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Admission hyperglycaemia as a predictor of mortality in patients hospitalized with COVID-19 regardless of diabetes status: data from the Spanish SEMI-COVID-19 Registry.

Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Francisco Javier Martínez-Marcos, Luis M Pérez-Belmonte, Alicia Hidalgo-Jiménez, Verónica Buonaiuto, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Davide Luordo, Paula Maria Pesqueira Fontan, Julio César Blázquez Encinar, Jeffrey Oskar Magallanes Gamboa, Andrés de la Peña Fernández, José David Torres Peña, Joaquim Fernández Solà, Jose Javier Napal Lecumberri, Francisco Amorós Martínez, María Esther Guisado Espartero, Carlos Jorge Ripper, Raquel Gómez Méndez, Natalia Vicente López, Berta Román Bernal, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Ricardo Gómez Huelgas, ,

BACKGROUND:Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS:This is a retrospective multi-centre study involving patients hospitalized in Spain. ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):103-116]

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Association between plasma immunoproteasome and 90-day prognosis after first-ever ischemic stroke.

Xing-Yong Chen, Ming Fu, Shao-Fen Wan, Xu Zhang, Yin-Zhou Wang,

Many blood biomarkers are reportedly helpful for predicting post-stroke cognitive impairment (PSCI), but no biomarkers are widely used in clinical practice. The purpose of this study was to investigate the association between the plasma immunoproteasome and patients' 90-day prognosis after first-ever acute ischemic stroke. In our prospective, single-center study, 259 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(4):790-795]

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Secondary release of the peripheral nerve with autologous fat derivates benefits for functional and sensory recovery.

Natalia E Krzesniak, Anna Sarnowska, Anna Figiel-Dabrowska, Katarzyna Osiak, Krystyna Domanska-Janik, Bartłomiej H Noszczyk,

The reconstruction of nerve continuity after traumatic nerve injury is the gold standard in hand surgery. Immediate, tension-free, end-to-end nerve suture ensures the best prognosis. The recovery is mostly promising; however, in a few cases, insufficient outcomes in motor or sensory function are observed. Intra- and extra-fascicular scarring accompanies the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(5):856-864]

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Effect of Compound Propofol Nanoemulsion on Immune Function in Patients with Pancreatic Cancer.

Zhihua Wang, Shengcai Zhou, Sourour Elloumi, Antony Pottier,

Pancreatic cancer is a common malignant tumor of the digestive system, and its incidence is increasing worldwide. The treatment of pancreatic cancer is mainly surgery, but the development of traditional surgery, chemoradiotherapy has entered the plateau stage, and immunotherapy has received more and more attention. Different anesthesia methods, anaesthetic drugs ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(2):1390-1396]

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Creatine kinase in the diagnosis and prognostic prediction of amyotrophic lateral sclerosis: a retrospective case-control study.

Xue-Ping Chen, Qian-Qian Wei, Ru-Wei Ou, Yan-Bing Hou, Ling-Yu Zhang, Xiao-Qin Yuan, Yun-Qian Yao, De-Sheng Jia, Qian Zhang, Wei-Xue Li, Hui-Fang Shang,

Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. In the present retrospective case-control study, we included 582 patients with amyotrophic lateral sclerosis and 582 age- and sex-matched healthy controls. All amyotrophic lateral sclerosis participants received treatment ... Read more >>

Neural Regen Res (Neural regeneration research)
[2021, 16(3):591-595]

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[Analysis of prognosis and risk factors of 730 patients with anterior communicating aneurysm].

Y B Chen, Z Wang, D Zhou, S M Zhang, Z Q Yu, G Chen,

Objective: To investigate the prognosis and risk factors of patients with anterior communicating aneurysm treated by aneurysm clipping or interventional embolization. Methods: The clinical data of 730 patients with anterior communicating aneurysm who underwent aneurysm clipping or interventional embolization in the department of neurosurgery, the first affiliated hospital of Soochow ... Read more >>

Zhonghua Yi Xue Za Zhi (Zhonghua yi xue za zhi)
[2020, 100(44):3515-3519]

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Differentiating Inflammatory Bowel Disease from Alimentary Lymphoma in Cats: Does It Matter?

Sina Marsilio,

Differentiation of feline inflammatory bowel disease and intestinal small cell lymphoma can be challenging, and some clinicians argue that it is unnecessary because prognosis and treatment are similar. Differentiation of feline inflammatory bowel disease and intestinal small cell lymphoma can be challenging and some clinicians argue that it is unnecessary ... Read more >>

Vet Clin North Am Small Anim Pract (The Veterinary clinics of North America. Small animal practice)
[2021, 51(1):93-109]

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Development of a 15-gene signature for predicting prognosis in advanced colorectal cancer.

Xiao Wang, Tianzuo Li,

Advanced colorectal cancer (CRC) is a significant cause of cancer mortality, with a poor prognosis. Here, we identified a novel prognostic signature for predicting survival of advanced CRC. Advanced CRC data were used (training set: n = 267 and validation set: n = 264). The survival analyses were investigated. The functional analysis ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):165-174]

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A glycolysis-related gene signature predicts prognosis of patients with esophageal adenocarcinoma.

Huafeng Kang, Nan Wang, Xuan Wang, Yu Zhang, Shuai Lin, Guochao Mao, Di Liu, Chengxue Dang, Zhangjian Zhou,

BACKGROUND:Esophageal adenocarcinoma (EAC) is a growing problem with a rapidly rising incidence and carries a poor prognosis. We aimed to develop a glycolysis-related gene signature to predict the prognostic outcome of patients with EAC. RESULTS:Five genes (CLDN9, GFPT1, HMMR, RARS and STMN1) were correlated with prognosis of EAC patients. Patients ... Read more >>

Aging (Albany NY) (Aging)
[2020, 12:]

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Beta-blockers in heart failure prognosis: Lessons learned by MECKI Score Group papers.

Gaia Cattadori, Silvia Di Marco, Stefania Farina, Giuseppe Limongelli, Emanuele Monda, Roberto Badagliacca, Silvia Papa, Lucia Tricarico, Michele Correale,

Heart failure is a complex syndrome affecting several organs including kidney, lungs, liver, brain muscles and sympathetic system. Each of these organs might contribute to its severity and prognosis. The prognosis assessment is critical for a correct heart failure management. It has already been demonstrated that a single parameter is ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(2_suppl):65-71]

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Association of liver steatosis and fibrosis with clinical outcomes in patients with SARS-CoV-2 infection (COVID-19)

Xiaofei Li,

Ann Hepatol (Annals of hepatology)
[2020, :]

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Communicating Oncologic Prognosis With Empathy: A Pilot Study of a Novel Communication Guide.

Megan Lippe, Phillips Farya, McCulloch Jennifer, Alexandra Stanley, Jones Barbara, Goodgame Boone,

BACKGROUND:Clear communication between patients, families, and health-care providers is imperative to maximize patient outcomes, particularly for patients diagnosed with incurable cancer who require prompt engagement in decision-making. In response to the need to engage in quality patient-centered communication, an interprofessional team, representing medicine, nursing, social work, spiritual care, and clinical ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2020, 37(12):1029-1036]

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Low expression of adenomatous polyposis coli 2 correlates with aggressive features and poor prognosis in colorectal cancer.

Yan Sun, Hua Tian, Xuehu Xu, Lin Wang,

Currently, there are no relevant findings on the diagnostic and prognostic roles of adenomatous polyposis coli 2 (APC2) in colorectal cancer (CRC). This study investigated the clinical value of APC2 dysregulation in the prognosis of CRC. Immunohistochemical scores obtained from tissue microarrays were used to quantify the expression of APC2 ... Read more >>

Bioengineered (Bioengineered)
[2020, 11(1):1027-1033]

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Clinical features and prognosis of normal karyotype acute myeloid leukemia pediatric patients with WT1 mutations: an analysis based on TCGA database.

Jing Xu, Yaofang Zhang, Jinjun Hu, Yan Ren, Hongwei Wang,

Objectives: To explore the clinical features and prognosis of normal karyotype acute myeloid leukemia (NK-AML) pediatric patients with WT1 mutations.Methods: The clinical data and prognostic information of 220 NK-AML pediatric patients were selected from target-AML project of The Cancer Genome Atlas (TCGA) database. Survival analyses were performed for NK-AML pediatric ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):79-84]

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[Correlation of serum PTTG1 expression level with clinicopathological features and prognosis in patients with laryngeal cancer].

Zhixuan Zhang, Xiaoye Wang, Xiaoye Tan,

Objective:To investigate the correlation between the expression level of serum pituitary tumor transforming gene(PTTG1) and clinicopathological characteristics and prognosis in patients with laryngeal cancer. Method:Enzyme-linked immunosorbent assay was used to detect the expression of serum PTTG1 in 80 patients with laryngeal cancer and 60 patients with vocal cord polyps. The ... Read more >>

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery)
[2020, 34(12):1128-1131]

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miR-30b-5p up-regulation related to the dismal prognosis for patients with renal cell cancer.

Chunduo Zhang, Xiang Pan, Xiqi Peng, Kaihao Liu, Jingyao Wang, Liwen Zhao, Xuan Chen, Guocheng Huang, Hang Li, Jing Ye, Yongqing Lai,

The diagnosis of renal cell carcinoma (RCC) is often made late since there is no early symptom, which thus results in dismal patient prognosis. As a result, new biomarkers are urgently needed and efforts should be made to identify their functions in predicting RCC prognosis. microRNAs (miRNAs) are a class ... Read more >>

J Clin Lab Anal (Journal of clinical laboratory analysis)
[2020, :e23599]

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Immune-related gene data-based molecular subtyping related to the prognosis of breast cancer patients.

Guoyu Mu, Hong Ji, Hui He, Hongjiang Wang,

BACKGROUND:Breast cancer (BC), which is the most common malignant tumor in females, is associated with increasing morbidity and mortality. Effective treatments include surgery, chemotherapy, radiotherapy, endocrinotherapy and molecular-targeted therapy. With the development of molecular biology, immunology and pharmacogenomics, an increasing amount of evidence has shown that the infiltration of immune ... Read more >>

Breast Cancer (Breast cancer (Tokyo, Japan))
[2020, :]

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Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV.

Keming Zhang, Hang Li, Lei Zhang, Wanqing Liao, Liyan Ling, Xiaojing Li, Jianjun Lin, Bin Xu, Weihua Pan, Qilong Zhang,

Aim: To evaluate the clinical data and quantitative cerebrospinal fluid for associations with the outcome of cryptococcal meningitis (CM) patients in the hospital. Patients & methods: We retrospectively analyzed a total of 139 CM patients comprising 108 without HIV and 31 with HIV admitted in a Jiang Xi hospital. Results: We ... Read more >>

Future Microbiol (Future microbiology)
[2020, :]

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Role of comorbidities in heart failure prognosis Part I: Anaemia, iron deficiency, diabetes, atrial fibrillation.

Stefania Paolillo, Angela B Scardovi, Jeness Campodonico,

Cardiovascular and non-cardiovascular comorbidities are frequently observed in heart failure patients, complicating the therapeutic management and leading to poor prognosis. The prompt recognition of associated comorbid conditions is of great importance to optimize the clinical management, the follow-up, and the treatment of patients affected by chronic heart failure. Anaemia and ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, 27(2_suppl):27-34]

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Clinical value and potential association of Rab1A and FoxM1 aberrant expression in colorectal cancer.

Menglin Xu, Xinyu Shao, Haoran Li, Zhengrong Zhang, Chunli Zhou, Zhengwu Cheng,

Colorectal carcinoma (CRC) is one of the most common malignancies with a dismal 5-year survival rate. Our recent study indicated that Rab1A expression was closely related to GLI1 expression. A previous study shows that aberrant overexpression of GLI1 promotes colorectal cancer metastasis via FoxM1 overexpression. However, the potential correlation between ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):20160]

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Identification of prognostic genes in uveal melanoma microenvironment.

Huan Luo, Chao Ma,

BACKGROUND:Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Many previous studies have demonstrated that the infiltrating of immune and stromal cells in the tumor microenvironment contributes significantly to prognosis. METHODS:Dataset TCGA-UVM, download from TCGA portal, was taken as the training cohort, and GSE22138, obtained from GEO ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242263]

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Screening of Methylation Gene Sites as Prognostic Signature in Lung Adenocarcinoma.

Min Dong, Zengli Yang, Xingfang Li, Zhenxiang Zhang, Ankang Yin,

PURPOSE:Most lung adenocarcinoma (LUAD) patients are diagnosed at the advanced stage and have poor prognosis. DNA methylation plays an important role in the prognosis prediction of cancers. The objective of this study was to identify new DNA methylation sites as biomarkers for LUAD prognosis. MATERIALS AND METHODS:We downloaded DNA methylation ... Read more >>

Yonsei Med J (Yonsei medical journal)
[2020, 61(12):1013-1023]

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WT1 overexpression predicted good outcomes in adult B-cell acute lymphoblastic leukemia patients receiving chemotherapy.

Shujuan Wang, Chong Wang, Tao Li, Weiqiong Wang, Qianqian Hao, Xinsheng Xie, Dingming Wan, Zhongxing Jiang, Yanfang Liu,

Objectives: The prognostic role of WT1 in acute lymphoblastic leukemia (ALL) is still controversial. No study has focused on the prognostic role of WT1 expression in adult B-ALL patients receiving chemotherapy only.Methods: Using TaqMan-based real time quantitative PCR (RQ-PCR), we detected the WT1 transcript levels of 162 de-novo adult B-ALL ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):118-124]

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A signature of 17 immune-related gene pairs predicts prognosis and immune status in HNSCC patients.

Pan Jiang, Yanli Li, Zheng Xu, Shengteng He,

Head and neck squamous cell carcinoma (HNSCC) is an invasive malignancy with high worldwide mortality. Growing evidence has indicated a pivotal correlation between HNSCC prognosis and immune signature. This study investigated an immune-related gene pairs (IRGPs) signature to predict the prognostic value of HNSCC patients. We constructed IRGPs via integrating ... Read more >>

Transl Oncol (Translational oncology)
[2020, 14(1):100924]

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Identification Sixteen Metabolic Genes as Potential Biomarkers for Colon Adenocarcinoma

Fu-qiang Zhao, Yan-long Liu, Xin-yue Gu, Bomiao Zhang, Chengxin Song, Bin-bin Cui,

Purpose Colon adenocarcinoma is the most common primary malignant tumor of the digestive tract. It is still important to find important markers that affect the prognosis of COAD. This research aims to identify some key prognosis-related metabolic genes (PRMG) and establish a clinical prognosis model for COAD patients. Method We ... Read more >>

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