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Periodic Limb Movement Disorder

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Determinants of ferritin response to oral iron supplementation in children with sleep movement disorders.

Lourdes M DelRosso, Troy Yi, Jeremy H M Chan, Joanna E Wrede, Carey T Lockhart, Raffaele Ferri,

STUDY OBJECTIVES:To identify children who respond to oral iron supplementation as evidenced by increased ferritin levels and to identify factors that correlate with improvement in ferritin levels in those who respond. METHODS:A retrospective chart review of the PLMS/RLS/RSD database at Seattle Children's Hospital was carried out. Data collected included nocturnal ... Read more >>

Sleep (Sleep)
[2020, 43(3):]

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Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study.

Jihui Wang, Xiaodong Chen, Jinchi Liao, Li Zhou, Hongying Han, Jiong Tao, Zhengqi Lu,

BACKGROUND:Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationship between non breathing-related sleep fragmentation and brain imaging markers in ... Read more >>

BMC Neurol (BMC Neurology)
[2020, 20(1):98]

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Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update.

Feng Zhang, Long Niu, Xinyao Liu, Yufei Liu, Song Li, Huan Yu, Weidong Le,

Rapid eye movement sleep behavior disorder (RBD) is a sleep behavior disorder characterized by abnormal behaviors and loss of muscle atonia during rapid eye movement (REM) sleep. RBD is generally considered to be associated with synucleinopathies, such as Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy ... Read more >>

Aging Dis (Aging and Disease)
[2020, 11(2):315-326]

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Comorbidities in children with elevated periodic limb movement index during sleep.

Lourdes M Delrosso, Carey Lockhart, Joanna E Wrede, Maida Lynn Chen, Maria Samson, Jennifer Reed, Sara Martin-Washo, Michelle Arp, Raffaele Ferri,

STUDY OBJECTIVES:Little is known about comorbidities in children who have elevated periodic limb movement index (PLMI) during overnight polysomnogram (PSG). The aim of this study is to identify comorbidities in children with elevated PLMI (PLMI > 5) versus children with PLMI < 5 presenting to a pediatric sleep center. METHODS:This ... Read more >>

Sleep (Sleep)
[2020, 43(2):]

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Age of Diagnosis and Comorbid PLMD Predict Poor Response of REM Behavior Disorder to Clonazepam.

Hyuk Joo Lee, Hayun Choi, In-Young Yoon,

Previous studies have shown the therapeutic effects of clonazepam for rapid eye movement sleep behavior disorder (RBD), but they had several limitations such as the lack of clear definition of treatment outcomes and little information about adjuvant therapy. The aims of this study were to evaluate the treatment outcomes with ... Read more >>

J Geriatr Psychiatry Neurol (Journal of geriatric psychiatry and neurology)
[2020, :891988720915517]

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Sex-Related Differences in Sleep-Related PSG Parameters and Daytime Complaints in a Clinical Population.

Sebastien Van Eycken, Daniel Neu, Johan Newell, Charles Kornreich, Olivier Mairesse,

Background:Recent research suggested that perception of sleep impairments might present sex-related effects (ie, women appear to be more prone to report fatigue rather than sleepiness). The latter has been evidenced in sleep-related breathing disorders (SRBD). Differently, it has been suggested that sleep-related movement disorders may also be associated to fatigue ... Read more >>

Nat Sci Sleep (Nature and science of sleep)
[2020, 12:161-171]

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An elevated leg movement index during sleep in atopic dermatitis and periodic leg movement disorder may be an indication of sympathetic activation common to both.

Madhulika A Gupta, Aditya K Gupta,

J Clin Sleep Med (Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine)
[2020, 16(3):463]

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High prevalence of periodic limb movements of sleep in children with Down syndrome.

Dennis Rosen, Laura Berbert, Edie Weller,

STUDY OBJECTIVES:Increased periodic limb movements of sleep (PLMS), > 5 events/h, are present in 1.2% to 7.7% of healthy children and associated with hypertension, attention deficit, and hyperactivity. This study sought to determine the prevalence of elevated PLMS in a large cohort of children with Down syndrome (DS) and their ... Read more >>

J Clin Sleep Med (Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine)
[2020, 16(3):347-352]

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Embolic Stroke of Undetermined Source and Sleep Disorders.

Laavanya Dharmakulaseelan, Nathan Chan-Smyth, Sandra E Black, Richard H Swartz, Brian J Murray, Mark I Boulos,

Background and Purpose- Compared with other causes of ischemic stroke, the mechanism of action of embolic stroke of undetermined source (ESUS) remains unclear, with previous literature suggesting that ESUS may be due to an undetected cardioembolic source. This study aimed to improve our understanding of the pathophysiology of ESUS through ... Read more >>

Stroke (Stroke)
[2020, 51(4):1294-1296]

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Periodic leg movements: A marker of cardiovascular risk?

Mark E Howard, Fergal J O'Donoghue,

Respirology (Respirology (Carlton, Vic.))
[2020, :]

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Markerless Measurement and Evaluation of General Movements in Infants.

Toshio Tsuji, Shota Nakashima, Hideaki Hayashi, Zu Soh, Akira Furui, Taro Shibanoki, Keisuke Shima, Koji Shimatani,

General movements (GMs), a type of spontaneous movement, have been used for the early diagnosis of infant disorders. In clinical practice, GMs are visually assessed by qualified licensees; however, this presents a difficulty in terms of quantitative evaluation. Various measurement systems for the quantitative evaluation of GMs track target markers ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1422]

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Non breathing-related sleep fragmentation and imaging markers in patients with atherosclerotic cerebral small vessel disease (CSVD): a cross-sectional case-control study

Zhengqi Lu, jihui wang, Xiaodong Chen, Jinchi Liao, Li Zhou, Hongying Han, Jiong Tao,

<title>Abstract</title> <p> Background : Sleep fragmentation was shown to be positively associated with cognitive impairment in patients with cerebral small vessel disease (CSVD); however, the underlying mechanisms are not well characterized. In this study, we sought to clarify this issue by investigating the relationship between non breathing-related sleep ... Read more >>

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Restless legs syndrome following the use of ziprasidone: a case report.

Cuizhen Zhu, Ran Bi, Yuliang Hu, Hui Zhou, Daomin Zhu, Brian Isaacson, Qingwei Li, Yezhe Lin,

Restless legs syndrome (RLS) is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity. Although there have been many case reports on antipsychotic-induced RLS, ziprasidone has never been reported as a cause of RLS. We present a case of ... Read more >>

Gen Psychiatr (General psychiatry)
[2020, 33(2):e100112]

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Why Are Women Prone to Restless Legs Syndrome?

Mary V Seeman,

Restless legs syndrome is a relatively common neurologic disorder considerably more prevalent in women than in men. It is characterized by an inactivity-induced, mostly nocturnal, uncomfortable sensation in the legs and an urge to move them to make the disagreeable sensation disappear. Some known genes contribute to this disorder and ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2020, 17(1):]

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Sleep disorders in children and adolescents on regular hemodialysis.

Nevine El-Baroudy, Mona El Falaki, Amal Hagras, Rasha Galal, Radwa Azmy, Basma El-Sayed, Marian Walaan, Happy Sawires,

Sleep disorders in children with chronic kidney disease have been assessed in a limited number of studies. Our aim was to characterize the types of sleep disorders in children on regular hemodialysis and to detect the predictors of sleep efficiency in those children. Forty children and adolescents on regular hemodialysis ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, :]

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Association of periodic limb movements during sleep and Parkinson disease: A retrospective clinical study.

Shang-Rung Hwang, Sheng-Wei Hwang, Jin-Cherng Chen, Juen-Haur Hwang,

Both of periodic limb movements during sleep (PLMS) and Parkinson disease (PD) were related with dopaminergic system dysfunction. We aimed to investigate the detailed association of PLMS severity and PD.Clinical and overnight polysomnographic data of 2230 adults older than 40 from a community hospital between November 2011 and June 2017 ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(51):e18444]

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Compromised Dynamic Cerebral Autoregulation in Patients With Idiopathic Rapid Eye Movement Behavior Disorder: A Case-Control Study Using Transcranial Doppler.

Shan Lv, Zan Wang, Xin Sun, Hang Jin, Jia Liu, Fang Deng, Yudan Lv, Meiyan Jia, Zhen-Ni Guo, Yi Yang,

Background:Patients with idiopathic rapid eye movement behavior disorder (IRBD) have been suggested to exhibit altered cerebral perfusion and abnormal cerebral blood flow, which imply a possibility of cerebral autoregulation (CA) impairment. We aimed to investigate the dynamic CA (dCA) in patients with IRBD during wakefulness and to explore the correlations ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2020, 11:51]

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Cervical Dystonia Mimics: A Case Series and Review of the Literature.

Srinivas Raju, Amogh Ravi, L K Prashanth,

Background:Cervical dystonia is mostly idiopathic in nature. However, a small subset of cases are mimics, leading to diagnostic pitfalls. There is paucity of literature on pseudodystonias affecting the cervical region. Method:We performed a retrospective review of patients attending a movement disorders clinic over a period of 7 years (2012-2018). Among ... Read more >>

Tremor Other Hyperkinet Mov (N Y) (Tremor and other hyperkinetic movements (New York, N.Y.))
[2019, 9:]

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Sleep spindles, K-complexes, limb movements and sleep stage proportions may be biomarkers for amnestic mild cognitive impairment and Alzheimer's disease.

Shunjie Liu, Junhao Pan, Ke Tang, Qingfeng Lei, Lu He, Yangyang Meng, Xiaodong Cai, Zhong Li,

PURPOSE:Sleep disturbances are common in Alzheimer's disease (AD) and mild cognitive impairment (MCI) patients. Non-rapid eye movement stage 3 (N3), rapid eye movement stage (REM), spindle density, and K-complex (KC) density are decreased in MCI and AD patients. Periodic limb movements in sleep (PLMS) are increased in other neurodegenerative diseases. ... Read more >>

Sleep Breath (Sleep & breathing = Schlaf & Atmung)
[2019, :]

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Subjective and objective features of sleep disorders in patients with acute ischemic or haemorrhagic stroke: It is not only sleep apnoea which is important.

Evelina Pajediene, Adomas Pajeda, Gintare Urnieziute, Erlandas Paulekas, Vanda Liesiene, Indre Bileviciute-Ljungar, Giedre Jurkeviciene, Daiva Rastenyte, Kestutis Petrikonis,

BACKGROUND:More than half of stroke patients present with a sleep-related breathing disorder including both central and obstructive forms of sleep apnoea. A cerebral infarction in different brain areas can disrupt sleep regulating pathways and cause insomnia, hypersomnia, circadian rhythm disturbances and other sleep disorders. Therefore, there is a need of ... Read more >>

Med. Hypotheses (Medical hypotheses)
[2020, 136:109512]

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Lack of Association between Periodic Limb Movements during Sleep and Neuroimaging Signatures of Cerebral Small Vessel Disease in Stroke-Free Community-Dwelling Older Adults. The Atahualpa Project.

Oscar H Del Brutto, Robertino M Mera, Victor J Del Brutto, Pablo R Castillo,

BACKGROUND:Evidence of the relationship between periodic limb movements during sleep (PLMS) and cerebral small vessel disease (cSVD) is limited and inconsistent. Here, we aimed to assess the independent association between PLMS and the different neuroimaging signatures of cSVD. METHODS:Atahualpa residents aged more than or equal to 60 years enrolled in ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(2):104497]

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Association between physical activity and Nocturnal Leg Cramps in patients over 60 years old: a case-control study.

Chloé Delacour, Juliette Chambe, François Lefebvre, Claire Bodot, Elodie Bigerel, Laetitia Epifani, Céline Granda, Dagmar M Haller, Hubert Maisonneuve,

Nocturnal Legs Cramps are a frequent disorder, which have a negative impact on quality of life, particularly among patients over 60 years old. Lifestyle factors such as alcohol consumption have been shown to be associated with Nocturnal Leg Cramps. This study aimed to explore the association between nocturnal leg cramps ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):2638]

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Inertial Sensor-Based Lower Limb Joint Kinematics: A Methodological Systematic Review.

Ive Weygers, Manon Kok, Marco Konings, Hans Hallez, Henri De Vroey, Kurt Claeys,

The use of inertial measurement units (IMUs) has gained popularity for the estimation of lower limb kinematics. However, implementations in clinical practice are still lacking. The aim of this review is twofold-to evaluate the methodological requirements for IMU-based joint kinematic estimation to be applicable in a clinical setting, and to ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2020, 20(3):]

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Canine Models of Inherited Musculoskeletal and Neurodegenerative Diseases.

Brett D Story, Matthew E Miller, Allison M Bradbury, Emily D Million, Dongsheng Duan, Toloo Taghian, Dominik Faissler, Deborah Fernau, Sidney J Beecy, Heather L Gray-Edwards,

Mouse models of human disease remain the bread and butter of modern biology and therapeutic discovery. Nonetheless, more often than not mouse models do not reproduce the pathophysiology of the human conditions they are designed to mimic. Naturally occurring large animal models have predominantly been found in companion animals or ... Read more >>

Front Vet Sci (Frontiers in Veterinary Science)
[2020, 7:80]

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Author response.

Anna B Fishbein, Stephen Sheldon, Daniela Grimaldi,

J Clin Sleep Med (Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine)
[2020, 16(3):465]

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