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Pediatric Periventricular Leukomalacia

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Neuropathology of Congenital Heart Disease in an Inpatient Autopsy Cohort 2000-2017.

Leigh A Rettenmaier, Patricia A Kirby, Benjamin E Reinking, Angela N Viaene, Marco M Hefti,

Background As a result of medical and surgical advancements in the management of congenital heart disease (CHD), survival rates have improved substantially, which has allowed the focus of CHD management to shift toward neurodevelopmental outcomes. Previous studies of the neuropathology occurring in CHD focused on cases preceding 1995 and reported ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(7):e013575]

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Effect of Earmuffs on Physiological Parameters in Preterm Infants: A Systematic Review.

Serap Ozdemir, Serap Balci,

Noise may cause stress responses such as apnea, hypoxemia, changing in oxygen saturation and augmented oxygen consumption secondary to elevated heart and respiratory rates. Moreover, stress results in increased intracranial pressure, abnormal sleep patterns, hearing impairment, and bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, retardate development and alterations ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2020, :]

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Use of Lipids in Neonates Requiring Parenteral Nutrition.

Girish C Deshpande, Wei Cai,

Neonates have limited antioxidative capacity and are at increased risk of infection and inflammation-a situation that is exacerbated in preterm neonates. Together, oxidative stress and inflammation are implicated in many serious conditions affecting neonates, such as bronchopulmonary dysplasia and periventricular leukomalacia. Neonates requiring parenteral nutrition have certain nutritional requirements. For ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2020, 44 Suppl 1:S45-S54]

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Early predictors of perinatal brain damage: the role of neurobiomarkers.

Iliana Bersani, Francesca Pluchinotta, Andrea Dotta, Immacolata Savarese, Francesca Campi, Cinzia Auriti, Natalia Chuklantseva, Fiammetta Piersigilli, Francesca Gazzolo, Alessandro Varrica, Angela Satriano, Diego Gazzolo,

The early detection of perinatal brain damage in preterm and term newborns (i.e. intraventricular hemorrhage, periventricular leukomalacia and perinatal asphyxia) still constitute an unsolved issue. To date, despite technological improvement in standard perinatal monitoring procedures, decreasing the incidence of perinatal mortality, the perinatal morbidity pattern has a flat trend. Against ... Read more >>

Clin. Chem. Lab. Med. (Clinical chemistry and laboratory medicine)
[2020, 58(4):471-486]

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Changes in Mortality and Cerebral Palsy in Extremely Low-Birth-Weight Infants in a Tertiary Center in Hong Kong.

Yuet Yee Chee, Rosanna Ming Sum Wong, Mabel Siu Chun Wong, Winnie Wan Yee Tso, Wilfred Hing Sang Wong, So Lun Lee,

Introduction. We retrospectively reviewed a cohort of extremely low-birth-weight (ELBW) babies born at Queen Mary Hospital and explored if there is any time trend in survival and short-term neurodevelopmental outcomes. Methods. We included ELBW infants born at Queen Mary Hospital between 2008 and 2015. The relationships between multiple risk factors ... Read more >>

Glob Pediatr Health (Global Pediatric Health)
[2020, 7:2333794X20901932]

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Neonatal Outcomes Following Culture-negative Late-onset Sepsis Among Preterm Infants.

Siyuan Jiang, Zuming Yang, Ruobing Shan, Yi Zhang, Weili Yan, Yi Yang, Prakesh S Shah, Shoo K Lee, Yun Cao, ,

BACKGROUND:Culture-negative late-onset sepsis (LOS) is commonly diagnosed in neonatal intensive care units, while the outcomes of neonatal culture-negative LOS are not reported for large cohorts. This study aimed to examine the incidence and neonatal outcomes for culture-negative LOS in a contemporary multicenter cohort of preterm infants. METHODS:We performed a retrospective ... Read more >>

Pediatr. Infect. Dis. J. (The Pediatric infectious disease journal)
[2020, 39(3):232-238]

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Cognitive Outcomes of Children with Very Low Birth Weight at 3 to 5 Years of Age.

Hee Sun Kim, Ee Kyung Kim, Hyun Kyung Park, Dong Hyun Ahn, Mi Jung Kim, Hyun Ju Lee,

BACKGROUND:The cognitive consequences and risk factors based long-term outcome of very-low-birth-weight (VLBW; < 1,500 g) infants in Korea has not been studied. The aim of this study was to determine the influence of perinatal and neonatal risk factors on the cognitive performance of VLBW children at 3 to 5 years ... Read more >>

J. Korean Med. Sci. (Journal of Korean medical science)
[2020, 35(1):e4]

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Combination of Steroid and Flavonoid for the Treatment of Regressive Autism.

Barış Ekici,

J Neurosci Rural Pract (Journal of neurosciences in rural practice)
[2020, 11(1):216-218]

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Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.

Abdulraoof Almadhoob, Arne Ohlsson,

BACKGROUND:Infants in the neonatal intensive care unit (NICU) are subjected to stress, including sound of high intensity. The sound environment in the NICU is louder than most home or office environments and contains disturbing noises of short duration and at irregular intervals. There are competing auditory signals that frequently challenge ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 1:CD010333]

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Risk factors for BiPAP failure as an initial management approach in moderate to late preterm infants with respiratory distress.

Heekwon Son, Eui Kyung Choi, Kyu Hee Park, Jeong Hee Shin, Byung Min Choi,

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(2):63-65]

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Distinguishing Encephaloclastic Lesions Resulting From Primary or Secondary Pyruvate Dehydrogenase Deficiency From Other Neonatal or Infantile Cavitary Brain Lesions.

Ahmed Gilani, Johan Lk Van Hove, Janet A Thomas, Bette K Kleinschmidt-DeMasters,

The central nervous system (CNS) is a highly complex and energy-dependent organ that is subject to a wide variety of metabolic, hypoxic-ischemic, and infectious insults that result in cystic changes. Diagnosis of metabolic defects causing extensive cystic changes is particularly challenging for the pediatric pathologist, due to the rarity of ... Read more >>

Pediatr. Dev. Pathol. (Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society)
[2019, :1093526619876448]

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Cerebral palsy in children: a clinical overview.

Dilip R Patel, Mekala Neelakantan, Karan Pandher, Joav Merrick,

Cerebral palsy (CP) is a disorder characterized by abnormal tone, posture and movement and clinically classified based on the predominant motor syndrome-spastic hemiplegia, spastic diplegia, spastic quadriplegia, and extrapyramidal or dyskinetic. The incidence of CP is 2-3 per 1,000 live births. Prematurity and low birthweight are important risk factors for ... Read more >>

Transl Pediatr (Translational pediatrics)
[2020, 9(Suppl 1):S125-S135]

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Neurodevelopmental impairment in necrotising enterocolitis survivors: systematic review and meta-analysis.

Andreea Matei, Louise Montalva, Alexa Goodbaum, Giuseppe Lauriti, Augusto Zani,

AIM:To determine (1) the incidence of neurodevelopmental impairment (NDI) in necrotising enterocolitis (NEC), (2) the impact of NEC severity on NDI in these babies and (3) the cerebral lesions found in babies with NEC. METHODS:Systematic review: three independent investigators searched for studies reporting infants with NDI and a history of ... Read more >>

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2019, :]

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Postnatal steroid therapy is associated with autism spectrum disorder in children and adolescents of very low birth weight infants.

Michael Davidovitch, Jacob Kuint, Liat Lerner-Geva, Inna Zaslavsky-Paltiel, Ran Shmuel Rotem, Gabriel Chodick, Varda Shalev, Brian Reichman, ,

BACKGROUND:This study evaluates the association between major neonatal morbidities and autism spectrum disorder (ASD) in children and adolescents born of very low birth weight (VLBW). METHODS:Historical cohort study using the Israel national VLBW infant database linked with the Maccabi Healthcare Services (MHS) medical records. The study cohort comprised 4963 VLBW ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, :]

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Thyroid dysfunction in preterm infants born before 32 gestational weeks.

Hye-Rim Kim, Young Hwa Jung, Chang Won Choi, Hye Rim Chung, Min-Jae Kang, Beyong Il Kim,

BACKGROUND:Thyroid hormones are critical for growth and brain development during the newborn period and infancy. Because of delayed maturation of the hypothalamic-pituitary-thyroid axis in preterm infants, thyroid dysfunction is common, and thyroid stimulating hormone (TSH) elevation is often delayed in preterm infants. The objective of this study was to determine ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):391]

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Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan.

Yuki Matsushita, Yasunari Sakai, Michiko Torio, Hirosuke Inoue, Masayuki Ochiai, Kazuaki Yasuoka, Hiroaki Kurata, Junko Fujiyoshi, Masako Ichiyama, Tomoaki Taguchi, Kiyoko Kato, Shouichi Ohga, ,

OBJECTIVE:To determine clinical features of very low birth weight infants (VLBWIs) who had developed epilepsy by age 3 years. STUDY DESIGN:Multicenter cohort study using the Neonatal Research Network of Japan database. We analyzed clinical variables of 8431 VLBWIs who had recorded data of neurological sequelae at age 3 years. Logistic ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2019, 39(11):1472-1479]

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Niemann-Pick Disease Type C Misdiagnosed as Cerebral Palsy: A Case Report.

Eun Jae Ko, In Young Sung, Han-Wook Yoo,

Niemann-Pick disease type C (NP-C) is a rare autosomal recessive neurovisceral lysosomal lipid storage disorder. The clinical manifestations of the disorder are variable. This report describes the case of a 27-month-old girl with NP-C whose condition had been misdiagnosed as spastic cerebral palsy (CP). She had spasticity, particularly at both ... Read more >>

Ann Rehabil Med (Annals of rehabilitation medicine)
[2019, 43(5):621-624]

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Newborn gender as a predictor of neonatal outcome in mixed gender twins born with very low birth weight.

Bernard Barzilay, Nina Shirman, Haim Bibi, Ibrahim Abu-Kishk,

BACKGROUND:Most studies have revealed that the incidence of morbidity and mortality of preterm male infants is greater than that of preterm female infants. Recently, conflicting outcomes have been reported regarding mixed-gender twins. The aim of this study was to estimate the association between gender and outcome in newborn twins of ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):328]

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The Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Setting.

Ragnhild Støen, Lynn Boswell, Raye-Ann de Regnier, Toril Fjørtoft, Deborah Gaebler-Spira, Espen Ihlen, Cathrine Labori, Marianne Loennecken, Michael Msall, Unn Inger Möinichen, Colleen Peyton, Annamarie Russow, Michael D Schreiber, Inger Elisabeth Silberg, Nils Thomas Songstad, Randi Vågen, Gunn Kristin Øberg, Lars Adde,

BACKGROUND:Early prediction of cerebral palsy (CP) using the General Movement Assessment (GMA) during the fidgety movements (FM) period has been recommended as standard of care in high-risk infants. The aim of this study was to determine the accuracy of GMA, alone or in combination with neonatal imaging, in predicting cerebral ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(11):]

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Short- and Long-Term Outcomes of Extremely Preterm Infants in Japan According to Outborn/Inborn Birth Status.

Yoshihito Sasaki, Kaoru Ishikawa, Akira Yokoi, Tomoaki Ikeda, Kazuo Sengoku, Satoshi Kusuda, Masanori Fujimura,

OBJECTIVES:Outborn (born outside tertiary centers) infants, especially extremely preterm infants, are at an increased risk of mortality and morbidity in comparison to inborn (born in tertiary centers) infants. Extremely preterm infants require not only skilled neonatal healthcare providers but also highly specialized equipment and environment surroundings. Maternal transport at an ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(10):963-969]

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Corticotrophin-releasing hormone stimulation tests in late-onset circulatory collapse.

Hiroko Ueda, Hiroki Kakita, Shintaro Ichimura, Mari Mori, Satoru Takeshita, Tatenobu Goto, Tomoko Kondo, Yasumasa Yamada,

BACKGROUND:Late-onset circulatory collapse (LCC) is the transient development of refractory hypotension and oliguria after the early neonatal period, which may cause periventricular leukomalacia (PVL). The aim of this study was to evaluate the endogenous cortisol response to corticotrophin-releasing hormone (CRH) and determine whether it is effective for elucidating the pathology ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(11):1114-1119]

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Neuroradiological findings in three cases of pontocerebellar hypoplasia type 9 due to AMPD2 mutation: typical MRI appearances and pearls for differential diagnosis.

Elisa Scola, Mario Ganau, Robert Robinson, Maureen Cleary, Laurens J L De Cocker, Kshitij Mankad, Fabio Triulzi, Felice D'Arco,

Pontocerebellar hypoplasia type 9 (PCH9) is a rare autosomal recessive neurodegenerative disorder with prenatal onset caused by mutations in adenosine monophosphate deaminase 2 (AMPD2). PCH9 patients demonstrate severe neurodevelopmental delay with early onset and typical magnetic resonance imaging (MRI) findings consisting in: pontine hypoplasia or atrophy with dragonfly cerebellar atrophy ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2019, 9(12):1966-1972]

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Development of Swallowing Function in Infants with Oral Feeding Difficulties.

Changhun Han, Jaeho Shin, Ga Won Jeon,

Background:Discharge of preterm infants is often delayed because of their oral feeding difficulties. Independent oral feeding is the last obstacle to pass after managing acute and chronic morbidities. We conducted this study to determine the prevalence, characteristics, and risk factors of swallowing dysfunction and suggest proper interventions to reduce aspiration ... Read more >>

Int J Pediatr (International Journal of Pediatrics)
[2020, 2020:5437376]

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Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm.

David Drummond, Alice Hadchouel, Heloise Torchin, Jean-Christophe Rozé, Catherine Arnaud, Adèle Bellino, Laure Couderc, Stéphane Marret, Marie Mittaine, Didier Pinquier, Marie Vestraete, Jessica Rousseau, Pierre-Yves Ancel, Christophe Delacourt, ,

INTRODUCTION:To evaluate the consequences of bronchopulmonary dysplasia (BPD) on academic outcomes and healthcare use in adolescents born very preterm. METHODS:This cohort study included 15-year-old adolescents born very preterm (< 32 weeks) between 2011 and 2013, with and without BPD, and controls born full term. Data regarding academic performance, current medical ... Read more >>

PLoS ONE (PloS one)
[2019, 14(9):e0222286]

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Analyses of pathological cranial ultrasound findings in neonates that fall outside recent indication guidelines: results of a population-based birth cohort: survey of neonates in Pommerania (SNiP-study).

Judith Weise, Matthias Heckmann, Hagen Bahlmann, Till Ittermann, Heike Allenberg, Grzegorz Domanski, Anja Erika Lange,

BACKGROUND:Recent guidelines recommend a cranial ultrasound (CU) in neonates born at < 30 weeks gestation, admitted to the neonatal intensive care unit (NICU), or with a CU indication. Here, we addressed the need to extend these recommendations. METHODS:We retrospectively reviewed 5107 CUs acquired in the population-based Survey of Neonates in Pomerania, conducted ... Read more >>

BMC Pediatr (BMC pediatrics)
[2019, 19(1):476]

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