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Prediction of diagnosis and prognosis of COVID-19 disease by blood gas parameters using decision trees machine learning model: a retrospective observational study.

Mehmet Tahir Huyut, Hilal Üstündağ,

The coronavirus disease 2019 (COVID-19) epidemic went down in history as a pandemic caused by corona-viruses that emerged in 2019 and spread rapidly around the world. The different symptoms of COVID-19 made it difficult to understand which variables were more influential on the diagnosis, course and mortality of the disease. ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(2):60-66]

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Current research progress of isoflurane in cerebral ischemia/reperfusion injury: a narrative review.

Shu-Jun Chen, Xia-Qing Yuan, Qun Xue, Hai-Feng Lu, Gang Chen,

Cerebral ischemia/reperfusion injury is an important factor leading to poor prognosis in ischemic stroke patients. Therefore, it is particularly important to find effective remedial measures to promote the health of patients to return to society. Isoflurane is a safe and reliable anesthetic gas with a long history of clinical application. ... Read more >>

Med Gas Res (Medical gas research)
[2022, 12(3):73-76]

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Leukoaraiosis is associated with clinical symptom severity, poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage: a prospective multi-center cohort study.

Tian-Qi Xu, Wei-Zhi Lin, Yu-Lan Feng, Fan-Xia Shen, Jie Chen, Wei-Wen Wu, Xiao-Dong Zhu, Lin Gu, Yi Fu,

Leukoaraiosis (LA) results from ischemic injury in small cerebral vessels, which may be attributable to decreased vascular density, reduced cerebrovascular angiogenesis, decreased cerebral blood flow, or microcirculatory dysfunction in the brain. In this study, we enrolled 357 patients with mild intracerebral hemorrhage (ICH) from five hospitals in China and analyzed ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(4):819-823]

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Can united airway disease be the cause of variable severity experience of COVID-19 in health care workers?

Merih Onal, Ozkan Onal, Alparslan Turan,

Med Gas Res (Medical gas research)
[2022, 12(2):69-71]

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AI-Based Detection, Classification and Prediction/Prognosis in Medical Imaging:: Towards Radiophenomics.

Fereshteh Yousefirizi, Pierre Decazes, Amine Amyar, Su Ruan, Babak Saboury, Arman Rahmim,

Artificial intelligence (AI) techniques have significant potential to enable effective, robust, and automated image phenotyping including the identification of subtle patterns. AI-based detection searches the image space to find the regions of interest based on patterns and features. There is a spectrum of tumor histologies from benign to malignant that ... Read more >>

PET Clin (PET clinics)
[2022, 17(1):183-212]

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The Pyroptosis-Related Signature Predicts Prognosis in Uterine Corpus Endometrial Carcinoma

Mengjun Zhang, Siyu Hou, Jialin Wang, Haodi Yue,

<h4>Background: </h4> Uterine Corpus Endometrial Carcinoma (UCEC) is difficult to evaluate the prognosis. The prognostic evaluation model based on pyroptosis-related genes (PRGs) has shown good predictive power for prognosis in tumors, but there is no relevant research in UCEC. <h4>Methods:</h4> Based on the gene expression data and clinical prognosis information ... Read more >>

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Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis.

Maria N Zakharova, Anna A Abramova,

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting, breathing and swallowing difficulties resulting in patient's death in two to five years after disease onset. In amyotrophic lateral sclerosis, both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2022, 17(1):65-73]

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Diverse functions of long noncoding RNAs in acute myeloid leukemia: emerging roles in pathophysiology, prognosis, and treatment resistance.

Srishti Mishra, Jun Liu, Li Chai, Daniel G Tenen,

Advancements in the next-generation sequencing technologies have identified rare transcripts of long noncoding RNAs (lncRNAs) in the genome of cancers, including in acute myeloid leukemia (AML). The purpose of this review is to highlight the contribution of lncRNAs in AML pathogenesis, prognosis, and chemoresistance. Several studies have recently reported that ... Read more >>

Curr Opin Hematol (Current opinion in hematology)
[2022, 29(1):34-43]

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Study on collateral circulation level and prognosis of acute ischemic stroke by 4D CTA-CTP integrated technology and serum S100B.

Gang Peng, Weiping Lu, Kai Chen, Xiaodan Yang, Jianguo Wei, Bo Wang, Bingcang Huang,

To evaluate the cerebral collateral circulation in patients with acute ischemic stroke (AIS) by Four-dimensional CT angiography-CT perfusion (4D CTA-CTP)-integrated technology, and to explore the feasibility of predicting the prognosis of patients with AIS by using cerebral collateral circulation and serum S100B protein concentration. Thirty-two patients with anterior circulation AIS ... Read more >>

Microvasc Res (Microvascular research)
[2021, :104270]

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A circadian rhythm-related gene signature associated with tumor immunity, cisplatin efficacy, and prognosis in bladder cancer.

Ranran Zhou, Xinyu Chen, Jingjing Liang, Qi Chen, Hu Tian, Cheng Yang, Cundong Liu,

Circadian dysregulation involves malignant tumor initiation and progression, but the understanding of circadian rhythm's roles in bladder cancer (BCa) remains insufficient. The circadian rhythm-related genes were collected and clustered based on the Cancer Genome Atlas (TCGA), and the clustering was significantly associated with the prognosis and risk clinicopathological features. Through ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(undefined):]

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Impact of statin use on the risk and prognosis of hepatocellular carcinoma: a meta-analysis.

Jianfeng Wang, Xiaogang Li,

<h4>Background</h4>Previous studies have demonstrated that statin use might be associated with a reduced risk of hepatocellular carcinoma (HCC). However, the value of statin on the prognosis still needs to be evaluated. Based on the above considerations, we conducted a meta-analysis regarding the value of statin on the prevention and prognosis ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(12):1603-1609]

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Effect of unfolded protein response on the immune infiltration and prognosis of transitional cell bladder cancer.

Xiaokai Yan, Min Chen, Chiying Xiao, Jiandong Fu, Xia Sun, Zuohuai Hu, Hang Zhou,

<b>Background:</b> Bladder cancer (BC) is one of the most common human malignancies worldwide. Previous researches have shown that the unfolded protein response (UPR) pathway could contribute to the tumorigenesis of BC. However, the role of UPR in the immune infiltration, progression, and prognosis of BC is unclear.<b>Methods:</b> The GSVA and ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1048-1058]

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Standard Modifiable Cardiovascular Risk Factors and Prognosis of Acute Coronary Syndrome in Younger Patients.

Xu Chen, Han-Xiong Liu, Xiu-Qiong Yu, Si-Qi Yang, Ling-Yao Qi, Lin Cai,

<h4>Objective</h4>To investigate standard modifiable cardiovascular risk factors (SMuRFs) and prognosis of patients with acute coronary syndrome (ACS) aged 50 years or younger.<h4>Study design</h4>An observational study.<h4>Place and duration of study</h4>Eleven general hospitals in Chengdu, Sichuan Province, China, from January 2017 to June 2019.<h4>Methodology</h4>Patients with ACS were stratified into younger group (≤50 ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2021, 31(12):1394-1398]

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Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer.

Yali Deng, Zewen Song, Li Huang, Zhenni Guo, Binghua Tong, Meiqing Sun, Jin Zhao, Huina Zhang, Zhen Zhang, Guoyin Li,

<h4>Background</h4>Tumor purity plays a vital role in the biological process of solid tumors, but its function in gynecologic cancers remains unclear. This study explored the correlation between tumor purity and immune function of gynecological cancers and its reliability as a prognostic indicator of immunotherapy.<h4>Methods</h4>Gynecological cancer-related datasets were downloaded from The ... Read more >>

Aging (Albany NY) (Aging)
[2021, 13(undefined):]

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Alternative Polyadenylation Associated with Prognosis and Therapy in Colorectal Cancer

Yuzhi Wang, Yunfei Xu, Yi Zhang,

Colorectal cancer (CRC) is among the most widely spread cancers globally. Aberrant alternative polyadenylation (APA) plays a role in cancer onset and its progression. Consequently, this study focused on highlighting the role of APA events and signals in the prognosis of patients with CRC. The APA events, RNA sequencing (RNA-seq), ... Read more >>

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An Accurate Prognostic Model and Treatment for Pancreatic Carcinoma Based on the Tumor Immune Microenvironment

Shujie Wang, zhenchong li, chunsheng liu, qi zhou, zuyi ma, zixuan zhou, Hongkai Zhuang, Shanzhou Huang, Chanzhao Zhang, Baohua Hou,

<h4>Background: </h4> Pancreatic adenocarcinoma (PAAD) is a highly malignant cancer with a poor prognosis. The tumor microenvironment (TME) is closely related to tumorigenesis, progression, and treatment. However, the relationship between TME immune cell genes and prognosis in PAAD is currently unclear.Methodsn this study, we identified three prognostic subtypes based on ... Read more >>

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Immune-associated molecular occurrence and prognosis predictor of hepatocellular carcinoma: an integrated analysis of GEO datasets.

Guanjun Liu, Dongmei Wu, Yiyang Wen, Shundong Cang,

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second most common cause of cancer-related deaths worldwide. As immune response failure is the main factor in the occurrence and poor prognosis of HCC, our study aimed to develop an immune-associated molecular occurrence and prognosis predictor (IMOPP) of HCC. ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):5253-5265]

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Prognosis and role of clinical and imaging features in patients with malignant pericardial effusion: a single-center study in China.

Shucai Wang, Jiazheng Zhao, Chanchan Wang, Ning Zhang,

<h4>Background</h4>The diagnosis of malignant pericardial effusion (MPE) is often associated with a poor prognosis, but due to the complexity and unspecific nature of MPE patients' clinical manifestations, imaging often performs an essential role in diagnosis and prognosis.<h4>Methods</h4>Patients diagnosed with MPE between 2013 and 2018 at one tumor hospital were included ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2021, 21(1):565]

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Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature.

Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li, Xiaobin Tian,

Cutaneous melanoma (CM) is a malignant and aggressive skin cancer that is the leading cause of skin cancer-related deaths. Increasing evidence shows that immunity plays a vital role in the prognosis of CM. In this study, we developed an immune-related gene pair (IRGP) signature to predict the clinical prognosis of ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1803-1812]

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Construction and validation of nomograms for predicting the prognosis of grade 3 endometrial endometrioid adenocarcinoma cancers: a SEER-based study.

Xiaofei Liu, Junbo Zhao, Zhiwei Sun, Guangwei Wang,

Most cases of endometrial adenocarcinoma (EAC) are diagnosed early and have a good prognosis; however, grade 3 (G3) EACs have poor outcomes. We retrospectively analyzed the data of 11,519 patients with G3 EACs registered between 2004 and 2015 in the Surveillance, Epidemiology, and End Results Program database and constructed a ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1752-1765]

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Normotensive and hypertensive Immunoglobulin a nephropathy with ischemic renal injury: clinicopathological characteristics and prognosis.

Yongli Wang, Xutong Wang, Dan Yu, Minhua Xie, Jingjing Ren, Yuze Zhu, Haonan Guo, Songxia Quan, Junjun Zhang,

<h4>Objectives</h4>This study aimed to investigate the clinicopathological characteristics and prognosis of normotensive and hypertensive IgAN patients with ischemic renal injury.<h4>Methods</h4>A total of 344 cases of IgAN with ischemic renal injury were included in the study, including 99 normotensive IgAN patients (28.8%) and 245 hypertensive IgAN patients (71.2%). In addition, 467 ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):1454-1462]

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A functional methylation signature to predict the prognosis of Chinese lung adenocarcinoma based on TCGA.

Ke Wang, Ying Liu, Guanzhong Lu, Jinrong Xiao, Jiao Huang, Lin Lei, Ji Peng, Yangkai Li, Sheng Wei,

Lung cancer is the leading cause of cancer morbidity and mortality worldwide, however, the individualized treatment is still unsatisfactory. DNA methylation can affect gene regulation and may be one of the most valuable biomarkers in predicting the prognosis of lung adenocarcinoma. This study was aimed to identify methylation CpG sites ... Read more >>

Cancer Med (Cancer medicine)
[2021, :]

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Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics.

Shuai Chen, Yi Wei, Hanyang Liu, Yu Gong, Yan Zhou, Haojun Yang, Liming Tang,

Collagen type X alpha 1 (COL10A1) is a member of the collagen family and the main matrix component. However, COL10A1 expression and prognosis relationship remains unclear in gastric cancer (GC). Through the analysis of database of Oncomine, the Cancer Genome Atlas (TCGA) as well as the Gene Expression Omnibus (GEO), ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):127-137]

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Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression.

Xiaoyue Ren, Alex Li, Edward Ying, Jhin Fang, Mingzhu Li, Jiao Yu,

Reportedly, ubiquitin-conjugating enzyme E2T (UBE2T) is closely related to the progression of several malignancies. This work is aimed to probe the role of UBE2T in the progression of hepatocellular carcinoma (HCC) patients. The microarray analysis was executed to screen the differentially expressed genes (DEGs) in HCC tissues. The Cancer Genome ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):1530-1542]

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Identification and clinical validation of EMT-associated prognostic features based on hepatocellular carcinoma.

Dafeng Xu, Yu Wang, Jincai Wu, Shixun Lin, Yonghai Chen, Jinfang Zheng,

<h4>Background</h4>The aim of this study was to construct a model based on the prognostic features associated with epithelial-mesenchymal transition (EMT) to explore the various mechanisms and therapeutic strategies available for the treatment of metastasis and invasion by hepatocellular carcinoma (HCC) cells.<h4>Methods</h4>EMT-associated genes were identified, and their molecular subtypes were determined ... Read more >>

Cancer Cell Int (Cancer cell international)
[2021, 21(1):621]

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