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Pediatric Respiratory Alkalosis

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A Delphi Analysis to Reach Consensus on Preoperative Care in Infants with Hypertrophic Pyloric Stenosis.

Fenne A I M van den Bunder, Nigel J Hall, L W Ernest van Heurn, Joep P M Derikx,

INTRODUCTION: Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal condition that can lead to metabolic alkalosis and, if uncorrected, to respiratory complications. A standardized approach to correct metabolic derangements and dehydration may reduce time until pyloromyotomy while preventing potential respiratory complications. Such an evidence-based policy regarding preoperative care is absent. ... Read more >>

Eur J Pediatr Surg (European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie)
[2020, :]

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Fatal Course of a Male Newborn with Double Duodenal Atresia.

Ahmed Elrouby, Ahmed Koraitim,

Multiple point duodenal atresia is an extremely rare condition with atretic segments in either two or three sites of the duodenum. We report a newborn male patient who presented to our institution with bilious vomiting, nonpassage of meconium, mild abdominal distension, and a palpable epigastric abdominal mass ∼1 × 1 cm. A faint ... Read more >>

European J Pediatr Surg Rep (European journal of pediatric surgery reports)
[2020, 8(1):e7-e9]

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Critical Care Education Day: A Novel, Multidisciplinary, and Interactive Critical Care Education Session for Emergency Medicine Residents.

Natalie N Htet, Alexandra June Gordon, Tsuyoshi Mitarai,

Critical care medicine (CCM) is central to emergency medicine (EM) resident education. We feel that the traditional lecture format is not the ideal way to teach EM critical care, which requires integration and prioritization of diagnostic workup and team-based resuscitation under time pressure. We describe a novel critical care education day where ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6785]

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Connecting two worlds: positive correlation between physicochemical approach with blood gases and pH in pediatric ICU setting.

Chanapai Chaiyakulsil, Papope Mueanpaopong, Rojjanee Lertbunrian, Somchai Chutipongtanate,

OBJECTIVE:Physicochemical approach such as strong ion difference provides a novel concept in understanding and managing acid-base disturbance in patients. However, its application in pediatrics is limited. This study aimed to evaluate a correlation between the physicochemical approach and blood gas pH for acid-base determination in critically ill pediatric patients. RESULTS:A ... Read more >>

BMC Res Notes (BMC research notes)
[2019, 12(1):742]

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Use of Sodium Bicarbonate During Pediatric Cardiac Admissions with Cardiac Arrest: Who Gets It and What Does It Do?

Rohit S Loomba, Mubbasheer Ahmed, Mubeena Abdulkarim, Enrique G Villarreal, Saul Flores,

The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(12):]

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Survival and Neurological Recovery After Prompt Diagnosis and Aggressive Management of Severe Idiopathic Hyperammonemic Encephalopathy in a Patient with Acute Myeloid Leukemia.

Ross Mangum, Claudia Soler-Alfonso, Sherri Birchansky, Alexandra Stevens,

A case of a 19-year-old female with low-risk acute myeloid leukemia is presented who was diagnosed with idiopathic hyperammonemic encephalopathy following the development of abrupt neurological decline, respiratory alkalosis, and elevated plasma ammonia levels of unknown etiology. Delayed symptom recognition of this exceedingly rare condition contributes to the often fatal ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2019, :]

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Antenatal Bartter Syndrome Caused by a Novel Homozygous Mutation in SLC12A1 Gene.

Filiz Aktürk Acar, Güneş Işik, Mehmet Mutlu, Şebnem Kader, Yakup Aslan, Mukaddes Kalyoncu,

Antenatal Bartter syndrome (BS) is an autosomal recessive hereditary renal tubular disorder caused by mutation in the solute carrier family 12 member 1 (SLC12A1) gene on chromosome 15q21.1. This syndrome is characterized by polyuria, hyponatremia, hypokalemic hypochloremic metabolic alkalosis, and hypercalciuria associated with increased urinary loss of electrolytes. Herein, we ... Read more >>

Indian J Nephrol (Indian journal of nephrology)
[2019, 29(5):360-363]

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Hyponatremia in infants with community-acquired infections on hospital admission.

Marta B Mazzoni, Gregorio P Milani, Silvia Bernardi, Ludovica Odone, Alessia Rocchi, Emanuela A D'Angelo, Marco Alberzoni, Carlo Agostoni, Mario G Bianchetti, Emilio F Fossali,

Acute moderate to severe gastroenteritis is traditionally associated with hypernatremia but recent observations suggest that hypernatremia is currently less common than hyponatremia. The latter has sometimes been documented also in children with acute community-acquired diseases, such as bronchiolitis and pyelonephritis. We investigated the prevalence of dysnatremia in children with acute ... Read more >>

PLoS ONE (PloS one)
[2019, 14(7):e0219299]

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Acute Kidney Injury Following High-Dose Methotrexate Administration in a Day Care Hospital.

Srimanta Chandra Misra, Alberto Santagostino, Gerard Dine, Larence Bonhomme Faivre,

Day care is a potential alternative to inpatient care of cancer patients. Using day care reduces medical costs substantially compared to inpatient care, which is driving the transfer of many inpatient chemotherapy protocols to day care hospitals (DCHs). However, in contrast to inpatient management, day care provides limited observation time, ... Read more >>

Drug Saf Case Rep (Drug safety - case reports)
[2019, 6(1):12]

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Gitelman syndrome combined with growth hormone deficiency: Three cases report.

Ke Huang, Yang-Li Dai, Jian-Wei Zhang, Li Zhang, Wei Wu, Guan-Ping Dong, Rahim Ullah, Yue Fei, Jun-Fen Fu,

RATIONALE:Gitelman syndrome (GS) is a rare autosomal recessive hereditary salt-losing tubulopathy caused by loss-of-function mutations in the SLC12A3 gene. It is usually characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. There are only a few reports on GS combined with growth hormone deficiency (GHD). PATIENT CONCERNS:Three patients presented with weakness, ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(40):e17244]

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Diuretic Use and Subsequent Electrolyte Supplementation in a Level IV Neonatal Intensive Care Unit.

Lauren L Dartois, Claire Levek, Theresa R Grover, Michael E Murphy, Emma L Ross,

OBJECTIVES:To evaluate the relationship between diuretic use, serum electrolyte concentrations, and supplementation requirements in infants admitted to the neonatal intensive care unit. METHODS:This was a single-center retrospective cohort study conducted in a freestanding children's hospital Level IV NICU. Data were collected for all infants younger than 6 months, admitted to ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(2):124-130]

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Should isolated Pseudo-Bartter syndrome be considered a CFTR-related disorder of infancy?

Piercarlo Poli, Domenico Umberto De Rose, Silviana Timpano, Gianfranco Savoldi, Rita Padoan,

BACKGROUND:Infants that are negative to cystic fibrosis (CF) newborn screening (NBS) programs, or in countries without NBS, may present with metabolic alkalosis and severe salt depletion, a well-known clinical manifestation of CF termed Pseudo-Bartter syndrome (PBS). Here, we report the cases of three CF-negative children, who carry rare mutations in ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(10):1578-1583]

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Fluid Therapy For Pediatric Patients With Diabetic Ketoacidosis: Current Perspectives.

Muralidharan Jayashree, Vijai Williams, Rajalakshmi Iyer,

Diabetic ketoacidosis (DKA) is a preventable life-threatening complication of type 1 diabetes. Fluids form a crucial component of DKA therapy, goals being the restoration of intravascular, interstitial and intracellular compartments. Hydration reduces hyperglycemia by decreased counter-regulatory hormones, enhanced renal glucose clearance and augmented insulin sensitivity. However, for the last several ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2019, 12:2355-2361]

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Subacute Myelopathy: Think Beyond Neuromyelitis Optica Spectrum Disorder.

Ananthanarayanan Kasinathan, Renu Suthar, Sameer Vyas, Arushi Gahlot Saini, Naveen Sankhyan, Savita Attri,

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2019, 22(4):541-542]

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SUN-LB031 An Atypical Case of Diabetic Keto-Alkalosis with Severe Hypernatremic Hyperosmolarity in a Patient with Amphetamine Abuse.

Khushpreet Kaur Saini, Sridhar Nambi,

Abstract - Acid base disturbances have a complex interplay in Diabetic Ketoacidosis (DKA). Substance abuse in DKA is associated with more severe metabolic acidosis with higher acidosis-ketosis gap. Severe hypernatremia and alkalosis are rare in DKA but were exhibited in our case. - A 31-year-old female with Type 1 diabetes ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

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Congenital chloride losing diarrhea: A single center experience in a highly consanguineous population.

Naglaa M Kamal, Hekmat Yaqoub Khan, Mortada H F El-Shabrawi, Laila M Sherief,

Congenital chloride losing diarrhea (CCLD) is a rare type of chronic watery diarrhea due to mutations in SLC26A3 gene leading to defective chloride-bicarbonate exchanges with the resultant loss of chloride and retention of bicarbonate.We aim to define pediatric Saudi CCLD patients' characteristics to achieve prompt diagnosis, management, follow up with ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(22):e15928]

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Pseudo-Bartter syndrome in children with cystic fibrosis.

Mojgan Faraji-Goodarzi,

Cystic fibrosis (CF) is an autosomal recessive genetic disorder. We report a case of a boy aged 4.5 years with cystic fibrosis, presenting under-weightness, hypocalcemia, metabolic alkalosis, hypokalemia, and hyponatremia. Sweat analysis of the patients concluded pseudo-Bartter syndrome, which was successfully treated using antibiotics, physiotherapy, fluids, vitamin supplements, and pancreatic ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(6):1123-1126]

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Cystic fibrosis revisited.

H Kulkarni, S Kansra, S Karande,

J Postgrad Med (Journal of postgraduate medicine)
[2019, 65(4):193-196]

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OUTPATIENT ANALYTIC ASSESSMENT OF ANOREXIA NERVOSA - THE IMPORTANCE OF VENOUS BLOOD GASES.

Sofia Alexandra Pereira Pires, Joana Costa Soares, Alexandra Maria Branco da Luz, Pascoal Moleiro,

OBJECTIVE:To evaluate serum biochemical parameters' evolution, especially venous blood gas (VBG), in anorexia nervosa (AN), correlating with clinical parameters. METHODS:Retrospective study including out-patient AN adolescents, between January 2014 and May 2017. Three evaluations were compared: t1) first consultation; t2) consultation with the lowest body mass index (BMI) z-score and t3) ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018358]

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Clinical Approach to Hypocalcemia in Newborn Period and Infancy: Who Should Be Treated?

Dogus Vuralli,

Introduction:Hypocalcemia is a common metabolic problem in newborn period and infancy. There is consensus on the treatment of the symptomatic cases while the calcium level at which the treatment will be initiated and the treatment options are still controversial in asymptomatic hypocalcemia. Methods:This review article will cover hypocalcemia with specific ... Read more >>

Int J Pediatr (International journal of pediatrics)
[2019, 2019:4318075]

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High blood pressure, a red flag for the neonatal manifestation of urea cycle disorders.

Ulrike Teufel, Peter Burgard, Jochen Meyburg, Martin Lindner, Johannes Poeschl, Peter Ruef, Georg F Hoffmann, Stefan Kölker,

BACKGROUND:Neonatal manifestation of life-threatening hyperammonemic encephalopathy in urea cycle disorders (UCD) is often misdiagnosed as neonatal sepsis, resulting in significantly delayed start of specific treatment and poor outcome. The major aim of this study was to identify specific initial symptoms or signs to clinically distinguish hyperammonemic encephalopathy in neonates from ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2019, 14(1):80]

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Postoperative cerebral oximetry monitoring helps in early detection of diminished flow in Blalock-Taussig shunt.

Abdul Rauf, Reena Khantwal Joshi, Neeraj Aggarwal, Raja Joshi,

Cerebral oximeter is a noninvasive device which provides continuous monitoring of the regional cerebral saturation using near-infrared spectroscopy (NIRS). After gaining popularity as an intraoperative monitoring tool, use of NIRS monitoring has also expanded to postoperative period of congenital heart diseases now. Shunt underflow is a known complication after Blalock-Taussig ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2019, 12(2):169-171]

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Assessment of Metabolic and Nutritional Imbalance in Mechanically Ventilated Multiple Trauma Patients: From Molecular to Clinical Outcomes.

Alexandru Florin Rogobete, Ioana Marina Grintescu, Tiberiu Bratu, Ovidiu Horea Bedreag, Marius Papurica, Zorin Petrisor Crainiceanu, Sonia Elena Popovici, Dorel Sandesc,

The critically ill polytrauma patient is characterized by a series of metabolic changes induced by inflammation, oxidative stress, sepsis, and primary trauma, as well as associated secondary injuries associated. Metabolic and nutritional dysfunction in the critically ill patient is a complex series of imbalances of biochemical and genetic pathways, as ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 9(4):]

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Wilson Disease Comorbid with Hereditary Sensory Autonomic Neuropathy Type IV and Gitelman Syndrome.

Ju Young Kim, Sung Sup Park, Hye Ran Yang,

Wilson disease a rare autosomal recessive inherited disorder of copper metabolism, is characterized by excessive deposition of copper in the liver, brain, and other tissues. Wilson disease is often fatal if it is not recognized early and treated when it is symptomatic. Gitelman syndrome is also an autosomal recessive kidney ... Read more >>

Pediatr Gastroenterol Hepatol Nutr (Pediatric gastroenterology, hepatology & nutrition)
[2019, 22(4):392-399]

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Evaluation and Treatment of Alkalosis in Children.

Matjaž Kopač,

Alkalosis is a disorder of acid-base balance defined by elevated pH of the arterial blood. Metabolic alkalosis is characterized by primary elevation of the serum bicarbonate. Due to several mechanisms, it is often associated with hypochloremia and hypokalemia and can only persist in the presence of factors causing and maintaining ... Read more >>

J Pediatr Intensive Care (Journal of pediatric intensive care)
[2019, 8(2):51-56]

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