Full Text Journal Articles about
Primary Insomnia

Advertisement

Find full text journal articles






Discovery of a multipotent chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus.

Satoshi Yamashita, Ryo Honda, Mayuko Fukuoka, Tsutomu Kimura, Junji Hosokawa-Muto, Kazuo Kuwata,

We previously discovered three carbazole derivatives, GJP14 (1-piperidinylmethyl-2-(1-oxo-6-methyl-1,2,3,4-tetrahydrocarbazol-9-yl)-ethan-1-ol) with anti-prion activity, GJC29 (benzylamino-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol) with anti-cancer activity, and THC19 (1-piperidinylmethyl-2-(1,2,3,4-tetrahydrocarnazol-9-yl)-ethan-1-ol) with anti-influenza virus activity. During optimization of GJP14 for the anti-prion activity, we discovered a compound, 1-(2,6-difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol, termed 5Y, had the most strong anti-prion activity among a series of newly synthesized ... Read more >>

Prion (Prion)
[2020, 14(1):42-46]

Cited: 0 times

View full text PDF listing >>



Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi,

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those ... Read more >>

Prion (Prion)
[2020, 14(1):20-23]

Cited: 0 times

View full text PDF listing >>



Advertisement

RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy.

Jung-Youn Han, Hyung-Sup Jang, Alison J E Green, Young Pyo Choi,

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrPSc). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) patients and in brains of G2-3 ... Read more >>

Prion (Prion)
[2020, 14(1):88-94]

Cited: 0 times

View full text PDF listing >>



The cellular prion protein promotes neuronal regeneration after acute nasotoxic injury.

Lindsay E Parrie, Jenna A E Crowell, Julie A Moreno, Stephanie S Suinn, Glenn C Telling, Richard A Bessen,

Adult neurogenesis, analogous to early development, is comprised of several, often concomitant, processes including proliferation, differentiation, and formation of synaptic connections. However, due to continual, asynchronous turn-over, newly-born adult olfactory sensory neurons (OSNs) must integrate into existing circuitry. Additionally, OSNs express high levels of cellular prion protein (PrPC), particularly in ... Read more >>

Prion (Prion)
[2020, 14(1):31-41]

Cited: 0 times

View full text PDF listing >>



Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus).

Mariella E Güere, Jørn Våge, Helene Tharaldsen, Sylvie L Benestad, Turid Vikøren, Knut Madslien, Petter Hopp, Christer M Rolandsen, Knut H Røed, Michael A Tranulis,

The emergence of CWD in Europe in 2016 and the first natural infection in wild reindeer warranted disease management. This led to the testing of 2424 hunted or culled reindeer during 2016-2018, from the infected subpopulation in the Nordfjella mountain range in Southern Norway. To identify any association between PRNP ... Read more >>

Prion (Prion)
[2020, 14(1):1-10]

Cited: 0 times

View full text PDF listing >>



Clinicopathological findings of a long-term survivor of V180I genetic Creutzfeldt-Jakob disease.

Yuichi Hayashi, Yasushi Iwasaki, Masahiro Waza, Shinei Kato, Akio Akagi, Akio Kimura, Takashi Inuzuka, Katsuya Satoh, Tetsuyuki Kitamoto, Mari Yoshida, Takayoshi Shimohata,

The clinical characteristics of genetic Creutzfeldt-Jakob disease (gCJD) with a V180I mutation in the PRNP gene (V180I gCJD) are unique: elderly-onset, gradual progression, sporadic fashion, and cortical oedematous hyper-intensity on diffusion-weighted MRI (DW-MRI). This phenotype may become a potential target of future clinical therapeutic trials. The average disease duration of ... Read more >>

Prion (Prion)
[2020, 14(1):109-117]

Cited: 0 times

View full text PDF listing >>



Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate species.

Catherine I Cullingham, Rhiannon M Peery, Anh Dao, Debbie I McKenzie, David W Coltman,

Wildlife disease incidence is increasing, resulting in negative impacts on the economy, biodiversity, and potentially human health. Chronic wasting disease (CWD) is a fatal, transmissible spongiform encephalopathy of cervids (wild and captive) which continues to spread geographically resulting in exposure to potential new host species. The disease agent (PrPCWD) is ... Read more >>

Prion (Prion)
[2020, 14(1):56-66]

Cited: 0 times

View full text PDF listing >>



A feasibility study of a mobile app to treat insomnia.

Melissa Aji, Nick Glozier, Delwyn Bartlett, Dorian Peters, Rafael A Calvo, Yizhong Zheng, Ronald Grunstein, Christopher Gordon,

Insomnia is a major public health concern. Sleep restriction therapy (SRT) is an effective behavioral treatment but its delivery is impeded by a shortage of trained clinicians. We developed a mobile app delivering SRT to individuals with insomnia. This feasibility study employed a mixed-methods design to examine the engagement, acceptability, ... Read more >>

Transl Behav Med (Translational behavioral medicine)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The role of insomnia in the association between posttraumatic stress disorder and hypertension.

Allison E Gaffey, Nancy S Redeker, Lindsey Rosman, Janet M Mullington, Cynthia A Brandt, Sally G Haskell, Matthew M Burg,

OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with incident hypertension. Although this relationship is poorly understood, PTSD is also associated with insomnia symptoms, which increases the risk for hypertension. Whether insomnia contributes to PTSD-associated risk for hypertension is unknown. METHODS:We examined self-report survey and electronic health record data from 1109 participants ... Read more >>

J. Hypertens. (Journal of hypertension)
[2020, 38(4):641-648]

Cited: 0 times

View full text PDF listing >>



Impact of sleep problems on daytime function in school life: a cross-sectional study involving Japanese university students.

Momoko Kayaba, Toshiko Matsushita, Minori Enomoto, Chieko Kanai, Noriko Katayama, Yuichi Inoue, Taeko Sasai-Sakuma,

BACKGROUND:The aims of this study were 1) to clarify the prevalence of sleep problems (insomnia, insufficient sleep, and delayed sleep-wake phase) among Japanese university students; 2) to examine sociodemographic characteristics, lifestyle, and sleep-related symptoms in each sleep problem; and 3) to evaluate the association between the above-mentioned sleep problems and ... Read more >>

BMC Public Health (BMC public health)
[2020, 20(1):371]

Cited: 0 times

View full text PDF listing >>



Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer.

Cigdem Sahbaz, Ahmet Elbay, Mine Ozcelik, Hakan Ozdemir,

Sleep may play a fundamental role in retinal regulation and the degree of retinal variables. However, no clinical study has investigated optical coherence tomography (OCT) parameters in patients with primary insomnia. All participants were evaluated with the insomnia severity index (ISI) and the Pittsburgh sleep quality index (PSQI). The retinal ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(3):]

Cited: 0 times

View full text PDF listing >>



The relationship between shift-work, sleep, and mental health among paramedics in Australia.

Wahaj Anwar A Khan, Russell Conduit, Gerard A Kennedy, Melinda L Jackson,

OBJECTIVES:This study aimed to investigate the prevalence of sleep and mental health issues, the role of chronotype, and the relationship between these variables in Australian paramedics. DESIGN:A cross-sectional study. SETTINGS:Cross-sectional survey. MEASUREMENTS:Paramedics were invited to complete an online survey to assess stress, posttraumatic stress disorder (PTSD), depression, anxiety, daytime sleepiness, ... Read more >>

Sleep Health (Sleep health)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Selecting a pharmacotherapy regimen for patients with chronic insomnia.

Amanda B Hassinger, Nikolas Bletnisky, Rizwan Dudekula, Ali A El-Solh,

Introduction: Chronic insomnia, whether it is primary or in combination with another medical or psychiatric disorder, is a prevalent condition associated with significant morbidity, reduced productivity, increased risk of accidents, and poor quality of life. Pharmacologic and behavioral treatments have equivalent efficacy with each having its own advantages and limitations.Areas ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2020, :1-9]

Cited: 0 times

View full text PDF listing >>



Insomnia and caregiver burden in chronic pain patients: A cross-sectional clinical study.

Masahiro Yamaguchi, Keiko Yamada, Masako Iseki, Yusuke Karasawa, Yasuko Murakami, Tatsuya Enomoto, Nobuko Kikuchi, Satoko Chiba, Atsuko Hara, Keisuke Yamaguchi, Eiichi Inada,

Insomnia is a major comorbid symptom of chronic pain and is likely to affect caregiver burden. This cross-sectional study investigated the association between insomnia in chronic pain patients and family caregiver burden. Participants were 60 patients with chronic pain of ≥3 months duration. Demographic and clinical information were collected using ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0230933]

Cited: 0 times

View full text PDF listing >>



Association between 5-HT gene polymorphism rs140700 and primary insomnia in Chinese population.

Peilin Hui, Jun Yang, Jing Wang, Lijun Zhao, Xubin Wang, Xiaoyan Su, Jinfeng Wang, Wei Ma, Jie Fan, Wenjuan Chen, Yuan Zhao, Bin Guo, Yu Liu, Shangli Zhang, Ning Zheng, Liyan Zhou, Yuping Xie,

BACKGROUND:Primary insomnia is a worldwide problem and it has a considerable negative impact on one's physical and mental health. Studies have shown that non-synonymous SNPs in 5-hydroxytryptamine(serotonin or 5 -HT)are related to primary insomnia. Previous studies have shown that 5 -HT polymorphism (rs140700) is related to depression, and insomnia is ... Read more >>

Intern Med J (Internal medicine journal)
[2020, :]

Cited: 0 times

View full text PDF listing >>



The Instant Spontaneous Neuronal Activity Modulation of Transcutaneous Auricular Vagus Nerve Stimulation on Patients With Primary Insomnia.

Bin Zhao, Yanzhi Bi, Liang Li, Jinling Zhang, Yang Hong, Lei Zhang, Jiakai He, Jiliang Fang, Peijing Rong,

Primary insomnia (PI) is associated with increased spontaneous neuronal activity. Transcutaneous auricular vagus nerve stimulation (taVNS) modulates brain function, and it is an effective treatment for primary insomnia. However, whether taVNS alleviates insomnia through modulating spontaneous neuronal activity is not fully clarified. This study aims to investigate the instant effect ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2020, 14:205]

Cited: 0 times

View full text PDF listing >>



Light-enhanced cognitive behavioural therapy for sleep and fatigue: study protocol for a randomised controlled trial during chemotherapy for breast cancer.

Helena R Bean, Lesley Stafford, Ruth Little, Justine Diggens, Maria Ftanou, Marliese Alexander, Prudence A Francis, Bei Bei, Joshua F Wiley,

BACKGROUND:Women with breast cancer experience a significantly higher prevalence of sleep disturbance and insomnia than the general population. The experience of persistent sleep disturbance places these women at a higher risk of psychological and physical morbidity and a reduced quality of life. Treatment for sleep in this population is not ... Read more >>

Trials (Trials)
[2020, 21(1):295]

Cited: 0 times

View full text PDF listing >>



A healthy dietary pattern may be associated with primary insomnia among Iranian adults: A case-control study.

Samaneh Sadat, Ammar Salehi-Sahlabadi, Makan Pourmasoumi, Awat Feizi, Cain C T Clark, Goudarz Akkasheh, Reza Ghiasvand,

Objective: While it has been reported that both foods and nutrients for individuals are connected with sleep, there is no evidence regarding the association of dietary patterns, identified by factor analysis, with primary insomnia. The present study sought to evaluate the association between major dietary patterns and the chance of ... Read more >>

Int J Vitam Nutr Res (International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition)
[2020, :1-12]

Cited: 0 times

View full text PDF listing >>



Subgrouping Poor Sleep Quality in Community-Dwelling Older Adults with Latent Class Analysis - The Yilan Study, Taiwan.

Hsi-Chung Chen, Nai-Wei Hsu, Pesus Chou,

The manifestation of older adults with poor sleep quality is heterogeneous. Using data-driven classifying methods, the study aims to subgroup community-dwelling older adults with poor sleep quality. Adults aged 65 and older participated in the Yilan study. Poor sleep quality was defined using the Pittsburgh Sleep Quality Index. Latent class ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5432]

Cited: 0 times

View full text PDF listing >>



Implementing a hybrid cognitive-behavioural therapy for pain-related insomnia in primary care: lessons learnt from a mixed-methods feasibility study.

Nicole K Y Tang, Corran Moore, Helen Parsons, Harbinder Kaur Sandhu, Shilpa Patel, David R Ellard, Vivien P Nichols, Jason Madan, Victoria Elizabeth Janet Collard, Uma Sharma, Martin Underwood,

OBJECTIVES:To test the feasibility of implementing a brief but intensive hybrid cognitive behavioural therapy (Hybrid CBT) for pain-related insomnia. DESIGN:Mixed-methods, with qualitative process evaluation on a two-arm randomised controlled feasibility trial. SETTING:Primary care. PARTICIPANTS:Twenty-five adult patients with chronic pain and insomnia. INTERVENTION:Hybrid CBT or self-help control intervention. PRIMARY AND SECONDARY ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e034764]

Cited: 0 times

View full text PDF listing >>



Dysfunction of processing task-irrelevant emotional faces in primary insomnia patients: an evidence from expression-related visual MMN.

Yue Zhang, Jian Chen, Xunyao Hou, Yunliang Guo, Renjun Lv, Song Xu, Shanjing Nie, Xueping Liu,

PURPOSE:According to the cognitive processing perspectives, patients with insomnia have insufficient neural management of expressional information. In this study, we compared the pre-attentive processing function of task-irrelevant facial expressions in patients with primary insomnia (PI) and matched healthy controls, with expression-related mismatch negativity (EMMN) elicited by emotional faces as the ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Lights on MsFLASH: a review of contributions.

Susan D Reed, Andrea Z LaCroix, Garnet L Anderson, Kristine E Ensrud, Bette Caan, Janet S Carpenter, Lee Cohen, Susan J Diem, Ellen W Freeman, Hadine Joffe, Joseph C Larson, Susan M McCurry, Caroline M Mitchell, Katherine M Newton, Barbara Sternfeld, Katherine A Guthrie,

OBJECTIVE:The Menopause Strategies: Finding Lasting Answers for Symptoms and Health clinical trials network was funded by the National Institutes of Health to find new ways to alleviate the most common, bothersome menopausal symptoms by designing and conducting multiple concurrent clinical intervention studies, accommodating a wide scope of populations and intervention ... Read more >>

Menopause (Menopause (New York, N.Y.))
[2020, 27(4):473-484]

Cited: 0 times

View full text PDF listing >>



Primary care treatment of insomnia: study protocol for a pragmatic, multicentre, randomised controlled trial comparing nurse-delivered sleep restriction therapy to sleep hygiene (the HABIT trial).

Simon D Kyle, Claire Madigan, Nargis Begum, Lucy Abel, Stephanie Armstrong, Paul Aveyard, Peter Bower, Emma Ogburn, Aloysius Siriwardena, Ly-Mee Yu, Colin A Espie,

INTRODUCTION:Insomnia is a prevalent sleep disorder that negatively affects quality of life. Multicomponent cognitive-behavioural therapy (CBT) is the recommended treatment but access remains limited, particularly in primary care. Sleep restriction therapy (SRT) is one of the principal active components of CBT and could be delivered by generalist staff in primary ... Read more >>

BMJ Open (BMJ open)
[2020, 10(3):e036248]

Cited: 0 times

View full text PDF listing >>



A Randomized Controlled Trial of CBT-I and PAP for Obstructive Sleep Apnea and Comorbid Insomnia: Main Outcomes from the MATRICS Study.

Jason C Ong, Megan R Crawford, Spencer C Dawson, Louis F Fogg, Arlener D Turner, James K Wyatt, Maria I Crisostomo, Bantu S Chhangani, Clete A Kushida, Jack D Edinger, Sabra M Abbott, Roneil G Malkani, Hrayr P Attarian, Phyllis C Zee,

STUDY OBJECTIVES:To investigate treatment models using cognitive-behavior therapy for insomnia (CBT-I) and positive airway pressure (PAP) for people with obstructive sleep apnea (OSA) and comorbid insomnia. METHODS:121 adults with OSA and comorbid insomnia were randomized to receive CBT-I followed by PAP, CBT-I concurrent with PAP, or PAP only. PAP was ... Read more >>

Sleep (Sleep)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Efficacy and Safety of Electro-Acupuncture (EA) on Insomnia in Patients with Lung Cancer: Study Protocol of a Randomized Controlled Trial

Shifen Xu, Hongyu Yue, Shuang Zhou, Huangan Wu, Xuan Yin, Shanshan Li, Tingting Liang, Yan Li, Zhihong Fang, Xufeng Zhang, Linglin Wang, Min Han, Xiaolei Chen, Ming Zhang, Wei Zhang, Zhangjin Zhang,

<title>Abstract</title> <p> Background : Cancer-related insomnia (CRI) is one of the most prevalent complaints among cancer survivors and severely impairs patients’ quality of life. As a popular non-pharmacological alternative treatment, acupuncture provides a good clinical curative effect on insomnia. The aim of this trial is to evaluate efficacy ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
2.1587 s