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Phytoconstituents

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Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Pukar Khanal, Taaza Duyu, B.M. Patil, Yadu Nandan Dey, Ismail Pasha, Manish Wanjari, Shailendra S. Gurav, Arindam Maity,

Background The Ministry of AYUSH recommended the use of a decoction of the mixture of Ocimum tenuiflorum,Cinnamomum verum, Piper nigrum, Zingiber officinale, and Vitis vinifera as a preventive measure to boost immunity and to inhibit the severity of infection caused by a novel coronavirus (COVID-19). Objective The present study aimed ... Read more >>

(Journal of Ayurveda and Integrative Medicine)
[2020, :]

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Inhibition of BACE1, MAO-B, cholinesterase enzymes, and anti-amyloidogenic potential of selected natural phytoconstituents: Multi-target-directed ligand approach.

Suman Chowdhury, Suresh Kumar,

Alzheimer's disease (AD) is a neurodegenerative disorder, and multiple factors are involved in disease progression. This is why there is an urgent need to develop novel molecules with multi-target-directed ligands (MTDLs) potential. The current study explores the active phytoconstituents from traditionally used medicinal spices, namely piperine, cinnamaldehyde, eugenol, cuminaldehyde, and ... Read more >>

J Food Biochem (Journal of food biochemistry)
[2020, :e13571]

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Exploring nature's bounty: identification of Withania somnifera as a promising source of therapeutic agents against COVID-19 by virtual screening and in silico evaluation.

Aditi Srivastava, Sahabjada Siddiqui, Rumana Ahmad, Sudhir Mehrotra, Bilal Ahmad, A N Srivastava,

Coronaviruses are etiological agents of extreme human and animal infection resulting in abnormalities primarily in the respiratory tract. Presently, there is no defined COVID-19 intervention and clinical trials of prospective therapeutic agents are still in the nascent stage. Withania somnifera (L.) Dunal (WS), is an important medicinal plant in Ayurveda. ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2020, :1-51]

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Potential anti-epileptic phytoconstituents: An updated review.

Jaskiran Kaur, Paras Famta, Mani Famta, Meenu Mehta, Saurabh Satija, Neha Sharma, Manish Vyas, Gopal Lal Khatik, Dinesh Kumar Chellappan, Kamal Dua, Navneet Khurana,

ETHNOPHARMACOLOGICAL RELEVANCE:Epilepsy is one of the most commonly occurring non-communicable neurological disorder that affects people of all age groups. Around 50 million people globally are epileptic, with 80% cases in developing countries due to lack of access to treatments determined by high cost and poor availability or it can be ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, :113565]

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Bioprospecting the antimicrobial, antibiofilm and antiproliferative activity of Symplocos racemosa Roxb. Bark phytoconstituents along with their biosafety evaluation and detection of antimicrobial components by GC-MS.

Henna Sood, Yashwant Kumar, Vipan Kumar Gupta, Daljit Singh Arora,

BACKGROUND:Plants provide a ray of hope to combat the ever increasing antibiotic resistance and Symplocos racemosa is a valuable medicinal plant. The study focused on highlighting the importance of this plant's phytoconstituents as potential source of novel antimicrobials against planktonic as well as biofilm forming microorganisms, along with their antiproliferative ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):78]

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Phytoperspective of Moringa oleifera for oral health care: An innovative ethnomedicinal approach.

Monalisa Mohanty, Samita Mohanty, Sanat Kumar Bhuyan, Ruchi Bhuyan,

The present era accentuate the use of alternative medicines as drugs extracted from several plant parts. These herbal medicines otherwise called ethnomedicines are now the source of many imperative drugs in this contemporary world. Furthermore with ever rising oral problems by luxurious lifestyle in this modern society, there is a ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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Improvements in HOMA Indices and Pancreatic Endocrinal Tissues in Type -2 Diabetic Rats by DPP-4 Inhibition and Antioxidant Potential of an Ethanol Fruit Extract of Withania Coagulans

Heera Ram, Pramod Kumar, Ashok Purohit, Priya Kashyap, Suresh Kumar, Shivani Kumar, Garima Singh, Abdulaziz Alqarawi, Abeer Hashem, Elsayed Fathi Abd_Allah, Bhim Pratap Singh,

Abstract Context : Withania coagulans (Stocks) Dunal fruits are used in the therapeutics of several ailments due to possessing of potent phytoconstituents which is also used traditionally for curing the diabetes. Objective: The present study was assessing the amelioration potential of the phytochemicals of an ethanol fruit extract of Withania ... Read more >>

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The anti-inflammatory properties of Acanthus Ebracteatus, Barleria Lupulina and Clinacanthus Nutans: a systematic review.

Naomi Temitope Olubusola Ilori, Crystal Xiao-Qi Liew, Chee-Mun Fang,

This appraisal is comprised of the inflammatory studies that have been conducted on Clinacanthus nutans, Acanthus ebracteatus, and Barleria lupulina. The review aims to provide a comprehensive evaluation of the supporting and contradictory evidence on each plants' anti-inflammatory properties, whilst addressing the gaps in the current literature. The databases used ... Read more >>

Mol Biol Rep (Molecular biology reports)
[2020, :]

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Extraction, GC-MS evaluation and anti-epileptic potential of seeds ethanolic extract of Putranjiva roxburghii Wall.

Chandra Kala, Syed Sarim Imam, Mohamad Taleuzzaman, Sadaf Jamal Gilani, Syed Salman Ali, Iqra Rahat, Adil Ahmad, Najam Ali Khan,

BACKGROUND:Putranjiva roxburghii Wall is traditionally known to cure many pathological conditions including epilepsy. OBJECTIVE:The present study is aimed at determining bioactive compounds in ethanolic extract of Putranjiva roxburghii test extract (PRTE) seeds by GCMS analysis and to assess its anti-epileptic potential using various experimental models of epilepsy. METHODS:The ethanolic extract ... Read more >>

Cent Nerv Syst Agents Med Chem (Central nervous system agents in medicinal chemistry)
[2020, :]

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Antimicrobial activity of selected plants against fungal species isolated from South African AIDS patients and their antigonococcal activity.

Lesibana Petrus Maema, Martin Potgieter, Ndivhaleni Anox Masevhe, Amidou Samie,

Background Sexually transmitted infections continue to be a major health concern in sub-Saharan Africa where antimicrobial drugs are becoming ineffective due to increasing resistance. Many healthcare seekers in lower socio-economic settings depend on invasive alien plants administered by traditional health practitioners to treat sexually transmitted infections. Methods Roots of selected ... Read more >>

J Complement Integr Med (Journal of complementary & integrative medicine)
[2020, 17(3):]

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Novel Phytoconstituents of an Aqueous Pod Extract of Prosopis Cineraria (L.) Druce Attenuate Atherosclerotic Plaque and Hypercholesterolemia in Rabbits

Heera Ram, Noopur Jaipal, Pramod Kumar, Jaykaran Charan, Priya Kashyap, Suresh Kumar, Garima Singh, Anshuman Dixit, Abeer Hashem, Abdulaziz Alqarawi, Elsayed Fathi Abd_Allah, Bhim Pratap Singh,

Abstract Background and objectives: The pod of Prosopis cineraria traditionally used in several ailments and key component of traditional food recipe of the Panchkuta of western Rajasthan, India. The current study was targeted to assess ability of phytoconstituents of aqueous pod extract of Prosopis cineraria to inhibit HMG-CoA reductase activity ... Read more >>

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Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19.

Pukar Khanal, Taaza Duyu, B M Patil, Yadu Nandan Dey, Ismail Pasha, Manish Wanjari, Shailendra S Gurav, Arindam Maity,

Background:The Ministry of AYUSH recommended the use of a decoction of the mixture of <i>Ocimum tenuiflorum</i> <b>,</b> <i>Cinnamomum verum</i>, <i>Piper nigrum</i>, <i>Zingiber officinale,</i> and <i>Vitis vinifera</i> as a preventive measure to boost immunity and to inhibit the severity of infection caused by a novel coronavirus (COVID-19). Objective:The present study aimed ... Read more >>

J Ayurveda Integr Med (Journal of Ayurveda and integrative medicine)
[2020, :]

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Recent Patents on Phytoconstituents based Formulations for Treatment of Acne Infection: A Review.

Vandana Singh, Ravinder Verma, Deepak Kaushik, Vineet Mittal,

BACKGROUND:Acne is a skin infection of skin, occurs in both men and women during their life span. There are various natural or synthetic products available in the market to prevent and cure this disease. INTRODUCTION:The majority of the world population depends on the herbs or natural resources for the relief ... Read more >>

Recent Pat Antiinfect Drug Discov (Recent patents on anti-infective drug discovery)
[2020, :]

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Phyto-Phospholipid Complexation as a Novel Drug Delivery System for Management of Cancer with Better Bioavailability: Current Perspectives and Future Prospects.

Ram K Sahu, Wael M Aboulthana, Dinesh K Mehta,

Cancer is the foremost cause of death, and it supports the need for the identification of novel anticancer drugs to improve the efficacy of current-therapy. While the synthetic anticancer drug is associated with numerous side effects. Hence the plant active or phytoconstituents are in high demand for the treatment of ... Read more >>

Anticancer Agents Med Chem (Anti-cancer agents in medicinal chemistry)
[2020, :]

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Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach.

Ashish Shah, Vaishali Patel, Bhumika Parmar,

BACKGROUND:Novel Corona virus is a type of enveloped viruses with a single stranded RNA enclosing helical nucleocapsid. The envelope consists of spikes on the surface which are made up of proteins through which virus enters into human cells. Until now there is no specific drug or vaccine available to treat ... Read more >>

Comb Chem High Throughput Screen (Combinatorial chemistry & high throughput screening)
[2020, :]

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Investigation on the biofilm eradication potential of selected medicinal plants against methicillin-resistant Staphylococcus aureus

Lakshmana Prabu S., Umamaheswari A., Grace Felciya S.J.,

Highlights • Investigation of A. indica, M. oleifera, M. koenigii and P. guajava extracts against MRSA biofilm.• Pet. ether extract of A. indica show superior antibiofilm activity.• Extracts are non-toxic with minimal hemolytic properties. Biofilms are multi-species bacterial communities with complex structures that create antibiotic resistance, cause life-threatening infections, thereby ... Read more >>

Biotechnol Rep (Amst) (Biotechnology reports (Amsterdam, Netherlands))
[2020, 28:]

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Isoeugenol and Hybrid Acetamides against Candida albicans Isolated from the Oral Cavity.

Daianne Medeiros, José Oliveira-Júnior, Jefferson Nóbrega, Laísa Cordeiro, Jeane Jardim, Helivaldo Souza, Gracielle Silva, Petrônio Athayde-Filho, José Barbosa-Filho, Luciana Scotti, Edeltrudes Lima,

Isougenol is a phytoconstituent found in several essential oils. Since many natural products are potent antimicrobials, the synthesis of hybrid molecules-combining the chemical skeleton of the phytochemical with synthetic groups-can generate substances with enhanced biological activity. Based on this, the objective of this study was to evaluate the antifungal activity ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2020, 13(10):]

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Journey of Hydrocotyle sibthorpioides Lam.: From traditional utilization to modern therapeutics-A review.

Iswar Hazarika, Geetha K Mukundan, P Sivakami Sundari, Damiki Laloo,

Hydrocotyle sibthorpioides Lam. (Araliaceae) is a short and edible medicinal herb, which is used in the traditional system of medicines. The review aims to report the current information of H. sibthorpioides on the basis of its botanical and taxonomical description, traditional use, active phytoconstituents, pharmacological use and toxicity. The information ... Read more >>

Phytother Res (Phytotherapy research : PTR)
[2020, :]

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An Ayurvedic Perspective along with in Silico Study of the Drugs for the Management of Sars-Cov-2.

Abhay Jayprakash Gandhi, Jalpa Deepak Rupareliya, V J Shukla, Shilpa B Donga, Rabinarayan Acharya,

Background:Covid-19 is the disease caused by SARS-CoV2, it was identified in Wuhan, China, in 2019. It then extended across the globe and was termed as a pandemic in 2020. Though research work on its vaccine and drugs are carried out across the globe, it is even necessary to look over ... Read more >>

J Ayurveda Integr Med (Journal of Ayurveda and integrative medicine)
[2020, :]

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Corrigendum: Anti-biofilm and Antibacterial Activities of Silver Nanoparticles Synthesized by the Reducing Activity of Phytoconstituents Present in the Indian Medicinal Plants.

Yugal Kishore Mohanta, Kunal Biswas, Santosh Kumar Jena, Abeer Hashem, Elsayed Fathi Abd Allah, Tapan Kumar Mohanta,

[This corrects the article DOI: 10.3389/fmicb.2020.01143.]. ... Read more >>

Front Microbiol (Frontiers in microbiology)
[2020, 11:1784]

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Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis.

Shareen Singh, Thakur Gurjeet Singh, Kriti Mahajan, Sonia Dhiman,

OBJECTIVES:Rheumatoid arthritis is a chronic autoimmune disease manifested clinically by polyarthralgia associated with joint dysfunction triggering the antibodies targeting against the self-neoepitopes determined by autoimmune responses associated with chronic arthritic attacks. The activation of macrophages and other defence cells in response to self-epitopes as biomarkers in RA provides a better ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2020, 72(10):1306-1327]

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Network pharmacology of AYUSH recommended immune-boosting medicinal plants against COVID-19

Pukar Khanal, Taaza Duyu, Yadu Nandan Dey, Patil, Iasmail Pasha, Manish Wanjari,

Abstract Background: The Ministry of AYUSH recommended the use of a decoction of the mixture of Ocimum tenuiflorum , Cinnamomum verum , Piper nigrum , Zingiber officinale, and Vitis vinifera as a preventive measure to boost immunity and to inhibit the severity of infection caused by a novel coronavirus (COVID-19). ... Read more >>

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Recent evolution on synthesis strategies and anti-leishmanial activity of β-carboline derivatives - An update.

Karan Kumar Banoth, Faheem, Kondapalli Venkata Gowri ChandraSekhar, Nandikolla Adinarayana, Sankaranarayanan Murugesan,

Leishmaniasis is the most widespread pathogenic disease in several countries. Currently, no effective vaccines are available, and the control of Leishmaniasis primarily relies on decade-old chemotherapy. The treatment for the Leishmaniasis is not up to the mark. Current therapy for Leishmaniasis is ancient and requires hospitalization for the administration. These ... Read more >>

Heliyon (Heliyon)
[2020, 6(9):e04916]

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Metabolite profiling and evaluation of CYP450 interaction potential of 'Trimada'- an Ayurvedic formulation.

Amit Kar, Pulok K Mukherjee, Sankarshan Saha, Subhadip Banerjee, Debayan Goswami, Motlalepula G Matsabisa, Rawiwan Charoensub, Thidarat Duangyod,

ETHNOPHARMACOLOGICAL RELEVANCE:Trimada is well-known polyherbal Ayurvedic formulation used in Indian Traditional medicine since ancient times. It consisted of three inebriant herbs including "Chitraka" (Plumbago zeylanica Linn. Family- Plumabaginaceae), "Musta" (Cyperus rotundus Linn. Family- Cyperaceae) and Vidanga (Embelia ribes Burm. F. Family- Myrsinaceae) in equal ratios as mentioned in Ayurveda. Trimada ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2020, 266:113457]

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Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants - Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) - a molecular docking study.

Priya Shree, Priyanka Mishra, Chandrabose Selvaraj, Sanjeev Kumar Singh, Radha Chaube, Neha Garg, Yamini Bhusan Tripathi,

COVID-19 (Coronavirus disease 2019) is a transmissible disease initiated and propagated through a new virus strain SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) since 31st December 2019 in Wuhan city of China and the infection has outspread globally influencing millions of people. Here, an attempt was made to recognize natural phytochemicals ... Read more >>

J Biomol Struct Dyn (Journal of biomolecular structure & dynamics)
[2020, :1-14]

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