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Effects of hormone replacement therapy on lens opacity, serum inflammatory cytokines, and antioxidant levels.

Donghyun Jee, Sang Hee Park, Ho Sik Hwang, Hyun Seung Kim, Man Soo Kim, Eun Chul Kim,

<h4>Purpose</h4>To evaluate the effect of hormone replacement therapy (HRT) on lens opacity as measured by Scheimpflug densitometry, serum inflammatory cytokines, and antioxidant levels.<h4>Methods</h4>A total of 264 women who were at least five years beyond menopause were included. The control group of 128 patients (Group 1) did not use HRT at ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):707-714]

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Utility of progesterone receptor-ires-Cre to generate conditional knockout mice for uterine study.

Takafumi Namiki, Maki Kamoshita, Atsuko Kageyama, Jumpei Terakawa, Junya Ito, Naomi Kashiwazaki,

In mice, the conditional knockout strategy using the Cre-loxP system is useful for various types of research. The Cre mouse line with progesterone receptor promoter (Pgr<sup>Cre</sup> ) has been widely used to produce specific uterine gene-deficient mice, but in the Cre line, endogenous Pgr gene is replaced by Cre recombinase ... Read more >>

Anim Sci J (Animal science journal = Nihon chikusan Gakkaiho)
[2021, 92(1):]

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Progesterone Receptors in AVPV Kisspeptin Neurons Are Sufficient for Positive Feedback Induction of the LH Surge.

Margaret A Mohr, Lourdes A Esparza, Paige Steffen, Paul E Micevych, Alexander S Kauffman,

Kisspeptin, encoded by Kiss1, stimulates gonadotropin-releasing hormone neurons to govern reproduction. In female rodents, estrogen-sensitive kisspeptin neurons in the rostral anteroventral periventricular (AVPV) hypothalamus are thought to mediate estradiol (E2)-induced positive feedback induction of the preovulatory luteinizing hormone (LH) surge. AVPV kisspeptin neurons coexpress estrogen and progesterone receptors (PGRs) and ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(11):]

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Autoantibodies in association with subchorionic haematoma in early pregnancy.

Yang Li, Ensheng Wang, Shisi Huang, Changling Zhu, Kemei Zhang, Jiaou Zhang, Haiyan Xu, Jing Shu,

<h4>Objective</h4>To explore the possible aetiology of subchorionic haematoma (SCH), especially its association with autoantibodies.<h4>Material and methods</h4>Early pregnant women who were detected SCH through ultrasonography were identified as the study group and those without SCH at comparable ages who visited the clinic at the same period of time were compared as ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):841-847]

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LH Induces De Novo Cholesterol Biosynthesis via SREBP Activation in Granulosa Cells During Ovulation in Female Mice.

Tomoya Nakanishi, Risa Tanaka, Shingo Tonai, Joo Yeon Lee, Manami Yamaoka, Tomoko Kawai, Asako Okamoto, Masayuki Shimada, Yasuhisa Yamashita,

In the liver, the sterol response element binding protein (SREBP) and the SREBP cleavage-activated protein (SCAP) complex upregulate cholesterol biosynthesis by gene induction of de novo cholesterol synthetic enzymes (Hmgcr, Cyp51, and Dhcr7). Insulin induced gene 1 (INSIG1) negatively regulates cholesterol biosynthesis by the inhibition of de novo cholesterol biosynthetic ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(11):]

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Prenatal Androgen Exposure Alters KNDy Neurons and Their Afferent Network in a Model of Polycystic Ovarian Syndrome.

Aleisha M Moore, Dayanara B Lohr, Lique M Coolen, Michael N Lehman,

Polycystic ovarian syndrome (PCOS), the most common endocrinopathy affecting women worldwide, is characterized by elevated luteinizing hormone (LH) pulse frequency due to the impaired suppression of gonadotrophin-releasing hormone (GnRH) release by steroid hormone negative feedback. Although neurons that co-express kisspeptin, neurokinin B, and dynorphin (KNDy cells) were recently defined as ... Read more >>

Endocrinology (Endocrinology)
[2021, 162(11):]

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May mepolizumab used in asthma correct subfertility?

Guzin Ozden, Pelin Pınar Deniz,

<h4>İntroduction</h4>Asthma is one of the most common chronic airway disease among reproductive period of women. Chronic inflammation in asthma, eosinophilia, high steroid treatment and uncontrolled asthma may cause infertility by affecting the reproductive organs, menstrual cycle and quality of life. Some patients with severe asthma have frequent exacerbations associated with ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):456-458]

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Hormones Nanofiltration in Carbon Nanotubes and Boron Nitride Nanotubes Using Uniform External Electric Field Through Molecular Dynamics.

Rosely Maria Dos Santos Cavaleiro, Tiago da Silva Arouche, Phelipe Seiichi Martins Tanoue, Tais Souza Sá Pereira, Raul Nunes de Carvalho Junior, Fabio Luiz Paranhos Costa, Tarciso Silva de Andrade Filho, Rosivaldo Dos Santos Borges, Antonio Maia de Jesus Chaves Neto,

Hormones are a dangerous group of molecules that can cause harm to humans. This study based on classical molecular dynamics proposes the nanofiltration of wastewater contaminated by hormones from a computer simulation study, in which the water and the hormone were filtered in two single-walled nanotube compositions. The calculations were ... Read more >>

J Nanosci Nanotechnol (Journal of nanoscience and nanotechnology)
[2021, 21(11):5499-5509]

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FIGO good practice recommendations on progestogens for prevention of preterm delivery.

Andrew Shennan, Natalie Suff, Joe Leigh Simpson, Bo Jacobsson, Ben W Mol, William A Grobman, ,

Women at high risk of preterm birth (either a previous spontaneous preterm birth and/or sonographic short cervix) with a singleton gestation should be offered daily vaginal progesterone or weekly 17-OHPC treatment to prevent preterm birth. Benefit is most significant in those with prior history of preterm birth and a short ... Read more >>

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 155(1):16-18]

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Serum Progesterone and Serial Beta-hcG Levels in Predicting the Outcome of Early Pregnancies With Doubtful Viability: A Prospective Observational Research

Mustafa YILDIZ, Esra Nur CICEK, Gokhan DEMIRAYAK, Orhan SAHIN, Yagmur OLMEZ, Veli MIHMANLI,

BACKGROUND: To evaluate the doubling rate of maternal serum serial β-hCG and a single initial serum progesterone level to predict fetal viability before ultrasonography in women diagnosed with intrauterine pregnancy of undetectable viability. METHODS: 336 pregnant women who applied to the outpatient clinic at Istanbul Okmeydanı City Hospital between March ... Read more >>

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Treatments for seizures in catamenial (menstrual-related) epilepsy.

Melissa J Maguire, Sarah J Nevitt,

<h4>Background</h4>This is an updated version of a Cochrane Review previously published in 2019. Catamenial epilepsy describes worsening seizures in relation to the menstrual cycle and may affect around 40% of women with epilepsy. Vulnerable days of the menstrual cycle for seizures are perimenstrually (C1 pattern), at ovulation (C2 pattern), and ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2021, 9:CD013225]

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Expression of estrogen and progesterone receptors, HER2 protein and Ki-67 proliferation index in breast carcinoma in both tumor tissue and tissue microarray.

U P Hacısalihoğlu, M A Dogan,

Breast cancer treatment is tailored to molecular subtypes, which are classified by cell type and by presence of estrogen and progesterone receptors, HER2 overexpression and Ki-67 proliferation index. In routine pathological practice, these markers are detected in tumor tissue using immunohistochemistry, which requires four immunohistochemical antibodies for each patient. We ... Read more >>

Biotech Histochem (Biotechnic & histochemistry : official publication of the Biological Stain Commission)
[2021, :1-8]

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Retraction Note: Vaginal progesterone for prevention of preterm labor in asymptomatic twin pregnancies with sonographic short cervix: a randomized clinical trial of efficacy and safety.

Waleed El-Refaie, Mohamed S Abdelhafez, Ahmed Badawy,

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 304(4):1113]

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Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.

John M Masterson, Chau Bui, Yi Zhang, Xiaopen Yuan, Carissa Huynh, Harneet Jawanda, Wohaib Hasan, Warren Tourtellotte, Daniel Luthringer, Maurice M Garcia,

It has been proposed that men hospitalised with COVID-19 be treated with oestrogen or progesterone to improve COVID-19 outcomes. Transgender women (male-to-female) are routinely treated with oestrogen or oestrogen +progesterone for feminisation which provides a model for the effect of feminising hormones on testicular tissue. Our goal was to analyse ... Read more >>

Andrologia (Andrologia)
[2021, :e14186]

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A Clinical Predictive Model of Progesterone Elevation on the Day of HCG Administration Was Establish Based on the Basal P, BMI and Ovarian Induction Regimen

chunmei yu, chao zhou, xiuliang dai, jianmei zhou, haiyan yang, yufeng wang, li Chen,

<h4>Background: </h4> The progesterone elevation (PE) on the day of human chorionic gonadotrophin (hCG) is associated with a significant decrease in the probability of clinical pregnancy after fresh embryo transfer. The goal of this study was to develop a nomogram to explore the baseline indexes to predict the occurrence of ... Read more >>

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A randomized controlled trial of two-doses of vaginal progesterone 400 vs. 200 mg for prevention of preterm labor in twin gestations.

Ahmed S Abdel Wahab, Mostafa I Abdelmonaem, Walaa M Mahmoud, Ahmed E Mansour,

<h4>Objectives</h4>To compare between the effectiveness and safety of two different daily doses of vaginal progesterone (400 vs. 200 mg) in the prevention of preterm labor in twin pregnancy.<h4>Methods</h4>This is a prospective single-blinded randomized controlled trial conducted on 100 primi-gravida who had twin pregnancy and attended the antenatal clinic of a University ... Read more >>

J Perinat Med (Journal of perinatal medicine)
[2021, :]

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Selective Progesterone Receptor Modulators (SPRMs) and Androgen Receptor Modulators (SARMs) as Treatment for Benign Gynecologic Diseases.

Md Soriful Islam, Lena W Chen, James H Segars,

Common benign gynecologic conditions such as uterine fibroids and endometriosis are linked to chronic pelvic pain, abnormal and heavy uterine bleeding, and infertility. Effective medical management of these diseases is an unmet need. The steroid hormones progesterone (P4), estrogen (E2), and testosterone play a major role in reproductive physiology and ... Read more >>

Clin Obstet Gynecol (Clinical obstetrics and gynecology)
[2021, :]

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Estrogen and progesterone receptors in endometriosis.

Luiz R Ferreira, Teresa Cavalcanti, Monica Zomer, William Kondo, Edward Araujo Júnior, Jaime Kulak Junior,

<h4>Background</h4>This study aims to identify the presence of estrogen and progesterone hormone receptors in endometriosis implants and to determine whether hormone treatment influences the receptors in these implants.<h4>Methods</h4>Cross-sectional study with historical data collection. The analysis was conducted on 156 endometriosis implants from 67 patients undergoing endometriosis laparoscopy. The patients were ... Read more >>

Minerva Obstet Gynecol (Minerva obstetrics and gynecology)
[2021, :]

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Double daily doses of cetrorelix may raise follicular phase progesterone more compared to single doses in poor ovarian response patients.

Mustafa Ozturk, Ulas Fidan, Temel Ceyhan, Ozlem Ozturk, Emre Karasahin, Lale Ozcan, Cem Korkmaz,

<h4>Purpose</h4>There is evidence that follicular phase progesterone rise [FPPR] adversely affects fresh in vitro fertilization [IVF] cycles. A single daily dose of cetrorelix has been used to prevent early luteinizing Hormone (LH) surge. We speculated that doubling the daily dose might have a positive effect in patients who have early ... Read more >>

J Gynecol Obstet Hum Reprod (Journal of gynecology obstetrics and human reproduction)
[2021, 50(10):102223]

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Characterization of Cycling in a Hoolock Gibbon (Hoolock leuconedys).

Erin B Guntrum, Alexandra M Haley, Susan W Margulis,

Here we examine the patterns of reproductive hormones (progesterone and estrone-3 glucuronide, or E1G) in one female hoolock gibbon (Hoolock leuconedys) housed at the Gibbon Conservation Center, throughout the maturation period. Three hundred forty-five fecal samples were collected from the individual over a 5-year period (2012-2017) beginning at the age ... Read more >>

Folia Primatol (Basel) (Folia primatologica; international journal of primatology)
[2021, :1-6]

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Determination of progesterone (steroid drug) in the semi - solid dosage form (vaginal gel) using a stability - indicating method by RP-HPLC/PDA detector.

Naresh Konduru, Vijay Babu Kethe, Rambabu Gundla, Naresh Kumar Katari, Ravindra Mallavarapu,

A simple stability-indicating method was developed and validated for the determination of progesterone (a steroid drug) in the semi-solid dosage form. All the impurities were separated from the main compound with simple stationary phase (Eclipse XDB, C8, 150 mm × 4.6 mm, 5μm). The mobile phase-A contains phosphate buffer and ... Read more >>

Biomed Chromatogr (Biomedical chromatography : BMC)
[2021, :e5246]

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Loss of β-Arrestins or six Gα proteins in HEK293 cells caused Warburg effect and prevented progesterone-induced rapid proteasomal degradation of progesterone receptor membrane component 1.

Mohammad Golam Sabbir, Asuka Inoue, Carla G Taylor, Peter Zahradka,

Hormonal dysregulation plays a significant role in the metabolic switching during malignant transformation. Progesterone Receptor Membrane Component 1 (PGRMC1) is a single-pass transmembrane receptor activated by the binding of progesterone (P4), a sex hormone. In a previous study, P4 treatment caused rapid (within 30 min) induction of aerobic glycolysis in ... Read more >>

J Steroid Biochem Mol Biol (The Journal of steroid biochemistry and molecular biology)
[2021, 214:105995]

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Delayed implantation induced by letrozole in mice

Fang Wang, Shijie Li, Lingshuai Meng, Ye Kuang, Zhonghua Liu, Xinghong Ma,

Implantation timing is key for a successful pregnancy. Short delay in embryo implantation caused by targeted gene ablation produced a cascading problem in the later stages of the pregnancy. Although several delayed implantation models have been established in wild mice, almost none of them is suitable for investigating the delay ... Read more >>

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Higher Follicular Fluid Progesterone Down-regulated HPGD and COX2 in Granulosa Cells via Suppressing NF-кB Signaling in Endometriosis

Jing-Yi Li, Jian-Peng Chen, Yu-Li Qian, Jun-Yan Ma, Fei-Da Ni, Yi-Feng Lin, Run-Ju Zhang, Si-Wen Wang, Yun Huang, Juan Liu, Mi-Xue Tu, Yan-Yun Ying, Yi-Qing Wu, Xue-Chen Wu, Bing-Bing Wu, Bo Zhu, Dan Zhang,

<h4>Background: </h4> Luteinized unruptured follicular follicle syndrome (LUFS) is a special type of ovulatory dysfunction and a common cause of infertility. It is estimated that its prevalence is 13% ~ 73% in endometriosis patients. Increasing evidences prove that LUFS is one of the reasons for endometriosis-related infertility. Any alteration in ... Read more >>

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Statins can benefit patients with primary membranous nephropathy on venous thromboembolism.

Peimei Zou, Hang Li, Jianfang Cai, Zhenjie Chen, Chao Li, Xuewang Li,

<h4>Objective</h4>The aim of this study was to investigate the role of prophylactic use of statin in venous thromboembolism (VTE) in patients with primary membranous nephropathy (PMN).<h4>Methods</h4>A total of 734 patients with PMN were consecutively enrolled in this retrospective study. 564 patients had received statins prescription, while 170 patients did not. ... Read more >>

Ren Fail (Renal failure)
[2021, 43(1):302-306]

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