laser Enucleation, Laparoscopic Simple Prostatectomy, or Open Prostatectomy: The Role of the Prostate Volume in terms of Operation Time.

Kadir Omur Gunseren, Serkan Akdemir, Mehmet Cagatay Çiçek, Ali Yıldız, Murat Arslan, İsmet Yavaşcaoğlu, Hakan Vuruskan,

INTRODUCTION:To compare the prostate removal speeds of 3 enucleation techniques and to evaluate how the operating times change depending on the prostate volume. METHODS:Medical records of patients with 80-g or larger prostates who underwent holmium laser enucleation of the prostate (HoLEP), laparoscopic simple prostatectomy (LSP), or open prostatectomy (OP) due ... Read more >>

Urol Int (Urologia internationalis)
[2020, :1-6]

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A rise in T3/T4 ratio reduces the growth of prostate tumors in a murine model.

Ana Sánchez-Tusie, Carlos Montes de Oca, Julia Rodríguez-Castelán, Evangelina Delgado-González, Zamira Ortiz, Lourdes Álvarez, Carlos Zarco, Carmen Aceves, Brenda Anguiano,

Thyroxine (T4) promotes cell proliferation and tumor growth in prostate cancer models, but it is unknown if the increase in the triiodothyronine (T3)/T4 ratio could attenuate prostate tumor development. We assessed T3 effects on thyroid response, histology, proliferation, and apoptosis in the prostate of wild-type (WT) and TRAMP (transgenic adenocarcinoma ... Read more >>

J Endocrinol (The Journal of endocrinology)
[2020, 247(3):225-238]

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