Full Text Journal Articles about
Periodic Paralyses

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Skeletal muscle CaV1.1 channelopathies.

Bernhard E Flucher,

CaV1.1 is specifically expressed in skeletal muscle where it functions as voltage sensor of skeletal muscle excitation-contraction (EC) coupling independently of its functions as L-type calcium channel. Consequently, all known CaV1.1-related diseases are muscle diseases and the molecular and cellular disease mechanisms relate to the dual functions of CaV1.1 in ... Read more >>

Pflugers Arch. (Pflugers Archiv : European journal of physiology)
[2020, :]

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Analysis of the genetic background associated with sporadic periodic paralysis in Japanese patients.

Maki Nakaza, Yuri Kitamura, Mitsuru Furuta, Tomoya Kubota, Ryogen Sasaki, Masanori P Takahashi,

Periodic paralysis (PP) is a rare disease caused by abnormal excitability of the sarcolemma, resulting in the episodic weakness in extremities. Two major subtypes have been identified: primary/familial PP showing Mendelian inheritance of a mutation in the ion channel genes expressed in skeletal muscle, and secondary/sporadic PP which does not ... Read more >>

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, :116795]

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Thyrotoxic Periodic Paralysis: An Incidental Diagnosis!

Jennifer T Batch, Muhammad U Jahngir, Ismael Rodriguez,

Thyrotoxic periodic paralysis is a rare presentation of thyrotoxicosis where the patient develops a transient motor deficit secondary to acute hypokalemia. The thyroid hormone augments gene transcription and post-transcriptional modification of Na-K ATPase, a cell membrane protein that regulates the electrical potential of the cell. Na-K ATPase increases active transport ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7041]

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THYROTOXIC PERIODIC PARALYSIS AND COMPLICATED THYROTOXICOSIS, TWO PRESENTATIONS OF HYPERTHYROIDISM WITH NOTABLE DIFFERENCES IN THEIR CLINICAL MANIFESTATIONS. AN EXPERIENCE FROM A TERTIARY CARE HOSPITAL IN THE UNITED STATES.

Ana M Rivas, Subhanudh Thavaraputta, Menfil Andres Orellana-Barrios, John Drew Payne, David Sotello, Myrian Vinan-Vega, Joaquin Lado-Abeal,

Thyrotoxic periodic paralysis (TPP) is a muscular disorder characterized by sudden episodes of muscle weakness and hypokalemia in the setting of thyrotoxicosis. OBJECTIVE:We aimed to report our experience with TPP in West Texas and compare its clinical presentation to that of patients admitted for complicated thyrotoxicosis. METHOD:Retrospective review of records ... Read more >>

Endocr Pract (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists)
[2020, :]

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Stroke Mimic: A Case of Unilateral Thyrotoxic Hypokalemic Periodic Paralysis.

Michael Lajeunesse, Scott Young,

Thyrotoxic hypokalemic periodic paralysis (THPP) is a condition that results in transient skeletal muscle paralysis secondary to intracellular potassium sequestration. Susceptible individuals often have an underlying channelopathy, which may be exacerbated by lifestyle factors or underlying medical comorbidities such as hyperthyroidism or diarrheal illness. Classically, THPP presents with paralysis of ... Read more >>

Clin Pract Cases Emerg Med (Clinical practice and cases in emergency medicine)
[2020, 4(1):75-78]

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In vivo assessment of interictal sarcolemmal membrane properties in hypokalaemic and hyperkalaemic periodic paralysis.

S Veronica Tan, Karen Suetterlin, Roope Männikkö, Emma Matthews, Michael G Hanna, Hugh Bostock,

OBJECTIVE:Hypokalaemic periodic paralysis (HypoPP) is caused by mutations of Cav1.1, and Nav1.4 which result in an aberrant gating pore current. Hyperkalaemic periodic paralysis (HyperPP) is due to a gain-of-function mutation of the main alpha pore of Nav1.4. This study used muscle velocity recovery cycles (MVRCs) to investigate changes in interictal ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2020, 131(4):816-827]

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Thyrotoxic periodic paralysis: A retrospective, observational study from India.

Vishesh Verma, Yogesh Kumar, Narendra Kotwal, Vimal Upreti, K V S Hari Kumar, Yashpal Singh, Anil S Menon,

Background & objectives:Thyrotoxic periodic paralysis (TPP) is an endocrine emergency presenting with acute-onset flaccid paralysis in a patient having thyrotoxicosis accompanied by hypokalaemia. This study was conducted to evaluate the clinical profile of patients with TPP presenting to three centres in India. Methods:This retrospective, observational study was conducted at three ... Read more >>

Indian J. Med. Res. (The Indian journal of medical research)
[2020, 151(1):42-46]

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The expanding phenotype of hypokalemic periodic paralysis in a Japanese family with p.Val876Glu mutation in CACNA1S.

Mari Kurokawa, Michiko Torio, Kazuhiro Ohkubo, Vlad Tocan, Noriko Ohyama, Naoko Toda, Kanako Ishii, Kei Nishiyama, Yuichi Mushimoto, Ryuichi Sakamoto, Maki Nakaza, Riho Horie, Tomoya Kubota, Masanori P Takahashi, Yasunari Sakai, Masatoshi Nomura, Shouichi Ohga,

BACKGROUND:Hypokalemic periodic paralysis (HypoPP) is an autosomal dominant disease characterized by the episodic weakness of skeletal muscles and hypokalemia. More than half patients with HypoPP carry mutations in CACNA1S, encoding alpha-1 subunit of calcium channel. Few reports have documented the non-neuromuscular phenotypes of HypoPP. METHODS:The proband is a Japanese woman ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2020, :e1175]

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Further evidence for shared genetic susceptibility in both sporadic and Thyrotoxic periodic paralysis.

Stephen C Cannon,

J. Neurol. Sci. (Journal of the neurological sciences)
[2020, :116794]

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Application of Continuous Intraoperative Neuromonitoring During VATS Lobectomy for Left Lung Cancer to Prevent Recurrent Laryngeal Nerve Injury.

Young Jun Chai, Jung-Man Lee, Yong Won Seong, Hyeon Jong Moon,

We applied continuous intraoperative neuromonitoring (CIONM) during video-assisted thoracoscopic surgery (VATS) lobectomy for left lung cancer and evaluated its safety and usefulness. An electrode was attached to a double-lumen tube, and placed at vocal cord level to detect the EMG signal evoked by vocal cord movement. Before 4 L lymph node ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4636]

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Low-dose oral propranolol for treatment of thyrotoxic periodic paralysis with hypokalaemia in the emergency department: A case report.

Chanie Wassner, Susan H Cheng,

WHAT IS KNOWN AND OBJECTIVE:Thyrotoxic periodic paralysis (TPP) with hypokalaemia is a rare acute phenomenon. Reports of the use of high-dose non-selective β-blockers describe symptom resolution, but often administration does not occur promptly enough in the treatment course and patients may experience overcorrection and hyperkalaemia. CASE DESCRIPTION:A 37-year-old Hispanic male ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2020, :]

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Episodic Muscle Disorders.

Valeria A Sansone,

PURPOSE OF REVIEW:This article reviews the episodic muscle disorders, including benign cramp-fasciculation syndrome, the periodic paralyses, and the nondystrophic myotonias. The core diagnostic criteria for a diagnosis of primary periodic paralysis, including clues to distinguish between the hypokalemic and hyperkalemic forms, and the distinctive elements that characterize Andersen-Tawil syndrome are ... Read more >>

Continuum (Minneap Minn) (Continuum (Minneapolis, Minn.))
[2019, 25(6):1696-1711]

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Thyrotoxic Periodic Paralysis: A Spine Consultation.

Samuel J Mease, Michael J Faloon, Conor J Dunn, Stuart Changoor, Nikhil Sahai, Awais K Hussain, Arash Emami,

As a consultant, the orthopaedic spine surgeon is often asked to evaluate patients with acute-onset extremity weakness. In some cases, patient's deficits can be attributed to nonspinal pathology; therefore, it is important to be aware of nonorthopaedic diagnoses when evaluating these patients. We report a case of thyrotoxic periodic paralysis ... Read more >>

J Am Acad Orthop Surg Glob Res Rev (Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews)
[2019, 3(11):]

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Systematic review and case report: Systemic lupus erythematosus with renal tubular acidosis.

Prashanth Rawla, Krishna Chaitanya Thandra, John Sukumar Aluru, Sarah Abdel Mageed, Eman Elsayed Sakr, Ghadeer Gamal Elsayed, Mohamed Zidan, Mostafa Ebraheem Morra,

Immune profile assessment-particularly for SLE-and subsequent specific therapy are beneficial in patients with persisting unexplained hyperkalemic or hypokalemic paralysis, especially in case of isolated RTA. ... Read more >>

Clin Case Rep (Clinical case reports)
[2020, 8(2):333-340]

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Child with acute weakness: don't forget the salts.

Kathryn Boyle, Ben McNaughten, Andrew Thompson, Stephen Mullen,

Case summaryA 10-year-old boy presented with severe progressive generalised weakness on a background of 3 days of diarrhoea and vomiting. Vital signs were normal. Peripheral neurological examination revealed grade 1-2 power in all limbs, hypotonia and hyporeflexia. Sensation was fully intact. Cranial nerve examination and speech were normal. The ECG (figure ... Read more >>

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, :]

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SCN4A p.R675Q Mutation Leading to Normokalemic Periodic Paralysis: A Family Report and Literature Review.

Jiejing Shi, Qianqian Qu, Haiyan Liu, Wenhao Cui, Yan Zhang, Haidong Lv, Zuneng Lu,

Objective: To investigate the clinical features, skeletal muscle imaging, and muscle pathological characteristics of normokalemic periodic paralysis (NormoKPP) caused by mutation of SCN4A gene p.R675Q. Methods: The clinical data, skeletal muscle imaging, pathological data, and gene test results of a family with NormoKPP were collected in detail in October 2018. ... Read more >>

Front Neurol (Frontiers in neurology)
[2019, 10:1138]

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Management of Conn's Syndrome Associated with Hypokalemic Nonperiodic Paralysis.

Molly J Elson, Vivian L Wang, Jyotirmay Sharma,

Am Surg (The American surgeon)
[2020, 86(1):e33-e34]

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Warthin's tumor with necrotizing tuberculous granulomatous inflammation causing severe facial nerve adhesion in parotid gland: A case report and literature review.

Shih-Lung Chen, Cheng-Cheng Hwang, Yu-Chih Liu, Wei-Ting Chen, Shih-Wei Yang,

RATIONALE:Warthin's tumor is the second most common tumor arising from the parotid gland, but it rarely occurs concomitantly with tuberculous granulomatous inflammation with only 13 documented case reports in the English literature. PATIENT CONCERNS:An 82-year-old woman had a left infraauricular mass for approximately 3 years that had significantly increased in ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(7):e18763]

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Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1220-1234]

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Hypokalemic Quadriparesis: A Rare Manifestation of Dengue Fever.

Veer Bahadur Singh, Harish Kumar,

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):519-520]

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Overlap of periodic paralysis and paramyotonia congenita caused by SCN4A gene mutations two family reports and literature review.

Shan Huang, Wei Zhang, Xueli Chang, Junhong Guo,

OBJECTIVE:To verify the diagnosis of channelopathies in two families and explore the mechanism of the overlap between periodic paralysis (PP) and paramyotonia congenita (PMC). METHODS:We have studied two cases with overlapping symptoms of episodic weakness and stiffness in our clinical center using a series of assessment including detailed medical history, ... Read more >>

Channels (Austin) (Channels (Austin, Tex.))
[2019, 13(1):110-119]

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Contribution of Asian Haplotype of KCNJ18 to Susceptibility to and Ethnic Differences in Thyrotoxic Periodic Paralysis.

Shinsuke Noso, Naru Babaya, Yoshihisa Hiromine, Hiroyuki Ito, Yasunori Taketomo, Sawa Yoshida, Fumimaru Niwano, Keisuke Monobe, Tatsuro Minohara, Takuya Okada, Mamiko Tsugawa, Yumiko Kawabata, Hiroshi Ikegami,

CONTEXT AND OBJECTIVES:Thyrotoxic periodic paralysis (TPP) is an acute complication of thyrotoxicosis that can be lethal. TPP is rare in Caucasians but often affects young men in East Asian populations. This study aimed to clarify the contribution of KCNJ18 to susceptibility to TPP in East Asian populations. PARTICIPANTS AND METHODS:The ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2019, 104(12):6338-6344]

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Sudden Night Palsy in a Young Man: Thyrotoxic Periodic Paralysis as a First Manifestation of Hyperthyroidism.

Damyan Penev, Christine Rotering, Thomas Pusl,

Am. J. Med. (The American journal of medicine)
[2019, :]

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Thyrotoxic Periodic Paralysis.

Miqdad Haider, Aijaz Zeeshan Khan Chachar, Atif Munir,

Thyrotoxic periodic paralysis is an uncommon disorder characterized by hypokalaemia, thyrotoxicosis and paralysis, most commonly seen in South Asian males. Aim of our case series is to highlight the significance of this reversible cause of patients presenting with neuromuscular paralysis. We present case series of 1 Asian and three Caucasian ... Read more >>

J Ayub Med Coll Abbottabad (Journal of Ayub Medical College, Abbottabad : JAMC)
[2019, 31(4):619-621]

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Clinical and neurophysiological variability in Andersen-Tawil syndrome.

Norito Kokubun, Reika Aoki, Takahide Nagashima, Tomoko Komagamine, Yusuke Kuroda, Minoru Horie, Koichi Hirata,

INTRODUCTION:Andersen-Tawil syndrome (ATS) is characterized by a triad of periodic paralysis, ventricular arrhythmias, and dysmorphism. However, patients often lack one or more of these features. METHODS:Clinical and neurophysiological features were reviewed of five members in two families with heterozygous mutations in KCNJ2 (R218Q and R67W). RESULTS:Only one patient had all ... Read more >>

Muscle Nerve (Muscle & nerve)
[2019, 60(6):752-757]

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