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Seroprevalence of human brucellosis and molecular characteristics of Brucella strains in Inner Mongolia Autonomous region of China, from 2012 to 2016.

Zhi-Guo Liu, Miao Wang, Na Ta, Meng-Gang Fang, Jing-Chuan Mi, Rui-Ping Yu, Yao Luo, Xiaoan Cao, Zhen-Jun Li,

In the present study, a total of 1102304 serum samples were collected to detected human brucellosis between the years 2012 and 2016 in Inner Mongolia. Overall, an average of 3.79% anti-Brucella positive in Inner Mongolia was presented but the range of positive rates were among 0.90 to 7.07% in 12 ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):263-274]

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Cloning and analysis of PRNP gene of Vulpes corsac in Qinghai plateau, China.

Xue-Hua Yang, Kang Xiao, Yuezhang Wu, Liping Gao, Dongdong Chen, Xiao-Ping Dong, Qi Shi,

PRNP gene encodes PrP protein, which is conservative among different species and associates with the susceptibility of prion disease. In this report, we cloned and sequenced the full-length PRNP gene of Vulpes corsac in Qinghai plateau, China. The amino acid sequence of Vulpes corsac PrP showed 100% homology with those ... Read more >>

Prion (Prion)
[2020, 14(1):20-23]

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Distribution of sickle cell disease and assessment of risk factors based on transcranial Doppler values in the Gulf region.

Yasser Wali, Vishwanatha Kini, Mohamed A Yassin,

Background/Objective: Stroke is a potentially fatal complication of sickle cell disease (SCD). Transcranial Doppler (TCD) is useful at identifying increased risk of stroke in children with SCD and vasospasm after subarachnoid hemorrhage. The main aim of this study was to determine the proportion of patients with SCD in the Gulf ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):55-62]

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A comparison of individual-level vs. hypothetically pooled mercury biomonitoring data from the Maternal Organics Monitoring Study (MOMS), Alaska, 1999-2012.

Emily Mosites, Ernesto Rodriguez, Samuel P Caudill, Thomas W Hennessy, James Berner,

Biomonitoring for heavy metals is important to assess health risks, especially in Arctic communities where rural residents rely on locally harvested foods. However, laboratory testing for blood contaminants is expensive and might not be sustainable for long-term monitoring. We assessed whether pooled specimen biomonitoring could be a part of a ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1726256]

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Seroreactivity against Marburg or related filoviruses in West and Central Africa.

Imke Steffen, Kai Lu, Nicole A Hoff, Prime Mulembakani, Emile Okitolonda Wemakoy, Jean-Jacques Muyembe-Tamfum, Nicaise Ndembi, Catherine A Brennan, John Hackett, William M Switzer, Sentob Saragosti, Guy O Mbensa, Syria Laperche, Anne W Rimoin, Graham Simmons,

A serological survey of 2,430 archived serum samples collected between 1997 and 2012 was conducted to retrospectively determine the prevalence of Marburg virus in five African countries. Serum samples were screened for neutralizing antibodies in a pseudotype micro-neutralization assay and confirmed by enzyme-linked immunosorbent assay (ELISA). Surprisingly, a seroprevalence for ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):124-128]

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Increased temperatures reduce the vectorial capacity of Aedes mosquitoes for Zika virus.

Maria Gorreti Onyango, Sean M Bialosuknia, Anne F Payne, Nicholas Mathias, Lili Kuo, Aurélien Vigneron, Matthew DeGennaro, Alexander T Ciota, Laura D Kramer,

Rapid and significant range expansion of both Zika virus (ZIKV) and its Aedes vector species has resulted in ZIKV being declared a global health threat. Mean temperatures are projected to increase globally, likely resulting in alterations of the transmission potential of mosquito-borne pathogens. To understand the effect of diurnal temperature ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):67-77]

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What happens when we modify mosquitoes for disease prevention? A systematic review.

Teresa Nazareth, Isabel Craveiro, Alanny Moutinho, Gonçalo Seixas, Cátia Gonçalves, Luzia Gonçalves, Rosa Teodósio, Carla A Sousa,

The release of modified mosquitoes to suppress/replace vectors constitutes a promising tool for vector control and disease prevention. Evidence regarding these innovative modification techniques is scarce and disperse. This work conducted a systematic review, gathering and analysing research articles from PubMed and Biblioteca Virtual em Saúde databases whose results report ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):348-365]

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The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan.

Tsai-Lu Lin, Shan-Chia Ou, Ken Maeda, Hiroshi Shimoda, Jacky Peng-Wen Chan, Wu-Chun Tu, Wei-Li Hsu, Chi-Chung Chou,

Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne zoonosis, has been rapidly spread in many Asian counties since 2010, which raises the great concern in East Asia. Nevertheless, the infection status of SFTS in Taiwan remains unclear. To investigate the existence of SFTSV in Taiwan, a total of 151 ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):148-151]

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Clostridioides difficile infection in the Asia-Pacific region.

Deirdre A Collins, Kyung Mok Sohn, Yuan Wu, Kentaro Ouchi, Yoshikazu Ishii, Briony Elliott, Thomas V Riley, Kazuhiro Tateda, ,

Clostridioides difficile causes healthcare-related diarrhoea in high-income countries. Highly resistant spores persist in healthcare facilities, primarily infecting patients who have recently received antimicrobials. C. difficile infection (CDI) has been studied in detail in North America and Europe; however, the epidemiology of CDI elsewhere, including the Asia-Pacific region, is largely unknown. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):42-52]

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Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes.

Adrian Villalba, Silvia Rodriguez-Fernandez, Rosa-Maria Ampudia, Mary Cano-Sarabia, David Perna-Barrull, Cesc Bertran-Cobo, Clara Ehrenberg, Daniel Maspoch, Marta Vives-Pi,

Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) -a feature of apoptotic cells- loaded with insulin peptides to mimic apoptotic beta-cells. PS-liposomes arrested autoimmunity ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):77-83]

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Setting the stage: The initial immune response to blood-stage parasites.

Allison N Bucşan, Kim C Williamson,

Individuals growing up in malaria endemic areas gradually develop protection against clinical malaria and passive transfer experiments in humans have demonstrated that this protection is mediated in part by protective antibodies. However, neither the target antigens, specific effector mechanisms, nor the role of continual parasite exposure have been elucidated, which ... Read more >>

Virulence (Virulence)
[2020, 11(1):88-103]

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Coronary artery bypass grafting vs. drug-eluting stent implantation in patients with end-stage renal disease requiring dialysis.

Zhi Wang, Yanjun Gong, Fangfang Fan, Fan Yang, Lin Qiu, Tao Hong, Yong Huo,

Objectives: To evaluate the optimal revascularization strategy for patients with coronary artery disease (CAD) and end stage renal disease (ESRD) in the drug-eluting stent (DES) era.Methods: One hundred and twelve patients with ESRD treated with coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) were enrolled from 2007 to ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):107-112]

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Pig as a reservoir of CRISPR type TST4 Salmonella enterica serovar Typhimurium monophasic variant during 2009-2017 in China.

Xiaolei Xie, Zhenyu Wang, Kai Zhang, Yang Li, Yachen Hu, Zhiming Pan, Xiang Chen, Qiuchun Li, Xinan Jiao,

CRISPR-based typing was performed to subtype isolates of S. Typhimurium and its monophasic variant Salmonella 4,[5],12:i:- from humans and animals between 2009 and 2017 in China. CRISPR typing classified all isolates into two lineages and four sub-lineages. All isolates from Lineage II and Lineage IB-1 were Salmonella Typhimurium. All of ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1-4]

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Ending student mistreatment: early successes and continuing challenges.

Katherine T Lind, Christina M Osborne, Brittany Badesch, Alyssa Blood, Steven R Lowenstein,

Problem: Student mistreatment represents an ongoing challenge for US medical schools. Students experiencing mistreatment may become marginalized and cynical, and they have higher rates of burnout, depression and substance use disorders. Although numerous attempts to eliminate mistreatment have been proposed, best practices remain elusive. We formed a unique student-faculty collaboration ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1690846]

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Determination of Colistin Resistance by Simple Disk Diffusion Test Using Modified Mueller-Hinton Agar.

Jean Damascene Uwizeyimana, Daewon Kim, Hyunsook Lee, Jung Hyun Byun, Dongeun Yong,

BACKGROUND:Colistin has become a last-resort antibiotic for the management of multidrug-resistant gram-negative bacteria. The disk diffusion test is cheap and easy to perform but may be unreliable for colistin susceptibility testing due to poor diffusion of the large colistin molecule. An improved agar diffusion test would increase the reliability of ... Read more >>

Ann Lab Med (Annals of laboratory medicine)
[2020, 40(4):306-311]

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Supramolecular self-assembly of a hybrid 'hyalurosome' for targeted photothermal therapy in non-small cell lung cancer.

Haipeng Xu, Lin Dong, Zhang Bin, Huo Yansong, Lin Shaofeng, Liu Chang, Chen Chen, Wang Changli,

Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):378-386]

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Broadly neutralizing antibodies for HIV-1: efficacies, challenges and opportunities.

Yubin Liu, Wei Cao, Ming Sun, Taisheng Li,

Combination antiretroviral therapy (cART) is effective but not curative, and no successful vaccine is currently available for human immunodeficiency virus-1 (HIV-1). Broadly neutralizing antibodies (bNAbs) provide a new approach to HIV-1 prevention and treatment, and these promising candidates advancing into clinical trials have shown certain efficacies in infected individuals. In ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):194-206]

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Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway.

Wang Cuiqiong, Xu Chao, Fu Xinling, Jiang Yinyan,

Schisandrin B (Sch B) and miR-101 family members play critical roles in the pathogenesis of liver fibrosis. However, the relationship between them has not been reported yet. Thus, this study aims to fill this research gap. Results showed that Sch B significantly upregulated the expression of miR-101-5p in HSC-T6 cells. ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):473-478]

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Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody.

Xiaolong Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhengli Shi, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, Tianlei Ying,

The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine. Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):382-385]

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A qualitative examination of barriers against effective medical education and practices related to breastfeeding promotion and support in Lebanon.

Sara Moukarzel, Christoforos Mamas, Antoine Farhat, Antoine Abi Abboud, Alan J Daly,

Background: Insufficient breastfeeding promotion and support by physicians contribute to suboptimal breastfeeding rates globally. Understanding setting-specific barriers against breastfeeding promotion and support from the perspective of medical students and addressing those that can be modified through undergraduate medical education may help improve learning outcomes, medical practice, and ultimately health outcomes ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1723950]

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Triglycerides and residual risk.

Antonio J Vallejo-Vaz, Pablo Corral, Laura Schreier, Kausik K Ray,

PURPOSE OF REVIEW:To review the recent evidence from observational/genetic/interventional studies addressing triglycerides and residual cardiovascular risk (CVRisk). RECENT FINDINGS:Large population-based and secondary prevention studies consistently show an association of higher triglycerides with increased CVRisk. This is compounded by genetic studies demonstrating an independent relationship between triglyceride raising or lowering genetic ... Read more >>

Curr Opin Endocrinol Diabetes Obes (Current opinion in endocrinology, diabetes, and obesity)
[2020, 27(2):95-103]

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Indications and Evidence for Dual Antiplatelet Therapy After Acute Ischemic Stroke.

Jessica Ringler, Mackenzie Steck, Samarth P Shah, Katleen W Chester,

The antiplatelet landscape for the secondary prevention of ischemic stroke has changed significantly over the past decade. Poststroke dual antiplatelet regimens are becoming increasingly routine as supported by recent literature and guideline recommendations. Dual antiplatelet therapy after stroke generally consists of aspirin and clopidogrel and is considered in the short ... Read more >>

Crit Care Nurs Q (Critical care nursing quarterly)
[2020, 43(2):122-137]

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Aspirin for the Primary Prevention of Cardiovascular Disease: A Review of the Literature and Considerations for Clinical Practice.

Jonathan D Cicci, Prashanth Iyer, Megan M Clarke, Anthony J Mazzella,

Cardiovascular disease is the leading cause of death globally, and deaths due to coronary heart disease or stroke account for over half of all cardiovascular deaths in the United States. While many important advances have been made in the treatment and secondary prevention of atherosclerotic cardiovascular disease (ASCVD), morbidity and ... Read more >>

Cardiol Rev (Cardiology in review)
[2020, 28(2):98-106]

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Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives.

Xiaole Chen, Min Gao, Rongchao Jian, Weiqian David Hong, Xiaowen Tang, Yuling Li, Denggao Zhao, Kun Zhang, Wenhua Chen, Xi Zheng, Zhaojun Sheng, Panpan Wu,

Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family. It was first discovered to have potent inhibitory activity (IC50 = 4.2 μM) against α-glucosidase in this study. Then, four series of novel embelin derivatives were designed, prepared and evaluated in α-glucosidase inhibition assays. The ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):565-573]

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The mediating role of psychological capital on the relation between distress and empathy of medical residents: a cross-sectional survey.

Jing Jin, Honghe Li, Wenwen Song, Nan Jiang, Weiyue Zhao, Deliang Wen,

Background: Medical residents usually suffer from work overload and experience both personal and professional distress, which affects their level of the empathy to patients. Psychological capital (PsyCap) is a psychological resource that is negatively associated with indicators of distress.Objective: This study explored the potential mediating effect of PsyCap on the ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1710326]

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