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Pediatric Partial and Intermediate Atrioventricular Septal Defects

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Percutaneous closure of an acquired and iatrogenic left ventricular-right atrium communication (Gerbode defect) with an Amplatzer Vascular Plug II.

Roberto Mijangos-Vázquez, Rogelio Hernández-Reyes, José R López-Jiménez,

Gerbode defect is defined as an abnormal left ventricle-right atrium shunting which may have congenital or acquired origin, first described by Thurman in 1838, representing 0.08% of intracardiac shunts and <1% of the congenital heart diseases. The acquired defect can be classified as iatrogenic or non-iatrogenic, with previous cardiac surgery ... Read more >>

J Cardiol Cases (Journal of cardiology cases)
[2020, 21(1):24-27]

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Long-term results after surgical repair of atrioventricular septal defect.

Anastasia Schleiger, Oliver Miera, Björn Peters, Katharina R L Schmitt, Peter Kramer, Jelena Buracionok, Peter Murin, Mi-Young Cho, Joachim Photiadis, Felix Berger, Stanislav Ovroutski,

OBJECTIVES:We analysed our 29-year experience of surgical repair of atrioventricular septal defect (AVSD) to define risk factors for mortality and reoperation. METHODS:Between 1988 and 2017, 508 patients received AVSD repair in our institution; 359 patients underwent surgery for complete AVSD, 76 for intermediate AVSD and 73 for partial AVSD. The ... Read more >>

Interact Cardiovasc Thorac Surg (Interactive cardiovascular and thoracic surgery)
[2019, 28(5):789-796]

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Indian guidelines for indications and timing of intervention for common congenital heart diseases: Revised and updated consensus statement of the Working group on management of congenital heart diseases.

Anita Saxena, Jay Relan, Ravi Agarwal, Neeraj Awasthy, Sushil Azad, Manisha Chakrabarty, Kulbhushan S Dagar, Velayoudam Devagourou, Baiju S Dharan, Saurabh K Gupta, Krishna S Iyer, M Jayranganath, Raja Joshi, Brj Kannan, Ashish Katewa, Vikas Kohli, Shyam S Kothari, K M Krishnamoorthy, Snehal Kulkarni, R Manoj Kumar, R Krishna Kumar, Sunita Maheshwari, Krishna Manohar, Ashutosh Marwah, Smita Mishra, Smruti R Mohanty, K Samba Murthy, K Nageswara Rao, P V Suresh, S Radhakrishnan, Palleti Rajashekar, S Ramakrishnan, Nitin Rao, Suresh G Rao, H M Chinnaswamy Reddy, Rajesh Sharma, Krishnanaik Shivaprakash, Raghavan Subramanyan, R Suresh Kumar, Sachin Talwar, Munesh Tomar, Sudeep Verma, R Vijaykumar,

A number of guidelines are available for the management of congenital heart diseases (CHD) from infancy to adult life. However, these guidelines are for patients living in high-income countries. Separate guidelines, applicable to Indian children, are required when recommending an intervention for CHD, as often these patients present late in ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2019, 12(3):254-286]

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Say NO to ROS: Their Roles in Embryonic Heart Development and Pathogenesis of Congenital Heart Defects in Maternal Diabetes.

Anish Engineer, Tana Saiyin, Elizabeth R Greco, Qingping Feng,

Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the development of CHDs, elevating the risk in the child by more than four-fold. As the prevalence of diabetes rapidly rises among ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2019, 8(10):]

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Management of Congenital Heart Disease: State of the Art; Part I-ACYANOTIC Heart Defects.

P Syamasundar Rao,

Since the description of surgery for patent ductus arteriosus in late 1930s, an innumerable number of advances have taken place in the management of congenital heart defects (CHDs). In this review the current status of treatment of seven of the most common acyanotic CHDs was reviewed. The discussion included indications ... Read more >>

Children (Basel) (Children)
[2019, 6(3):]

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The role of microRNAs in congenital heart disease.

Orsolya Nagy, Sándor Baráth, Anikó Ujfalusi,

Congenital heart diseases (CHDs) are the leading inherited cause of perinatal and infant mortality. CHD refers to structural anomalies of the heart and blood vessels that arise during cardiac development and represents a broad spectrum of malformations, including septal and valve defects, lesions affecting the outflow tract and ventricules. Advanced ... Read more >>

EJIFCC (EJIFCC)
[2019, 30(2):165-178]

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Growth patterns and cerebroplacental hemodynamics in fetuses with congenital heart disease.

M J Mebius, S A B Clur, A S Vink, E Pajkrt, W S Kalteren, E M W Kooi, A F Bos, G J du Marchie Sarvaas, C M Bilardo,

OBJECTIVES:Congenital heart disease (CHD) has been associated with reduced fetal head circumference (HC), although the underlying pathophysiology remains undetermined. We aimed to define trends in fetal growth and cerebroplacental Doppler flow, and to investigate their relationship, in fetuses with CHD. METHODS:This was a retrospective study in two fetal medicine units ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2019, 53(6):769-778]

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Consensus Report on Diagnosis, Treatment and Prevention of Infective Endocarditis by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Clinical Microbiology and Infectious Diseases (KLIMIK), Turkish Society of Cardiology (TSC), Turkish Society of Nuclear Medicine (TSNM), Turkish Society of Radiology (TSR), Turkish Dental Association (TDA) and Federation of Turkish Pathology Societies (TURKPATH) Cardiovascular System Study Group.

Serap Şimşek-Yavuz, Ahmet Rüçhan Akar, Sinan Aydoğdu, Denef Berzeg-Deniz, Hakan Demir, Tuncay Hazırolan, Mehmet Ali Özatik, Necla Özer, Murat Sargın, Emine Nursen Topcuoğlu, Nesrin Turhan, Mehmet Birhan Yılmaz, Özlem Azap, Seniha Başaran, Yasemin Çağ, Atahan Çağatay, Güle Çınar, Sibel Doğan-Kaya, Lokman Hızmalı, Mehmet Emirhan Işık, Nirgül Kılıçaslan, Şirin Menekşe, Meliha Meriç-Koç, Serpil Öztürk, Ayfer Şensoy, Yasemin Tezer-Tekçe, Elif Tükenmez-Tigen, Yeşim Uygun-Kızmaz, Mutlu Şeyda Velioğlu-Öcalmaz, Ayşegül Yeşilkaya, Emel Yılmaz, Neziha Yılmaz, Fatma Yılmaz-Karadağ,

Infective endocarditis (IE) is rare, but associated with significant morbidity and mortality rates. Estimates of the incidence of IE in Turkey are compromised by the absence of population-based prospective studies. Due to the frequent presence of predisposing cardiac conditions and higher rates of nosocomial bacteremia in highrisk groups, the incidence ... Read more >>

Turk Gogus Kalp Damar Cerrahisi Derg (Turk gogus kalp damar cerrahisi dergisi)
[2020, 28(1):2-42]

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Long-term outcomes in patients who underwent surgical correction for atrioventricular septal defect.

Özlem Sarısoy, Canan Ayabakan, Kürşad Tokel, Murat Özkan, Rıza Türköz, Sait Aşlamacı,

OBJECTIVE:The follow-up results of patients operated for atrioventricular septal defect (AVSD) during 1996-2016 at Başkent University are presented. METHODS:Data obtained from hospital records consists of preoperative echocardiographic and angiographic details, age and weight at surgery, operative details, Down syndrome presence, postoperative care details, early postoperative and latest echocardiographic findings and ... Read more >>

Anatol J Cardiol (Anatolian journal of cardiology)
[2018, 20(4):229-234]

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Characterization of Patients with Pulmonary Arterial Hypertension: Data from the Polish Registry of Pulmonary Hypertension (BNP-PL).

Grzegorz Kopeć, Marcin Kurzyna, Ewa Mroczek, Łukasz Chrzanowski, Tatiana Mularek-Kubzdela, Ilona Skoczylas, Beata Kuśmierczyk, Piotr Pruszczyk, Piotr Błaszczak, Ewa Lewicka, Danuta Karasek, Katarzyna Mizia-Stec, Michał Tomaszewski, Wojciech Jacheć, Katarzyna Ptaszyńska-Kopczyńska, Małgorzata Peregud-Pogorzelska, Anna Doboszyńska, Agnieszka Pawlak, Zbigniew Gąsior, Wiesława Zabłocka, Robert Ryczek, Katarzyna Widejko-Pietkiewicz, Marcin Waligóra, Szymon Darocha, Michał Furdal, Michał Ciurzyński, Jarosław D Kasprzak, Marek Grabka, Karol Kamiński, Piotr Hoffman, Piotr Podolec, Adam Torbicki,

Current knowledge of pulmonary arterial hypertension (PAH) epidemiology is based mainly on data from Western populations, and therefore we aimed to characterize a large group of Caucasian PAH adults of Central-Eastern European origin. We analyzed data of incident and prevalent PAH adults enrolled in a prospective national registry involving all ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(1):]

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Cardiac Surgery in Patients With Trisomy 13 and 18: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

David S Cooper, Kyle W Riggs, Farhan Zafar, Jeffrey P Jacobs, Kevin D Hill, Sara K Pasquali, Sara K Swanson, Sarah K Gelehrter, Amelia Wallace, Marshall L Jacobs, David L S Morales, Roosevelt Bryant,

Background Congenital heart disease is common in patients with Trisomy 13 (T13) and Trisomy 18 (T18), but offering cardiac surgery to these patients has been controversial. We describe the landscape of surgical management across the United States, perioperative risk factors, and surgical outcomes in patients with T13 and T18. Methods ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(13):e012349]

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Hypertrophic cardiomyopathy: genetics and clinical perspectives.

Cordula Maria Wolf,

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and defined by unexplained isolated progressive myocardial hypertrophy, systolic and diastolic ventricular dysfunction, arrhythmias, sudden cardiac death and histopathologic changes, such as myocyte disarray and myocardial fibrosis. Mutations in genes encoding for proteins of the contractile apparatus of the cardiomyocyte, ... Read more >>

Cardiovasc Diagn Ther (Cardiovascular diagnosis and therapy)
[2019, 9(Suppl 2):S388-S415]

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Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland.

Mehreen Farooqi, John Stickley, Rami Dhillon, David J Barron, Oliver Stumper, Timothy J Jones, Paul F Clift, William J Brawn, Nigel E Drury,

OBJECTIVE:To evaluate time trends in the use of catheter and surgical procedures, and associated survival in isolated congenital shunt lesions. METHODS:Nationwide, retrospective observational study of the UK National Congenital Heart Disease Audit database from 2000 to 2016. Patients undergoing surgical or catheter procedures for atrial septal defect (including sinus venosus ... Read more >>

Heart (Heart (British Cardiac Society))
[2019, 105(14):1103-1108]

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Transposition of the great arteries: A laterality defect in the group of heterotaxy syndromes or an outflow tract malformation?

Rana S Al-Zahrani, Samaher H Alharbi, Rawan M A Tuwaijri, Bayan T Alzomaili, Alaa Althubaiti, Talat Mesud Yelbuz,

Background/Aim:Transposition of the great arteries (TGA) is traditionally classified as a "conotruncal heart defect", implying that TGA evolves from abnormal development of the outflow tract (OFT) of the embryonic heart. However, recently published genetic data suggest that TGA may be linked to laterality gene defects rather than OFT gene defects. ... Read more >>

Ann Pediatr Cardiol (Annals of pediatric cardiology)
[2018, 11(3):237-249]

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Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms.

Madhumita Basu, Vidu Garg,

Congenital heart disease (CHD) is the most common type of birth defect and is both a significant pediatric and adult health problem, in light of a growing population of survivors. The etiology of CHD has been considered to be multifactorial with genetic and environmental factors playing important roles. The combination ... Read more >>

Birth Defects Res (Birth defects research)
[2018, 110(20):1504-1516]

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Cantrell Syndrome-A Rare Complex Congenital Anomaly: A Case Report and Literature Review.

Claudiu Mărginean, Cristina Oana Mărginean, Liliana Gozar, Lorena Elena Meliţ, Horaţiu Suciu, Horea Gozar, Andrada Crişan, Manuela Cucerea,

Cantrell syndrome (CS) or pentalogy of Cantrell is defined as a rare condition involving a midline anterior abdominal wall defect, a distal sternal cleft, a defect of the anterior diaphragm, and a defect of the apical pericardium with pericardio-peritoneal communication, as well as intracardiac anomalies. We report the case of ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2018, 6:201]

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Recent advances in managing septal defects: ventricular septal defects and atrioventricular septal defects.

P Syamasundar Rao, Andrea D Harris,

This review discusses the management of ventricular septal defects (VSDs) and atrioventricular septal defects (AVSDs). There are several types of VSDs: perimembranous, supracristal, atrioventricular septal, and muscular. The indications for closure are moderate to large VSDs with enlarged left atrium and left ventricle or elevated pulmonary artery pressure (or both) ... Read more >>

F1000Res (F1000Research)
[2018, 7:]

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Placental epigenetics for evaluation of fetal congenital heart defects: Ventricular Septal Defect (VSD).

Uppala Radhakrishna, Samet Albayrak, Rita Zafra, Alosh Baraa, Sangeetha Vishweswaraiah, Avinash M Veerappa, Deepthi Mahishi, Nazia Saiyed, Nitish K Mishra, Chittibabu Guda, Rouba Ali-Fehmi, Ray O Bahado-Singh,

Ventricular Septal Defect (VSD), the most common congenital heart defect, is characterized by a hole in the septum between the right and left ventricles. The pathogenesis of VSD is unknown in most clinical cases. There is a paucity of data relevant to epigenetic changes in VSD. The placenta is a ... Read more >>

PLoS ONE (PloS one)
[2019, 14(3):e0200229]

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Study on the Potential Biomarkers of Maternal Urine Metabolomics for Fetus with Congenital Heart Diseases Based on Modified Gas Chromatograph-Mass Spectrometer.

Donghua Xie, Yingchun Luo, Xiyue Xiong, Mingxing Lou, Zhiyu Liu, Aihua Wang, Lili Xiong, Fanjuan Kong, Yichao Wang, Hua Wang,

Background:There has been significant research on the genetic and environmental factors of congenital heart defects (CHDs), but few causes of teratogenicity, especially teratogenic mechanisms, can be clearly identified. Metabolomics has a potential advantage in researching the relationship between external factors and CHD. Objective:To find and identify the urinary potential biomarkers ... Read more >>

Biomed Res Int (BioMed Research International)
[2019, 2019:1905416]

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Cardiac Implantable Electronic Devices (CIEDs).

J Arrhythm (Journal of Arrhythmia)
[2019, 35(Suppl 1):328-472]

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Some Isolated Cardiac Malformations Can Be Related to Laterality Defects.

Paolo Versacci, Flaminia Pugnaloni, Maria Cristina Digilio, Carolina Putotto, Marta Unolt, Giulio Calcagni, Anwar Baban, Bruno Marino,

Human beings are characterized by a left⁻right asymmetric arrangement of their internal organs, and the heart is the first organ to break symmetry in the developing embryo. Aberrations in normal left⁻right axis determination during embryogenesis lead to a wide spectrum of abnormal internal laterality phenotypes, including situs inversus and heterotaxy. ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2018, 5(2):]

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Surgery for partial atrioventricular septal defect with pulmonary hypertension in an adult dog.

Seijirow Goya, Nobuyuki Kanno, Kenji Teshima, Takanori Anndo, Takahiro Fujioka,

A 4-year-old, 5.9-kg female Japanese Spitz presented with syncope and exercise intolerance. Echocardiography revealed an ostium primum atrial septal defect (ASD), a cleft mitral valve, mitral valve regurgitation (MR), and tricuspid regurgitation (TR) (velocity: 3.6 m/sec, pressure gradient: 52 mmHg), leading to a diagnosis of partial atrioventricular septal defect (AVSD) ... Read more >>

J. Vet. Med. Sci. (The Journal of veterinary medical science)
[2018, 80(7):1183-1189]

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Myotonic Dystrophy and Anesthetic Challenges: A Case Report and Review.

Chanchal Mangla, Kimmy Bais, Joel Yarmush,

Providing anesthesia to patients with myotonic dystrophy (DM) can be very challenging due to the multisystemic effects of the disease and extreme sensitivity of these patients to sedatives, opioids, and anesthetic agents. Other factors such as hypothermia, shivering, or mechanical or electric stimulation during surgery can precipitate myotonia which is ... Read more >>

Case Rep Anesthesiol (Case reports in anesthesiology)
[2019, 2019:4282305]

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Impact of Cardiac Risk Factors on Complications Following Cranial Vault Remodeling: Analysis of the 2012 to 2016 National Safety Quality Improvement Program-Pediatric Database.

Marisa Bartz-Kurycki, Shuyan Wei, Karla Bernardi, Joseph K Moffitt, Matthew R Greives,

Congenital cardiac malformations have been reported in 8% of patients with craniosynostosis undergoing cranial vault remodeling (CVR), but associations with surgical outcomes are unknown. This study evaluated postoperative complications in patients who underwent CVR for craniosynostosis with or without cardiac risk factors (CRF) using the National Safety Quality Improvement Program-Pediatric ... Read more >>

J Craniofac Surg (The Journal of craniofacial surgery)
[2019, 30(2):442-447]

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Atrioventricular septal defects.

Sandeep Chauhan,

Ann Card Anaesth (Annals of cardiac anaesthesia)
[2018, 21(1):1-3]

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