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Pediatric Status Epilepticus

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Treatment Outcomes of Pediatric Status Epilepticus in a Tertiary Pediatric Intensive Care Unit.

Dilek Cavusoglu, Elif Esra Sınmaz, Nihal Olgac Dundar, Fulya Kamit Can, Ayse Berna Anil, Berrak Sarioglu,

OBJECTIVE:Status epilepticus is associated with high rates of morbidity and mortality; thus, early diagnosis and proper treatment are crucial. We aimed to study the etiology, clinical features, and treatment among pediatric patients with convulsive status epilepticus. METHODS:The medical records of 100 patients were retrospectively obtained from pediatric intensive care unit. ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, :]

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Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric Convulsive Status Epilepticus: A Randomized Double-blind Controlled Clinical Trial.

Vinayagamoorthy Vignesh, Ramachandran Rameshkumar, Subramanian Mahadevan,

OBJECTIVE:To compare the efficacy of phenytoin, valproate, and levetiracetam in the management of pediatric convulsive status epilepticus. DESIGN:Randomized double-blind controlled clinical trial. SETTING:Pediatric critical care division in a tertiary care institute from June, 2016 to December, 2018. PARTICIPANTS:110 children aged three month to 12 year with convulsive status epilepticus. INTERVENTION:Patients ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(3):222-227]

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Clinical Profile and Short-term Outcome of Pediatric Status Epilepticus at a Tertiary-care Center in Northern India.

Chinmay Chetan, Suvasini Sharma, Surendra B Mathur, Puneet Jain, Satinder Aneja,

OBJECTIVE:To assess clinical profile and short term treatment outcomes of pediatric status epilepticus (SE) at a tertiary-care center in northern India. METHODS:Prospective cohort study enrolled children aged 1 month to 18 years presenting with SE to the emergency department. Enrolled children (109) were treated as per hospital protocols. Clinical features ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(3):213-217]

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Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study.

Dan Sun, Hui Li, Xiao-Xia Lu, Han Xiao, Jie Ren, Fu-Rong Zhang, Zhi-Sheng Liu,

BackgroundAn outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People of all ages are susceptible to SARS-CoV-2 infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed to describe the clinical features of severe pediatric patients with COVID-19.MethodsWe ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[0, :1-9]

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Clinical Profile and Short-term Outcome of Pediatric Status Epilepticus.

Mahesh Kamate,

Indian Pediatr (Indian pediatrics)
[2020, 57(3):207-208]

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Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.

James M Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm, Maija Holsti, Lynn Babcock, Alex Rogers, William Barsan, James Cloyd, Daniel Lowenstein, Thomas P Bleck, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan B Fountain, Ellen Underwood, Jason T Connor, Robert Silbergleit, , ,

BACKGROUND:Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established ... Read more >>

Lancet (Lancet (London, England))
[2020, :]

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Pediatric Convulsive Status Epilepticus: Act Fast, No matter With What!

P A Mohammed Kunju, H Ahamed Subir,

Indian Pediatr (Indian pediatrics)
[2020, 57(3):211-212]

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Clinical Effectiveness of Levetiracetam Compared to Fosphenytoin in the Treatment of Benzodiazepine Refractory Convulsive Status Epilepticus.

Sricharantheja Nalisetty, Sasidaran Kandasamy, Balaji Sridharan, Vimalraj Vijayakumar, Thangavelu Sangaralingam, Nedunchelian Krishnamoorthi,

OBJECTIVES:To determine whether levetiracetam is an alternative to fosphenytoin to control Benzodiazepine Refractory Status Epilepticus (BRSE) in pediatric population and also to compare the acute drug related side-effects and ventilation requirement among the both arms of anti-epileptic drug therapy. METHODS:All consecutive children admitted with BRSE were randomized to group A, ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2020, :]

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Efficacy, Tolerability and Serum Phenytoin Levels after Intravenous Fosphenytoin Loading Dose in Children with Status Epilepticus.

Kavita Srivastava, Shirish Bhartiya, Vrushabh Gavli, Rahul Patil, Surekha Rajadhyaksha,

OBJECTIVE:To evaluate the efficacy and tolerability of intravenous fosphenytoin in children with status epilepticus, and resulting serum total phenytoin levels. METHODS:In this prospective study, 51 children aged less than 18 years received intravenous loading dose of fosphenytoin (18-20 mg/kg). Serum total phenytoin levels were estimated at 90 -100 minutes. Outcomes ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, 57(3):218-221]

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Ketogenic Diet: A Role in Immunity?

Andrea C Pardo,

Investigators from The Department of Comparative Medicine, from Yale School of Medicine report the effect of the ketogenic diet on the T cell immune function in mice exposed to influenza virus. ... Read more >>

Pediatr Neurol Briefs (Pediatric Neurology Briefs)
[2020, 34:5]

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Identification of PCDH19 Gene Mutations/Deletions in Patients with Early Onset Epilepsy.

Semra Gursoy, Esra Ataman, Bahar Toklu Baysal, Berk Özyılmaz, Pınar Gençpınar, Ayşe Semra Hız, Uluç Yiş, Aycan Ünalp, Nihal Olgaç Dündar, Ayfer Ülgenalp, Derya Erçal,

Background and Aims:PCDH19 gene, which encodes protocadherin 19, is associated with epilepsy and intellectual disability, mainly in affected females. The clinical manifestations are heterogeneous and the main features include early onset seizure, generalized or focal seizures sensitive to fever, and brief seizures occurring in clusters. The disorders exhibit a unique ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):206-210]

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A Novel WAC Loss of Function Mutation in an Individual Presenting with Encephalopathy Related to Status Epilepticus during Sleep (ESES).

Emanuela Leonardi, Mariagrazia Bellini, Maria C Aspromonte, Roberta Polli, Anna Mercante, Claudia Ciaccio, Elisa Granocchio, Elisa Bettella, Ilaria Donati, Elisa Cainelli, Stefania Boni, Stefano Sartori, Chiara Pantaleoni, Clementina Boniver, Alessandra Murgia,

WAC (WW Domain Containing Adaptor With Coiled-Coil) mutations have been reported in only 20 individuals presenting a neurodevelopmental disorder characterized by intellectual disability, neonatal hypotonia, behavioral problems, and mildly dysmorphic features. Using targeted deep sequencing, we screened a cohort of 630 individuals with variable degrees of intellectual disability and identified ... Read more >>

Genes (Basel) (Genes)
[2020, 11(3):]

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Surgical management of pediatric patients with encephalopathy due to electrical status epilepticus during sleep (ESES).

Shelly Wang, Alexander G Weil, George M Ibrahim, Aria Fallah, Brandon Korman, John Ragheb, Sanjiv Bhatia, Michael Duchowny,

ESES is a developmental epileptic disorder directly responsible for progressive encephalopathy and neurocognitive regression. The natural history, indications for surgical intervention, and predictors for favorable seizure and neuropsychological outcome remain unclear. We performed a retrospective review of children who underwent resective or disconnective surgery for ESES between January 2009 and ... Read more >>

Epileptic Disord (Epileptic disorders : international epilepsy journal with videotape)
[2020, 22(1):39-54]

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Dravet Syndrome: A Review of Current Management.

James W Wheless, Stephen P Fulton, Basanagoud D Mudigoudar,

Dravet syndrome is a debilitating epileptic encephalopathy of childhood with few treatment options available in the United States before 2018. In the modern era, new genetic testing options will allow diagnosis closer to disease onset. Three new medicines-stiripentol, cannabidiol, and fenfluramine-have documented efficacy and safety as adjunctive therapies for treating ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2020, :]

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Epilepsy surgery reduced seizure frequency for patients with severe motor and intellectual disorders.

Ayataka Fujimoto, Tohru Okanishi, Naoki Ichikawa, Kazuki Sakakura, Shimpei Baba, Keishiro Sato, Mitsuyo Nishimura, Hideo Enoki,

INTRODUCTION:Little is known about epilepsy surgery for patients with severe motor and intellectual disorders (SMIDs). We hypothesized that epilepsy surgery could reduce epileptic seizure frequency in these patients. The purpose of this study was to compare pre- and postoperative seizure frequency in patients with SMIDs. METHODS:A total of 288 surgeries ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107031]

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Pediatric autoimmune encephalitis: Recognition and diagnosis.

Marienke A A M de Bruijn, Arlette L Bruijstens, Anna E M Bastiaansen, Agnes van Sonderen, Marco W J Schreurs, Peter A E Sillevis Smitt, Rogier Q Hintzen, Rinze F Neuteboom, Maarten J Titulaer, ,

OBJECTIVE:The aims of this study were (1) to describe the incidence of autoimmune encephalitis (AIE) and acute disseminated encephalomyelitis (ADEM) in children, (2) to validate the currently used clinical criteria to diagnose AIE, and (3) to describe pitfalls in the diagnosis of pediatric autoimmune (AI) and inflammatory neurologic disorders. METHODS:This ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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Status Epilepticus as a Consequence of Hemophagocytic Lymphohistiocytosis in a Previously Healthy Infant.

Saeed M Nassar, Muath A AlBattah, Ahmad A Bukhari, Aryaf Alslimah, Assalh A Nahass,

Hemophagocytic lymphohistiocytosis (HLH) is a rare and fatal entity with an incidence rate of 1.2 cases per million people per year. HLH is explained as a highly destructive inflammatory consequence of rampant hypercytokinemia due to excessive lymphocyte-mediated activation of macrophages and histiocytes. Primary HLH is a product of genetic dysfunction ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6824]

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Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.

J Le Coz, G Chéron, R Nabbout, G Patteau, C Heilbronner, P Hubert, S Renolleau, M Oualha,

OBJECTIVES:The purpose of this study was to describe and compare the initial management, including clinical/biological investigation and treatment, of new-onset seizures and status epilepticus (SE) in children versus seizures and SE in those with known epilepsy. METHODS:This was a retrospective, single-center, observational study conducted in an urban pediatric hospital in ... Read more >>

Arch Pediatr (Archives de pediatrie : organe officiel de la Societe francaise de pediatrie)
[2020, 27(2):66-71]

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Attitudes and Awareness Towards Organ Donation Among Parents of Pediatric Brain Death Patients in a Pediatric Intensive Care Unit in Eastern Turkey.

Osman Yeşilbaş,

BACKGROUND The real causes of organ donation refusal decisions of parents after pediatric brain death and the factors that most influence their decisions are not known sufficiently in Turkey. This study aimed to investigate the detailed factors that may be relevant to parents' refusal, including their education level and knowledge ... Read more >>

Ann. Transplant. (Annals of transplantation)
[2020, 25:e920527]

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Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.

Katrien Stouffs, Patrick Verloo, Stefanie Brock, Luc Régal, Diane Beysen, Berten Ceulemans, Anna C Jansen, Marije E C Meuwissen,

NEDD4L encodes an ubiquitin ligase which is expressed in the cortex and ventricular zone of the fetal brain. Missense variants in NEDD4L have been reported in nine patients with periventricular nodular heterotopia (PNH), polymicrogyria, cleft palate, and syndactyly. All reported variants are located in the HECT domain, causing deregulation of ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:26]

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Status Epilepticus: The Slow and Agonizing Death of Phenytoin.

Elizabeth A Hall, James W Wheless, Stephanie J Phelps,

Since its introduction in 1950, phenytoin (PHT) has been the premier parenteral anticonvulsant used in the management of generalized convulsive status epileptics (GCSE) that is refractory to benzodiazepines. Without question, its arrival was vital to the care of patients with acute seizures and was a welcomed alternative to paraldehyde and ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(1):4-6]

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Pharmacotherapy for Pediatric Convulsive Status Epilepticus.

Avantika Singh, Coral M Stredny, Tobias Loddenkemper,

Convulsive status epilepticus (CSE) is one of the most common pediatric neurological emergencies. Ongoing seizure activity is a dynamic process and may be associated with progressive impairment of gamma-aminobutyric acid (GABA)-mediated inhibition due to rapid internalization of GABAA receptors. Further hyperexcitability may be caused by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA ... Read more >>

CNS Drugs (CNS drugs)
[2020, 34(1):47-63]

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Development of a model to predict electroencephalographic seizures in critically ill children.

France W Fung, Marin Jacobwitz, Darshana S Parikh, Lisa Vala, Maureen Donnelly, Jiaxin Fan, Rui Xiao, Alexis A Topjian, Nicholas S Abend,

OBJECTIVE:Electroencephalographic seizures (ESs) are common in encephalopathic critically ill children, but ES identification with continuous electroencephalography (EEG) monitoring (CEEG) is resource-intense. We aimed to develop an ES prediction model that would enable clinicians to stratify patients by ES risk and optimally target limited CEEG resources. We aimed to determine whether ... Read more >>

Epilepsia (Epilepsia)
[2020, 61(3):498-508]

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Methylprednisolone pulse therapy as an adjuvant treatment of Streptococcus pneumoniae meningitis complicated by cerebral infarction-a case report and review of the literature.

Oi-Wa Chan, Jainn-Jim Lin, Shao-Hsuan Hsia, Chia-Ying Lin, Kung-Lin Lin,

PURPOSE:The role of methylprednisolone pulse therapy as adjuvant treatment of Streptococcus pneumoniae meningitis complicated by cerebral infarction has rarely been reported. METHODS:We reported a case report and also performed a systematic literature review. RESULTS:A 1-year 2-month-old boy who presented with high fever, status epilepticus, and septic shock was diagnosed with ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, 36(2):229-233]

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PIRSE: Philosophical Investigations in Refractory Status Epilepticus.

Mark S Wainwright,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(1):98-99]

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