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Pediatric Viral Myocarditis

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Immunosuppressive Treatment for Myocarditis in the Pediatric Population: A Meta-Analysis.

Bing He, Xiaoou Li, Dan Li,

The use of immunosuppressants in the treatment of myocarditis in children remains controversial. The aim of this meta-analysis is to summarize the current empirical evidence for immunosuppressive treatment for myocarditis in the pediatric population. We searched PubMed, MEDLINE, and Embase for articles to identify studies analyzing the efficiency of immunosuppressive ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:430]

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miR‑217 and miR‑543 downregulation mitigates inflammatory response and myocardial injury in children with viral myocarditis by regulating the SIRT1/AMPK/NF‑κB signaling pathway.

Kun Xia, Yong Zhang, Dongming Sun,

The aim of the present study was to investigate the expression levels and roles of microRNA (miR)‑217 and miR‑543 in viral myocarditis, and to examine their underlying mechanisms. Coxsackievirus B3 (CVB3) was used to establish in vivo and in vitro models of viral myocarditis. The levels of miR‑217 and miR‑543 were detected ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 45(2):634-646]

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Maternal Gut Virome in Pregestational Diabetes-Possible Cause of Congenital Heart Disease?

Horacio G Carvajal, Anoop K Brar, Pirooz Eghtesady,

Open Forum Infect Dis (Open forum infectious diseases)
[2020, 7(1):ofaa013]

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Myocarditis as the initial presentation of Epstein-Barr virus infection in a 17-year-old male patient.

Olga Ace, Sharon Domb,

Can Fam Physician (Canadian family physician Medecin de famille canadien)
[2019, 65(12):897-899]

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Pediatric-onset systemic lupus erythematosus with coronary artery dilation: A case report.

Hui Zhang, Lijuan Zhang, Nan Guo,

INTRODUCTION:Though pediatric-onset systemic lupus erythematosus (SLE) is at high risk of coronary artery involvement, coronary artery dilation appears to be a rare characteristic of pediatric-onset SLE. In this article, we described 1 pediatric-onset SLE patient with coronary artery dilation at the diagnosis of SLE, in order to better diagnose and ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(5):e18946]

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134. A Comparison of Lyme Carditis in Children and Adults, a Case Series.

Richard V Shen, Carol A McCarthy, Robert P Smith,

AbstractBackgroundLyme disease is a common entity in Maine, and Lyme carditis is an uncommon manifestation of this disease. This case series describes and compares the presentation, management, and outcomes of Lyme carditis in pediatric and adult populations.MethodsCharts of pediatric and adult patients with heart block and positive Lyme serologies hospitalized ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2019, 6(Suppl 2):S95-S95]

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Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020.

Licia Bordi, Emanuele Nicastri, Laura Scorzolini, Antonino Di Caro, Maria Rosaria Capobianchi, Concetta Castilletti, Eleonora Lalle, On Behalf Of Inmi Covid-Study Group And Collaborating Centers,

A novel coronavirus (SARS-CoV-2) has been identified as the causative pathogen of an ongoing outbreak of respiratory disease, now named COVID-19. Most cases and sustained transmission occurred in China, but travel-associated cases have been reported in other countries, including Europe and Italy. Since the symptoms are similar to other respiratory ... Read more >>

Euro Surveill. (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(8):]

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The diagnostic expertise acceleration module (DEAM): promoting the formation of organized knowledge.

Brian Rissmiller, Danny Castro, Charles G Minard, Moushumi Sur, Kevin Roy, Teri Turner, Satid Thammasitboon,

Background: Ensuring that learners acquire diagnostic competence in a timely fashion is critical to providing high quality and safe patient care. Resident trainees typically gain experience by undertaking repetitive clinical encounters and receiving feedback from supervising faculty. By critically engaging with the diagnostic process, learners encapsulate medical knowledge into discrete ... Read more >>

Med Educ Online (Medical education online)
[2019, 24(1):1679945]

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Corticosteroids and Intravenous Immunoglobulin in Pediatric Myocarditis: A Meta-Analysis.

Yining Li, Yuqing Yu, Selena Chen, Ying Liao, Junbao Du,

Background: The efficacy of corticosteroids and intravenous immunoglobulin (IVIG) in pediatric myocarditis remains controversial. Objectives: The authors performed a meta-analysis to assess the therapeutic efficacy of corticosteroids and IVIG in children with myocarditis. Methods: We retrieved the trials on corticosteroids and IVIG therapy, respectively, in pediatric myocarditis from nine databases ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:342]

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Complete Fetal Atrioventricular Block Associated with Maternal Autoinflammatory Diseases: Case Report and Literature Review.

Ali Ulas Tugcu, Deniz Anuk Ince, Sertac Esin, Ozden Turan, Ilkay Erdogan, Ayse Ecevit,

Acta Cardiol Sin (Acta Cardiologica Sinica)
[2020, 36(1):72-75]

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Corrigendum: Ivabradine Treatment Reduces Cardiomyocyte Apoptosis in a Murine Model of Chronic Viral Myocarditis.

Ge Li-Sha, Liu Li, Zhou De-Pu, Shi Zhe-Wei, Gu Xiaohong, Chen Guang-Yi, Li Jia, Lin Jia-Feng, Chu Maoping, Li Yue-Chun,

[This corrects the article DOI: 10.3389/fphar.2018.00182.]. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1126]

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Parvovirus B19 Myocarditis: Looking Beyond the Heart.

Jaume Izquierdo-Blasco, María Teresa Salcedo Allende, Maria Gemma Codina Grau, Ferran Gran, Elena Martínez Sáez, Joan Balcells,

Human parvovirus B19 represents the most common etiology of myocarditis in the pediatric population. Although it usually causes a benign exanthematic viral infection, parvovirus B19 may also present as disseminated disease with tropism for the myocardium, causing heart failure with high mortality. We present the case of a 2-year-old patient ... Read more >>

Pediatr. Dev. Pathol. (Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society)
[2020, 23(2):158-162]

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The efficacy observation of ulinastatin combined with creatine phosphate sodium in pediatric viral myocarditis.

C-L Li, L-B Jia, J Gao, Z-Z Wang, X-J An,

OBJECTIVE:This study aimed to compare the efficacy and safety of ulinastatin combined with creatine phosphate sodium and ribavirin combined with creatine phosphate sodium in the treatment of pediatric viral myocarditis. PATIENTS AND METHODS:155 children with viral myocarditis in the Xuzhou Children's Hospital, were retrospectively analyzed. 80 of them received ulinastatin ... Read more >>

Eur Rev Med Pharmacol Sci (European review for medical and pharmacological sciences)
[2019, 23(16):7144-7151]

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Enteroviral infection in neonates.

Yu-Yu Chuang, Yhu-Chering Huang,

Enteroviruses generally cause mild and self-limited diseases, but they have been found to affect neonates much differently, and often more severely than older children. Clinical manifestations are difficult to differentiate from those of bacterial sepsis, such as fever, poor feeding, lethargy, respiratory distress and cardiovascular collapse. Severe life threatening complications, ... Read more >>

J Microbiol Immunol Infect (Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi)
[2019, :]

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A Rare Presentation of Fulminant Viral Myocarditis Associated with H1N1: A Series of Four Cases.

Teju P Thomas, Sudhaya Kumar, Ashok Anand, Rajagopal Kiran, Vincy Sabu, Abdul Gaffoor,

The viral infection during influenza includes several complications like primary pneumonitis, ARDS, bacterial pneumonia, otitis media along with severe increase in the ongoing chronic conditions. Fulminant myocarditis as a primary manifestation of H1N1 is rare. We are reporting four cases that developed fulminant viral myocarditis caused by the H1N1 strain ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(11):538-541]

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Role of intravenous immunoglobulin therapy in the survival rate of pediatric patients with acute myocarditis: A systematic review and meta-analysis.

Chun-Yu Yen, Miao-Chiu Hung, Ying-Chi Wong, Chia-Yuan Chang, Chou-Cheng Lai, Keh-Gong Wu,

The treatment of pediatric myocarditis is controversial, and the benefits of intravenous immunoglobulin (IVIG) are inconclusive due to limited data. We searched studies from PubMed, MEDLINE, Embase, and Cochrane Library databases since establishment until October 1st, 2018. Thirteen studies met the inclusion criteria. We included a total of 812 patients ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):10459]

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The Clinical Features of Children With Acute Fulminant Myocarditis and the Diagnostic and Follow-Up Value of Cardiovascular Magnetic Resonance.

Jianli Lv, Bo Han, Cuiyan Wang, Jing Wang, Diandong Jiang, Lijian Zhao, Yingchun Yi, Jianjun Zhang,

Objective: To investigate the clinical features and the diagnostic and follow-up value of acute fulminant myocarditis (AFM) in children. Methods: A total of 20 children diagnosed with AFM admitted to our department were reviewed, and the clinical manifestations; pathogenic examination results; myocardial injury biomarkers; and electrocardiography, echocardiogram, and cardiovascular magnetic ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:388]

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Identification of Viral Signatures Using High-Throughput Sequencing on Blood of Patients With Kawasaki Disease.

Arnaud G L'Huillier, Francisco Brito, Noemie Wagner, Samuel Cordey, Evgeny Zdobnov, Klara M Posfay-Barbe, Laurent Kaiser,

Aims: Kawasaki disease is an acute pediatric vasculitis whose etiology remains unknown but epidemiology and clinical presentation suggest a viral etiology. We performed unbiased high-throughput-sequencing on blood of patients with Kawasaki Disease (KD). Materials and Methods: High-throughput-sequencing was performed directly on blood of children with typical KD. Sequences were aligned ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:524]

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Sudden unexpected death in asymptomatic infants due to PPA2 variants.

Colin K L Phoon, Matthew Halvorsen, David B Goldstein, Rachel Rabin, Frank Cecchin, Laura Crandall, Orrin Devinsky,

BACKGROUND:Sudden death in children is a tragic event that often remains unexplained after comprehensive investigation. We report two asymptomatic siblings who died unexpectedly at approximately 1 year of age found to have biallelic (compound heterozygous) variants in PPA2. METHODS:The index case, parents, and sister were enrolled in the Sudden Unexplained Death ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2020, 8(1):e1008]

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Influenza a H1N1 associated acute glomerulonephritis in an adolescent.

Garyfallia Syridou, Ioannis Drikos, Artemis Vintila, Antigoni Pegkou, Loukia Zografou, Panagiotis Roungas, Eleni Papa, Dimitris Kyriazopoulos, Olga Savelieva, Eleni Antonopoulou,

Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children. Acute glomerulonephritis as a complication of H1N1 influenza virus infection has been described only sporadically.Herein we present a case of acute glomerulonephritis in a previously healthy ... Read more >>

IDCases (IDCases)
[2020, 19:]

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Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection-Characteristics and Diagnostic Criteria of PANDAS Recognition.

Jacek Baj, Elżbieta Sitarz, Alicja Forma, Katarzyna Wróblewska, Hanna Karakuła-Juchnowicz,

The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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The assessment of treatment outcomes in patients with acute viral myocarditis by speckle tracking and tissue Doppler methods.

Hazım Alper Gursu, Ibrahim Ilker Cetin, Emine Azak, Ayse Esin Kibar, Murat Surucu, Ali Orgun, Utku Pamuk,

OBJECTIVES:The aim was to evaluate the role of tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE), to identify myocardial dysfunction, and to evaluate myocardial segmental deformation in acute viral myocarditis. METHODS:Twenty-one patients and twelve healthy children were studied prospectively. The TDI and STE were performed before and after treatment. ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2019, 36(9):1666-1674]

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IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis.

Gongliang Guo, Liqun Sun, Lili Yang, Haiming Xu,

Inflammation and myocardial weakness, two major hallmarks of chronic viral myocarditis (VMC), often lead to dilated cardiomyopathy or chronic heart failure. It has been reported that indoleamine 2,3-dioxygenase-1 (IDO1) may play a pathogenic role in the progression of inflammatory diseases. Hence, the study is set out to investigate the potential ... Read more >>

Cell Cycle (Cell cycle (Georgetown, Tex.))
[2019, 18(20):2598-2613]

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Fever-Associated Supraventricular Tachycardia after 4CMenB Vaccination in an Infant.

Erdem Gönüllü, Burcu Topçu, Naci Öner, Ahmet Soysal, Metin Karaböcüoğlu,

Meningococcal serogroup B vaccine 4CMenB (Bexsero) is a new four-component protein vaccine developed to prevent Neisseria meningitidis serogroup B infections. Case. We report a girl with fever and supraventricular tachycardia (SVT) 6-8 hours after the second dose of 4CMenB. SVT was unresponsive to the first dose of adenosine but terminated ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2019, 2019:4591964]

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Comparison of clinical outcomes of influenza A and B at the 2017–2018 influenza season: a cohort study.

T. Avni, T. Babich, A. Nir, D. Yahav, H. Shaked, N. Sorek, H. Ben Zvi, J. Bishara, A. Atamna,

Influenza has significant morbidity and mortality. Some experts consider infection with influenza B as milder than that with influenza A. The objective of this study is to evaluate the outcomes of hospitalized patients with laboratory-confirmed influenza A or B in 2017–2018 influenza season. All hospitalized patients between October 2017 and ... Read more >>

Eur. J. Clin. Microbiol. Infect. Dis. (European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology)
[0, :1-6]

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