Full Text Journal Articles about
Prostaglandins

Advertisement

Find full text journal articles






15-Hydroxyprostaglandin dehydrogenase inhibitor prevents contrast-induced acute kidney injury.

Byeong Woo Kim, Hye Jung Kim, Sun-Hee Kim, Hyung Joo Baik, Mi Seon Kang, Dong-Hyun Kim, Sanford D Markowitz, Sun Woo Kang, Ki Beom Bae,

The two primary mechanisms by which iodinated contrast media (CM) causes contrast-induced acute kidney injury (CIAKI) are the hemodynamic effect causing intrarenal vasoconstriction and the tubular toxic effect causing acute tubular necrosis. Inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which degrades prostaglandin E<sub>2</sub> (PGE2), promotes tissue repair and regeneration in many organs. ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):168-179]

Cited: 0 times

View full text PDF listing >>



Ameliorative effects of Cuscuta reflexa and Peucedanum grande on letrozole induced polycystic ovary syndrome in Wistar rats.

Firdaus Kausar, Muzafar Ahmad Rather, Showkeen Muzamil Bashir, Rana M Alsaffar, Showkat Ul Nabi, Sofi Imtiyaz Ali, Pankaj Goswami, Ansar Ahmad, Summya Rashid, Adil Farooq Wali,

<h4>Objectives</h4>The current study was designed to examine the therapeutic role of hydroalcoholic extract of <i>Cuscuta reflexa</i> Roxb (CRE) and <i>Peucedanum grande</i> C.B. Clarke (PGE) on letrozole (1 mg/kg) induced polycystic ovary syndrome (PCOS) in female Wistar albino rats.<h4>Methods</h4>PCOS rats were treated with CRE (280 mg/kg), PGE (140 mg/kg) or CRE + PGE p.o. for 3 ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):94-104]

Cited: 0 times

View full text PDF listing >>



Advertisement

Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo.

Jianrong Yang, Jingtao Zhong, Mi Zhou, Yinghong Zhou, Peng Xiu, Feng Liu, Fuhai Wang, Zelun Li, Yuntian Tang, Yuanyuan Chen, Siyang Yao, Tao Huang, Tianqi Liu, Xiaofeng Dong,

T7 peptide is considered as an antiangiogenic polypeptide. The presents study aimed to further detect the antiangiogenic mechanisms of T7 peptide and determine whether combining T7 peptide and meloxicam (COX-2/PGE2 specific inhibitor) could offer a better therapy to combat hepatocellular carcinoma (HCC). T7 peptide suppressed the proliferation, migration, tube formation, ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):844-855]

Cited: 0 times

View full text PDF listing >>



Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction.

Tarek S Ibrahim, Amr H Moustafa, Ahmad J Almalki, Rasha M Allam, Abdulhamid Althagafi, Shadab Md, Mamdouh F A Mohamed,

Two series of chalcone/aryl carboximidamide hybrids <b>4a-f</b> and <b>6a-f</b> were synthesised and evaluated for their inhibitory activity against iNOS and PGE2. The most potent derivatives were further checked for their <i>in vivo</i> anti-inflammatory activity utilising carrageenan-induced rat paw oedema model. Compounds <b>4c</b>, <b>4d</b>, <b>6c</b> and <b>6d</b> were proved to be the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):1067-1078]

Cited: 0 times

View full text PDF listing >>



Mechanism of allergic rhinitis treated by Centipeda minima from different geographic areas.

Yanzhuo Jia, Junbo Zou, Yao Wang, Xiaofei Zhang, Yajun Shi, Yulin Liang, Dongyan Guo, Ming Yang,

<h4>Context</h4>The coriander plant <i>Centipeda minima</i> (L.) A. Braun et Aschers (Compositae) is used for the treatment of allergic rhinitis.<h4>Objective</h4>Analyze the difference of the <i>C. minima</i> volatile oil from 7 geographic areas and its therapeutic effect on allergic rhinitis.<h4>Materials and methods</h4>The volatile oils from different geographic areas were extracted and analyzed, ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):606-618]

Cited: 0 times

View full text PDF listing >>



Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria.

Ritika Chatterjee, Atish Roy Chowdhury, Debapriya Mukherjee, Dipshikha Chakravortty,

Lipids are complex organic compounds made up of carbon, oxygen, and hydrogen. These play a diverse and intricate role in cellular processes like membrane trafficking, protein sorting, signal transduction, and bacterial infections. Both Gram-positive bacteria (<i>Staphylococcus sp., Listeria monocytogenes, etc</i>.) and Gram-negative bacteria (<i>Chlamydia sp., Salmonella sp., E. coli</i>, etc.) ... Read more >>

Virulence (Virulence)
[2021, 12(1):195-216]

Cited: 2 times

View full text PDF listing >>



Karafsin, a unique mono-acylated flavonoid apiofurnoside from the leaves of Apium graveolens var. secalinum Alef: In vitro and in vivo anti-inflammatory assessment

Eman S Mostafa, Mahmoud A M Nawwar, Dalia A Mostafa, Mai F Ragab, Noha Swilam,

Celery ethanol extract (CEE) of leaves of Apium graveolens var. secalinum Alef, showed high phenolic content with significant antioxidant activity using DPPH and ORAC assay. Two unique unknown compounds, apigenin 7-O-mono-apiofuranoside and acylated flavonoid, 7-O- (5″-E-p-coumaroyl)-apiofuranside (karafsin) were identified in CEE for the first time by a full structural analysis, ... Read more >>

(Industrial crops and products.)
[2021, 158:Not Available]

Cited: 0 times

View full text PDF listing >>



Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing.

Zhimin Li, Yu Sun, Maolin He, Jianwei Liu,

The underlying molecular mechanisms of intervertebral disc degeneration (IDD) remain unclear. This study aimed to identify the crucial molecules and explore the function of noncoding RNAs and related pathways in IDD. We randomly selected three samples each from an IDD and a spinal cord injury group (control) for RNA-sequencing. We ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1026-1039]

Cited: 0 times

View full text PDF listing >>



Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology.

Lizhu Han, Jing Kou, Kunxia Hu, Yunlan Wang, Zhishu Tang, Zhisheng Wu, Xiao Song,

<h4>Context</h4>Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis.<h4>Objective</h4>To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia.<h4>Materials and methods</h4>Using the network pharmacology approach, the multiple components, component candidate ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):209-221]

Cited: 0 times

View full text PDF listing >>



Anti-allergic actions of a Chinese patent medicine, huoxiangzhengqi oral liquid, in RBL-2H3 cells and in mice.

Jianbin Sun, Sixing Huang, Yao Qin, Ping Zhang, Ziwei Li, Li Zhang, Xin Wang, Ruijun Wu, Shaorong Qin, Jiayong Huo, Kunquan Xiao, Weizao Luo,

<h4>Context</h4>Huoxiangzhengqi oral liquid (HXZQ-OL), a traditional Chinese medicine formula, has antibacterial, anti-inflammation and gastrointestinal motility regulation effects.<h4>Objective</h4>The study investigates the anti-allergic activity and underlying mechanism of HXZQ-OL.<h4>Materials and methods</h4>IgE/Ag-mediated RBL-2H3 cells were used to evaluate the anti-allergic activity of HXZQ-OL (43.97, 439.7 and 4397 μg/mL) <i>in vitro</i>. The release of cytokines and ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):672-682]

Cited: 0 times

View full text PDF listing >>



Aconiti lateralis Radix Praeparata inhibits Alzheimer's disease by regulating the complex regulation network with the core of GRIN1 and MAPK1.

Yutao Wang, Huixiang Zhang, Jing Wang, Ming Yu, Qianqian Zhang, Shan Yan, Dingyun You, Lanlan Shi, Lihuan Zhang, Limei Wang, Hongxiang Wu, Xue Cao,

<h4>Context</h4>Current medicine for Alzheimer's disease (AD) cannot effectively reverse or block nerve injury. Traditional Chinese Medicine practice and research imply <i>Aconiti lateralis Radix Praeparata</i> (Fuzi) may meet this goal.<h4>Objective</h4>Analysing the anti-AD effect of Fuzi and its potential molecular mechanism.<h4>Materials and methods</h4>AD model cells were treated with Fuzi in 0-300 mg/mL for ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):311-320]

Cited: 0 times

View full text PDF listing >>



A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents.

Narges Marefati, Vahideh Ghorani, Farzaneh Shakeri, Marzie Boskabady, Farzaneh Kianian, Ramin Rezaee, Mohammad Hosein Boskabady,

<h4>Context</h4><i>Allium cepa</i> L. (Liliaceae), known as onion, is consumed throughout the world. Onion and its derivatives including saponins, aglycones, quercetin, cepaenes, flavonoids, organosulfurs, and phenolic compounds, showed various pharmacological properties and therapeutic effects.<h4>Objective</h4>Anti-inflammatory, antioxidant, and immunomodulatory effects of <i>A. cepa</i> and its main constituents, along with the underlying molecular mechanisms ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):287-302]

Cited: 0 times

View full text PDF listing >>



Efficacy and safety of novel-targeted drugs in the treatment of pulmonary arterial hypertension: a Bayesian network meta-analysis.

Wenhai Fu, Wenjun He, Yuexin Li, Yangxiao Chen, Jingyi Liang, Hui Lei, Lin Fu, Yanghang Chen, Ni Ren, Qian Jiang, Yi Shen, Ran Ma, Tao Wang, Xinni Wang, Nuofu Zhang, Dakai Xiao, Chunli Liu,

<b>Background:</b> Pulmonary arterial hypertension (PAH) is a severe and fatal clinical syndrome characterized by high blood pressure and vascular remodeling in the pulmonary arterioles, which is also a rapidly progressing disease of the lung vasculature with a poor prognosis. Although PAH medication made great advances in recent years, the efficacy ... Read more >>

Drug Deliv (Drug delivery)
[2021, 28(1):1007-1019]

Cited: 0 times

View full text PDF listing >>



The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies.

Taofik Rusdiana, Yanni D Mardhiani, Norisca A Putriana, Dolih Gozali, Daisuke Nagano, Takuya Araki, Koujirou Yamamoto,

<h4>Context</h4>Co-administration between warfarin (WF) and <i>Curcuma xanthorrhiza</i> Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated.<h4>Objective</h4>This study assesses the effect of concomitant administration of CX extract on the pharmacokinetics of WF in rats.<h4>Materials and methods</h4>Wistar rats were divided into 4 groups (<i>n</i> = 6) and administered with 2% ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):639-646]

Cited: 0 times

View full text PDF listing >>



Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agents.

Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis,

Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (<b>Flu-AM4</b>). The compound is a competitive, reversible inhibitor of FAAH with a K<sub>i</sub> value of 13 nM and which inhibits COX activity in a substrate-selective manner. Molecular modelling ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):940-953]

Cited: 0 times

View full text PDF listing >>



Contribution of oxidative stress in the mechanisms of postoperative complications and multiple organ dysfunction syndrome.

Javier Toro-Pérez, Ramón Rodrigo,

<h4>Background</h4>The extent of the damage following surgery has been subject of study for several years. Numerous surgical complications can impact postoperative quality of life of patients and even can cause mortality. Although these complications are generally due to multifactorial mechanisms, oxidative stress plays a key pathophysiological role. Moreover, oxidative stress ... Read more >>

Redox Rep (Redox report : communications in free radical research)
[2021, 26(1):35-44]

Cited: 0 times

View full text PDF listing >>



Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones.

Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib, Mohamed G Temraz, Ahmed S F Belal, Ahmed F El-Yazbi,

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC<sub>50</sub> values of 0.09-0.14 µM) with significant 15-LOX inhibitory activities (IC<sub>50</sub>s ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):669-684]

Cited: 0 times

View full text PDF listing >>



Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling.

Alla F Fomina, Hai M Nguyen, Heike Wulff,

In the last 5 years inhibitors of the potassium channel K<sub>V</sub>1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer's disease, Parkinson's disease and traumatic brain injury. At the systemic level these beneficial actions are mediated by a reduction in microglia activation and a suppression of pro-inflammatory ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2021, 15(1):67-78]

Cited: 2 times

View full text PDF listing >>



High mobility group box 1 mediates inflammatory response of astrocytes via cyclooxygenase 2/prostaglandin E2 signaling following spinal cord injury.

Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang,

High mobility group box 1 (HMGB1) interacts with pattern-recognition receptors of immune cells to activate the inflammatory response. Astrocytes play a positive role in the inflammatory response of the central nervous system by expressing a broad range of pattern-recognition receptors. However, the underlying relationship between HMGB1 and the inflammatory reaction ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(9):1848-1855]

Cited: 0 times

View full text PDF listing >>



Lipoprotein-associated phospholipase A2 (Lp-PLA2) - possible diagnostic and risk biomarker in chronic ischaemic heart disease.

Adriana Diaconu, Bogdan-Ioan Coculescu, Gheorghe Manole, Horațiu Vultur, Elena Claudia Coculescu, Cristina Maria Stocheci, Ioan-Sorin Tudorache, Alexandra-Ligia Dincă, Valeriu Gabi Dincă,

In a group of 208 patients with chronic ischaemic heart disease, the variation of A<sub>2</sub>-associated-LDL phosphatase (Lp-PLA<sub>2</sub>) serum concentration values was analysed in dynamics at a two-week interval. The conclusion of the study is that the values of serum concentration of Lp-PLA<sub>2</sub> can be accepted as a biomarker with diagnostic ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):68-73]

Cited: 0 times

View full text PDF listing >>



Establishment of an anti-inflammation-based bioassay for the quality control of the 13-component TCM formula (Lianhua Qingwen).

Shuaishuai Chen, Xiaojuan Yang, Ziying Wei, Yanru Zhang, Ying Huang, Zhuo Shi, Ziteng Zhang, Jiabo Wang, Haizhu Zhang, Jianli Ma, Xiaohe Xiao, Ming Niu,

<h4>Context</h4>Owing to the complexity of chemical ingredients in traditional Chinese medicine (TCM), it is difficult to maintain quality and efficacy by relying only on chemical markers.<h4>Objective</h4>Lianhua Qingwen capsule (LHQW) was selected as an example to discuss the feasibility of a bioassay for quality control.<h4>Materials and methods</h4>Network pharmacology was used to ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):537-545]

Cited: 0 times

View full text PDF listing >>



Ethanol extract of Gynura bicolour reduces atherosclerosis risk by enhancing antioxidant capacity and reducing adhesion molecule levels.

Shu-Ling Hsieh, Jinn-Chyi Wang, Yun-Shan Huang, Chih-Chung Wu,

<h4>Context</h4><i>Gynura bicolour</i> (Roxb. and Willd.) DC (Asteraceae) leaf is a common vegetable. Ethanol extracts of fresh <i>G. bicolour</i> leaves (GBEE) have several physiological effects, but studies on atherosclerosis are limited.<h4>Objective</h4>We investigated the oxidant scavenging ability and vascular adhesion molecule expression of these extracts.<h4>Materials and methods</h4>The antioxidant effects of 0.05-0.4 mg/mL GBEE ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):504-512]

Cited: 0 times

View full text PDF listing >>



Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells.

Patrycja Sosińska-Zawierucha, Andrzej Bręborowicz,

<h4>Background</h4>Uremia induces various pathologic changes in the endothelium. However, there is limited information about the differences of these effects in endothelial cells originating from different parts of the vascular tree.<h4>Methods</h4>The effect of uremic serum obtained from patients with end stage renal failure on the gene expression and secretory activity of ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):401-405]

Cited: 0 times

View full text PDF listing >>



Visfatin promotes intervertebral disc degeneration by inducing IL-6 expression through the ERK/JNK/p38 signalling pathways.

Haitao Cui, Xianfa Du, Caijun Liu, Shunlun Chen, Haowen Cui, Hui Liu, Jianru Wang, Zhaomin Zheng,

Visfatin reportedly induces the expression of proinflammatory cytokines. Severe grades of intervertebral disc disease (IVDD) exhibit higher expression of visfatin than mild ones. However, the direct relationship between visfatin and IVDD remains to be elucidated. This study aimed to clarify whether stimulation of visfatin in IVDD is mediated by IL-6. ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):201-215]

Cited: 0 times

View full text PDF listing >>



Bersaldegenin-1,3,5-orthoacetate induces caspase-independent cell death, DNA damage and cell cycle arrest in human cervical cancer HeLa cells.

Justyna Stefanowicz-Hajduk, Magdalena Gucwa, Barbara Moniuszko-Szajwaj, Anna Stochmal, Anna Kawiak, J Renata Ochocka,

<h4>Context</h4>Bufadienolide compounds occur in many plants and animal species and have strong cardiac and anti-inflammatory properties. The compounds have been recently investigated for cytotoxic and antitumor activity.<h4>Objective</h4>The cytotoxic effect of bersaldegenin-1,3,5-orthoacetate <b>-</b> a bufadienolide steroid occuring in plants from <i>Kalanchoe</i> genus (Crassulaceae), was evaluated with cervical cancer HeLa cells <i>in vitro</i>.<h4>Materials ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):54-65]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1 s