Full Text Journal Articles about
Primary CNS Lymphoma

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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer.

Qinghua Wu, Wenda Wu, Vesna Jacevic, Tanos C C Franca, Xu Wang, Kamil Kuca,

c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer. The pro-survival JNK oncoprotein functions in a cell context- and cell type-specific manner to affect signal pathways ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):574-583]

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Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds.

Ahmed K Farag, Ahmed H E Hassan, Byung Sun Ahn, Ki Duk Park, Eun Joo Roh,

Hybridization of reported weakly active antiproliferative hit 5-amino-4-pyrimidinol derivative with 2-anilino-4-phenoxypyrimidines suggests a series of 2,5-diamino-4-pyrimidinol derivatives as potential antiproliferative agents. Few compounds belonging to the proposed series were reported as CSF1R/DAPK1 inhibitors as anti-tauopathies. However, the correlation between CSF1R/DAPK1 signalling pathways and cancer progression provides motives to reprofile them ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):311-324]

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The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphoma.

Manuel Montesinos-Rongen, Monica Terrao, Caroline May, Katrin Marcus, Ingmar Blümcke, Martin Hellmich, Ralf Küppers, Anna Brunn, Martina Deckert,

The immunoglobulin (Ig) heavy and light chain variable gene mutational pattern of the B cell receptor (BCR) in primary central nervous system (CNS) lymphoma (PCNSL) cells suggests antigenic selection to drive pathogenesis and confinement to the CNS. This hypothesis is supported by the observation that the tumor B cell receptor ... Read more >>

Haematologica (Haematologica)
[2020, :]

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Primary CNS lymphoma in a patient on Adalimumab (Humira) therapy for chronic plaque psoriasis.

Riyaq Abdi Farah, Ahmad Alduaij, Carlos Ugas, Ramon Navarro,

BACKGROUND:Adalimumab (Humira) is a recombinant human monoclonal antibody against tumor necrosis factor alpha (TNF- α), which works by blocking the interaction of TNF- α with its cell-surface receptors, thereby limiting the progression of inflammatory pathways. Its use is approved for several autoimmune conditions including chronic plaque psoriasis for which it ... Read more >>

World Neurosurg (World neurosurgery)
[2020, :]

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Viral infections and multiple sclerosis.

Donatella Donati,

The etiology and pathogenesis of MS is likely to involve multiple factors interacting with each other, and the role of infectious and viral agents is still under debate, however a consistent amount of studies suggests that some viruses are associated with the disease. The strongest documentation has come from the ... Read more >>

Drug Discov Today Dis Models (Drug discovery today. Disease models)
[0, :]

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Durable Response to Brentuximab Vedotin-Based Chemotherapy in Refractory Hodgkin Lymphoma with Central Nervous System (CNS) Involvement.

Heidi Mociková, Hana Malikova, Michal Holesta, Abdulfattah Elturki, Vit Campr, Tomas Kozak,

BACKGROUND CNS involvement in Hodgkin lymphoma is rare. Despite various treatment options, median overall survival is only 13 months after diagnosis of CNS involvement in relapsed/refractory HL. CASE REPORT A 29-year-old woman with classical HL (mixed cellularity) in clinical stage IIB was treated with multilineage chemotherapy and radiotherapy without achieving ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e921657]

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Progressive multifocal leukoencephalopathy after CAR T therapy.

Konstantinos Sdrimas, Meilin Diaz-Paez, Jose F Camargo, Lazaros J Lekakis,

Progressive multifocal leukoencephalopathy (PML) remains a life-threatening central nervous system infection in immunocompromised patients. Although outcomes have improved in cases that immune reconstitution is feasible with anti-retroviral therapy (ART) in HIV + patients or natalizumab removal in those with multiple sclerosis, in individuals with hematological malignancies, the prognosis is usually dismal. Anti-viral ... Read more >>

Int. J. Hematol. (International journal of hematology)
[2020, :]

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Cerebrospinal Fluid Flow Cytometry: Utility in Central Nervous System Lymphoma Diagnosis.

Ka Loong Kelvin Au, Sarah Latonas, Afshin Shameli, Iwona Auer, Christopher Hahn,

BACKGROUND:Flow cytometry of the cerebrospinal fluid (CSF) is used in isolation or as an adjunct to cytology to increase the sensitivity of detecting central nervous system (CNS) lymphoma. We aimed to evaluate the sensitivity of CSF flow cytometry as a diagnostic screening tool for primary CNS lymphoma in patients presenting ... Read more >>

Can J Neurol Sci (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques)
[2020, :1-7]

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Primary dural lymphomas: Clinical presentation, management, and outcome.

Philipp Karschnia, Tracy T Batchelor, Justin T Jordan, Brian Shaw, Sebastian F Winter, Frank J Barbiero, Leon D Kaulen, Niklas Thon, Joerg-Christian Tonn, Anita J Huttner, Robert K Fulbright, Jay Loeffler, Jorg Dietrich, Joachim M Baehring,

BACKGROUND:Clinical experience is limited for primary central nervous system (CNS) lymphoma that arises from the dura mater, which is denoted with the term primary dural lymphoma (PDL). This study was aimed at determining the relative incidence, presentation, and outcomes of PDL. METHODS:The institutional databases of the Divisions of Neuro-Oncology at ... Read more >>

Cancer (Cancer)
[2020, :]

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Ibrutinib in primary central nervous system diffuse large B-cell lymphoma.

Justin T Low, Katherine B Peters,

The standard regimen for the treatment of newly diagnosed primary CNS lymphoma (PCNSL) remains regimens that contain high-dose methotrexate (MTX). While these regimens can provide control for some patients, there is a dearth of options for the treatment of patients with PCNSL who cannot tolerate MTX-containing regimens, or whose cancers are ... Read more >>

CNS Oncol (CNS oncology)
[2020, :CNS51]

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Patterns of relapse after successful completion of initial therapy in primary central nervous system lymphoma: a case series.

Mallika P Patel, John P Kirkpatrick, Margaret O Johnson, Patrick Healy, James E Herndon, Eric S Lipp, Elizabeth S Miller, Annick Desjardins, Dina Randazzo, Henry S Friedman, David M Ashley, Katherine B Peters,

PURPOSE:Primary central nervous system lymphoma (PCNSL) is a subtype of non-Hodgkin's lymphoma that involves the brain, spinal cord, or leptomeninges, without evidence of systemic disease. This rare disease accounts for ~ 3% of all primary central nervous system (CNS) tumors. Methotrexate-based regimens are the standard of care for this disease with ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2020, 147(2):477-483]

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MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model.

Xi Lu, Hui-Yuan Zhang, Zhi-Yi He,

Apoptosis is an important factor during the early stage of intracerebral hemorrhage. MiR-181c plays a key regulatory role in apoptosis. However, whether miR-181c is involved in apoptosis of prophase cells after intracerebral hemorrhage remains unclear. Therefore, in vitro and in vivo experiments were conducted to test this hypothesis. In vivo ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1274-1282]

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Safety of Donation From Brain-dead Organ Donors With Central Nervous System Tumors: Analysis of Transplantation Outcomes in Korea.

Mi-Sung Lee, Won-Hyun Cho, Jongwon Ha, Eun-Suk Yu, Young-Soon Jeong, Jae-Sook Oh, Jeong-Rim Lee, Jae-Myeong Lee,

BACKGROUND:This study aims to verify the condition of recipients of solid organs from donors with central nervous system (CNS) tumors and determine the risk of disease transmission due to transplantation. METHODS:Twenty-eight brain-dead organ donors with CNS tumors and 91 recipients who received solid organs from January 1, 2005, to December ... Read more >>

Transplantation (Transplantation)
[2020, 104(3):460-466]

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Adult primary testicular lymphoma: clinical features and survival in a series of patients treated at a high-volume institution in China.

Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu, Qiang Wei,

BACKGROUND:To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases of our institute. METHODS:From December 2008 to July 2018, all patients with PTL were included in this study. Kaplan-Meier method was used to estimate ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):220]

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Pre-treatment serum IL-10 predicts the risk of secondary central nervous system involvement in patients with diffuse large B-cell lymphoma.

Jun Ho Yi, Sang Eun Yoon, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim, Seok Jin Kim,

BACKGROUND:As diffuse large B-cell lymphoma (DLBCL) is a very heterogeneous group of lymphomas, much effort has gone in trying to identify patients with increased risk for early death or secondary central nervous system (CNS) involvement. To better predict their outcomes, we measured the levels of various cytokines in serum samples ... Read more >>

Cytokine (Cytokine)
[2020, 129:155048]

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A Rare Case of Central Nervous System Vasculitis in a Patient with Perinuclear Antineutrophil Cytoplasmic Antibodies-associated Interstitial Lung Disease.

Ammar Haikal, Tanawat Attachaipanich, Kyle Myers, Paul Schmidt, Arsany Anis,

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing inflammation of the small vessels. Central nervous system (CNS) ANCA-associated vasculitis is a rare manifestation of AAV. Three mechanisms of AAV affecting the CNS have been reported which include contiguous granulomatous invasion from nasal and paranasal sinuses, remote granulomatous lesions, and vasculitis ... Read more >>

Cureus (Cureus)
[2020, 12(2):]

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Cell free circulating tumor DNA in cerebrospinal fluid detects and monitors central nervous system involvement of B-cell lymphomas.

Sabela Bobillo, Marta Crespo, Laura Escudero, Regina Mayor, Priyanka Raheja, Cecilia Carpio, Carlota Rubio-Perez, Bárbara Tazón-Vega, Carlos Palacio, Júlia Carabia, Isabel Jiménez, Juan C Nieto, Julia Montoro, Francisco Martínez-Ricarte, Josep Castellvi, Marc Simó, Lluis Puigdefàbregas, Pau Abrisqueta, Francesc Bosch, Joan Seoane,

The levels of cell free circulating tumor DNA (ctDNA) in plasma correlated with treatment response and outcome in systemic lymphomas. Notably, in brain tumors, the levels of ctDNA in the cerebrospinal fluid (CSF) are higher than in plasma. Nevertheless, their role in central nervous system (CNS) lymphomas remains elusive. We ... Read more >>

Haematologica (Haematologica)
[2020, :]

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Eye involvement in primary central nervous system lymphoma.

Alexandra L Farrall, Justine R Smith,

Primary central nervous system lymphoma (PCNSL) may manifest initially in the eye (termed vitreoretinal lymphoma or VRL) or in non-ocular CNS compartments, or in both. The nature of the onset of PCNSL implies two clinical specialists - ophthalmologists and neuro-oncologists - independently may assess the primary presentation of this rare ... Read more >>

Surv Ophthalmol (Survey of ophthalmology)
[2020, :]

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Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma.

Naoki Kawakami, Ho Namkoong, Masayuki Shimoda, Hiroshi Kotani, Hiroshi Fujiwara, Naoki Hasegawa,

A 68-year-old man with past medical history of multiple cerebral infarctions presented to our hospital with subacute paresis. His vital signs on presentation were normal, and his physical examination, other than his neurological findings, was unremarkable. Neurological examinations suggested cerebellar ataxia. Laboratory testing confirmed positive for human immunodeficiency virus (HIV) ... Read more >>

IDCases (IDCases)
[2020, 19:e00716]

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Durable Survival Outcomes in Primary and Secondary Central Nervous System Lymphoma After High-dose Chemotherapy and Autologous Stem Cell Transplantation Using a Thiotepa, Busulfan, and Cyclophosphamide Conditioning Regimen.

Patricia A Young, Daria Gaut, Davis K Kimaiyo, Jonathan Grotts, Tahmineh Romero, John Chute, Gary Schiller, Sven de Vos, Herbert A Eradat, John Timmerman,

BACKGROUND:High-dose chemotherapy (HDC) with autologous stem cell transplantation (ASCT) has been investigated in patients with primary central nervous system lymphoma (PCNSL) and non-Hodgkin lymphoma (NHL) with CNS involvement and has shown promising results. PATIENTS AND METHODS:A retrospective analysis was performed of 48 consecutive patients who had undergone HDC/ASCT with TBC ... Read more >>

Clin Lymphoma Myeloma Leuk (Clinical lymphoma, myeloma & leukemia)
[2020, :]

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A case of MOG encephalomyelitis with T- cell lymphoma.

Young Nam Kwon, Jiwon Koh, Yoon Kyung Jeon, Jung-Joon Sung, Sung-Hye Park, Sung-Min Kim,

BACKGROUND:Myelin oligodendrocyte glycoprotein immunoglobulin-G (IgG)-associated encephalomyelitis (MOG-EM) is a distinct inflammatory demyelinating disease. We present an unusual MOG-EM cases with concomitant T-cell lymphoma. CASE REPORT:A 38-year-old Caucasian male presented with bilateral optic neuritis and multifocal transverse myelitis. He tested positive for MOG-IgG1 and his neurologic symptoms improved with high dose ... Read more >>

Mult Scler Relat Disord (Multiple sclerosis and related disorders)
[2020, 41:102038]

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[Case of isolated neurosarcoidosis requiring differentiation from tuberculous meningitis].

Ichiro Deguchi, Takashi Osada, Tomonari Suzuki, Shinya Tabata, Eiichi Arai, Akira Uchino, Takeshi Hayashi, Shinichi Takahashi, Suketaka Momoshima, Masaki Takao,

A 62-year-old woman was transported to our hospital for management of generalized clonic seizures. Cerebrospinal fluid examination showed an increased monocyte-dominant cell count, high protein concentration, and low glucose concentration that was 17% of the plasma glucose concentration. Contrast-enhanced cranial magnetic resonance imaging revealed diffuse leptomeningeal enhancement with multiple nodular ... Read more >>

Rinsho Shinkeigaku (Rinsho shinkeigaku = Clinical neurology)
[2020, 60(3):213-218]

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Primary central nervous system marginal zone B-cell lymphoma arising from the dural meninges: A case report and review of literature.

Nerea Lopetegui-Lia, Lukas Delasos, Syed Daniyal Asad, Manish Kumar, Jonathan S Harrison,

Primary central nervous system (CNS) marginal zone B-cell lymphoma (MZBCL) arising from the dural meninges is a rare but indolent disease. This malignancy can present in various ways, hence making it difficult to diagnose. Biopsy results dictate an appropriate treatment plan, which commonly consists of a combination of surgical resection, ... Read more >>

Clin Case Rep (Clinical Case Reports)
[2020, 8(3):491-497]

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En mann i 60-årene med gangvansker, dysartri og lett kognitiv svikt.

Ludmila Nordaa, Elin Bjelland Forsaa, Audun Odland, Soffien Ajmi,

BACKGROUND:Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is an immune-mediated, treatable and inflammatory CNS disease first reported by Pittock et al. (2010). CASE PRESENTATION:We describe a 66-year-old man with previous history of diabetes, atrial fibrillation and hypertension, who was admitted to hospital with reduced general ... Read more >>

Tidsskr. Nor. Laegeforen. (Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke)
[2020, 140(4):]

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A case of T-cell chronic lymphocytic leukemia progressing to Richter syndrome with central nervous system involvement in a dog.

Elizabeth A Conway, Elspeth M Waugh, Clare Knottenbelt,

An 8-year-old neutered Beagle dog was presented with polyuria and polydipsia. Routine clinicopathologic testing showed a significant lymphocytosis and proteinuria. Lymphocytes were of small to intermediate in size with a mature morphology. Infectious disease screening was negative. PCR for antigen receptor gene rearrangements showed a clonal T-cell receptor (TCR) rearrangement ... Read more >>

Vet Clin Pathol (Veterinary clinical pathology)
[2020, :]

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