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Pediatric Selective Serotonin Reuptake Inhibitor Toxicity

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Antidepressant Use in Medicaid-Insured Youth: Trends, Covariates, and Future Research Needs.

Julie M. Zito, Dinci Pennap, Daniel J. Safer,

BackgroundDetailed research on long-term antidepressant (AD) trends within a single large US Medicaid population of youth has not heretofore been reported.MethodsAdministrative claims data for eight annual timepoints across 28 years (1987–2014) were organized for youth (<20 years old) who were continuously enrolled during each study year in a mid-Atlantic state ... Read more >>

Front Psychiatry (Frontiers in Psychiatry)
[2020, 11:]

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Assessing SSRIs' effects on fetal cardiomyocytes utilizing placenta-fetus model.

Navein Arumugasaamy, Amelia Hurley-Novatny, Josephine Lembong, Peter C W Kim, John P Fisher,

Selective serotonin reuptake inhibitors (SSRIs) have been shown to hinder cardiomyocyte signaling, raising concerns about their safety during pregnancy. Approaches to assess SSRI-induced effects on fetal cardiovascular cells following passage of drugs through the placental barrier in vitro have only recently become available. Herein, we report that the SSRIs, fluoxetine ... Read more >>

Acta Biomater (Acta biomaterialia)
[2019, 99:258-268]

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Antidepressants for Pediatric Patients.

Jennifer B Dwyer, Michael H Bloch,

Curr Psychiatr (Current psychiatry)
[2019, 18(9):26-42F]

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Toxicity of Bupropion Overdose Compared With Selective Serotonin Reuptake Inhibitors.

Adam Overberg, Shannon Morton, Emily Wagner, Blake Froberg,

OBJECTIVES:Adolescent depression and attempted and completed suicide are increasing in the United States. Because suicide is often impulsive, the means of self-harm are frequently items of convenience like medication. Authors of a recent study compared tricyclic antidepressant overdose to bupropion overdose. Fluoxetine and escitalopram are the only agents with Food ... Read more >>

Pediatrics (Pediatrics)
[2019, 144(2):]

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Drug-induced bruxism.

Leanne Teoh, Geraldine Moses,

Aust Prescr (Australian prescriber)
[2019, 42(4):121]

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Adverse drug reactions in primary care: a scoping review.

H Khalil, C Huang,

BACKGROUND:Medication-related adverse events, or adverse drug reactions (ADRs) are harmful events caused by medication. ADRs could have profound effects on the patients' quality of life, as well as creating an increased burden on the healthcare system. ADRs are one of the rising causes of morbidity and mortality internationally, and will ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):5]

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Perceptions and Beliefs Regarding NSAIDs in the Asia-Pacific Region.

Kok-Yuen Ho,

Background:Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in the treatment of pain and inflammation. However, chronic NSAID use may result in gastrointestinal (GI), cardiovascular (CV), renal or other safety concerns, especially in high-risk populations. The aim of this review is to systematically identify relevant literature and to organize available evidence ... Read more >>

J Pain Res (Journal of pain research)
[2020, 13:437-446]

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Prevalence of potential drug-drug interactions in Swedish pediatric outpatients.

Johan Holm, Birgit Eiermann, Elin Kimland, Buster Mannheimer,

PURPOSE:To describe the occurrence of potential drug-drug interactions (DDIs) in prescribed drugs, dispensed to pediatric outpatients in Sweden. METHODS:A cross sectional study was conducted based on data from a national register of prescribed drugs, dispensed at pharmacies, to children 0-17 years old. The study period was January 1 to April ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220685]

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Neonatal Outcomes in Maternal Depression in Relation to Intrauterine Drug Exposure.

Silvia Corti, Paola Pileri, Martina I Mazzocco, Chiara Mandò, Anna F Moscatiello, Dario Cattaneo, Stefania Cheli, Sara Baldelli, Laura Pogliani, Emilio Clementi, Irene Cetin,

Background: SSRIs (Selective Serotonin Reuptake Inhibitors) are the most useful drugs to treat depression during pregnancy. Intrauterine exposure to SSRIs may increase the risk of growth restriction, preterm birth and neonatal complications. However, advantages in treating depression seem to exceed potential drug side effects in respect un-treated depression. SSRIs undergo ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:309]

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Gene-Based Dose Optimization in Children.

Laura B Ramsey, Jacob T Brown, Susan I Vear, Jeffrey R Bishop, Sara L Van Driest,

Pharmacogenetics is a key component of precision medicine. Genetic variation in drug metabolism enzymes can lead to variable exposure to drugs and metabolites, potentially leading to inefficacy and drug toxicity. Although the evidence for pharmacogenetic associations in children is not as extensive as for adults, there are several drugs across ... Read more >>

Annu. Rev. Pharmacol. Toxicol. (Annual review of pharmacology and toxicology)
[2020, 60:311-331]

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Latest Update on Prevention of Acute Chemotherapy-Induced Nausea and Vomiting in Pediatric Cancer Patients.

Farha Sherani, Catherine Boston, Nkechi Mba,

PURPOSE OF REVIEW:Chemotherapy-induced nausea and vomiting (CINV) is a common cause of acute morbidity that impacts quality of life in children receiving cancer treatment. Here, we review the evolution of CINV prophylaxis guidelines in children, with an emphasis on the literature published in the last 5 years, to bring the reader ... Read more >>

Curr Oncol Rep (Current oncology reports)
[2019, 21(10):89]

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Serotonin Syndrome in a Pediatric Patient After Vilazodone Ingestion.

Benjamin Laliberte, Omayma A Kishk,

Serotonin syndrome (SS) is a serious toxicity that manifests with symptoms such as tremor, hyperthermia, agitation, and altered mental status that may lead to seizures, coma, or death. Selective serotonin reuptake inhibitors may precipitate SS, particularly in combination with other drugs that possess serotonergic activity. We present a case of ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2018, 34(12):e226-e228]

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Molecular Basis of Cancer Pain Management: An Updated Review.

Ayappa V Subramaniam, Ashwaq Hamid Salem Yehya, Chern Ein Oon,

Pain can have a significantly negative impact on the quality of life of patients. Therefore, patients may resort to analgesics to relieve the pain. The struggle to manage pain in cancer patients effectively and safely has long been an issue in medicine. Analgesics are the mainstay treatment for pain management ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(9):]

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Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection-Characteristics and Diagnostic Criteria of PANDAS Recognition.

Jacek Baj, Elżbieta Sitarz, Alicja Forma, Katarzyna Wróblewska, Hanna Karakuła-Juchnowicz,

The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Anna V Wojcicki, Meena Kadapakkam, Adam Frymoyer, Norman Lacayo, Hee-Don Chae, Kathleen M Sakamoto,

Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of myeloid progenitor cells that affects patients of all ages. Despite decades of research and improvement in overall outcomes, standard therapy remains ineffective for certain subtypes of AML. Current treatment is intensive and leads to a number of secondary ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

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Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial.

Christoph Beuter, Gisela Volkers, Tatjana Radic, Jutta Goldberg, John van den Anker,

Background:Well-controlled trials of analgesics in the pediatric population are scarce. Tapentadol is a strong centrally acting analgesic which has undergone a pediatric development program investigating its suitability for treating moderate to severe acute pain across the entire pediatric age range from birth to adolescence. Here, we report data from a ... Read more >>

J Pain Res (Journal of Pain Research)
[2019, 12:3099-3112]

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Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes.

Catherine E Creeley, Lisa K Denton,

This paper reviews the findings from preclinical animal and human clinical research investigating maternal/fetal, neonatal, and child neurodevelopmental outcomes following prenatal exposure to psychotropic drugs. Evidence for the risks associated with prenatal exposure was examined, including teratogenicity, neurodevelopmental effects, neonatal toxicity, and long-term neurobehavioral consequences (i.e., behavioral teratogenicity). We conducted ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(9):]

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The Use of Medication in Pregnancy.

Katarina Dathe, Christof Schaefer,

BACKGROUND:Drug safety has the highest priority in the treatment of pregnant women, as any effect on fetal development will not be immediately evident, and the harm that ensues may have lifelong adverse consequences. METHODS:This review is based on pertinent publications retrieved by a selective literature search and on expert assessment ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2019, 116(46):783-790]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[0, :1-53]

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Surprising Anticancer Activities of Psychiatric Medications: Old Drugs Offer New Hope for Patients With Brain Cancer.

Chuanjun Zhuo, Zhiyuan Xun, Weihong Hou, Feng Ji, Xiaodong Lin, Hongjun Tian, Weifang Zheng, Min Chen, Chuanxin Liu, Wenqiang Wang, Ce Chen,

Despite decades of research and major efforts, malignant brain tumors remain among the deadliest of all cancers. Recently, an increasing number of psychiatric drugs has been proven to possess suppressing activities against brain tumors, and rapid progress has been made in understanding the potential mechanisms of action of these drugs. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1262]

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Highlights From the Annual Meeting of the American Epilepsy Society 2018.

Barbara C Jobst, Elinor Ben-Menachem, Kevin E Chapman, Aradia Fu, Alica Goldman, Lawrence J Hirsch, Lara E Jehi, Eric H Kossoff, Madona Plueger, Jong M Rho, Catherine A Schevon, Shlomo Shinnar, Michael R Sperling, Timothy A Simeone, Janelle L Wagner, Fred Lado,

The American Epilepsy Society Meeting in New Orleans attracted more than 5900 attendees. There was a lively exchange of new science, innovation, education, clinical practice, and many other items related to epilepsy. Educational symposia were a major part of the meeting and explored varying topics of interest for all types ... Read more >>

Epilepsy Curr (Epilepsy currents)
[2019, 19(3):152-158]

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Ketamine as treatment for post-traumatic stress disorder: a review.

Felix Liriano, Candace Hatten, Thomas L Schwartz,

Post-traumatic stress disorder (PTSD) continues to make headlines given multiple military engagements across the world and civilian traumas, and resultant PTSD development continues at an even pace. Currently, antidepressant and cognitive-behavioral therapy have the greatest evidence base but still do not yield a remission of PTSD symptoms in many patients. ... Read more >>

Drugs Context (Drugs in context)
[2019, 8:212305]

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Diving and attention deficit hyperactivity disorder.

Abraham L Querido, Robert A van Hulst,

Attention deficit hyperactivity disorder (ADHD) is a psychiatric condition that affects attention, concentration, impulse control and awareness. Not only these symptoms, but also the medications used to treat ADHD (psychostimulants) pose a risk to both the diver and his or her buddy. This article presents guidelines for recreational diving in ... Read more >>

Diving Hyperb Med (Diving and hyperbaric medicine)
[2019, 49(1):41-47]

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Pharmacologic Management of Agitation and Aggression in a Pediatric Emergency Department - A Retrospective Cohort Study.

Jennifer G Kendrick, Ran D Goldman, Roxane R Carr,

BACKGROUND:Benzodiazepine and antipsychotic use for acute management of agitation and aggression in the pediatric emergency department (ED) setting has not been well described. OBJECTIVES:To describe medication utilization in the management of agitation and aggression in a pediatric ED and to assess the safety of their use. METHODS:This was a retrospective ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2018, 23(6):455-459]

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Emerging therapeutic potential of anti-psychotic drugs in the management of human glioma: A comprehensive review.

Muhamad N A Kamarudin, Ishwar Parhar,

Despite numerous advancements in the last decade, human gliomas such as astrocytoma and glioblastoma multiforme have the worst prognoses among all cancers. Anti-psychotic drugs are commonly prescribed to treat mental disorders among cancer patients, and growing empirical evidence has revealed their antitumor, anti-metastatic, anti-angiogenic, anti-proliferative, chemo-preventive, and neo-adjuvant efficacies in ... Read more >>

Oncotarget (Oncotarget)
[2019, 10(39):3952-3977]

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