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Pediatric Ventricular Tachycardia

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Novel variants in TECRL cause recessive inherited CPVT type 3 with severe and variable clinical symptoms.

Alexander Moscu-Gregor, Christoph Marschall, Carsten Müntjes, Anne Schönecker, Franziska Schuessler-Hahn, Felix Hohendanner, Abdul Shokor Parwani, Leif-Hendrik Boldt, Claus-Eric Ott, Anja Bennewiz, Thomas Paul, Ulrich Krause, Imma Rost,

INTRODUCTION:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by adrenergically stimulated ventricular tachycardia. The most common form of CPVT is due to autosomal dominant variants in the cardiac ryanodine-receptor gene (RYR2). However, trans-2,3-enoyl-CoA reductase-like (TECRL) was recently suggested to be a novel candidate gene for life-threatening inherited ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2020, :]

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Adverse event rate during inpatient sotalol initiation for the management of supraventricular and ventricular tachycardia in the pediatric and young adult population.

Stephanie F Chandler, Esther Chu, Robert D Whitehill, Laura M Bevilacqua, Vassilios J Bezzerides, Elizabeth S DeWitt, Mark E Alexander, Dominic J Abrams, John K Triedman, Edward P Walsh, Douglas Y Mah,

BACKGROUND:Sotalol is an important antiarrhythmic drug in the pediatric population. Given the risk of proarrhythmia, sotalol is initiated in inpatient settings, with adult studies as recent as 2015 supporting this practice. OBJECTIVE:The purpose of this study was to determine the frequency of adverse events (AEs) during sotalol initiation for the ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, :]

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Magnetic Resonance Imaging Risk Factors for Ventricular Arrhythmias in Tetralogy of Fallot.

Judy Rizk, Nerejda Shehu, Heiner Latus, Stefan Martinoff, Peter Ewert, Heiko Stern, Christian Meierhofer,

Sudden cardiac death (SCD) is the most common cause of late mortality in tetralogy of Fallot (TOF). Pulmonary regurgitation (PR) was previously found to be the most common hemodynamic abnormality associated with ventricular arrhythmias (VA), but cardiovascular magnetic resonance (CMR)-based studies did not show this association. The aim of this ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, :]

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Ventricular Tachycardia in an Infant Without Congenital Anomaly: A Case Report.

Nouhad El Joueid, Marianne Touma Boulos, Simon Abou Jaoude, Linda Daou,

Ventricular tachycardia (VT) is a serious form of arrhythmia that can be life-threatening; that's why diagnosis and treatment are very important in order to avoid serious complications. We are reporting this case of VT which is a rare entity, especially, in healthy infants. This infant, without cardiac pathology known from ... Read more >>

Cardiol Res (Cardiology research)
[2020, 11(1):61-65]

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Successful left coronary cusp cryoablation in an adolescent with premature ventrıcular extrasystoles-associated cardiomyopathy.

Yakup Ergül, Senem Özgür, Hasan Candaş Kafalı,

Ventricular arrhythmias arising from coronary cusps are not uncommon. However, the mapping and ablation of outflow tract ventricular arrhythmias originating from aortic cusps can be challenging. Radiofrequency ablation of this area can cause rare but serious complications. This was a report of a 17-year-old male patient with very frequent, nonsustained ... Read more >>

Turk Kardiyol Dern Ars (Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir)
[2020, 48(2):171-176]

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Initially unexplained cardiac arrest in children and adolescents: A national experience from the Canadian Pediatric Heart Rhythm Network.

Taylor Cunningham, Thomas M Roston, Sonia Franciosi, Michelle Chang Liu, Joseph Atallah, Carolina A Escudero, Sharmila Udupa, Jason D Roberts, Santokh Dhillon, Frédéric Dallaire, Anne Fournier, Meena Fatah, Robert Hamilton, Shubhayan Sanatani,

BACKGROUND:Unexplained cardiac arrest (UCA) is rare in children. Despite investigations, the etiology in up to one-half of patients remains unknown. OBJECTIVE:The purpose of this study was to assess the management and outcomes of pediatric UCA survivors through the Canadian Pediatric Heart Rhythm Network. METHODS:A retrospective case series of children (age ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, :]

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Implantable Cardioverter Defibrillator Use in Males with Duchenne Muscular Dystrophy and Severe Left Ventricular Dysfunction.

Michael A McCulloch, Ashwin K Lal, Kenneth Knecht, Ryan J Butts, Chet R Villa, Jonathan N Johnson, Jennifer Conway, Matthew J Bock, Kurt R Schumacher, Sabrina P Law, Joshua M Friedland-Little, Shriprasad R Deshpande, Shawn C West, Irene D Lytrivi, Katheryn E Gambetta, Carol A Wittlieb-Weber,

Duchenne muscular dystrophy (DMD) is characterized by myocardial fibrosis and left ventricular (LV) dysfunction. Implantable cardioverter defibrillator (ICD) use has not been characterized in this population but is considered for symptomatic patients with severe LV dysfunction (SLVD) receiving guideline-directed medical therapy (GDMT). We evaluated ICD utilization and efficacy in patients ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, :]

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Approach to induce infrequent premature ventricular complexes.

Fatme Charafeddine, Marwan M Refaat,

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, :]

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Lidocaine versus amiodarone for pediatric in-hospital cardiac arrest: An observational study.

Mathias J Holmberg, Catherine E Ross, Dianne L Atkins, Santiago O Valdes, Michael W Donnino, Lars W Andersen, ,

BACKGROUND:Lidocaine and amiodarone are both included in the pediatric cardiac arrest guidelines as treatments of shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, although there is limited evidence to support this recommendation. METHODS:In this cohort study from the Get With The Guidelines - Resuscitation registry, we included pediatric patients (≤18 years) ... Read more >>

Resuscitation (Resuscitation)
[2020, :]

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Non-invasive Risk Stratification in Pediatric Ventricular Pre-excitation.

Rana Khaznadar, Stephanie F Chandler, A Sami Chaouki, Sabrina Tsao, Gregory Webster,

Children with ventricular pre-excitation are at risk for sudden death. This retrospective pediatric study identified patients > 8 years of age who had undergone electrophysiology study (EPS). Our primary objective was to determine the performance characteristics of non-invasive risk stratification. Subjects were separated into two groups. Group 1 was asymptomatic or had non-specific ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, :]

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MALIGNANT HYPERTHERMIA IN A CHILD AFTER MAGNETIC RESONANCE IMAGING: A CASE REPORT.

Carlos Gustavo de Almeida, José Colleti Junior,

OBJECTIVE:To report on a case of malignant hyperthermia in a child after a magnetic resonance imaging of the skull was performed using sevoflurane anesthesia. CASE DESCRIPTION:A 3-year-old boy admitted to the pediatric intensive care unit after presenting clinical and laboratory findings consistent with unspecified viral meningoencephalitis. While the patient was ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018267]

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Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children.

Audrey Dionne, John N Kheir, Lynn A Sleeper, Jesse J Esch, Roger E Breitbart,

Background Troponin levels are frequently obtained in pediatric patients, but the benefit remains unclear. Methods and Results This retrospective study included 1993 patients aged 0 to 21 years without history of cardiac disease in whom troponin levels were obtained during clinical evaluation of cardiac and noncardiac presentations. Troponin was elevated (≥0.1 ng/mL) ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(4):e012897]

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Catheter ablation of ventricular tachycardia in the pediatric patients: A single-center experience.

Jinjin Wu, Yiwei Chen, Wei Ji, Beiyin Gu, Jie Shen, Lijun Fu, Fen Li,

BACKGROUND:Ventricular tachycardia (VT) with or without structural heart disease is uncommon but well-recognized clinically in children. With this retrospective study, we collected the data from the in-hospital pediatric patients of VT with catheter ablation therapy. The purpose of this study is to assess the acute results and the long-term outcome ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, 43(1):37-46]

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Accelerated idioventricular rhythm resulting in torsades de pointes and cardiac arrest in a child: successfully cryoablated in left'coronary cusp.

Yakup Ergul, Hasan C Kafali, Fahrettin Uysal,

Known as a benign arrhythmia and normally requiring no specific treatment, accelerated idioventricular rhythm can rarely degenerate to a life-threatening arrhythmia. Here, we present a child with left coronary cusp-originating accelerated idioventricular rhythm, degenerating into torsades de pointes and resulting in cardiac arrest, which was ablated with a cryocatheter. An ... Read more >>

Cardiol Young (Cardiology in the young)
[2020, 30(3):418-421]

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Risk factors for development of ventricular tachycardia in patients with ventricular premature contraction with a structurally normal heart.

Yuichi Nomura, Syunji Seki, Daisuke Hazeki, Kentaro Ueno, Yuji Tanaka, Kiminori Masuda, Makoto Nishibatake, Masao Yoshinaga,

Background:We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart. Methods:The subjects were 81 844 first graders and 88 244 seventh graders of Kagoshima City School-based cardiovascular screening (SCV-screening) between 2001 and 2015. We retrospectively reviewed the clinical data ... Read more >>

J Arrhythm (Journal of arrhythmia)
[2020, 36(1):127-133]

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Junctional Ectopic Tachycardia: Recognition and Modern Management Strategies.

Kirsti G Catton, Jennifer K Peterson,

Junctional ectopic tachycardia is a common dysrhythmia after congenital heart surgery that is associated with increased perioperative morbidity and mortality. Risk factors for development of junctional ectopic tachycardia include young age (neonatal and infant age groups); hypomagnesemia; higher-complexity surgical procedure, especially near the atrioventricular node or His bundle; and use ... Read more >>

Crit Care Nurse (Critical care nurse)
[2020, 40(1):46-55]

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Critical isthmus of ventricular tachycardia covered by transcatheter pulmonary valve in a patient with tetralogy of Fallot.

Nicolas Combes, Stefano Bartoletti, François Heitz, Victor Waldmann,

Eur. Heart J. (European heart journal)
[2020, 41(5):723]

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Pediatrics and GUCHs.

J Arrhythm (Journal of Arrhythmia)
[2019, 35(Suppl 1):693-711]

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A proposed approach to the asymptomatic pediatric patient with Wolff-Parkinson-White pattern.

Henry Chubb, Scott R Ceresnak,

HeartRhythm Case Rep (HeartRhythm case reports)
[2020, 6(1):2-7]

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Heart Rate Recovery After Exercise Is Associated With Arrhythmic Events in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia.

Krystien V V Lieve, Veronica Dusi, Christian van der Werf, J Martijn Bos, Conor M Lane, Mathis Korseberg Stokke, Thomas M Roston, Aurora Djupsjöbacka, Yuko Wada, Isabelle Denjoy, Henning Bundgaard, Ferran Roses I Noguer, Christopher Semsarian, Tomas Robyns, Nynke Hofman, Michael W Tanck, Maarten P van den Berg, Janneke A E Kammeraad, Andrew D Krahn, Sally-Ann B Clur, Frederic Sacher, Jan Till, Jonathan R Skinner, Jacob Tfelt-Hansen, Vincent Probst, Antoine Leenhardt, Minoru Horie, Heikki Swan, Jason D Roberts, Shubhayan Sanatani, Kristina H Haugaa, Peter J Schwartz, Michael J Ackerman, Arthur A M Wilde,

BACKGROUND:Risk stratification in catecholaminergic polymorphic ventricular tachycardia remains ill defined. Heart rate recovery (HRR) immediately after exercise is regulated by autonomic reflexes, particularly vagal tone, and may be associated with symptoms and ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. Our objective was to evaluate whether HRR after maximal ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2020, 13(3):e007471]

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Prediction of prognosis in patients with tetralogy of Fallot based on deep learning imaging analysis.

Gerhard Paul Diller, Stefan Orwat, Julius Vahle, Ulrike M M Bauer, Aleksandra Urban, Samir Sarikouch, Felix Berger, Philipp Beerbaum, Helmut Baumgartner, ,

OBJECTIVE:To assess the utility of machine learning algorithms for automatically estimating prognosis in patients with repaired tetralogy of Fallot (ToF) using cardiac magnetic resonance (CMR). METHODS:We included 372 patients with ToF who had undergone CMR imaging as part of a nationwide prospective study. Cine loops were retrieved and subjected to ... Read more >>

Heart (Heart (British Cardiac Society))
[2020, :]

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Effects of humeral intraosseous epinephrine in a pediatric hypovolemic cardiac arrest porcine model.

Michael James Neill, James M Burgert, Dawn Blouin, Benjamin Tigges, Kari Rodden, Rachel Roberts, Phillip Anderson, Travis Hallquist, John Navarro, Joseph O'Sullivan, Don Johnson,

Background:Aims of the study were to determine the effects of humerus intraosseous (HIO) versus intravenous (IV) administration of epinephrine in a hypovolemic, pediatric pig model. We compared concentration maximum (Cmax), time to maximum concentration (Tmax), mean concentration (MC) over time and return of spontaneous circulation (ROSC). Methods:Pediatric pig were randomly ... Read more >>

Trauma Surg Acute Care Open (Trauma surgery & acute care open)
[2020, 5(1):e000372]

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Anesthetic management of a child with catecholaminergic polymorphic ventricular tachycardia undergoing insertion of implantable cardioverter defibrillator : a case report.

Keisuke Omiya, Kazuha Mitsui, Takashi Matsukawa,

BACKGROUND:Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a fatal cardiac ion channelopathy that causes sudden unexpected death in the young. CASE PRESENTATION:The patient was a 3-year-old girl with CPVT. Insertion of an implantable cardioverter defibrillator (ICD) using epicardial pacing was scheduled. After premedication of rectal midazolam was given, general anesthesia was ... Read more >>

JA Clin Rep (JA clinical reports)
[2020, 6(1):16]

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Rare accessory pathway between a giant left atrial appendage and the left ventricle.

Misugi Emi, Hisaaki Aoki, Yoshihide Nakamura, Yasuhiro Hirano, Kunihiko Takahashi, Futoshi Kayatani,

HeartRhythm Case Rep (HeartRhythm case reports)
[2020, 6(3):131-134]

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Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosis.

Min-Hua Tseng, Jing-Long Huang, Shih-Ming Huang, Jeng-Daw Tsai, Tai-Wei Wu, Wen-Lang Fan, Jhao-Jhuang Ding, Shih-Hua Lin,

BACKGROUND:Type IV renal tubular acidosis (RTA) is a severe complication of urinary tract infection (UTI) in infants. A detailed clinical and molecular analysis is still lacking. METHODS:Infants with UTI who exhibited features of type IV RTA were prospectively enrolled. Clinical, laboratory, and image characteristics and sequencing of genes responsible for ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, :]

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