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Pediatric Theophylline Toxicity

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Therapeutic Drug Monitoring Characteristics in a Tertiary University Hospital in 2019.

Zeynep Günes Ozunal, Belkiz Ongen İpek,

Introduction Therapeutic drug monitoring (TDM) is defined as measuring drug concentration in a biological sample to optimize pharmacotherapy. This study aims to evaluate TDM requests in a tertiary university hospital retrospectively. Materials and methods TDM requests were evaluated retrospectively for lithium, valproic acid, carbamazepine, and digoxin in 2019. The age ... Read more >>

Cureus (Cureus)
[2020, 12(4):e7612]

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Characteristics of pediatric adverse drug reaction reports in the Japanese Adverse Drug Event Report Database.

Aoi Noda, Takamasa Sakai, Taku Obara, Makoto Miyazaki, Masami Tsuchiya, Gen Oyanagi, Yuriko Murai, Nariyasu Mano,

BACKGROUND:There are no reports on investigations of the characteristics of adverse drug reaction (ADR) reports for pediatric patients in the Japanese Adverse Drug Event Report database (JADER) and the utility of database for drug safety surveillance in these patients. METHOD:We aimed to evaluate ADR reports for pediatric patients in the ... Read more >>

BMC Pharmacol Toxicol (BMC pharmacology & toxicology)
[2020, 21(1):36]

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Management of Fluid Overload in the Pediatric ICU.

Grace L. Ker, Sandeep Gangadharan,

The implications and management of fluid overload in pediatric critical care remain areas of ongoing controversy. Consensus definitions and methods of quantitating fluid overload continue to evolve, paralleling our growing understanding of fluid dynamics in critically ill patients. Fluid overload has been associated with adverse outcomes in some patient populations; ... Read more >>

(Pediatric Critical Care)
[0, :193-209]

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Medication-induced hyperglycemia: pediatric perspective.

Mustafa Tosur, Johanna Viau-Colindres, Marcela Astudillo, Maria Jose Redondo, Sarah K Lyons,

Medication-induced hyperglycemia is a frequently encountered clinical problem in children. The intent of this review of medications that cause hyperglycemia and their mechanisms of action is to help guide clinicians in prevention, screening and management of pediatric drug-induced hyperglycemia. We conducted a thorough literature review in PubMed and Cochrane libraries ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Modulation of CYP2E1 metabolic activity in a cohort of confirmed caffeine ingesting pregnant women with preterm offspring.

M R Alcorta-García, C N López-Villaseñor, G Sánchez-Ferrer, H Flores-Mendoza, F Castorena-Torres, M A Aguilar-Torres, C M Sepúlveda-Treviño, J A Hernández-Hernández, R C López-Sánchez, V J Lara-Díaz,

BACKGROUND:To ascertain interactions of caffeine ingestion, food, medications, and environmental exposures during preterm human gestation, under informed consent, we studied a cohort of Mexican women with further preterm offspring born at ≤ 34 completed weeks. At birth, blood samples were taken from mothers and umbilical cords to determine caffeine and ... Read more >>

Mol Cell Pediatr (Molecular and cellular pediatrics)
[2020, 7(1):4]

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Prediction of Clearance in Children from Adults Following Drug-Drug Interaction Studies: Application of Age-Dependent Exponent Model.

Iftekhar Mahmood,

BACKGROUND AND OBJECTIVE:Pharmacokinetic drug-drug interaction (DDI) studies are conducted in adult subjects during drug development but there are limited studies that have characterized pharmacokinetic DDI studies in children. The objective of this study was to evaluate if the DDI clearance values from adults can be allometrically extrapolated from adults to ... Read more >>

Drugs R D (Drugs in R&D)
[2020, 20(1):47-54]

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Escalation in Therapy Based on Intravenous Magnesium Sulfate Dosing in Pediatric Patients With Asthma Exacerbations.

Christine A Kapuscinski, Sierra D Stauber, David J Hutchinson,

OBJECTIVE:Our objective was to compare doses of intravenous magnesium sulfate and their association with escalations in therapy in children and adolescents presenting to the emergency department with an asthma exacerbation. METHODS:This was a retrospective cohort study among children who received both magnesium sulfate and standard of care therapy for asthma ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(4):314-319]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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2018 Annual Report of the University of Kansas Health System Poison Control Center.

Elizabeth Silver, Lisa K Oller, Doyle M Coons, Stephen L Thornton,

Introduction:This is the 2018 Annual Report of the Kansas Poison Control Center at The University of Kansas Health System (KSPCC). The KSPCC serves the state of Kansas 24-hours per day, 365 days a year with certified specialists in poison information and clinical and medical toxicologists. Methods:All encounters reported to the ... Read more >>

Kans J Med (Kansas journal of medicine)
[2020, 13:90-100]

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Drug Therapy Problems and the Role of Clinical Pharmacist in Surgery Ward: Prospective Observational and Interventional Study.

Gosaye Mekonen Tefera, Ameha Zewudie Zeleke, Yitagesu Mamo Jima, Tsegaye Melaku Kebede,

Background:Drug therapy problems (DTPs) are of major concern in health care because of the associated increased cost of treatment, morbidity, and mortality. Thus, clinical practice should constitute the mainstream practice of clinical pharmacy in every ward. However, nothing is known about DTPs and the role of clinical pharmacist in the ... Read more >>

Drug Healthc Patient Saf (Drug, healthcare and patient safety)
[2020, 12:71-83]

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A Young Woman with Someone Else's Heart.

George Waits, Ju Kim,

Methodist Debakey Cardiovasc J (Methodist DeBakey cardiovascular journal)
[2020, 16(1):e8]

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Neonatal pharmacology and clinical implications.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Pietro Ferrara, Giorgio Attinà,

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212608]

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A Loading Dose of IV Salbutamol in an Adolescent with Severe Acute Asthma and Cardiac Arrest.

Shelley A Boeschoten, Ruben S van der Crabben, Annemie L M Boehmer, Matthijs de Hoog, Corinne M P Buysse,

Severe acute asthma (SAA) can lead to respiratory failure and can be fatal. For rational use of intravenous (IV) bronchodilators, evidence regarding the pharmacokinetics and pharmacodynamics is lacking in children. The use of a loading dose IV salbutamol is not mentioned in any international guideline, and its use varies greatly ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2019, 2019:5057390]

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Neonatal Hyperglycemia, which threshold value, diagnostic approach and treatment?: Turkish Neonatal and Pediatric Endocrinology and Diabetes Societies consensus report.

Damla Gökşen Şimşek, Ayşe Ecevit, Nihal Hatipoğlu, Asuman Çoban, Ayşe Engin Arısoy, Firdevs Baş, Gül Yeşiltepe Mutlu, Aysun Bideci, Eren Özek,

Hyperglycemia has become an important risk factor for mortality and morbidity in the neonatal period, especially with increased survival rates of very low birth weight neonates. Hyperglycemia in the neonatal period develops as a result of various mechanisms including iatrogenic causes, inability to supress hepatic glucose production, insulin resistance or ... Read more >>

Turk Pediatri Ars (Turk pediatri arsivi)
[2018, 53(Suppl 1):S234-S238]

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A Retrospective Evaluation of Allometry, Population Pharmacokinetics, and Physiologically-Based Pharmacokinetics for Pediatric Dosing Using Clearance as a Surrogate.

Qier Wu, Sheila Annie Peters,

Physiologically-based pharmacokinetic models are increasingly applied for pediatric dose selection along with traditional methods such as allometry and population pharmacokinetic models. We report a retrospective evaluation of the three methods. Pediatric population pharmacokinetic models sourced from literature for a subset of eight compounds were used to predict clearances for children ... Read more >>

CPT Pharmacometrics Syst Pharmacol (CPT: pharmacometrics & systems pharmacology)
[2019, 8(4):220-229]

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No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.

Katie Park, Lindsay C Trout, Cong Xu, Ming Wang, Robert F Tamburro, E Scott Halstead,

OBJECTIVES:To determine the relationship between theophylline trough levels and urine output in critically ill children administered aminophylline as adjunctive diuretic therapy. DESIGN:Retrospective cohort study. SETTING:The PICU of a tertiary care children's hospital. PATIENTS:A mixed population of medical/surgical including postoperative cardiothoracic surgery patients less than 18 years old. INTERVENTIONS:Electronic medical records ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):e425-e432]

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COVID-19 pandemic: A review based on current evidence.

Vidya M Mahalmani, Dhruv Mahendru, Ankita Semwal, Sukhmeet Kaur, Harpinder Kaur, Phulen Sarma, Ajay Prakash, Bikash Medhi,

In December 2019, severe acute respiratory syndrome-coronavirus-2, a novel coronavirus, initiated an outbreak of pneumonia from Wuhan in China, which rapidly spread worldwide. The clinical characteristics of the disease range from asymptomatic cases or mild symptoms, which include nonspecific symptoms such as fever, cough, sore throat, headache, and nasal congestion ... Read more >>

Indian J Pharmacol (Indian journal of pharmacology)
[2020, 52(2):117-129]

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The Challenges of Pediatric Drug Development.

Klaus Rose,

Introduction and Background:"Pediatric Drug Development" is being used to describe not the development of drugs for children, but rather the planning & conducting separate efficacy and safety (E&S) studies requested/demanded by regulatory authorities designed to produce pediatric labels. Pediatric studies required for drug approval enroll "children"; defined as <17 years ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:128-134]

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Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

Gemma L Saint, Malcolm G Semple, Ian Sinha, Daniel B Hawcutt,

Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a target therapeutic range between 10 ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(3):209-214]

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Caffeine and Clinical Outcomes in Premature Neonates.

Vasantha H S Kumar, Steven E Lipshultz,

Caffeine is the most widely used drug by both adults and children worldwide due to its ability to promote alertness and elevate moods. It is effective in the management of apnea of prematurity in premature infants. Caffeine for apnea of prematurity reduces the incidence of bronchopulmonary dysplasia in very-low-birth-weight infants ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(11):]

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A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.

Katarzyna Wójcik-Pszczoła, Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Paweł E Ferdek, Agnieszka A Kusiak, Artur Świerczek, Krzysztof Pociecha, Paulina Koczurkiewicz-Adamczyk, Elżbieta Wyska, Elżbieta Pękala, Reinoud Gosens,

Phosphodiesterase (PDE) inhibitors are currently a widespread and extensively studied group of anti-inflammatory and anti-fibrotic compounds which may find use in the treatment of numerous lung diseases, including asthma and chronic obstructive pulmonary disease. Several PDE inhibitors are currently in clinical development, and some of them, e.g., roflumilast, are already ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(11):]

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Theophylline toxicity: An old poisoning for a new generation of physicians.

Spencer Corey Greene, Thiago Halmer, John Morgan Carey, Brian John Rissmiller, Matthew Allen Musick,

A healthy 4-year-old female presented to the emergency department for vomiting and diarrhea. She was diagnosed with a urinary tract infection, treated with antibiotics and anti-emetics and discharged. Within four hours, her symptoms recurred, followed by decreasing responsiveness and seizures. She had significant hypokalemia, hyperglycemia, and a combined respiratory and ... Read more >>

Turk J Emerg Med (Turkish journal of emergency medicine)
[2018, 18(1):37-39]

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Abstracts of the 28th Annual Meeting of the Pediatric Pharmacy Advocacy Group on Ambulatory Care and Pediatric Intensive Care.

(The Journal of Pediatric Pharmacology and Therapeutics : JPPT)
[2019, 24(4):330-372]

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Effect of theobromine in antimicrobial activity: An in vitro study.

Arthi Lakshmi, C Vishnurekha, Parisa Norouzi Baghkomeh,

Background:This study aims to compare the antimicrobial activity of theobromine and two commercially available kid's fluoride toothpastes. Materials and Methods:In this in vitro study a chocolate-based nonfluoride toothpaste, Theobromine (Group A) and two commercially available kid's fluoride toothpaste, Kidodent (Group B), Colgate kids toothpaste (Group C) were used in this ... Read more >>

Dent Res J (Isfahan) (Dental research journal)
[2019, 16(2):76-80]

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Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review.

Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet,

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(11):]

Cited: 1 time

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