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Methylation of the D2 dopamine receptor affects binding with the human regulatory proteins Par-4 and Calmodulin.

Alexander Bowitch, Ansuman Sahoo, Andrea M Clark, Christiana Ntangka, Krishna K Raut, Paul Gollnick, Michael C Yu, Steven M Pascal, Sarah E Walker, Denise M Ferkey,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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A genome-wide screen in Saccharomyces cerevisiae identifies Tannic Acid-sensitive mutants.

Emily M Pilc, Shriie Ganesh, Oliver Kerscher,

MicroPubl Biol (microPublication biology)
[2021, 2021:]

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Pelvic lymph node dissection in high-risk prostate cancer.

Luciano Haiquel, Xavier Cathelineau, Rafael Sanchez-Salas, Petr Macek, Fernando Secin,

<h4>Introduction</h4>The therapeutic role of pelvic lymph node dissection (PLND) in prostate cancer (PCa) is unknown due to absence of randomized trials.<h4>Objective</h4>to present a critical review on the therapeutic benefits of PLND in high risk localized PCa patients.<h4>Materials and methods</h4>A search of the literature on PLND was performed using PubMed, Cochrane, ... Read more >>

Int Braz J Urol (International braz j urol : official journal of the Brazilian Society of Urology)
[2022, 48:]

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Curcumin attenuates prostatic hyperplasia caused by inflammation via up-regulation of bone morphogenetic protein and activin membrane-bound inhibitor.

Yuhang Liu, Zhaohui Wang, Yu Gan, Xiang Chen, Bo Zhang, Zhi Chen, Peihuan Liu, Bingsheng Li, Feng Ru, Yao He,

<h4>Context</h4>Inflammation and epithelial-mesenchymal transition (EMT) play important roles in the occurrence and development of benign prostatic hyperplasia (BPH); curcumin exerts anti-proliferative, anti-inflammatory, and anti-EMT effects.<h4>Objective</h4>To explore the anti-inflammatory and anti-EMT mechanisms of curcumin in BPH.<h4>Materials and methods</h4>Ten-week-old male C57BL/6 mice were administered lipopolysaccharide (LPS, 100 µg/kg) in the prostate lobules to ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):1026-1035]

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M2 subtype tumor associated macrophages (M2-TAMs) infiltration predicts poor response rate of immune checkpoint inhibitors treatment for prostate cancer.

Zhou JiaWei, Dou ChunXia, Liu CunDong, Liu Yang, Yang JianKun, Duan HaiFeng, Yang Cheng, Huang ZhiPeng, Wang HongYi, Liao DeYing, Liang ZhiJian, Xie Xiao, Zhou QiZhao, Xue KangYi, Guo WenBing, Xia Ming, Zhou JunHao, Bao JiMing, Zhao ShanChao, Chen MingKun,

<h4>Background</h4>Prostate cancer (PCa) is poor response to the immunotherapy for its high heterogeneity of immune microenvironment. In this study, we aim to introduce a new immune subtype for PCa involving M2 tumour associated macrophages <b>(</b>M2-TAMs).<h4>Methods</h4>Three hundred and sixty-two PCa patients and matched normal prostate tissues were selected from the Cancer ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):730-740]

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The efficiency of prostate-specific antigen density measurement using three different methods on the prediction of biochemical recurrence.

Yavuz Onur Danacioglu, Ferhat Keser, Özgür Efiloğlu, Meftun Culpan, Salih Polat, Ramazan Gokhan Atis, Asif Yildirim,

<h4>Background</h4>The aim of this study was to evaluate the efficiency of prostate-specific antigen (PSA) density (PSAD) calculated through prostate volume (PV) obtained <i>via</i> transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) and actual prostate weight (PW) methods obtained <i>via</i> pathological evaluation on the prediction of biochemical recurrence (BCR) in the ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):15-23]

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Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway.

Jianjun Li, Chuan Xiong, Pan Xu, Qiang Luo, Ronggui Zhang,

In this study, we examined the antitumor effects of Puerarin (PEU) on androgen-independent (DU145 and PC-3) and androgen-dependent (LNCaP) prostate cancer cells, and explored its potential mechanisms. Supplement with PEU (2.5 μM, 5 μM, and 10 μM) exhibited a marked inhibitory effect against the growth of DU145 and PC-3 cells, especially beyond 24 h, ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):402-413]

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Is there still a role for digital rectal examination in the prostate cancer diagnostic pathway in the COVID-19 and post COVID-19 era?

Wei Shen Tan, Anton Wong, Wasim Mahmalji, Asif Raza,

Digital rectal examination (DRE) is routinely performed as part of a urology clinical assessment in patients with a clinical suspicion of prostate cancer. An abnormal DRE or a raised prostate specific antigen (PSA) level are part of the criteria for primary care referral to secondary care due to a suspicion ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):92-94]

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Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.

Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang,

<h4>Background</h4>Progression of Benign Prostate hyperplasia (BPH) is vulnerable to oxidative stress (OS) and prostatic enlargement among the aging males through apoptosis deregulation. Our present study aimed to investigate the effect of neferine (NF) in the regulation of oxidative stress and apoptosis in human BPH-1 cells.<h4>Methods</h4>BPH epithelial cell line BPH-1 was ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):1-9]

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Analysis of RNA m6A methylation regulators and tumour immune cell infiltration characterization in prostate cancer.

Yue Zhao, Huimin Sun, Jianzhong Zheng, Chen Shao,

Potential roles of RNA N6-methyladenosine (m<sup>6</sup>A) modification in tumour microenvironment (TME) cell infiltration has been demonstrated in recent studies. Nonetheless, the mechanism of its regulation remains unknown and immunotherapy has been marginal in prostate cancer. We demonstrated the expression of different m<sup>6</sup>A regulators within prostate cancer related to genetic variation, ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2021, 49(1):407-435]

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Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells.

Yuefu Han, Xingqiao Wen, Xiaojuan Li, Dong Chen, Lian Peng, Bin Lai, Hongcai Huang,

Numerous differentially expressed circular RNAs (circRNAs) have been identified; however, their roles have not been fully elucidated. Since dysregulated circRNAs may have clinical applications, it is vital to study their expression characteristics, function, and mechanism in prostate cancer cells. The role, regulatory mechanism, and expression of hsa_circ_0075542 were analyzed using ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5620-5631]

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Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways.

Zhenhua Gu, Zhixin You, Yucheng Yang, Rui Ding, Meili Wang, Jianming Pu, Jian Chen,

To probe into the efffects of miR-101-3p via regulating CUL4B within PI3K/AKT/mTOR signaling pathway on progression of prostate cancer (PCA). Western blot and qRT-PCR were adopted to detect CUL4B and miR-101-3p expressions in 75 cases with PCA . The cellular strains of PCA (LNCaP and PC3) were chose as the ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):4719-4735]

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Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Francesca Lessi, Paolo Aretini, Milena Rizzo, Mariangela Morelli, Michele Menicagli, Sara Franceschi, Chiara Maria Mazzanti,

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . ... Read more >>

Cell Adh Migr (Cell adhesion & migration)
[2021, 15(1):180-201]

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New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies.

Nadia A Khalil, Eman M Ahmed, Ashraf F Zaher, Eman A Sobh, Samiha A El-Sebaey, Mona S El-Zoghbi,

A series of [1]benzothieno[2,3-<i>c</i>]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds <b>5a-c</b> showed prominent growth inhibition against most cell lines. <b>5c</b> was selected at five dose concentration levels. It exhibited potent broad-spectrum anticancer activity with a GI<sub>50</sub> of 4 nM-37 µM. Cytotoxicity of <b>5a-c</b> was ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1839-1859]

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Association of the inflammatory potential of diet and lower urinary tract symptoms among men in the United States.

Xinyang Liao, Haiyang Bian, Xiaonan Zheng, Jianzhong Ai, Lu Yang, Liangren Liu, Shi Qiu, Qiang Wei,

<h4>Background</h4>Inflammation is crucial in the pathogenesis of lower urinary tract symptoms (LUTS) in men. Diet modulates inflammation. Therefore, diet could be a modifiable factor in male LUTS prevention and treatment. We aimed to investigate the association between dietary inflammatory potential and male LUTS.<h4>Methods</h4>We used two cycles of National Health and ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):72-79]

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MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to downregulate cell proliferation and metastasis to mitigate prostate cancer.

Juanni Liu, Junhai Li, Yongtu Ma, Changbao Xu, Yigang Wang, Yanfeng He,

Prostate cancer (PCa), a frequently detected malignant tumor, is the fifth leading global cancer mortality cause in men. Although research has improved the PCa survival rate, significantly reduced survival occurs among patients at the metastatic stage. MiRNAs, which are short non-coding proteins, are crucial for several biological roles, essential for ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3240-3251]

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A DNA methylation profile of long non-coding RNAs can predict OS in prostate cancer.

Wei Cheng, Jie Cao, Yong Xia, Xin Lei, Lili Wu, Liang Shi,

Prostate cancer (PCa) is the most common male reproductive tract malignant tumor, accurate evaluation of PCa characterization and prognostic prediction at diagnosis are vital for the effective administration of the disease, especially at the molecular level. In this study, 48 CpG sites with differential methylation associated with overall survival (OS) ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3252-3262]

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Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling.

Xiang Ding, Xu Xu, Xue-Feng He, Ye Yuan, Chuang Chen, Xin-Yu Shen, Sai Su, Zhang Chen, Song-Tao Xu, Yu-Hua Huang,

The present study aimed to investigate the role and underlying mechanisms of long non-coding RNA (lncRNA) muscleblind-like 1 antisense RNA 1 (MBNL1-AS1) in the progression of Prostate cancer (PCa). MBNL1-AS1 and microRNA (miR)-181a-5p expression in PCa tissues and several human PCa cell lines were analyzed, respectively, using StarBasev3.0 project and ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):803-814]

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Prognosis of primary or metachronous prostate cancer in multiple primary genitourinary cancers; a single center experience with long-term results.

Caner Ediz, Serkan Akan, Hasan Huseyin Tavukcu, Muhammed Esad Kayhan, Omer Yilmaz,

<h4>Objective</h4>This study aims to analyze the challenges, approaches and long-term results of primary or metachronous prostate cancer (PCa) in cases with multiple primary genitourinary cancers.<h4>Methodology</h4>A total of 17 patients were included in the study. Patients with multiple primary genitourinary cancers were divided into two groups according to the diagnosis of ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):37-41]

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The efficacy and tolerability of ultra-hypofractionated radiotherapy in low-intermediate risk prostate cancer patients: single center experience.

Selvi Dinçer, Emre Uysal, Tanju Berber, Mustafa Halil Akboru,

<h4>Background</h4>We aimed to investigate the efficacy and tolerability of ultra-hypofractionated radiotherapy (UHRT) in the treatment of low and intermediate-risk prostate cancer patients.<h4>Methods</h4>This retrospective study was conducted using data derived from 44 patients who underwent UHRT, and toxicity assessment and clinical response were investigated. Treatment consisted of 35-36.25 Gy in 5 fractions ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2021, 24(1):50-57]

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Clinical significance and potential molecular mechanism of miRNA-222-3p in metastatic prostate cancer.

Yu Sun, Gang Chen, Juan He, Zhi-Guang Huang, Sheng-Hua Li, Yuan-Ping Yang, Lu-Yang Zhong, Shu-Fan Ji, Ying Huang, Xin-Hua Chen, Mao-Lin He, Hao Wu,

The clinical significance and underlying molecular mechanism of miRNA-222-3p in metastatic prostate cancer (MPCa) remain unclear. The present study used a large number of cases (n = 1,502) based on miRNA chip and miRNA sequencing datasets to evaluate the expression and diagnostic potential of miRNA-222-3p in MPCa. We applied a variety of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):325-340]

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Long non-coding RNA CRNDE regulates the growth and migration of prostate cancer cells by targeting microRNA-146a-5p.

Dewang Fu, Li'e Zang, Zhaowei Li, Chenghui Fan, Huamao Jiang, Tongyi Men,

The function of lncRNA CRNDE and its role in prostate cancer (PC) remains unclear. The aim of this study was to determine the expression level of lncRNA CRNDE in PC tissues and to elucidate its role in PC. The expression levels of lncRNA CRNDE were measured by quantitative reverse transcription ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):2469-2479]

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Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data.

Hang Huang, Haokai Xu, Ping Li, Xueting Ye, Wei Chen, Wei Chen, Xixi Huang,

The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis of public datasets from The Cancer Genome Atlas database (TCGA). The results showed that the expression levels of ZFC3H1 were notably lower than the corresponding non-cancerous tissues in prostate adenocarcinoma ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5504-5515]

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Synthesis, potential antitumor activity, cell cycle analysis, and multitarget mechanisms of novel hydrazones incorporating a 4-methylsulfonylbenzene scaffold: a molecular docking study.

Alaa A-M Abdel-Aziz, Adel S El-Azab, Nawaf A AlSaif, Ahmad J Obaidullah, Abdulrahman M Al-Obaid, Ibrahim A Al-Suwaidan,

Hydrazone is a bioactive pharmacophore that can be used to design antitumor agents. We synthesised a series of hydrazones (compounds <b>4-24</b>) incorporating a 4-methylsulfonylbenzene scaffold and analysed their potential antitumor activity. Compounds <b>6</b>, <b>9</b>, <b>16</b>, and <b>20</b> had the most antitumor activity with a positive cytotoxic effect (PCE) of 52/59, ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1521-1539]

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A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents.

Narges Marefati, Vahideh Ghorani, Farzaneh Shakeri, Marzie Boskabady, Farzaneh Kianian, Ramin Rezaee, Mohammad Hosein Boskabady,

<h4>Context</h4><i>Allium cepa</i> L. (Liliaceae), known as onion, is consumed throughout the world. Onion and its derivatives including saponins, aglycones, quercetin, cepaenes, flavonoids, organosulfurs, and phenolic compounds, showed various pharmacological properties and therapeutic effects.<h4>Objective</h4>Anti-inflammatory, antioxidant, and immunomodulatory effects of <i>A. cepa</i> and its main constituents, along with the underlying molecular mechanisms ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):287-302]

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