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The conserved multi-functional nuclear protein dss-1/Sem1 is required for C9orf72-associated ALS/FTD dipeptide toxicity.

Noah Puleo, Todd Lamitina,

MicroPubl Biol (microPublication. Biology)
[2020, 2020:]

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Association between hospital admissions and healthcare provider communication for individuals with sickle cell disease.

Robert M Cronin, Manshu Yang, Jane S Hankins, Jeannie Byrd, Brandi M Pernell, Adetola Kassim, Patricia Adams-Graves, Alexis A Thompson, Karen Kalinyak, Michael DeBaun, Marsha Treadwell,

Objective: To test the hypothesis that caregivers' or adult participants' low ratings of provider communication are associated with more hospital admissions among adults and children with sickle cell disease (SCD), respectively. Secondarily, we determined whether there was an association between the caregivers' or participants' health literacy and rating of providers' ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):229-240]

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SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East.

Yu-Nong Gong, Kuo-Chien Tsao, Mei-Jen Hsiao, Chung-Guei Huang, Peng-Nien Huang, Po-Wei Huang, Kuo-Ming Lee, Yi-Chun Liu, Shu-Li Yang, Rei-Lin Kuo, Kuan-Fu Chen, Yen-Chin Liu, Sheng-Yu Huang, Hsing-I Huang, Ming-Tsan Liu, Ji-Rong Yang, Cheng-Hsun Chiu, Cheng-Ta Yang, Guang-Wu Chen, Shin-Ru Shih,

Taiwan experienced two waves of imported infections with Coronavirus Disease 2019 (COVID-19). This study aimed at investigating the genomic variation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Taiwan and compared their evolutionary trajectories with the global strains. We performed culture and full-genome sequencing of SARS-CoV-2 strains followed by ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1457-1466]

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General Pediatricians' Performance of Accreditation Agency's Recommended Procedures: A Complementary Analysis Using Administrative Data and the Knowledge Translation Model.

Maya S Iyer, Charmaine B Lo, Rachel M Stanley,

INTRODUCTION:The Accreditation Council for Graduate Medical Education provided guidelines, in 2013, regarding 13 clinical procedures pediatric residents should learn. Previous studies show that, when asked, general pediatricians (GPeds) self-report performing these procedures infrequently. When examined using the knowledge translation model, this low procedural performance frequency, especially by GPeds, may indicate ... Read more >>

J Contin Educ Health Prof (The Journal of continuing education in the health professions)
[2020, 40(1):11-18]

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Professional development for clerkship administrators: a 16-year overview of the clerkship administrator certificate program.

Donnita Pelser, Cathy Chavez, Lindsey Allison, Virginia Cleppe, Gary L Beck Dallaghan,

BACKGROUND:Increasing accreditation requirements as well as transformations in medical school curricula necessitate administrative staff who are not only invested in the clerkship coordinator role but also view what they do as a career. To date, there has been a lack of professional development opportunities for clerkship administrators. METHODS:In 2003, the ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1710327]

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Evolving roles of clerkship directors: have expectations changed?

Gary L Beck Dallaghan, Cynthia H Ledford, Douglas Ander, John Spollen, Sherilyn Smith, Scott Graziano, Susan M Cox,

BACKGROUND:Physician educators directing medical student programs face increasingly more complex challenges to ensure students receive appropriate preparation to care for patients. The Alliance for Clinical Education (ACE) defined expectations of and for clerkship directors in 2003. Since then, much has changed in medical education and health care. METHODS:ACE conducted a ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1714201]

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Idle medical students review emerging COVID-19 research.

Carl Boodman, Santina Lee, Jared Bullard,

The coronavirus disease (COVID-19) pandemic is causing wide-spread interruptions in medical education. With little warning, clinical rotations were cancelled and medical students were sent home. While pre-clinical students transitioned to online curricula, clinical students were left without discreet educational goals. Simultaneously, medical doctors were scrambling to maintain competence in the ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1770562]

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CD32a polymorphism rs1801274 affects the risk of Kawasaki disease.

Zhiyong Wang, Pei-Liang Geng,

Aim: To analyze the impact of CD32a polymorphism rs1801274 on the occurrence of Kawasaki disease (KD) through the meta-analysis.Methods: The correlation between CD32a polymorphism rs1801274 and the susceptibility to KD was appraised using summarized odds ratios (ORs) with their 95% confidence intervals (95% CIs). Besides, stratification analyses were further implemented ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):620-626]

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A qualitative examination of barriers against effective medical education and practices related to breastfeeding promotion and support in Lebanon.

Sara Moukarzel, Christoforos Mamas, Antoine Farhat, Antoine Abi Abboud, Alan J Daly,

Background: Insufficient breastfeeding promotion and support by physicians contribute to suboptimal breastfeeding rates globally. Understanding setting-specific barriers against breastfeeding promotion and support from the perspective of medical students and addressing those that can be modified through undergraduate medical education may help improve learning outcomes, medical practice, and ultimately health outcomes ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1723950]

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LINC02163 promotes colorectal cancer progression via miR-511-3p/AKT3 axis.

Junwen Ma, Lihai Zhang, Anquan Shang, Hu Song, Jiege Huo, Mingjian Zhang, Liuqin Jiang,

Long non-coding RNAs and microRNAs are functional regulators in tumour progression. Herein, we revealed the level LINC02163 was up-regulated in CRC tissues and cell lines, and the expression of LINC02163 negatively correlated with prognosis of CRC patients. Functional experiments demonstrated knockdown of LINC02163 significantly attenuated CRC cells proliferation and metastasis. ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):961-968]

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NIR triggered PLGA coated Au-TiO2 core loaded CPT-11 nanoparticles for human papillary thyroid carcinoma therapy.

Tianyu Yu, Lingling Tong, Yu Ao, Genmao Zhang, Yunpeng Liu, Hejia Zhang,

MDR (multi-drug resistance) is one of the significant deterrents of effective chemotherapy for malignant growth. One of the powerful ways to deal with defeat of the MDR is to utilize inorganic nanoparticle-intervened tranquilize conveyance to build the medication aggregations in cancerous growth cells. In this work, we have developed the ... Read more >>

Drug Deliv (Drug delivery)
[2020, 27(1):855-863]

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Long non-coding RNA NKILA weakens TNF-α-induced inflammation of MRC-5 cells by miR-21 up-regulation.

Dandan Wang, Jiajie Zhang, Yan Sun, Nan Lv, Jianwei Sun,

Background: Infantile pneumonia (IP) seriously affects the health of children. This article mainly discussed the protective effect of long non-coding RNA NKILA (lnc NKILA) on IP by detecting cell viability, apoptosis and inflammatory response of MRC5 cells.Methods: Cell counting kit-8 (CCK-8) was used to detect cell viability, while flow cytometry ... Read more >>

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):498-505]

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Identification of potential miRNA-mRNA interaction network in bone marrow T cells of acquired aplastic anemia.

Shuanglong Lu, Anil Kumar Yadav, Xiaohong Qiao,

Background: MicroRNAs(miRNAs) can regulate T cell differentiation and plasticity by targeting their corresponding message RNAs (mRNAs), which play important roles in many autoimmune diseases. But the effect of miRNAs and their targeted mRNAs in acquired AA is not fully understood.Methods: The Gene Expression Omnibus data-sets of bone marrow T cells ... Read more >>

Hematology (Hematology (Amsterdam, Netherlands))
[2020, 25(1):168-175]

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Inhibition of γ-secretase in adipocytes leads to altered IL-6 secretion and adipose inflammation.

David P Sparling, Nile McCullough, Utpal Pajvani, Mary Beth Humphrey,

Adipocyte-mediated inflammatory signalling has been proposed to alter adipose physiology in obesity and Type 2 diabetes mellitus. Novel targets for alteration of inflammatory signalling are needed to improve obesity-related outcomes. The γ-secretase enzyme complex has been suggested to play a role both in adipocyte function as well as in immune ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):325-334]

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Ending student mistreatment: early successes and continuing challenges.

Katherine T Lind, Christina M Osborne, Brittany Badesch, Alyssa Blood, Steven R Lowenstein,

Problem: Student mistreatment represents an ongoing challenge for US medical schools. Students experiencing mistreatment may become marginalized and cynical, and they have higher rates of burnout, depression and substance use disorders. Although numerous attempts to eliminate mistreatment have been proposed, best practices remain elusive. We formed a unique student-faculty collaboration ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1690846]

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Clinical and Molecular Description of 16 Families With Heterozygous IHH Variants.

Lucía Sentchordi-Montané, Sara Benito-Sanz, Miriam Aza-Carmona, Arrate Pereda, Manuel Parrón-Pajares, Carolina de la Torre, Gabriela A Vasques, Mariana F A Funari, André M Travessa, Patrícia Dias, Larisa Suarez-Ortega, Jesús González-Buitrago, Nancy Elizabeth Portillo-Najera, Isabel Llano-Rivas, María Martín-Frías, Joaquín Ramírez-Fernández, Jaime Sánchez Del Pozo, Lucía Garzón-Lorenzo, Gabriel A Martos-Moreno, Cristina Alfaro-Iznaola, Inés Mulero-Collantes, Pablo Ruiz-Ocaña, Paula Casano-Sancho, Ana Portela, Lorea Ruiz-Pérez, Angela Del Pozo, Elena Vallespín, Mario Solís, Antônio M Lerario, Isabel González-Casado, Purificación Ros-Pérez, Guiomar Pérez de Nanclares, Alexander A L Jorge, Karen E Heath,

CONTEXT:Heterozygous variants in the Indian hedgehog gene (IHH) have been reported to cause brachydactyly type A1 and mild hand and feet skeletal anomalies with short stature. Genetic screening in individuals with short stature and mild skeletal anomalies has been increasing over recent years, allowing us to broaden the clinical spectrum ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(8):]

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Emergence of a butterfly: the life experiences of type 1 diabetes Taiwanese patients during the 16-25 years old transition period.

Yueh-Tao Chiang, Hsing-Yi Yu, Fu-Sung Lo, Chi-Wen Chen, Tzu-Ting Huang, Chi-Wen Chang, Philip Moons,

Purpose: To explore the life experiences of patients with type 1 diabetes transition from adolescence into adulthood in Taiwan.Methods: Descriptive phenomenological design was used. Fourteen participants were individually interviewed using a semi-structured interview.Results: The life experiences of patients with type 1 diabetes transition from adolescence into adulthood experience a metamorphosis ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1748362]

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A medical student scholarly concentrations program: scholarly self-efficacy and impact on future research activities.

Rebecca M DiBiase, Mary Catherine Beach, Joseph A Carrese, Jennifer A Haythornthwaite, Sarah J Wheelan, Meredith A Atkinson, Gail Geller, Kelly A Gebo, Jeremy A Greene, Stephen M Sozio,

BACKGROUND:The Scholarly Concentrations program was established at Johns Hopkins University School of Medicine in 2009 with the aim of instilling passion for scholarship. OBJECTIVE:Our study aimed to determine whether the Scholarly Concentrations program achieves positive changes in medical student self-efficacy in conducting research and, if so, whether this results in ... Read more >>

Med Educ Online (Medical education online)
[2020, 25(1):1786210]

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Adding video-debriefing to Helping-Babies-Breathe training enhanced retention of neonatal resuscitation knowledge and skills among health workers in Uganda: a cluster randomized trial.

Beatrice Odongkara, Thorkild Tylleskär, Nicola Pejovic, Vincentina Achora, David Mukunya, Grace Ndeezi, James K Tumwine, Victoria Nankabirwa,

BACKGROUND:Skilled birth attendants must be competent to provide prompt resuscitation to save newborn lives at birth. Both knowledge and skills (competence) decline with time after training but the optimal duration for refresher training among frontline-skilled birth attendants in low-resource settings is unknown. OBJECTIVES:We assessed the effect of an innovative Helping-Babies-Breathe ... Read more >>

Glob Health Action (Global health action)
[2020, 13(1):1743496]

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Cytotoxin-producing Klebsiella oxytoca in the preterm gut and its association with necrotizing enterocolitis.

Sara Paveglio, Nagender Ledala, Karim Rezaul, Qingqi Lin, Yanjiao Zhou, Anthony A Provatas, Erin Bennett, Tristan Lindberg, Melissa Caimano, Adam P Matson,

Necrotizing enterocolitis (NEC) is a devastating intestinal inflammatory disease of premature infants associated with gut bacterial dysbiosis. Using 16S rRNA-based methods, our laboratory identified an unclassified Enterobacteriaceae sequence (NEC_unk_OTU) with high abundance in NEC fecal samples. We aimed to identify this bacterium and determine its potential role in the disease. ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):1321-1329]

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Patients' experiences and effects of non-pharmacological treatment for myalgic encephalomyelitis/chronic fatigue syndrome - a scoping mixed methods review.

Anne Marit Mengshoel, Ingrid Bergliot Helland, Mira Meeus, Jesus Castro-Marrero, Derek Pheby, Elin Bolle Strand,

PURPOSE:The EU COST Action 15111 collaboration on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) aims to assess current research and identify knowledge gaps in Europe. Presently, our purpose is to map the effects of non-pharmacological therapies (NPTs) for ME/CFS, and what patients find important in the treatment process. METHODS:A scoping mixed methods ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1764830]

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The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19.

Liang Su, Xiang Ma, Huafeng Yu, Zhaohua Zhang, Pengfei Bian, Yuling Han, Jing Sun, Yanqin Liu, Chun Yang, Jin Geng, Zhongfa Zhang, Zhongtao Gai,

This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after ... Read more >>

Emerg Microbes Infect (Emerging microbes & infections)
[2020, 9(1):707-713]

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Using the Attachment Relationship and Positive Parenting Principles to Build Childhood Resilience.

Sasha Svendsen, Jessica Griffin, Heather Forkey,

Adv Pediatr (Advances in pediatrics)
[2020, 67:15-28]

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[Cooperation of pediatrics and social pediatrics to create a biopsychosocial medicine for children with medical complexity].

Florian Heinen,

Pediatrics in Germany is going through a crisis in which healthcare, especially for children and adolescents with medical complexity, is seriously compromised.Specialized outpatient clinics are being closed and hospital beds for inpatient treatment - even where specially allocated - cannot be occupied due to shortcomings in care. A multitude of critical factors ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(7):806-812]

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Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages.

K McKernan, M Varghese, R Patel, K Singer,

In obesity, high levels of saturated fatty acids (SFAs) contribute to adipose tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itself may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, ... Read more >>

Adipocyte (Adipocyte)
[2020, 9(1):212-222]

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