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Polypharmacy

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Association between polypharmacy and the persistence of delirium: a retrospective cohort study

Ken Kurisu, Daisuke Miyabe, Yoshiko Furukawa, Osamu Shibayama, Kazuhiro Yoshiuchi,

Abstract Background : Although the association between polypharmacy and the occurrence of delirium has been well studied, the influence of polypharmacy on the persistence of delirium remains unclear. We aimed to explore the effect of polypharmacy on the persistence of delirium. Methods : This retrospective cohort study was conducted at ... Read more >>

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Polypharmacy Among Older Brazilians: Prevalence, Factors Associated and Sociodemographic Disparities (ELSI-Brazil)

Brayan Viegas Seixas, Gabriel Freitas,

Abstract Background : Polypharmacy has become an increasingly public health issue as populations age and novel drugs are developed. Yet, evidence on low- and middle-income countries (LMIC) is still scarce. This work aims to estimate the prevalence of polypharmacy among Brazilians aged 50 and over, and investigate associated factors. Methods ... Read more >>

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A national study on prescribed medicine use in Australia on a typical day.

Claire E Wylie, Benjamin Daniels, Jonathan Brett, Sallie-Anne Pearson, Nicholas A Buckley,

PURPOSE:To describe Australians' prescribed medicine use on a typical day (September 25, 2018). METHODS:We conducted a cross-sectional study using nationally representative dispensing claims data using the Australian Government Department of Human Services random 10% sample of all Australians eligible for prescription medicines subsidised through the Australian Pharmaceutical Benefits Scheme (PBS). ... Read more >>

Pharmacoepidemiol Drug Saf (Pharmacoepidemiology and drug safety)
[2020, :]

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Impact of multimorbidity and polypharmacy on the management of patients with atrial fibrillation: insights from the BALKAN-AF survey.

Monika Kozieł, Stefan Simovic, Nikola Pavlovic, Aleksandar Kocijancic, Vilma Paparisto, Ljilja Music, Elina Trendafilova, Anca Rodica Dan, Zumreta Kusljugic, Gheorghe-Andrei Dan, Gregory Y H Lip, Tatjana S Potpara,

OBJECTIVE:We investigated the impact of multimorbidity and polypharmacy on the management of atrial fibrillation (AF) patients in clinical practice and assessed factors associated with polypharmacy and oral anticoagulation (OAC) use in AF patients with multimorbidity and polypharmacy. METHODS:A 14-week prospective study of consecutive non-valvular AF patients was performed in seven ... Read more >>

Ann. Med. (Annals of medicine)
[2020, :1-9]

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Polypharmacy, potentially serious clinically relevant drug-drug interactions, and inappropriate medicines in elderly people with type 2 diabetes and their impact on quality of life.

Labib Al-Musawe, Carla Torre, Jose Pedro Guerreiro, Antonio Teixeira Rodrigues, Joao Filipe Raposo, Helder Mota-Filipe, Ana Paula Martins,

The aim of the study is to investigate the patterns of polypharmacy, clinical-relevant drug-drug interactions (DDIs), and potentially inappropriate medicines (PIMs), and whether polypharmacy, potential serious clinically-relevant DDIs, or PIMs can be associated with low quality of life (QoL) index scores of older adults with type 2 diabetes (T2D). A ... Read more >>

Pharmacol Res Perspect (Pharmacology research & perspectives)
[2020, 8(4):e00621]

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Health Professionals Perception And Beliefs About Drug- Related Problems on Polymedicated Older Adults- A Focus Group Study

Ana Isabel Plácido, Maria Teresa Herdeiro, João Lindo Simões, Odete Amaral, Adolfo Figueiras, Fátima Roque,

Abstract Background: Polymedicated older patients are at greater risk of suffering adverse events. For this reason, the detection of both inappropriate polypharmacy and polypharmacy-associated drug-related problems (DRPs) are essential to improve the health and wellbeing of older adults and to reduce healthcare costs. This work aims to explore health professionals’ ... Read more >>

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Patient Survey on Polypharmacy in the Clinic and Its Impact on Health Professionals' Management of Polypharmacy: a Before-after Study

Yuta Hirose, Kiyoshi Shikino, Yoshiyuki Ohira, Sumihide Matsuoka, Chihiro Mikami, Hayami Tsuchiya, Daiki Yokokawa, Akiko Ikegami, Tomoko Tsukamoto, Kazutaka Noda, Takanori Uehara, Masatomi Ikusaka,

Abstract Background: Patient awareness surveys on polypharmacy have been reported previously, but no previous study has examined the effects of sending feedback to health professionals on reducing medication use. Our study aimed to conduct a patient survey to examine factors contributing to polypharmacy, feedback the results to health professionals, and ... Read more >>

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A nurse practitioner led protocol to address polypharmacy in long-term care.

Brenda Bergman-Evans,

Polypharmacy is common in long term care facilities and frequently associated with poor outcomes. This study sought to determine if a medication management protocol completed at four month intervals by nurse practitioners (NP) could impact polypharmacy and administration times for long term care residents. The data was collected as part ... Read more >>

Geriatr Nurs (Geriatric nursing (New York, N.Y.))
[2020, :]

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Polypharmacy in three different spontaneous adverse drug event databases
.

Takayuki Mabuchi, Kouichi Hosomi, Satoshi Yokoyama, Mitsutaka Takada,

OBJECTIVE:Polypharmacy has become a major problem in medical care worldwide, including in Japan. The purpose of this study was to investigate the current situation of polypharmacy using different spontaneous adverse drug event report databases. MATERIALS AND METHODS:A retrospective data analysis was performed using reports from 2007 to 2015 from three ... Read more >>

Int J Clin Pharmacol Ther (International journal of clinical pharmacology and therapeutics)
[2020, :]

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Long-term trajectories of medicine use among older adults experiencing polypharmacy in Australia.

Michael O Falster, Rayan Charrier, Sallie-Anne Pearson, Nicholas A Buckley, Benjamin Daniels,

AIM:To explore longitudinal changes in the number and type of medicines used among older people who experience polypharmacy. METHODS:We used pharmaceutical claims for a 10% sample of Australian Pharmaceutical Benefits Scheme beneficiaries to identify people aged 70 years and over who were exposed to five or more medicines on February ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2020, :]

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Inflammatory processes linked to major depression and schizophrenic disorders and the effects of polypharmacy in psychiatry: evidence from a longitudinal study of 279 patients under therapy.

H H Stassen, S Bachmann, R Bridler, K Cattapan, D Herzig, A Schneeberger, E Seifritz,

Over the past 2 decades, polypharmacy has become the de-facto standard of acute treatment in psychiatry where patients with psychiatric disorders receive a multiple medication regimen. There is growing evidence for a potential link between major psychiatric disorders and inflammatory processes. Combining these two aspects aims at avoiding polypharmacy attempts ... Read more >>

Eur Arch Psychiatry Clin Neurosci (European archives of psychiatry and clinical neuroscience)
[2020, :]

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Baseline Prevalence of Polypharmacy in Older Hypertensive Study Subjects with Elevated Dementia Risk: Findings from the Risk Reduction for Alzheimer's Disease Study (rrAD).

Eric D Vidoni, Ashwini Kamat, William P Gahan, Victoria Ourso, Kaylee Woodard, Diana R Kerwin, Ellen F Binder, Jeffrey M Burns, Munro Cullum, Linda S Hynan, Wanpen Vongpatanasin, David C Zhu, Rong Zhang, Jeffrey N Keller,

BACKGROUND:Little is known about the prevalence of polypharmacy, the taking of five or more medications a day, in older adults with specific dementia risk factors. OBJECTIVE:To examine the prevalence of polypharmacy in participants at baseline in a vascular risk reduction focused Alzheimer's disease (rrAD) trial targeting older patients with hypertension ... Read more >>

J. Alzheimers Dis. (Journal of Alzheimer's disease : JAD)
[2020, :]

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Using INTERCheck® to Evaluate the Incidence of Adverse Events and Drug-Drug Interactions in Out- and Inpatients Exposed to Polypharmacy.

Antonio Martocchia, Valerio Spuntarelli, Francesco Aiello, Anna Laura Meccariello, Maria Proietta, Flavia Del Porto, Roberta Di Rosa, Simonetta Salemi, Massimiliano Rocchietti March, Bruno Laganà, Paolo Martelletti, Giorgio Sesti,

BACKGROUND:Polypharmacy exposes patients with comorbidities (particularly elderly patients) to an increased risk of drug-specific adverse events and drug-drug interactions. These adverse events could be avoided with the use of a computerized prescription support system in the primary care setting. The INTERCheck® software is a prescription support system developed with the ... Read more >>

Drugs Real World Outcomes (Drugs - real world outcomes)
[2020, 7(3):243-249]

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Evaluation of the Effect of an Intervention on Potentially Inappropriate Medications (PIMS), Polypharmacy and Anticholinergic Burden Scores for People with Dementia; Results from the SMS Dementia Study†: A Quasi-Experimental Study

Ashley Kable, Samantha Fraser, Anne Fullerton, Carolyn Hullick, Kerrin Palazzi, Christopher Oldmeadow, Dimity Pond, Andrew Searles, Rod Ling, Remia Bruce, Wendy Murdoch, John Attia,

Abstract Background People with dementia (PWD) are at risk for medication related harm due to their impaired cognition and frequently being prescribed many medications. Few previous studies of PWD inpatients have been focused on medication safety interventions.This study aimed to evaluate an intervention designed to improve medication safety for people ... Read more >>

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An Interprofessional Workshop to Enhance De-prescribing Practices Among Health Care Providers.

Kristin M Zimmerman, Amy M Linsky, Krista L Donohoe, Sarah E Hobgood, Lana Sargent, Teresa M Salgado,

INTRODUCTION:De-prescribing is a complex behavior that benefits from a multifaceted approach to learning. We sought to create and deliver a 1-day interprofessional workshop to enhance de-prescribing knowledge and skills among health care professionals. METHODS:Workshop development was based on the Adult Learning Theory and the Theoretical Domains Framework. The workshop addressed ... Read more >>

J Contin Educ Health Prof (The Journal of continuing education in the health professions)
[2020, 40(1):49-57]

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Barriers and facilitators to deprescribing in primary care: a systematic review.

Alison Jayne Doherty, Paul Boland, Janet Reed, Andrew J Clegg, Anne-Marie Stephani, Nefyn Howard Williams, Beth Shaw, Lynn Hedgecoe, Ruaraidh Hill, Lauren Walker,

BACKGROUND:Managing polypharmacy is a challenge for healthcare systems globally. It is also a health inequality concern as it can expose some of the most vulnerable in society to unnecessary medications and adverse drug-related events. Care for most patients with multimorbidity and polypharmacy occurs in primary care. Safe deprescribing interventions can ... Read more >>

BJGP Open (BJGP open)
[2020, :]

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Psychosocial job strain and polypharmacy: a national cohort study.

Edwin Ck Tan, Kuan-Yu Pan, Linda L Magnusson Hanson, Johan Fastbom, Hugo Westerlund, Hui-Xin Wang,

Objectives Psychosocial job strain has been associated with a range of adverse health outcomes. The aim of this study was to examine the association between psychosocial job strain and prospective risk of polypharmacy (the prescription of ≥5 medications) and to evaluate whether coping strategies can modify this risk. Methods Cohort ... Read more >>

Scand J Work Environ Health (Scandinavian journal of work, environment & health)
[2020, :]

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Thoughtful Prescribing and Deprescribing.

Vassiliki Pravodelov,

Polypharmacy, the use of five or more medications, is common in older adults. It can lead to the use of potentially inappropriate medications and severe adverse outcomes. Deprescribing is an essential step of the thoughtful prescribing process and it can decrease the use of potentially inappropriate medications. Studies have demonstrated ... Read more >>

Med. Clin. North Am. (The Medical clinics of North America)
[2020, 104(5):751-765]

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Polypharmacy Is Associated with Frailty, Nutritional Risk and Chronic Disease in Chilean Older Adults: Remarks from PIEI-ES Study.

Diego Arauna, Alvaro Cerda, José Francisco García-García, Sergio Wehinger, Felipe Castro, Diego Méndez, Marcelo Alarcón, Eduardo Fuentes, Iván Palomo,

Aim:To analyze the relationship between polypharmacy and variables as frailty and other chronic comorbidities in Chilean older adults. Design:Cross-sectional study. Participants:One thousand two hundred and five older adults aged 65 and older. Methods:The presence or absence of frailty syndrome was determined according to Fried criteria. Data collection was made through ... Read more >>

Clin Interv Aging (Clinical interventions in aging)
[2020, 15:1013-1022]

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Recent trends in antipsychotic polypharmacy in the treatment of schizophrenia.

Norio Yasui-Furukori, Kazutaka Shimoda,

Ichihashi et al reported that 43% of patients had antipsychotic polypharmacy. Number of antipsychotics used in patients with schizophrenia in Japan was the greatest among Asian countries. However, the antipsychotic polypharmacy rate in Japan decreased gradually. Recent systematic review, meta-analysis and meta-regression analysis demonstrated that antipsychotic augmentation was superior to ... Read more >>

Neuropsychopharmacol Rep (Neuropsychopharmacology reports)
[2020, :]

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Prevalence of potential drug- drug interactions and associated factors among outpatients and inpatients in Ethiopian Hospitals: a systematic review and Meta-analysis of observational studies

Wondim Ayenew, Getahun Asmamaw, Arebu Issa,

Abstract Background: Drug-drug interaction is an emerging threat to public health. Currently, there is an increase in comorbid disease, polypharmacy, and hospitalization in Ethiopia. Thus, the possibility of drug-drug interaction occurrence is high in hospitals. This study aims to summarize the prevalence of potential drug-drug interactions and associated factors in ... Read more >>

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Polypharmacy, socioeconomic indicators and number of diseases: results from ELSA-Brasil.

Isabella Ribeiro Silva, Luana Giatti Gonçalves, Dora Chor, Maria de Jesus Mendes da Fonseca, Sotero Serrate Mengue, Francisco de Assis Acurcio, Mariana Linhares Pereira, Sandhi Maria Barreto, Roberta Carvalho de Figueiredo,

OBJECTIVE:To estimate the prevalence of polypharmacy, describe the pharmacotherapeutic classes used, and investigate whether polypharmacy is associated with demographic and socioeconomic indicators, regardless of the number of diseases, among participants in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline (2008-2010). METHOD:In this analysis, 14,523 adults and elderly (35-74 years) ... Read more >>

Rev Bras Epidemiol (Revista brasileira de epidemiologia = Brazilian journal of epidemiology)
[2020, 23:e200077]

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Polypharmacy, Medication Possession, and Deprescribing of Potentially Non-Beneficial Drugs in Hospice Patients.

Ian Duncan, Terri L Maxwell, Nhan Huynh, Marisa Todd,

Patients frequently have comorbidities that when combined with their primary diagnosis qualifies the patient for hospice. Consequently, patients are at risk for polypharmacy due to the number of medications prescribed to treat both the underlying conditions and the related symptoms. Polypharmacy is associated with negative consequences, including increased risk for ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2020, :1049909120939091]

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Frailty and the Risk of Polypharmacy in the Older Person: Enabling and Preventative Approaches.

Martin C Nwadiugwu,

Frail older people have an inherent risk of polypharmacy due to the need to treat multiple comorbidities, thus leading to various negative effects on their health due to the adverse actions from the drugs. This issue was discussed from a person-centered perspective, highlighting the category of frail older adults who ... Read more >>

J Aging Res (Journal of aging research)
[2020, 2020:6759521]

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Multimorbidity and psychotropic polypharmacy among participants with autism spectrum disorder with intellectual disability.

Cristina Espadas, Pura Ballester, Ana Carolina Londoño, Susana Almenara, Víctor Aguilar, César Belda, Enrique Pérez, Ana María Peiró,

Nowadays, adults with autism spectrum disorder (ASD) experience several comorbidities whose treatment implies a wide range of psychotropic prescriptions. This study aimed to evaluate medication-related safety, drug-drug interactions, and psychotropics prescription trends. We conducted an observational and multicentric pharmacovigilance study in subjects with ASD and Intellectual disability (ID, n = 83). Clinical ... Read more >>

Psychiatry Res (Psychiatry research)
[2020, 292:113321]

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