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Pediatric Theophylline Toxicity

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Effect of theobromine in antimicrobial activity: An in vitro study.

Arthi Lakshmi, C Vishnurekha, Parisa Norouzi Baghkomeh,

Background:This study aims to compare the antimicrobial activity of theobromine and two commercially available kid's fluoride toothpastes. Materials and Methods:In this in vitro study a chocolate-based nonfluoride toothpaste, Theobromine (Group A) and two commercially available kid's fluoride toothpaste, Kidodent (Group B), Colgate kids toothpaste (Group C) were used in this ... Read more >>

Dent Res J (Isfahan) (Dental research journal)
[2019, 16(2):76-80]

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Effects of Drugs and Excipients on Hydration Status.

Ana M Puga, Sara Lopez-Oliva, Carmen Trives, Teresa Partearroyo, Gregorio Varela-Moreiras,

Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or ... Read more >>

Nutrients (Nutrients)
[2019, 11(3):]

Cited: 1 time

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Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study.

Mohammad Ismail, Sidra Noor, Umme Harram, Inamul Haq, Iqbal Haider, Faiza Khadim, Qasim Khan, Zahid Ali, Tahir Muhammad, Muhammad Asif,

BACKGROUND:Potential drug-drug interactions (pDDIs) are one of the preventable drug related problems having the risk of serious adverse events or therapeutic failure. In developing countries like Pakistan, this issue remains poorly addressed. The objective of this study was to explore prevalence of pDDIs in the Outpatient Department (OPD) of a ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):762]

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Gastroesophageal reflux in children: an updated review.

Alexander Kc Leung, Kam Lun Hon,

Background:Gastroesophageal reflux is a common disorder in pediatrics. Clinicians should be familiar with the proper evaluation and management of this condition. Objective:To provide an update on the current understanding, evaluation, and management of gastroesophageal reflux in children. Methods:A PubMed search was performed with Clinical Queries using the key term 'gastroesophageal ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212591]

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Interventions for bacterial folliculitis and boils (furuncles and carbuncles).

Huang‐Shen Lin, Pei‐Tzu Lin, Yu‐Shiun Tsai, Shu‐Hui Wang, Ching‐Chi Chi,

AbstractThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of interventions (such as topical antibiotics, topical antiseptic agents, systemic antibiotics, phototherapy, and incision and drainage) for people with bacterial folliculitis and boils. ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 2018(8):]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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Prevention, Treatment, and Monitoring of Seizures in the Intensive Care Unit.

Micheal Strein, John P Holton-Burke, LaTangela R Smith, Gretchen M Brophy,

The diagnosis and management of seizures in the critically ill patient can sometimes present a unique challenge for practitioners due to lack of exposure and complex patient comorbidities. The reported incidence varies between 8% and 34% of critically ill patients, with many patients often showing no overt clinical signs of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

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Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Genny Raffaeli, Pavla Pokorna, Karel Allegaert, Fabio Mosca, Giacomo Cavallaro, Enno D Wildschut, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. As the survival and the overall outcome of patients rely on the treatment and reversal of the underlying disease, effective and preferentially evidence-based pharmacotherapy is crucial to target recovery. Currently limited data exist ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:360]

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Using Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation.

Andrea N Edginton,

Clin Transl Sci (Clinical and translational science)
[2018, 11(2):109-111]

Cited: 2 times

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Validating the Chinese geriatric trigger tool and analyzing adverse drug event associated risk factors in elderly Chinese patients: A retrospective review.

Qiaozhi Hu, Zhou Qin, Mei Zhan, Zhaoyan Chen, Bin Wu, Ting Xu,

OBJECTIVE:The aim was to evaluate the performance of the initial Chinese geriatric trigger tool to detect adverse drug events (ADEs) in Chinese older patients, to attempt to shorten this list for improving the efficiency of the trigger tool, and to study the incidence and characteristics of ADEs in this population. ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0232095]

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Diagnosis of Systemic Capillary Leak Syndrome in a Young Child Treated with Intravenous Immunoglobulin in the Acute Phase.

Anna Sofi E Asmundsson, Ashley R Bjorklund, Gwenyth A Fisher,

Systemic capillary leak syndrome (SCLS) is a potentially life-threatening disorder characterized by distributive shock, hypoalbuminemia, and hemoconcentration. It is exceedingly rare in children with less than 20 cases reported to date. The underlying cause for this syndrome remains largely unknown and acute treatment has remained mainly supportive. Prophylaxis with intravenous ... Read more >>

J Pediatr Intensive Care (Journal of pediatric intensive care)
[2018, 7(2):94-96]

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Emerging therapeutic potential of anti-psychotic drugs in the management of human glioma: A comprehensive review.

Muhamad N A Kamarudin, Ishwar Parhar,

Despite numerous advancements in the last decade, human gliomas such as astrocytoma and glioblastoma multiforme have the worst prognoses among all cancers. Anti-psychotic drugs are commonly prescribed to treat mental disorders among cancer patients, and growing empirical evidence has revealed their antitumor, anti-metastatic, anti-angiogenic, anti-proliferative, chemo-preventive, and neo-adjuvant efficacies in ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(39):3952-3977]

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Tuberculosis and HIV-An Update on the "Cursed Duet" in Children.

Samantha H-L Fry, Shaun L Barnabas, Mark F Cotton,

HIV and tuberculosis (TB) often occur together with each exacerbating the other. Improvements in vertical transmission prevention has reduced the number of HIV-infected children being born and early antiretroviral therapy (ART) protects against tuberculosis. However, with delayed HIV diagnosis, HIV-infected infants often present with tuberculosis co-infection. The number of HIV ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:159]

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Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study.

Ferit Kuscu, Aslihan Ulu, Ayse S Inal, Bedia M Suntur, Hande Aydemir, Serdar Gul, Kenan Ecemis, Suheyla Komur, Behice Kurtaran, Ozlem Ozkan Kuscu, Yesim Tasova,

BACKGROUND Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. MATERIAL AND METHODS This study was conducted on the same day in 5 different hospitals in Turkey. ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2018, 24:4240-4247]

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Two Sides of the Same Coin?-Treatment of Chronic Asthma in Children and Adults.

Li Ping Chung, James Y Paton,

Globally, asthma is one of the most common chronic conditions that affect individuals of all ages. When poorly controlled, it negatively impacts patient's ability to enjoy life and work. At the population level, effective use of recommended strategies in children and adults can reduce symptom burden, improve quality of life ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:62]

Cited: 1 time

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Adverse drug events in Chinese pediatric inpatients and associated risk factors: a retrospective review using the Global Trigger Tool.

Huan-Huan Ji, Lin Song, Jian-Wen Xiao, Yu-Xia Guo, Ping Wei, Ting-Ting Tang, Xiao-Jiang Tian, Xue-Wen Tang, Yun-Tao Jia,

Understanding the epidemiology and risk factors of adverse drug events (ADEs) in pediatric inpatient is essential if we are to prevent, reduce or ameliorate the harm experienced. The Global Trigger Tool (GTT) is a method of retrospective medical record review that measures harm in hospitalized children. We employed a three-stage ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):2573]

Cited: 2 times

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Fluid Overload in Critically Ill Children.

Rupesh Raina, Sidharth Kumar Sethi, Nikita Wadhwani, Meghana Vemuganti, Vinod Krishnappa, Shyam B Bansal,

Background: A common practice in the management of critically ill patients is fluid resuscitation. An excessive administration of fluids can lead to an imbalance in fluid homeostasis and cause fluid overload (FO). In pediatric critical care patients, FO can lead to a multitude of adverse effects and increased risk of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2018, 6:306]

Cited: 1 time

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Serious adverse drug reactions at two children's hospitals in South Africa.

Johannes P Mouton, Melony C Fortuin-de Smidt, Nicole Jobanputra, Ushma Mehta, Annemie Stewart, Reneé de Waal, Karl-Günter Technau, Andrew Argent, Max Kroon, Christiaan Scott, Karen Cohen,

BACKGROUND:The high HIV prevalence in South Africa may potentially be shaping the local adverse drug reaction (ADR) burden. We aimed to describe the prevalence and characteristics of serious ADRs at admission, and during admission, to two South African children's hospitals. METHODS:We reviewed the folders of children admitted over sequential 30-day ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):3]

Cited: 0 times

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A Viral Polymyositis Masquerade: Life-Threatening Case of Juvenile Dermatomyositis Complicated by Systemic Capillary Leak Syndrome.

Bhaskara P Shelley, Shrijeet Chakraborti,

This is a case report of an 8-year-old boy who developed an atypical, rare subphenotype of autoimmune inflammatory acute juvenile dermatomyositis (JDM), initially masquerading as viral polymyositis (PM)-like presentation, that was complicated by a hitherto unreported fulminant, life-threatening pediatric systemic capillary leak syndrome (SCLS). We highlight the close differential between ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2018, 21(1):70-74]

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Transient endocrinologic problems in the newborn period.

Selim Kurtoğlu, Gül Direk, Zeynep Uzan Tatlı, Nihal Hatipoğlu,

Many transient endocrinologic disorders are frequently seen in newborn period. Early diagnosis and treatment is important for babies. In this article, transient endocrinopathy of newborn and relevant literature were reviewed. Blood sugar problems, especially adrenal insufficiency due to adrenal problems, thyroid problems such as transient hypotirotropinemia, are frequently encountered by ... Read more >>

Turk Pediatri Ars (Turk pediatri arsivi)
[2019, 54(1):3-12]

Cited: 0 times

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Optimal infusion rate in antimicrobial therapy explosion of evidence in the last five years.

Ling-Ling Zhu, Quan Zhou,

Sporadic studies in antimicrobial therapy have evaluated the effects of infusion rates on therapeutic and economic outcomes, and new findings may challenge the regular infusion regimen.Focusing on studies comparing the outcomes of different infusion regimens, the relevant literature was identified by searching PubMed, Web of Science, and Scopus from January ... Read more >>

Infect Drug Resist (Infection and drug resistance)
[2018, 11:1105-1117]

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A case of life-threatening supraventricular tachycardia storm associated with theophylline toxicity.

Keishi Ichikawa, Tadashi Wada, Takahiro Nishihara, Masahiro Tsuji, Atsushi Mori, Fumi Yokohama, Daiji Hasegawa, Kenji Kawamoto, Machiko Tanakaya, Yusuke Katyama, Satoru Sakuragi, Hiroshi Ito,

A 76-year-old man taking theophylline was admitted to our hospital with congestive heart failure and supraventricular tachycardia (SVT). After admission, he developed cardiogenic shock as a result of SVT storm, which was refractory to medical treatment including adenosine and electrical cardioversion. The serum theophylline concentration at admission was identified as ... Read more >>

J Cardiol Cases (Journal of cardiology cases)
[2017, 15(4):125-128]

Cited: 1 time

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Assessment of Regional Perfusion and Organ Function: Less and Non-invasive Techniques.

Wolfgang Huber, Robert Zanner, Gerhard Schneider, Roland Schmid, Tobias Lahmer,

Sufficient organ perfusion essentially depends on preserved macro- and micro-circulation. The last two decades brought substantial progress in the development of less and non-invasive monitoring of macro-hemodynamics. However, several recent studies suggest a frequent incoherence of macro- and micro-circulation. Therefore, this review reports on interactions of macro- and micro-circulation as ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2019, 6:50]

Cited: 1 time

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Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants.

Pierre Gaudriault, Séverine Mazaud-Guittot, Vincent Lavoué, Isabelle Coiffec, Laurianne Lesné, Nathalie Dejucq-Rainsford, Martin Scholze, Andreas Kortenkamp, Bernard Jégou,

Numerous chemicals are capable of disrupting androgen production, but the possibility that they might act together to produce effects greater than those of the most effective component in the mixture has not been studied directly in human tissues. Suppression of androgen synthesis in fetal life has been associated with testis ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2017, 125(8):087004]

Cited: 4 times

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