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A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease.

Robert Siblerud, Joachim Mutter, Elaine Moore, Johannes Naumann, Harald Walach,

Mercury is one of the most toxic elements and causes a multitude of health problems. It is ten times more toxic to neurons than lead. This study was created to determine if mercury could be causing Alzheimer's disease (AD) by cross referencing the effects of mercury with 70 factors associated ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(24):]

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Quality of life in long-term survivors of advanced melanoma treated with checkpoint inhibitors.

Maha Mamoor, Michael A Postow, Jessica A Lavery, Shrujal S Baxi, Niloufer Khan, Jun J Mao, Lauren J Rogak, Robert Sidlow, Bridgette Thom, Jedd A Wolchok, Deborah Korenstein,

BACKGROUND:Immune checkpoint inhibitors (CIs) have revolutionized treatment of advanced melanoma, leading to an emerging population of long-term survivors. Survivors' quality of life (QOL) and symptom burden are poorly understood. We set out to evaluate symptom burden and QOL in patients with advanced melanoma alive more than 1 year after initiating CI ... Read more >>

J Immunother Cancer (Journal for immunotherapy of cancer)
[2020, 8(1):]

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Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Anna V Wojcicki, Meena Kadapakkam, Adam Frymoyer, Norman Lacayo, Hee-Don Chae, Kathleen M Sakamoto,

Acute myeloid leukemia (AML) is a clinically and genetically heterogenous malignancy of myeloid progenitor cells that affects patients of all ages. Despite decades of research and improvement in overall outcomes, standard therapy remains ineffective for certain subtypes of AML. Current treatment is intensive and leads to a number of secondary ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

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Teaching an Old Molecule New Tricks: Drug Repositioning for Duchenne Muscular Dystrophy.

Libero Vitiello, Lucia Tibaudo, Elena Pegoraro, Luca Bello, Marcella Canton,

: Duchenne muscular dystrophy (DMD) is one of the most severe forms of inherited muscular dystrophies. The disease is caused by the lack of dystrophin, a structurally essential protein; hence, a definitive cure would necessarily have to pass through some form of gene and/or cell therapy. Cell- and genetic-based therapeutics ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(23):]

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Monitoring Immune Responses in Neuroblastoma Patients during Therapy.

Celina L Szanto, Annelisa M Cornel, Saskia V Vijver, Stefan Nierkens,

Neuroblastoma (NBL) is the most common extracranial solid tumor in childhood. Despite intense treatment, children with this high-risk disease have a poor prognosis. Immunotherapy showed a significant improvement in event-free survival in high-risk NBL patients receiving chimeric anti-GD2 in combination with cytokines and isotretinoin after myeloablative consolidation therapy. However, response ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(2):]

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Surprising Anticancer Activities of Psychiatric Medications: Old Drugs Offer New Hope for Patients With Brain Cancer.

Chuanjun Zhuo, Zhiyuan Xun, Weihong Hou, Feng Ji, Xiaodong Lin, Hongjun Tian, Weifang Zheng, Min Chen, Chuanxin Liu, Wenqiang Wang, Ce Chen,

Despite decades of research and major efforts, malignant brain tumors remain among the deadliest of all cancers. Recently, an increasing number of psychiatric drugs has been proven to possess suppressing activities against brain tumors, and rapid progress has been made in understanding the potential mechanisms of action of these drugs. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2019, 10:1262]

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Gut Microbiota Shapes the Efficiency of Cancer Therapy.

Weidong Ma, Qixing Mao, Wenjie Xia, Gaochao Dong, Changhua Yu, Feng Jiang,

Systems biology provides an opportunity to discover the role that gut microbiota play in almost all aspects of human health. Existing evidence supports the hypothesis that gut microbiota is closely related to the pharmacological effects of chemical therapy and novel targeted immunotherapy. Gut microbiota shapes the efficiency of drugs through ... Read more >>

Front Microbiol (Frontiers in Microbiology)
[2019, 10:1050]

Cited: 3 times

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Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial.

Christoph Beuter, Gisela Volkers, Tatjana Radic, Jutta Goldberg, John van den Anker,

Background:Well-controlled trials of analgesics in the pediatric population are scarce. Tapentadol is a strong centrally acting analgesic which has undergone a pediatric development program investigating its suitability for treating moderate to severe acute pain across the entire pediatric age range from birth to adolescence. Here, we report data from a ... Read more >>

J Pain Res (Journal of Pain Research)
[2019, 12:3099-3112]

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Pain management strategies in penile implantation.

Jeffrey L Ellis, Andrew M Higgins, Jay Simhan,

The opioid epidemic continues to be a serious public health concern. Many have pointed to prescription drug misuse as a nidus for patients to become addicted to opioids and as such, urologists and other surgical subspecialists must critically define optimal pain management for the various procedures performed within their respective ... Read more >>

Asian J. Androl. (Asian journal of andrology)
[2020, 22(1):34-38]

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Monoamine Oxidase-Related Vascular Oxidative Stress in Diseases Associated with Inflammatory Burden.

Adrian Sturza, Călin M Popoiu, Mihaela Ionică, Oana M Duicu, Sorin Olariu, Danina M Muntean, Eugen S Boia,

Monoamine oxidases (MAO) with 2 isoforms, A and B, located at the outer mitochondrial membrane are flavoenzyme membranes with a major role in the metabolism of monoaminergic neurotransmitters and biogenic amines in the central nervous system and peripheral tissues, respectively. In the process of oxidative deamination, aldehydes, hydrogen peroxide, and ... Read more >>

Oxid Med Cell Longev (Oxidative Medicine and Cellular Longevity)
[2019, 2019:8954201]

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Recent Advances on the Anti-Inflammatory and Antioxidant Properties of Red Grape Polyphenols: In Vitro and In Vivo Studies.

Thea Magrone, Manrico Magrone, Matteo Antonio Russo, Emilio Jirillo,

In this review, special emphasis will be placed on red grape polyphenols for their antioxidant and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways responsible for activation of oxidative systems and expression and release of proinflammatory cytokines and chemokines will be discussed. Furthermore, regulation of immune cells by polyphenols ... Read more >>

Antioxidants (Basel) (Antioxidants (Basel, Switzerland))
[2019, 9(1):]

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Prevention, Treatment, and Monitoring of Seizures in the Intensive Care Unit.

Micheal Strein, John P Holton-Burke, LaTangela R Smith, Gretchen M Brophy,

The diagnosis and management of seizures in the critically ill patient can sometimes present a unique challenge for practitioners due to lack of exposure and complex patient comorbidities. The reported incidence varies between 8% and 34% of critically ill patients, with many patients often showing no overt clinical signs of ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 8(8):]

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Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.

Payam Nahid, Sundari R Mase, Giovanni Battista Migliori, Giovanni Sotgiu, Graham H Bothamley, Jan L Brozek, Adithya Cattamanchi, J Peter Cegielski, Lisa Chen, Charles L Daley, Tracy L Dalton, Raquel Duarte, Federica Fregonese, C Robert Horsburgh, Faiz Ahmad Khan, Fayez Kheir, Zhiyi Lan, Alfred Lardizabal, Michael Lauzardo, Joan M Mangan, Suzanne M Marks, Lindsay McKenna, Dick Menzies, Carole D Mitnick, Diana M Nilsen, Farah Parvez, Charles A Peloquin, Ann Raftery, H Simon Schaaf, Neha S Shah, Jeffrey R Starke, John W Wilson, Jonathan M Wortham, Terence Chorba, Barbara Seaworth,

Background: The American Thoracic Society, U.S. Centers for Disease Control and Prevention, European Respiratory Society, and Infectious Diseases Society of America jointly sponsored this new practice guideline on the treatment of drug-resistant tuberculosis (DR-TB). The document includes recommendations on the treatment of multidrug-resistant TB (MDR-TB) as well as isoniazid-resistant but ... Read more >>

Am. J. Respir. Crit. Care Med. (American journal of respiratory and critical care medicine)
[2019, 200(10):e93-e142]

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Internalization, distribution, and activity of peptide H2 against the intracellular multidrug-resistant bovine mastitis-causing bacterium Staphylococcus aureus.

Xiao Wang, Da Teng, Xiumin Wang, Ya Hao, Huixian Chen, Ruoyu Mao, Jianhua Wang,

Bovine mastitis is mainly caused by Staphylococcus aureus, which is difficult to eliminate, prone to escape from antibacterial agents, and may cause recurring infections due to the intracellular nature of its infection and multidrug resistance. In this study, the intracellular activities of the NZ2114 derivative peptide H18R (H2) against methicillin-resistant ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):7968]

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Insights into novel emerging epigenetic drugs in myeloid malignancies.

Namrata S Chandhok, Thomas Prebet,

Epigenetics has been defined as 'a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence' and several epigenetic regulators are recurrently mutated in hematological malignancies. Epigenetic modifications include changes such as DNA methylation, histone modifications and RNA associated gene silencing. Transcriptional regulation, chromosome stability, ... Read more >>

Ther Adv Hematol (Therapeutic advances in hematology)
[2019, 10:2040620719866081]

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Intranasal Esketamine (SpravatoTM) for Use in Treatment-Resistant Depression In Conjunction With an Oral Antidepressant.

Rebecca Bahr, Alicia Lopez, Jose A Rey,

Intranasal esketamine for treatment-resistant depression. ... Read more >>

P T (P & T : a peer-reviewed journal for formulary management)
[2019, 44(6):340-375]

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Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?

Laura Papetti, Fabiana Ursitti, Romina Moavero, Michela Ada Noris Ferilli, Giorgia Sforza, Samuela Tarantino, Federico Vigevano, Massimiliano Valeriani,

Migraine is a frequent and very disabling disease, especially at pediatric age. Despite this, there are few controlled data on the prophylactic treatment of primary headaches in this category of age. Given that the recently introduced calcitonin gene-related peptide (CGRP) inhibitors (CGRP-r) are still limited to adulthood, there is no ... Read more >>

Front Neurol (Frontiers in Neurology)
[2019, 10:771]

Cited: 1 time

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Sudden Sensorineural Hearing Loss in Children: Clinical Characteristics, Etiology, Treatment Outcomes, and Prognostic Factors.

Yuqing Lu, Liangqiang Zhou, Tejvansh Shenoy Imrit, Aiguo Liu,

OBJECTIVE:To investigate the clinical characteristics, etiology, treatment outcomes, and prognostic factors of sudden sensorineural hearing loss (SSNHL) in children to guide the clinical diagnosis and treatment of SSNHL in the pediatric population. STUDY DESIGN:Retrospective case review. SETTING:Tertiary referral center. PATIENTS:Patients diagnosed with SSNHL from November 2011 to December 2017 with ... Read more >>

Otol. Neurotol. (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology)
[2019, 40(4):446-453]

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Targeting the Immune system and Epigenetic Landscape of Urological Tumors.

João Lobo, Carmen Jerónimo, Rui Henrique,

In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic (chemo)therapies, given the associated short- and long-term side effects, by introducing more specific targeted therapies as single or combination agents. ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(3):]

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Sorcin: a novel potential target in therapies of cancers.

Xinyi Zhou, Xue Wu, Baoan Chen,

Soluble resistance-related calcium-binding protein (sorcin) is a member of the penta-EF-hand protein family. Sorcin is widely distributed in normal human tissues, such as the brain, heart, lymphocytes, kidneys, breast and skin. Findings suggest that sorcin is associated with the regulation of calcium homeostasis, cell cycle and vesicle trafficking. It has ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:7327-7336]

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Use of Prescribed Psychotropics during Pregnancy: A Systematic Review of Pregnancy, Neonatal, and Childhood Outcomes.

Catherine E Creeley, Lisa K Denton,

This paper reviews the findings from preclinical animal and human clinical research investigating maternal/fetal, neonatal, and child neurodevelopmental outcomes following prenatal exposure to psychotropic drugs. Evidence for the risks associated with prenatal exposure was examined, including teratogenicity, neurodevelopmental effects, neonatal toxicity, and long-term neurobehavioral consequences (i.e., behavioral teratogenicity). We conducted ... Read more >>

Brain Sci (Brain sciences)
[2019, 9(9):]

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LSD1/KDM1A, a Gate-Keeper of Cancer Stemness and a Promising Therapeutic Target.

Panagiotis Karakaidos, John Verigos, Angeliki Magklara,

A new exciting area in cancer research is the study of cancer stem cells (CSCs) and the translational implications for putative epigenetic therapies targeted against them. Accumulating evidence of the effects of epigenetic modulating agents has revealed their dramatic consequences on cellular reprogramming and, particularly, reversing cancer stemness characteristics, such ... Read more >>

Cancers (Basel) (Cancers)
[2019, 11(12):]

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Pediatrics and GUCHs.

J Arrhythm (Journal of Arrhythmia)
[2019, 35(Suppl 1):693-711]

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Increase expression of CD177 in Kawasaki disease.

Ying-Hsien Huang, Mao-Hung Lo, Xin-Yuan Cai, Shih-Feng Liu, Ho-Chang Kuo,

BACKGROUND:Kawasaki disease (KD) is the most common acute coronary vasculitis disease to occur in children. Its incidence has been attributed to the combined effects of infection, genetics, and immunity. Although the etiopathogenesis of KD remains unknown, we have performed a survey of global genetic DNA methylation status and transcripts expression ... Read more >>

Pediatr Rheumatol Online J (Pediatric rheumatology online journal)
[2019, 17(1):13]

Cited: 1 time

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Epigenetic Targeting of Glioblastoma.

Massimo Romani, Maria Pia Pistillo, Barbara Banelli,

Glioblastoma is one of the first tumors where the biological changes accompanying a single epigenetic modification, the methylation of the MGMT gene, were found to be of clinical relevance. The exploration of the epigenomic landscape of glioblastoma has allowed to identify patients carrying a diffuse hypermethylation at gene promoters and ... Read more >>

Front Oncol (Frontiers in oncology)
[2018, 8:448]

Cited: 9 times

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