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Progressive Polyradiculopathy in HIV

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Early Aggressive Immunotherapy Improves Functional Outcome in Chronic Immune Sensory Polyradiculopathy.

Jasmine Shimin Koh, James Wei Min Tung, Genevieve Lynn Yu Tan-Yu, Thirugnanam Umapathi,

Chronic immune sensory polyradiculopathy (CISP) is an uncommon and treatable inflammatory disorder of the proximal sensory nerve roots. Patients typically present with severe sensory ataxia, normal motor examination, unsteady gait, and normal nerve conduction studies (NCS). We describe an elderly man who presented with a two-week history of progressive numbness ... Read more >>

Case Rep Neurol Med (Case reports in neurological medicine)
[2020, 2020:6595086]

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N2 year in review.

Josep Dalmau, Marinos C Dalakas, Dennis L Kolson, Friedemann Paul, Scott S Zamvil,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(1):]

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Motor lumbosacral radiculopathy in HIV-infected patients.

Kaminie Moodley, Pierre L A Bill, Vinod B Patel,

Background:This study is a review of the clinical findings and treatment outcome of 11 HIV-infected patients with motor lumbosacral radiculopathy. Objectives:To describe the clinical, laboratory, electrophysiological features and treatment outcome in HIV-infected motor lumbosacral radiculopathy which is a rare manifestation of HIV. Method:A retrospective review of HIV-infected patients with motor ... Read more >>

South Afr J HIV Med (Southern African journal of HIV medicine)
[2019, 20(1):992]

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Polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin (POEMS) changes syndrome presenting with a pseudosensory level: a case report.

Shiran Paranavitane, Lallindra Gooneratne, Thashi Chang,

INTRODUCTION:Polyneuropathy is a key feature of polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome, which is a paraneoplastic manifestation of an underlying lymphoproliferative neoplasm. We report the first case of polyneuropathy, organomegaly, endocrinopathy, monoclonal band, and skin changes syndrome presenting with a pseudosensory level. CASE PRESENTATION:A 59-year-old Tamil woman ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):384]

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Amyotrophic Lateral Sclerosis-like Syndrome after Chikungunya.

Felipe César Andrade, Vinicius Vergetti, Gabriella Cozza, Maria Clara Falcao, Gustavo Azevedo,

Amyotrophic lateral sclerosis (ALS)-like syndrome refers to a group of conditions whose outcome is similar to that of amyotrophic lateral sclerosis, but with different characteristics in the initial phase and response to therapy. The involvement of an earlier age group, the subacute course, and the stabilization or improvement of the ... Read more >>

Cureus (Cureus)
[2019, 11(10):e5876]

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Nonsystemic vasculitic neuropathy in a patient with IgG-monoclonal gammopathy of undetermined significance: A case report.

Ryuta Kinno, Yuyuko Osakabe, Seiya Takahashi, Shinji Kurokawa, Yoshiyuki Owan, Kenjiro Ono, Yasuhiko Baba,

RATIONALE:Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell proliferative disorder that consistently precedes multiple myeloma. Peripheral neuropathy in patients with IgG-MGUS tends to vary in clinical phenotype. We report a rare case of a patient with IgG-MGUS who had nonsystemic vasculitic neuropathy (NSVN). PATIENT CONCERNS:A 56-year-old Japanese woman ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(5):e19036]

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Multiple Neurologic Deficits and Cognitive Decline in a Young Woman.

Arunmozhimaran Elavarasi, Jacob George, Mehar Chand Sharma, Kalpana Kumari, Ajay Garg, Awadh Kishor Pandit, Abhishek Satapathy, Vinay Goyal,

We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia, reversal of albumin globulin ratio, mediastinal adenopathy, ANA positivity, low ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):506-512]

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Diagnosis and management of Guillain-Barré syndrome in ten steps.

Sonja E Leonhard, Melissa R Mandarakas, Francisco A A Gondim, Kathleen Bateman, Maria L B Ferreira, David R Cornblath, Pieter A van Doorn, Mario E Dourado, Richard A C Hughes, Badrul Islam, Susumu Kusunoki, Carlos A Pardo, Ricardo Reisin, James J Sejvar, Nortina Shahrizaila, Cristiane Soares, Thirugnanam Umapathi, Yuzhong Wang, Eppie M Yiu, Hugh J Willison, Bart C Jacobs,

Guillain-Barré syndrome (GBS) is a rare, but potentially fatal, immune-mediated disease of the peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and ... Read more >>

Nat Rev Neurol (Nature reviews. Neurology)
[2019, 15(11):671-683]

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How we treat neurological toxicity from immune checkpoint inhibitors.

Lavinia Spain, Zayd Tippu, James M Larkin, Aisling Carr, Samra Turajlic,

Neurological adverse events from immune checkpoint inhibition are increasingly recognised, especially with combination anti-cytotoxic T-lymphocyte antigen 4 (CTLA4) and anti-programmed death receptor 1 (anti-PD-1) therapies. Their presenting symptoms and signs are often subacute and highly variable, reflecting the numerous components of the nervous system. Given the risk of substantial morbidity ... Read more >>

ESMO Open (ESMO open)
[2019, 4(Suppl 4):e000540]

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Guillain Barre syndrome with pulmonary tuberculosis: A case series from a tertiary care hospital.

Sayan Malakar, Tarun D Sharma, Sujeet Raina, Kailash N Sharma, Dhiraj Kapoor,

Introduction:Guillain-Barre syndrome (GBS) is post-infectious autoimmune polyradiculopathy which characteristically presents with a monophasic illness with CSF albumino-cytological dissociation with partial or complete recovery. The incidence of GBS is about 1 to 2/100,000 per year.[1] Subtypes are described based on electrophysiological patterns, the most common being acute inflammatory demyelinating polyneuropathy (AIDP) ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(5):1794-1797]

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Neurological disorders in HIV in Africa: a review.

William P Howlett,

Background:Neurological disorders in HIV infection are a common cause of morbidity and mortality. The aim of this paper is to provide a narrative overview of up to date information concerning neurological disorders affecting HIV infected persons in Africa. Methods:Seminal research concerning neurological disorders among HIV-infected adults in sub-Saharan Africa from ... Read more >>

Afr Health Sci (African health sciences)
[2019, 19(2):1953-1977]

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Coincidence of Guillain-Barré syndrome presenting with Landry's acute flaccid paralysis and transverse myelitis.

Desislava Kalinova, Rasho Rashkov,

Transverse myelitis is one of the causes of acute transverse myelopathy; three main categories are described in the differential diagnosis of transverse myelitis: demyelination (multiple sclerosis, neuromyelitis optica), infections (herpes zoster and herpes simplex virus), and some autoimmune connective tissue disorders (systemic lupus erythematosus, vasculitis). The authors present a clinical ... Read more >>

Reumatologia (Reumatologia)
[2019, 57(2):120-122]

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Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease.

Yhojan Rodríguez, Nikhil Vatti, Carolina Ramírez-Santana, Christopher Chang, Oscar Mancera-Páez, M Eric Gershwin, Juan-Manuel Anaya,

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by neurological symptoms and signs of progressive weakness, paresthesias, and sensory dysfunction. Other symptoms include reduced or absent tendon reflexes, cranial nerve involvement, autonomic symptoms, ataxia, and neuropathic pain. Unlike other autoimmune diseases, CIDP generally affects older individuals and has ... Read more >>

J. Autoimmun. (Journal of autoimmunity)
[2019, 102:8-37]

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Two comparative assessments of intravenous immunoglobulin therapy switching patterns in the treatment of chronic inflammatory demyelinating polyneuropathy in the US.

Jeffrey T Guptill, M Chris Runken, Michael Eaddy, Orsolya E Lunacsek, Rupali M Fuldeore, Christopher M Blanchette, Emily Zacherle, Joshua M Noone,

Purpose: For chronic inflammatory demyelinating polyneuropathy (CIDP) patients, each branded intravenous immunoglobulin (IVIG) treatment differs in production processes, virus elimination, formulation, and composition. Given the limited availability of real-world data comparing IVIGs for CIDP, this study evaluated switching patterns between IVIG products in 2 separate retrospective databases. Patients and methods: ... Read more >>

Patient Prefer Adherence (Patient preference and adherence)
[2019, 13:649-655]

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Nivolumab-Associated Acute Demyelinating Encephalitis: A Case Report and Literature Review.

Zubair Zafar, Carrie Vogler, Tamer Hudali, Mukul Bhattarai,

Nivolumab is a checkpoint inhibiting immunotherapeutic agent prescribed for the treatment of resistant cancers. Many immune-related adverse effects including neurological effects have been described, but central nervous system (CNS) toxicities are rarely reported. We present a 59-year-old Caucasian woman with a history of treatment-resistant, progressive, laryngeal squamous cell carcinoma. She ... Read more >>

Clin Med Res (Clinical medicine & research)
[2019, 17(1-2):29-33]

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Cerebellar syndrome in a man treated with natalizumab: From the National Multiple Sclerosis Society Case Conference Proceedings.

David A Lapides, Prem P Batchala, Joseph H Donahue, Robert P Lisak, Ethan I Meltzer, Ram N Narayan, Avi Nath, Teresa C Frohman, Kathleen Costello, Myla D Goldman, Scott S Zamvil, Elliot M Frohman,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(3):e546]

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Cataclysmically disseminating neurologic presentation in an immunosuppressed lupus patient: From the National Multiple Sclerosis Society Case Conference Proceedings.

Christopher M Perrone, Robert P Lisak, Ethan I Meltzer, Peter Sguigna, Etsegenet Tizazu, Dina Jacobs, Esther Melamed, Ashlea Lucas, Leorah Freeman, Gabriel Pardo, Andrew Goodman, Edward J Fox, Kathleen Costello, Matthew S Parsons, Scott S Zamvil, Elliot M Frohman, Teresa C Frohman,

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2019, 6(4):e582]

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Combined central and peripheral demyelination: A case report and literature review.

Hamza Nouha, Hdiji Olfa, Farhat Nouha, Feki Sawsan, Sakka Salma, Haj Kacem Hanen, Dammak Mariem, Mhiri Chokri,

Iran J Neurol (Iranian journal of neurology)
[2019, 18(1):35-37]

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Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient.

Pedro Palma, Andreia Costa, Raquel Duro, Nélia Neves, Cândida Abreu, António Sarmento,

BACKGROUND:Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and central nervous system ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2018, 18(1):554]

Cited: 1 time

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Role of Anti-ganglioside Antibodies in the Diagnosis of Guillain-Barré Syndrome as an Alternate Investigation.

Muhammad Luqman Saeed, Behzad Kaleem Baloch, Syed Nayer Mahmud, Muhammad Tariq Khan, Muhammad Shoaib Safdar Qureshi, Zahid Siddique Shad, Syed Waqar Hussain, Kamran Munawar, Aayesha Qadeer, Azmat Abdullah,

Objective The goal of the study was to see if anti-ganglioside antibodies have a role in the diagnosis of Guillain-Barré syndrome (GBS). Study design Between May 2016 to October 2017, we conducted a prospective pilot study of 15 patients with a clinical diagnosis of GBS with equivocal cerebrospinal fluid (CSF) ... Read more >>

Cureus (Cureus)
[2019, 11(5):e4625]

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Cytomegalovirus encephalitis radiographically mimicking lateral medullary stroke.

Damon Li, Stephen van Gaal,

Neurol Clin Pract (Neurology. Clinical practice)
[2018, 8(6):e37-e39]

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Clinical diagnosis and treatment recommendations for immune checkpoint inhibitor-related adverse reactions in the nervous system.

Jiayu Shi, Jingwen Niu, Dongchao Shen, Mingsheng Liu, Ying Tan, Yi Li, Yangyu Huang, Liying Cui, Yuzhou Guan, Li Zhang,

Immune checkpoint inhibitors (ICIs) can cause adverse reactions in the nervous system. The incidence rate is 0.1%-12% and 80% of nervous system adverse reactions occur within the first four months of application. ICIs can cause diseases of various parts of the nervous system including central nervous system diseases such as ... Read more >>

Thorac Cancer (Thoracic cancer)
[2020, 11(2):481-487]

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Atypical Lyme Neuroborreliosis, Guillain-Barré Syndrome or Conversion Disorder: Differential Diagnosis of Unusual Neurological Presentations.

Tomás Teodoro, Renato Oliveira, Pedro Afonso,

Nervous system Lyme disease and Guillain-Barré syndrome are common neurological conditions that may present with unusual symptoms rendering differential diagnosis difficult. We report the case of a 62-year-old woman presenting with asymmetrical tetraparesis and hyporeflexia. Initially the presumed diagnosis of Guillain-Barré syndrome with a possible functional component was suspected and ... Read more >>

Case Rep Neurol (Case reports in neurology)
[2019, 11(1):142-147]

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Clinical Mimickers of Amyotrophic Lateral Sclerosis-Conditions We Cannot Afford to Miss.

Nishita Singh, Sucharita Ray, Achal Srivastava,

Giving a diagnosis of amyotrophic lateral sclerosis to a patient is akin to handing out a death certificate. However, not all patients presenting with the classical dysphagia, wasting, and weakness may have motor neuron diseases. In these cases, it is extremely important not to miss little cues which can suggest ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2018, 21(3):173-178]

Cited: 2 times

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Leptospirosis complicated with Guillain Barre syndrome, papillitis and thrombotic thrombocytopenic Purpura; a case report.

Kavinga Kalhari Kobawaka Gamage, Harshini Fernando,

BACKGROUND:Leptospirosis is a zoonosis commonly prevalent in tropical countries. Clinical course of leptospirosis varies from mild to severe disease. Here we present a case of leptospirosis complicated with Guillain-Barre Syndrome (GBS), papillitis, and Thrombotic Thrombocytopenic Purpura(TTP). CASE PRESENTATION:A 21-year-old Asian male presented with fever, myalgia, oliguria and dyspnoea where he ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2018, 18(1):691]

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