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Pediatric Organophosphates Toxicity

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Profile of acute poisoning cases and their outcome in a teaching hospital of north India.

Roshan Mathew, Nayer Jamshed, Praveen Aggarwal, Shivam Patel, R M Pandey,

Objectives:Aim of this study was to characterize acute poisoning and snakebite cases and their outcome in the Emergency Department (ED). Methods:This was a prospective study done in the ED of a tertiary healthcare center. Study included 184 patients of acute poisoning and 16 cases of snakebite. Data regarding demographics, type, ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2019, 8(12):3935-3939]

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Extracorporeal treatment in children with acute severe poisoning.

Xiaomei Sun, Xiuying Chen, Jing Lu, Yuhong Tao, Lijuan Zhang, Liqun Dong,

Acute poisoning in children is a clinical emergency. Prompt and effective treatment is critical for life-threatening poisoning. Extracorporeal treatment (ECTR) is a practical option for enhancing the elimination of poisons.We conducted a retrospective observational study on 338 children with severe acute poisoning who received ECTR during hospitalization from January 2010 ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(47):e18086]

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"That's Not His Regular Formula": A Case of Organophosphate Poisoning in an Infant.

Jeannette Dodson, Sing-Yi Feng, David Rodriguez,

INTRODUCTION:Organophosphates (OPs) are the basis of many insecticides and herbicides and are also used as nerve agents. Approximately 1 million unintentional and 2 million suicidal poisonings as well as more than 300,000 fatalities that are reportedly due to OPs are reported each year worldwide. The mortality rate from OP toxicity ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2019, :]

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The Relationship between Pesticide Exposure and Umbilical Serum IGF-1 Levels and Low-birth Weight: A Case-control Study in Brebes, Indonesia.

Sigit Ambar Widyawati, Suhartono Suhartono, Maria Mexitalia, Ariawan Soejoenoes,

BACKGROUND:Birth weight is very important for long-term physical, mental, health, and brain development. Pesticide exposure is thought to interfere with fetal growth, among others, through disruption of the function of the insulin-like growth hormone-1 (IGF-1) hormone. OBJECTIVE:To analyze the relationship between exposure to pesticides during pregnancy and low-birth weight (LBW) ... Read more >>

Int J Occup Environ Med (The international journal of occupational and environmental medicine)
[2020, 11(1):15-23]

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Status Epilepticus Caused by an Herbicide Poisoning.

Mohammed Sidayne, Adnane Lahlou, Saïd Benlamkaddem, Mohamed Adnane Berdai, Mustapha Harandou,

Triclopyr is a pyridine derivative, widely used as an herbicide. It controls plant growth by interfering with plant growth hormones, auxins. It should have few effects in humans as these are nonexistent in mammals. It can prove however very severe in cases of acute poisoning. ... Read more >>

Case Rep Emerg Med (Case Reports in Emergency Medicine)
[2019, 2019:3014138]

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An epidemiological snapshot of toxicological exposure in children 12 years of age and younger in Riyadh.

Nahar Dakeel Alruwaili, Bachar Halimeh, Mohammed Al-Omar, Badria Alhatali, Ismail Ibrahim Sabie, Mohammed Alsaqoub,

BACKGROUND:Poisoning among the pediatric population is an important public health concern that is responsible for frequent pediatric emergency department visits and hospital admissions. Surveillance of poisoning cases is essential for designing and implementing effective preventive strategies. OBJECTIVE:Describe the characteristics of acute poison exposure and related therapeutic interventions in children aged ... Read more >>

Ann Saudi Med (Annals of Saudi medicine)
[2019, 39(4):229-235]

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Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11.

Jeremiah N Shields, Eric C Hales, Lillian E Ranspach, Xixia Luo, Steven Orr, Donna Runft, Alan Dombkowski, Melody N Neely, Larry H Matherly, Jeffrey Taub, Tracie R Baker, Ryan Thummel,

Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to pesticide exposure warrants further investigation. In the present study, we examined the impact of the carbamate insecticide propoxur on zebrafish ... Read more >>

Toxics (Toxics)
[2019, 7(4):]

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Towards a Multidisciplinary Approach to Improve Cattle Health and Production in Uganda.

José de la Fuente, Marinela Contreras, Paul D Kasaija, Christian Gortazar, Jose F Ruiz-Fons, Rafael Mateo, Fredrick Kabi,

A meeting and course supported by the Vice-Presidency for International Affairs of the Spanish National Research Council (CSIC) and the National Agricultural Research Organization of Uganda (NARO) were held at the National Livestock Resources Research Institute (NaLIRRI) in Nakyesasa, Wakiso, Uganda on September 2-9, 2019. The activities were conducted within ... Read more >>

Vaccines (Basel) (Vaccines)
[2019, 7(4):]

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Organophosphorus-Induced Toxic Myeloneuropathy: Series of Three Adolescent Patients with Short Review.

Priyabrata Nayak, Ashok K Mallick, Shubhankar Mishra, Debasish Panigrahy,

Organophosphate (OP) poisoning is the most common poisoning in India, accounting for almost half of the hospital admissions due to poisoning. Delayed neuropathy is initiated by an attack on a nervous tissue esterase. Although uncommon, delayed neurotoxicity has been consistently reported in literature. This mechanism is implicated not only in ... Read more >>

J Pediatr Neurosci (Journal of pediatric neurosciences)
[2019, 14(1):42-45]

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The First Use of Pralidoxime in a Child With Rivastigmine Poisoning.

Eylem Ulaş Saz, Ali Yurtseven, Mehmet Arda Kilinç, Ferhat Sari, Hasan Ağin,

The aim of this report is to describe the successful use of pralidoxime in a pediatric patient who accidentally ingested 12 mg of rivastigmine and presented to the emergency department with weakness, drowsiness, hyporeactivity to environmental stimuli, and full cholinergic syndrome. CASE:The patient presented to the emergency department 2 hours ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2018, 34(10):e184-e186]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of Medical Toxicology)
[0, :1-53]

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Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries.

Eleni Papadopoulou, Line Småstuen Haug, Amrit Kaur Sakhi, Sandra Andrusaityte, Xavier Basagaña, Anne Lise Brantsaeter, Maribel Casas, Sílvia Fernández-Barrés, Regina Grazuleviciene, Helle Katrine Knutsen, Lea Maitre, Helle Margrete Meltzer, Rosemary R C McEachan, Theano Roumeliotaki, Remy Slama, Marina Vafeiadi, John Wright, Martine Vrijheid, Cathrine Thomsen, Leda Chatzi,

BACKGROUND:Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. OBJECTIVES:Our objective was to study the association between diet and measured blood and urinary levels of environmental contaminants in mother-child pairs from six European birth ... Read more >>

Environ. Health Perspect. (Environmental health perspectives)
[2019, 127(10):107005]

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Insecticide Exposure Triggers a Modulated Expression of ABC Transporter Genes in Larvae of Anopheles gambiae s.s.

Valentina Mastrantonio, Marco Ferrari, Agata Negri, Tommaso Sturmo, Guido Favia, Daniele Porretta, Sara Epis, Sandra Urbanelli,

Insecticides remain a main tool for the control of arthropod vectors. The urgency to prevent the insurgence of insecticide resistance and the perspective to find new target sites, for the development of novel molecules, are fuelling the study of the molecular mechanisms involved in insect defence against xenobiotic compounds. In ... Read more >>

Insects (Insects)
[2019, 10(3):]

Cited: 3 times

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Amitraz Poisoning: The (Un) Common Poisoning.

William Wilson, Shakuntala Murty,

Pesticide poisoning is always a clinical conundrum for the emergency physician (EP), the complexity of which increases when the pesticide has no antidote! Over the past decade, there has been a sharp increase in cases of Amitraz poisoning, a pesticide routinely used in veterinary medicine, available without a prescription. The ... Read more >>

J Emerg Trauma Shock (Journal of emergencies, trauma, and shock)
[2018, 11(2):140-142]

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Rodenticide Poisoning.

Carol D'Silva, Bhuvana Krishna,

How to cite this article: D'Silva C, Krishna B. Rodenticide Poisoning. Indian J Crit Care Med 2019;23(Suppl 4):S272-S277. ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(Suppl 4):S272-S277]

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Several household chemical exposures are associated with pediatric-onset multiple sclerosis.

Soe Mar, Shannon Liang, Michael Waltz, T Charles Casper, Manu Goyal, Benjamin Greenberg, Bianca Weinstock-Guttman, Moses Rodriguez, Gregory Aaen, Anita Belman, Lisa F Barcellos, John Rose, Mark Gorman, Leslie Benson, Meghan Candee, Tanjua Chitnis, Yolanda Harris, Ilana Kahn, Shelly Roalsted, Janace Hart, Timothy Lotze, Manikum Moodley, Jayne Ness, Mary Rensel, Jennifer Rubin, Teri Schreiner, Jan-Mendelt Tillema, Amy Waldman, Lauren Krupp, Jennifer S Graves, Emmanuelle Waubant, ,

Background:There is limited information about the potential associations of multiple sclerosis (MS) and commonly used household chemicals. Methods:We performed a case-control study of exposures to common household chemicals during childhood in children with MS and healthy pediatric controls. Exposures to household products were collected from a comprehensive questionnaire (http://www.usnpmsc.org/Documents/EnvironmentalAssessment.pdf) completed ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2018, 5(12):1513-1521]

Cited: 1 time

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Patterns and epidemiology of acute poisoning in Ethiopia: systematic review of observational studies.

Legese Chelkeba, Abera Mulatu, Dessalegn Feyissa, Firomsa Bekele, Behailu Terefe Tesfaye,

Acute poisoning is a common reason for emergency department visit and hospitalization worldwide with major morbidity and mortality. The burden of poisoning exposures in Africa is a significant public health concern, but only 10 of 58 countries have poisons information centers (PICs).The primary intention of our current review is to ... Read more >>

Arch Public Health (Archives of public health = Archives belges de sante publique)
[2018, 76:34]

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Urinary Pesticide Levels in Children and Adolescents Residing in Two Agricultural Communities in Mexico.

Erick Sierra-Diaz, Alfredo de Jesus Celis-de la Rosa, Felipe Lozano-Kasten, Leonardo Trasande, Alejandro Aarón Peregrina-Lucano, Elena Sandoval-Pinto, Humberto Gonzalez-Chavez,

The use of pesticides in agricultural activities has increased significantly during the last decades. Several studies have reported the health damage that results from exposure to pesticides. In Mexico, hundreds of communities depend economically on agricultural activities. The participation of minors in this type of activity and their exposure to ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(4):]

Cited: 1 time

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Serum Paraoxonase, Arylesterase, and Glutathione-S-Transferase Activities and Oxidative Stress Levels in Patients with Mushroom Poisoning.

Sevki Hakan Eren, Ilhan Korkmaz, Fatma Mutlu Kukul Guven, Yusuf Kenan Tekin, Levent Ozdemir,

OBJECTIVES:Consumption of toxic species of mushrooms may have detrimental effects and increase oxidative stress. Paraoxonase, arylesterase and glutathione-S-transferase are antioxidants that resist oxidative stress. In this study, we analyzed the changes in these enzymes during intoxication due to mushrooms. METHODS:The study enrolled 49 adult patients with a diagnosis of mushroom ... Read more >>

Clinics (Sao Paulo) (Clinics (Sao Paulo, Brazil))
[2018, 73:e16550]

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The patterns of children poisoning cases in community teaching hospital in Riyadh, Saudi Arabia.

Sultan Alghadeer, Manal Alrohaimi, Abeer Althiban, Nora A Kalagi, Bander Balkhi, Anas A Khan,

Although the majority of poisoning-related cases can be managed in home settings, reduction of hospital visits and admissions are still important challenge. Thousands of interventions are involved and the appropriate management of poisoning is therefore a major task and burden to any institution. Therefore, the present study was aimed to ... Read more >>

Saudi Pharm J (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society)
[2018, 26(1):93-97]

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Childhood Ingestions of Environmental Toxins: What Are the Risks?

Marissa Hauptman, Alan D Woolf,

Infants and children are at higher risk than adolescents and adults for exposure to environmental toxins via ingestion for a number of reasons: their smaller size (and proportionately larger dose of ingested toxins), their closer proximity to the ground, dirt, and indoor dust, their boundless curiosity and oral exploratory behaviors, ... Read more >>

Pediatr Ann (Pediatric annals)
[2017, 46(12):e466-e471]

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Age-dependent behaviors, seizure severity and neuronal damage in response to nerve agents or the organophosphate DFP in immature and adult rats.

Erika A Scholl, Stephanie M Miller-Smith, Steven L Bealer, Mark J Lehmkuhle, Jeffrey J Ekstrand, F Edward Dudek, John H McDonough,

Exposure to nerve agents (NAs) and other organophosphates (OPs) can initiate seizures that rapidly progress to status epilepticus (SE). While the electrographic and neuropathological sequelae of SE evoked by NAs and OPs have been characterized in adult rodents, they have not been adequately investigated in immature animals. In this study ... Read more >>

Neurotoxicology (Neurotoxicology)
[2018, 66:10-21]

Cited: 5 times

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Utility of 2-Pyridine Aldoxime Methyl Chloride (2-PAM) for Acute Organophosphate Poisoning: A Systematic Review and Meta-Analysis.

Adam Blumenberg, Roshanak Benabbas, Ian S deSouza, Alyssa Conigliaro, Lorenzo Paladino, Elliot Warman, Richard Sinert, Sage W Wiener,

Organophosphates (OP) account for the majority of pesticide-related unintentional or intentional poisonings in lower- and middle-income countries. The therapeutic role of atropine is well-established for patients with acute OP poisoning. The benefit of adding 2-pyridine aldoxime methyl chloride (2-PAM), however, is controversial. We performed a systematic review and meta-analysis of ... Read more >>

J Med Toxicol (Journal of Medical Toxicology)
[2018, 14(1):91-98]

Cited: 3 times

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Food Additives and Child Health.

Leonardo Trasande, Rachel M Shaffer, Sheela Sathyanarayana, ,

Our purposes with this policy statement and its accompanying technical report are to review and highlight emerging child health concerns related to the use of colorings, flavorings, and chemicals deliberately added to food during processing (direct food additives) as well as substances in food contact materials, including adhesives, dyes, coatings, ... Read more >>

Pediatrics (Pediatrics)
[2018, 142(2):]

Cited: 2 times

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Association of pesticide exposure with human congenital abnormalities.

Charikleia Kalliora, Charalampos Mamoulakis, Eleni Vasilopoulos, George A Stamatiades, Lydia Kalafati, Roza Barouni, Triantafyllia Karakousi, Mohammad Abdollahi, Aristidis Tsatsakis,

Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, ... Read more >>

Toxicol. Appl. Pharmacol. (Toxicology and applied pharmacology)
[2018, 346:58-75]

Cited: 1 time

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