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Pediatric Theophylline Toxicity

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Medication-induced hyperglycemia: pediatric perspective.

Mustafa Tosur, Johanna Viau-Colindres, Marcela Astudillo, Maria Jose Redondo, Sarah K Lyons,

Medication-induced hyperglycemia is a frequently encountered clinical problem in children. The intent of this review of medications that cause hyperglycemia and their mechanisms of action is to help guide clinicians in prevention, screening and management of pediatric drug-induced hyperglycemia. We conducted a thorough literature review in PubMed and Cochrane libraries ... Read more >>

BMJ Open Diabetes Res Care (BMJ open diabetes research & care)
[2020, 8(1):]

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Prediction of Clearance in Children from Adults Following Drug-Drug Interaction Studies: Application of Age-Dependent Exponent Model.

Iftekhar Mahmood,

BACKGROUND AND OBJECTIVE:Pharmacokinetic drug-drug interaction (DDI) studies are conducted in adult subjects during drug development but there are limited studies that have characterized pharmacokinetic DDI studies in children. The objective of this study was to evaluate if the DDI clearance values from adults can be allometrically extrapolated from adults to ... Read more >>

Drugs R D (Drugs in R&D)
[2020, 20(1):47-54]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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Neonatal pharmacology and clinical implications.

Antonio Ruggiero, Anna Ariano, Silvia Triarico, Michele Antonio Capozza, Pietro Ferrara, Giorgio Attinà,

During the neonatal period, there is physiological immaturity of organs, systems and metabolic pathways that influences the pharmacokinetics and pharmacodynamics of administered drugs, the dosage of which should be constantly amended, considering the progressive increase in weight and the maturation of the elimination pathways. In this article, we analyse the ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212608]

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A Loading Dose of IV Salbutamol in an Adolescent with Severe Acute Asthma and Cardiac Arrest.

Shelley A Boeschoten, Ruben S van der Crabben, Annemie L M Boehmer, Matthijs de Hoog, Corinne M P Buysse,

Severe acute asthma (SAA) can lead to respiratory failure and can be fatal. For rational use of intravenous (IV) bronchodilators, evidence regarding the pharmacokinetics and pharmacodynamics is lacking in children. The use of a loading dose IV salbutamol is not mentioned in any international guideline, and its use varies greatly ... Read more >>

Case Rep Pediatr (Case reports in pediatrics)
[2019, 2019:5057390]

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Neonatal Hyperglycemia, which threshold value, diagnostic approach and treatment?: Turkish Neonatal and Pediatric Endocrinology and Diabetes Societies consensus report.

Damla Gökşen Şimşek, Ayşe Ecevit, Nihal Hatipoğlu, Asuman Çoban, Ayşe Engin Arısoy, Firdevs Baş, Gül Yeşiltepe Mutlu, Aysun Bideci, Eren Özek,

Hyperglycemia has become an important risk factor for mortality and morbidity in the neonatal period, especially with increased survival rates of very low birth weight neonates. Hyperglycemia in the neonatal period develops as a result of various mechanisms including iatrogenic causes, inability to supress hepatic glucose production, insulin resistance or ... Read more >>

Turk Pediatri Ars (Turk pediatri arsivi)
[2018, 53(Suppl 1):S234-S238]

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A Retrospective Evaluation of Allometry, Population Pharmacokinetics, and Physiologically-Based Pharmacokinetics for Pediatric Dosing Using Clearance as a Surrogate.

Qier Wu, Sheila Annie Peters,

Physiologically-based pharmacokinetic models are increasingly applied for pediatric dose selection along with traditional methods such as allometry and population pharmacokinetic models. We report a retrospective evaluation of the three methods. Pediatric population pharmacokinetic models sourced from literature for a subset of eight compounds were used to predict clearances for children ... Read more >>

CPT Pharmacometrics Syst Pharmacol (CPT: pharmacometrics & systems pharmacology)
[2019, 8(4):220-229]

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No Requirement for Targeted Theophylline Levels for Diuretic Effect of Aminophylline in Critically Ill Children.

Katie Park, Lindsay C Trout, Cong Xu, Ming Wang, Robert F Tamburro, E Scott Halstead,

OBJECTIVES:To determine the relationship between theophylline trough levels and urine output in critically ill children administered aminophylline as adjunctive diuretic therapy. DESIGN:Retrospective cohort study. SETTING:The PICU of a tertiary care children's hospital. PATIENTS:A mixed population of medical/surgical including postoperative cardiothoracic surgery patients less than 18 years old. INTERVENTIONS:Electronic medical records ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2018, 19(8):e425-e432]

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The Challenges of Pediatric Drug Development.

Klaus Rose,

Introduction and Background:"Pediatric Drug Development" is being used to describe not the development of drugs for children, but rather the planning & conducting separate efficacy and safety (E&S) studies requested/demanded by regulatory authorities designed to produce pediatric labels. Pediatric studies required for drug approval enroll "children"; defined as <17 years ... Read more >>

Curr Ther Res Clin Exp (Current therapeutic research, clinical and experimental)
[2019, 90:128-134]

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Caffeine and Clinical Outcomes in Premature Neonates.

Vasantha H S Kumar, Steven E Lipshultz,

Caffeine is the most widely used drug by both adults and children worldwide due to its ability to promote alertness and elevate moods. It is effective in the management of apnea of prematurity in premature infants. Caffeine for apnea of prematurity reduces the incidence of bronchopulmonary dysplasia in very-low-birth-weight infants ... Read more >>

Children (Basel) (Children)
[2019, 6(11):]

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Optimizing the Dosing of Intravenous Theophylline in Acute Severe Asthma in Children.

Gemma L Saint, Malcolm G Semple, Ian Sinha, Daniel B Hawcutt,

Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a target therapeutic range between 10 ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2018, 20(3):209-214]

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Abstracts of the 28th Annual Meeting of the Pediatric Pharmacy Advocacy Group on Ambulatory Care and Pediatric Intensive Care.

(The Journal of Pediatric Pharmacology and Therapeutics : JPPT)
[2019, 24(4):330-372]

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Effects of Drugs and Excipients on Hydration Status.

Ana M Puga, Sara Lopez-Oliva, Carmen Trives, Teresa Partearroyo, Gregorio Varela-Moreiras,

Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water balance is affected by numerous factors, either internal (i.e., a lack of thirst sensation) or ... Read more >>

Nutrients (Nutrients)
[2019, 11(3):]

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Gastroesophageal reflux in children: an updated review.

Alexander Kc Leung, Kam Lun Hon,

Background:Gastroesophageal reflux is a common disorder in pediatrics. Clinicians should be familiar with the proper evaluation and management of this condition. Objective:To provide an update on the current understanding, evaluation, and management of gastroesophageal reflux in children. Methods:A PubMed search was performed with Clinical Queries using the key term 'gastroesophageal ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212591]

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Theophylline toxicity: An old poisoning for a new generation of physicians.

Spencer Corey Greene, Thiago Halmer, John Morgan Carey, Brian John Rissmiller, Matthew Allen Musick,

A healthy 4-year-old female presented to the emergency department for vomiting and diarrhea. She was diagnosed with a urinary tract infection, treated with antibiotics and anti-emetics and discharged. Within four hours, her symptoms recurred, followed by decreasing responsiveness and seizures. She had significant hypokalemia, hyperglycemia, and a combined respiratory and ... Read more >>

Turk J Emerg Med (Turkish journal of emergency medicine)
[2018, 18(1):37-39]

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Prevention, Treatment, and Monitoring of Seizures in the Intensive Care Unit.

Micheal Strein, John P Holton-Burke, LaTangela R Smith, Gretchen M Brophy,

The diagnosis and management of seizures in the critically ill patient can sometimes present a unique challenge for practitioners due to lack of exposure and complex patient comorbidities. The reported incidence varies between 8% and 34% of critically ill patients, with many patients often showing no overt clinical signs of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Effect of theobromine in antimicrobial activity: An in vitro study.

Arthi Lakshmi, C Vishnurekha, Parisa Norouzi Baghkomeh,

Background:This study aims to compare the antimicrobial activity of theobromine and two commercially available kid's fluoride toothpastes. Materials and Methods:In this in vitro study a chocolate-based nonfluoride toothpaste, Theobromine (Group A) and two commercially available kid's fluoride toothpaste, Kidodent (Group B), Colgate kids toothpaste (Group C) were used in this ... Read more >>

Dent Res J (Isfahan) (Dental research journal)
[2019, 16(2):76-80]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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The Side Effects of the Most Commonly Used Group of Antibiotics in Periodontal Treatments.

Saimir Heta, Ilma Robo,

Antibiotic combinations are preferred for the treatment of periodontal diseases, with the aim of hitting the bacterial flora, according to its characteristics-aerobic, anaerobic, gram-negative, and gram-positive-with certain antibiotics that act on certain bacteria. The aim of this study is to analyze the side effects of the antibiotics used. Data on ... Read more >>

Med Sci (Basel) (Medical sciences (Basel, Switzerland))
[2018, 6(1):]

Cited: 1 time

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Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Genny Raffaeli, Pavla Pokorna, Karel Allegaert, Fabio Mosca, Giacomo Cavallaro, Enno D Wildschut, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. As the survival and the overall outcome of patients rely on the treatment and reversal of the underlying disease, effective and preferentially evidence-based pharmacotherapy is crucial to target recovery. Currently limited data exist ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:360]

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Potential drug-drug interactions in outpatient department of a tertiary care hospital in Pakistan: a cross-sectional study.

Mohammad Ismail, Sidra Noor, Umme Harram, Inamul Haq, Iqbal Haider, Faiza Khadim, Qasim Khan, Zahid Ali, Tahir Muhammad, Muhammad Asif,

BACKGROUND:Potential drug-drug interactions (pDDIs) are one of the preventable drug related problems having the risk of serious adverse events or therapeutic failure. In developing countries like Pakistan, this issue remains poorly addressed. The objective of this study was to explore prevalence of pDDIs in the Outpatient Department (OPD) of a ... Read more >>

BMC Health Serv Res (BMC health services research)
[2018, 18(1):762]

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Interventions for bacterial folliculitis and boils (furuncles and carbuncles).

Huang‐Shen Lin, Pei‐Tzu Lin, Yu‐Shiun Tsai, Shu‐Hui Wang, Ching‐Chi Chi,

AbstractThis is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effects of interventions (such as topical antibiotics, topical antiseptic agents, systemic antibiotics, phototherapy, and incision and drainage) for people with bacterial folliculitis and boils. ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2018, 2018(8):]

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G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.

Stacy Gelhaus Wendell, Hao Fan, Cheng Zhang,

Asthma is a heterogeneous inflammatory disease of the airways that is associated with airway hyperresponsiveness and airflow limitation. Although asthma was once simply categorized as atopic or nonatopic, emerging analyses over the last few decades have revealed a variety of asthma endotypes that are attributed to numerous pathophysiological mechanisms. The ... Read more >>

Pharmacol. Rev. (Pharmacological reviews)
[2020, 72(1):1-49]

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

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Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review.

Jae Il Shin, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Tae Seong Eo, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet,

Systemic capillary leak syndrome (SCLS) is a rare disease characterized by shock caused by capillary hyperpermeability. The disease can occur in cancer patients and effective therapeutic strategies have not been established yet. The aim of the study was to analyze the clinical and laboratory data, treatment modalities, and mortality rate ... Read more >>

J Clin Med (Journal of clinical medicine)
[2018, 7(11):]

Cited: 1 time

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