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Pediatric Respiratory Failure

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Adult outcomes of childhood bronchiectasis.

Dawn Sibanda, Rosalyn Singleton, John Clark, Christine Desnoyers, Ellen Hodges, Gretchen Day, Gregory Redding,

Recent literature has highlighted the importance of transition from paediatric to adult care for children with chronic conditions. Non-cystic fibrosis bronchiectasis is an important cause of respiratory morbidity in low-income countries and in indigenous children from affluent countries; however, there is little information about adult outcomes of childhood bronchiectasis. We ... Read more >>

Int J Circumpolar Health (International journal of circumpolar health)
[2020, 79(1):1731059]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Ketofol performance to reduce postoperative emergence agitation in children undergoing adenotonsillectomy.

Idress Ali, Murad Alahdal, Haifa Xia, Arafa S El Moughrabi, Huang Shiqian, Shanglong Yao,

Background: Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adenotonsillectomy.Methods: A total of 60 children aged 3-15 ... Read more >>

Libyan J Med (The Libyan journal of medicine)
[2020, 15(1):1688450]

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Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study.

Dan Sun, Hui Li, Xiao-Xia Lu, Han Xiao, Jie Ren, Fu-Rong Zhang, Zhi-Sheng Liu,

BackgroundAn outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People of all ages are susceptible to SARS-CoV-2 infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed to describe the clinical features of severe pediatric patients with COVID-19.MethodsWe ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[0, :1-9]

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Extracorporeal Membrane Oxygenation Support for Pediatric Burn Patients: Is It Worth the Risk?

Kelly B Thompson, Fakhry Dawoud, Shannon Castle, John B Pietsch, Melissa E Danko, Brian C Bridges,

OBJECTIVES:Examine the outcomes of pediatric burn patients requiring extracorporeal membrane oxygenation to determine whether extracorporeal membrane oxygenation should be considered in this special population. DESIGN:Retrospective cohort study. SETTING:All extracorporeal membrane oxygenation centers reporting to the Extracorporeal Life Support Organization. SUBJECTS:Pediatric patients (birth to younger than 18 yr) who were supported ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Factors Behind Decline of Venovenous Extracorporeal Membrane Oxygenation to Support Neonatal Respiratory Failure.

Jon Lillie, Liz Boot, Simone Speggiorin, Andrew G Nyman,

OBJECTIVES:Neonates with respiratory failure are ideally supported with venovenous rather than venoarterial extracorporeal membrane oxygenation due to the reduced rate of neurologic complications. However, the proportion of neonates supported with venovenous extracorporeal membrane oxygenation is declining. We aimed to explore the factors behind this decline. DESIGN:We conducted a survey in ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Admission Characteristics Identify Risk of Pediatric Acute-on-chronic Liver Failure.

Anna M Banc-Husu, Katie Neighbors, Karen Rychlik, Saeed Mohammad, Zena Leah Harris, Estella M Alonso,

OBJECTIVES:Acute-on-chronic liver failure (ACLF) is well-studied in adults and characterized by decompensated cirrhosis, multi-organ failure, and early mortality. Studies of ACLF in children are limited. We sought to characterize the prevalence and clinical factors associated with pediatric ACLF (PACLF). METHODS:A retrospective review of children 3 months to 18 years listed ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, :]

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Risk Factors for Mortality in Refractory Pediatric Septic Shock Supported with Extracorporeal Life Support.

Jennifer K Workman, David K Bailly, Ron W Reeder, Heidi J Dalton, Robert A Berg, Thomas P Shanley, Christopher J L Newth, Murray M Pollack, David Wessel, Joseph Carcillo, Rick Harrison, J Michael Dean, Kathleen L Meert, ,

Risk factors for mortality in children with refractory pediatric septic shock who are supported with extracorporeal life support (ECLS) are largely unknown. Therefore, we performed univariable and multivariable analyses to determine risk factors for mortality among children (<19 years) who underwent an ECLS run between January 2012 and September 2014 ... Read more >>

ASAIO J. (ASAIO journal (American Society for Artificial Internal Organs : 1992))
[2020, :]

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Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure.

John T Berger, Aline B Maddux, Ron W Reeder, Russell Banks, Peter M Mourani, Robert A Berg, Joseph A Carcillo, Todd Carpenter, Mark W Hall, Kathleen L Meert, Patrick S McQuillen, Murray M Pollack, Anil Sapru, Andrew R Yates, Daniel A Notterman, Richard Holubkov, J Michael Dean, David L Wessel, ,

OBJECTIVES:To characterize contemporary use of inhaled nitric oxide in pediatric acute respiratory failure and to assess relationships between clinical variables and outcomes. We sought to study the relationship of inhaled nitric oxide response to patient characteristics including right ventricular dysfunction and clinician responsiveness to improved oxygenation. We hypothesize that prompt ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Intrathecal Morphine in the Presence of a Syrinx in Pediatric Spinal Deformity Surgery.

Jason Ina, Connie Poe-Kochert, Christina K Hardesty, Jochen P Son-Hing, Paul Tripi, George H Thompson,

BACKGROUND:Intrathecal morphine (IM) is a popular adjunct for pain relief during pediatric spinal deformity surgery. There is no literature regarding its usefulness and safety in the presence of a spinal cord syrinx for patients undergoing spinal instrumentation. Anesthesiologists have previously been reluctant to use IM in the presence of any ... Read more >>

J Pediatr Orthop (Journal of pediatric orthopedics)
[2020, 40(4):e272-e276]

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Emergency Endotracheal Intubation With a Rigid Stylet of an Infant With Severe Subglottic Stenosis.

Jonathan R Strutt, Nicole R Thompson, Jennifer L Stotesbery, Balazs Horvath,

BACKGROUND:Subglottic stenosis is a frequent complication of endotracheal intubation in children and can create a difficult airway situation for subsequent respiratory illnesses. Difficult airway algorithms are an essential aid when dealing with respiratory failure in clinical situations where ventilation or intubation is unsuccessful. CASE REPORT:A 4-month-old infant with a history ... Read more >>

J Emerg Med (The Journal of emergency medicine)
[2020, :]

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MANAGEMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN A CHILD WITH ADENOVIRUS PNEUMONIA: CASE REPORT AND LITERATURE REVIEW.

Felipe Rezende Caino de Oliveira, Krisna de Medeiros Macias, Patricia Andrea Rolli, José Colleti Junior, Werther Brunow de Carvalho,

OBJECTIVE:To report the case of a child who developed acute respiratory distress syndrome (ARDS) from a pulmonary infection by adenovirus. CASE DESCRIPTION:A female patient aged 2 years and 6 months, weighting 10,295 grams developed fever, productive cough and vomiting, later on progressing to ARDS despite initial therapy in accordance with ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018280]

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Clinical Characteristics, Major Morbidity, and Mortality in Trauma-Related Pediatric Acute Respiratory Distress Syndrome.

Alison B Nair, Mitchell J Cohen, Heidi R Flori,

OBJECTIVES:To determine the presence, central characteristics, and impact on major morbidity and mortality of trauma-related pediatric acute respiratory distress syndrome. DESIGN:Retrospective review of a prospective trauma database. SETTING:American College of Surgeons verified level 1 trauma center in an urban setting. PATIENTS:Trauma patients age 0 to 18 years old inclusive. INTERVENTIONS:None. ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(2):122-128]

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Impact of an Immersive Virtual Reality Curriculum on Medical Students' Clinical Assessment of Infants With Respiratory Distress.

Matthew W Zackoff, Francis J Real, Rashmi D Sahay, Lin Fei, Amy Guiot, Corinne Lehmann, Ken Tegtmeyer, Melissa Klein,

OBJECTIVE:To determine whether exposure to an immersive virtual reality curriculum on pediatric respiratory distress improves medical students' recognition of impending respiratory failure. DESIGN:Randomized, controlled, prospective study conducted from July 2017 to June 2018. Evaluators blinded to student groupings. SETTING:Academic, free-standing children's hospital. PARTICIPANTS:All third-year medical students (n = 168) were ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Fatal pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis: Three case reports.

Tingting Shi, Huan Chen, Li Huang, Huifeng Fan, Diyuan Yang, Dongwei Zhang, Gen Lu,

RATIONALE:Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are extremely rare but potentially life-threatening disorders. We presented 3 fatal pediatric SJS/TEN cases. PATIENT CONCERNS:Our patients had some severe complications such as septic shock, respiratory failure and obliterans bronchiolitis (BO) etc. DIAGNOSIS:: Three patients diagnosed SJS/TEN with clinical symptoms that were triggered ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(12):e19431]

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22q11.2 Deletion Status Influences Resource Utilization in Infants Requiring Repair of Tetralogy of Fallot and Common Arterial Trunk.

Laxmi V Ghimire, Christie Devoe, Anita J Moon-Grady,

22q11.2 deletion syndrome leads to both cardiac and non-cardiac developmental defects. We aimed to study the impact of 22q11.2 deletion syndrome on in-hospital outcomes in children undergoing surgical repair for tetralogy of Fallot (TOF) and truncus arteriosus (TA). Using the nationally representative Kids Inpatient Database (KID), we analyzed data from ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2020, :]

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Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency.

Sule Haskologlu, Sevgi Kostel Bal, Candan Islamoglu, Caner Aytekin, Sukru Guner, Selin Sevinc, Sevgi Keles, Tanil Kendirli, Serdar Ceylaner, Figen Dogu, Aydan Ikinciogullari,

Biallelic mutations in the dedicator of cytokinesis 8 gene (DOCK8) cause a progressive combined immunodeficiency (CID) characterized by susceptibility to severe viral skin infections, atopic diseases, recurrent respiratory infections, and malignancy. Hematopoietic stem cell transplantation (HSCT) is only curative treatment for the disease. However, there is limited information about long-term ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, :]

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Amitriptyline Intoxication in Children: Twenty Years' Experience in a Tertiary Care Center in Turkey.

Tülay Kamasak, Şebnem Kader, Mehmet Mutlu, Kagan Özkaya, Erol Erduran, Fazil Orhan, Embiya Dilber, Mukaddes Kalyoncu, Gülay Karagüzel, Murat Cakir, Elif Bahat, Ali Cansu,

BACKGROUND:Amitriptyline ingestion is an important cause of poisoning morbidity and mortality in Turkey and other countries. In contrast to adults, data concerning amitriptyline intoxication in children are limited. The purpose of this study was to investigate amitriptyline intoxication findings in the pediatric population, based on age groups and reported dosages. ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, :]

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Midazolam use in pediatric dentistry: a review.

Shreyans Aditya Jain, Nilesh Rathi, Nilima Thosar, Sudhindra Baliga,

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment for this patient population. Midazolam is a benzodiazepine used as an adjunct to behavior management techniques in the dental treatment ... Read more >>

J Dent Anesth Pain Med (Journal of dental anesthesia and pain medicine)
[2020, 20(1):1-8]

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Temporal condition pattern mining in large, sparse electronic health record data: A case study in characterizing pediatric asthma.

Elizabeth A Campbell, Ellen J Bass, Aaron J Masino,

OBJECTIVE:This study introduces a temporal condition pattern mining methodology to address the sparse nature of coded condition concept utilization in electronic health record data. As a validation study, we applied this method to reveal condition patterns surrounding an initial diagnosis of pediatric asthma. MATERIALS AND METHODS:The SPADE (Sequential PAttern Discovery ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2020, 27(4):558-566]

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Pediatric extracorporeal membrane oxygenation: Our experience with single-vessel cannulation.

Muhterem Duyu, Asena Pınar Sefer,

Background:In this study, we present our experience with bicaval, dual-lumen, venovenous extracorporeal membrane oxygenation in pediatric patients with severe respiratory failure. Methods:Between September 2015 and May 2019, a total of nine pediatric patients (7 males, 2 females; median age 3.1 years; range, 0.3 to 7.4 years) hospitalized in the pediatric ... Read more >>

Turk Gogus Kalp Damar Cerrahisi Derg (Turk gogus kalp damar cerrahisi dergisi)
[2020, 28(1):92-100]

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Incidence and Predictors of Treatment Failure Among Children Receiving First-Line Antiretroviral Treatment in General Hospitals of Two Zones, Tigray, Ethiopia, 2019.

Migbar Sibhat, Mekuria Kassa, Haftom Gebrehiwot,

Background:Despite many efforts undertaken to control the human immunodeficiency virus epidemic, it remains to be the major global public health challenge. With expanding access to pediatric antiretroviral therapy, children are more likely to experience treatment failure. All previous studies conducted in Ethiopia estimated treatment failure using only clinical and CD4 ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2020, 11:85-94]

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Inhaled Tranexamic Acid As a Novel Treatment for Pulmonary Hemorrhage in Critically Ill Pediatric Patients: An Observational Study.

Erika R O'Neil, Lindsay R Schmees, Karla Resendiz, Henri Justino, Marc M Anders,

Objectives:To describe the use of inhaled or endotracheally instilled tranexamic acid in critically ill pediatric patients for the treatment of pulmonary hemorrhage, which can be severe, life-threatening, and include potentially high-risk management procedures. Design:Retrospective observational study from 2011-2018 with patients followed until hospital discharge. Setting:Free-standing children's hospital with an annual ... Read more >>

Crit Care Explor (Critical Care Explorations)
[2020, 2(1):e0075]

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Systemic BK Virus Infection in a Pediatric Patient With Severe Combined Immunodeficiency.

Ricardo Espinosa-González, Diana E Aguilar León, Rodolfo Rodríguez-Jurado, Norma O Uribe-Uribe,

Human BK virus (BKV) infection is known to occur mostly during childhood with the establishment of latent infection with no tissue damage or clinical manifestations. However, conditions causing immunosuppression can lead to increased virus replication and tissue damage. Although the tissues most commonly involved are the kidneys, bladder, ureters and, ... Read more >>

Pediatr. Dev. Pathol. (Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society)
[2020, :1093526619892181]

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Improving the performance of the Revised Trauma Score using Shock Index, Peripheral Oxygen Saturation, and Temperature-a National Trauma Database study 2011 to 2015.

Radu Filipescu, Colin Powers, Han Yu, Jihnhee Yu, David H Rothstein, Carroll M Harmon, Brian Clemency, Weidun A Guo, Kathryn D Bass,

BACKGROUND:The Revised Trauma Score is the standard physiologic injury severity indicator used in trauma research and quality control. Shock index, peripheral oxygen saturation, and temperature have emerged as strong predictors for mortality and morbidity. We hypothesized that replacing systolic blood pressure and respiratory rate with age-adjusted shock index and peripheral ... Read more >>

Surgery (Surgery)
[2020, :]

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