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Pediatric Metabolic Alkalosis

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A rare case of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Answers.

Pediredla Karunakar, Sriram Krishnamurthy, Aakash Chandran Chidambaram, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Sambandan Kumaravel, Bheemanathi Hanuman Srinivas, Biswajit Dubashi,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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A rare cause of severe hypertension with hypokalemic metabolic alkalosis in a 14-year-old girl: Questions.

Pediredla Karunakar, Sriram Krishnamurthy, Aakash Chandran Chidambaram, Jayaprakash Sahoo, Sadishkumar Kamalanathan, Sambandan Kumaravel, Bheemanathi Hanuman Srinivas, Biswajit Dubashi,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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A Delphi Analysis to Reach Consensus on Preoperative Care in Infants with Hypertrophic Pyloric Stenosis.

Fenne A I M van den Bunder, Nigel J Hall, L W Ernest van Heurn, Joep P M Derikx,

INTRODUCTION: Infantile hypertrophic pyloric stenosis (IHPS) is a common gastrointestinal condition that can lead to metabolic alkalosis and, if uncorrected, to respiratory complications. A standardized approach to correct metabolic derangements and dehydration may reduce time until pyloromyotomy while preventing potential respiratory complications. Such an evidence-based policy regarding preoperative care is absent. ... Read more >>

Eur J Pediatr Surg (European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie)
[2020, :]

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Improvement Of Congenital Chloride Diarrhea With Corticosteroids: An Incidental Finding.

Ehsan Valavi, Hazhir Javaherizadeh, Mehran Hakimzadeh, Parisa Amoori,

Congenital chloride diarrhea of infancy is a life threatening disease. We discuss two boys with congenital chloride diarrhea over a long time period before and after kidney transplantation. In the first case, prenatal sonography revealed polyhydramnios and generalized bowel loop distention. The genetic study confirmed congenital chloride diarrhea of infancy. ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2019, 10:153-156]

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Connecting two worlds: positive correlation between physicochemical approach with blood gases and pH in pediatric ICU setting.

Chanapai Chaiyakulsil, Papope Mueanpaopong, Rojjanee Lertbunrian, Somchai Chutipongtanate,

OBJECTIVE:Physicochemical approach such as strong ion difference provides a novel concept in understanding and managing acid-base disturbance in patients. However, its application in pediatrics is limited. This study aimed to evaluate a correlation between the physicochemical approach and blood gas pH for acid-base determination in critically ill pediatric patients. RESULTS:A ... Read more >>

BMC Res Notes (BMC research notes)
[2019, 12(1):742]

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Hypokalemia and hearing loss in a 3-year-old boy: Questions.

Ozlem Yuksel Aksoy, Fatma Semsa Cayci, Serdar Ceylaner, Sibel Alicura Tokgoz, Gunay Kaplan, Umut Selda Bayrakci,

Bartter syndrome with sensorineural deafness (Bartter syndrome type 4) is an autosomal recessive disorder characterized with polyhydramniosis, premature birth, massive polyuria, renal salt-wasting, hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and hearing loss. Homozygous mutations in BSND, CLCNKA, and CLCNKB mutations cause the disorder. Here we report a 3-year-old boy who ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):615]

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Diuretic Use and Subsequent Electrolyte Supplementation in a Level IV Neonatal Intensive Care Unit.

Lauren L Dartois, Claire Levek, Theresa R Grover, Michael E Murphy, Emma L Ross,

OBJECTIVES:To evaluate the relationship between diuretic use, serum electrolyte concentrations, and supplementation requirements in infants admitted to the neonatal intensive care unit. METHODS:This was a single-center retrospective cohort study conducted in a freestanding children's hospital Level IV NICU. Data were collected for all infants younger than 6 months, admitted to ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(2):124-130]

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Critical Care Education Day: A Novel, Multidisciplinary, and Interactive Critical Care Education Session for Emergency Medicine Residents.

Natalie N Htet, Alexandra June Gordon, Tsuyoshi Mitarai,

Critical care medicine (CCM) is central to emergency medicine (EM) resident education. We feel that the traditional lecture format is not the ideal way to teach EM critical care, which requires integration and prioritization of diagnostic workup and team-based resuscitation under time pressure. We describe a novel critical care education day where ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6785]

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Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl.

Gowri Shankar Barathidasan, Sriram Krishnamurthy, Pediredla Karunakar, Ranjitha Rajendran, Kagnur Ramya, Gunasekaran Dhandapany, Jaikumar Govindaswamy Ramamoorthy, Rajesh Nachiappa Ganesh,

An 8-year-old girl with recently diagnosed Systemic Lupus Erythematosus (SLE) (class 4 lupus nephritis with autoimmune hemolytic anemia) presented to the pediatric nephrology clinic with polyuria, tiredness and cramps; laboratory investigations revealed refractory hypokalemia, hypomagnesemia, metabolic alkalosis, hypocalciuria and hyperchloriuria. There was no history of diuretic administration. These features were ... Read more >>

CEN Case Rep (CEN case reports)
[2019, :]

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Bartter and Gitelman syndromes: Questions of class.

Martine T P Besouw, Robert Kleta, Detlef Bockenhauer,

Bartter and Gitelman syndromes are rare inherited tubulopathies characterized by hypokalaemic, hypochloraemic metabolic alkalosis. They are caused by mutations in at least 7 genes involved in the reabsorption of sodium in the thick ascending limb (TAL) of the loop of Henle and/or the distal convoluted tubule (DCT). Different subtypes can ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, :]

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Inherited salt-losing tubulopathy: an old condition but a new category of tubulopathy.

Kandai Nozu, Tomohiko Yamamura, Tomoko Horinouchi, China Nagano, Nana Sakakibara, Kenji Ishikura, Riku Hamada, Naoya Morisada, Kazumoto Iijima,

Bartter syndrome (BS) and Gitelman syndrome (GS) are syndromes associated with congenital tubular dysfunction characterized by hypokalemia and metabolic alkalosis. Clinically, BS is classified into two types: the severe antenatal/neonatal type, which develops during the fetal period with polyhydramnios and preterm delivery; and the relatively mild classical type, which is ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, :]

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Recurrent Metabolic Alkalosis in a Cystic Fibrosis Patient: Coexistence with Congenital Chloride Diarrhea.

Etna Masip, Ester Donat, Begoña Polo, Silvestre Oltra, Pedro Ortega, Carmen Ribes-Koninckx,

Metabolic alkalosis is uncommon in infancy. Cystic fibrosis (CF) patients can develop dehydration because of sweat salt or gastrointestinal losses; with the correct salt supplementation, the electrolyte alterations can be reversed. Here, we present a CF patient with recurrent metabolic alkalosis, initially oriented as pseudo-Bartter's syndrome. However, despite accurate treatment, ... Read more >>

J Pediatr Genet (Journal of pediatric genetics)
[2020, 9(1):44-47]

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Fatal Course of a Male Newborn with Double Duodenal Atresia.

Ahmed Elrouby, Ahmed Koraitim,

Multiple point duodenal atresia is an extremely rare condition with atretic segments in either two or three sites of the duodenum. We report a newborn male patient who presented to our institution with bilious vomiting, nonpassage of meconium, mild abdominal distension, and a palpable epigastric abdominal mass ∼1 × 1 cm. A faint ... Read more >>

European J Pediatr Surg Rep (European journal of pediatric surgery reports)
[2020, 8(1):e7-e9]

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Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity.

Xin He, Zubin Modi, Tobias Else,

Secondary hypertension is a common condition with a broad differential diagnosis. Identification of the true cause of hypertension can be critical for guiding appropriate management. Here, we review hereditary conditions underlying the most common cause of secondary hypertension, primary aldosteronism, as well as other disorders impacting various levels of mineralocorticoid ... Read more >>

Gland Surg (Gland surgery)
[2020, 9(1):150-158]

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Use of Sodium Bicarbonate During Pediatric Cardiac Admissions with Cardiac Arrest: Who Gets It and What Does It Do?

Rohit S Loomba, Mubbasheer Ahmed, Mubeena Abdulkarim, Enrique G Villarreal, Saul Flores,

The objectives of this study were to characterize the use of sodium bicarbonate in pediatric cardiac admissions that experience cardiac arrest, to determine sodium bicarbonate use over the years, and to determine the impact of sodium bicarbonate on length of admissions, billed charges, and inpatient mortality. A cross-sectional study was ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2019, 6(12):]

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Antenatal Bartter Syndrome Caused by a Novel Homozygous Mutation in SLC12A1 Gene.

Filiz Aktürk Acar, Güneş Işik, Mehmet Mutlu, Şebnem Kader, Yakup Aslan, Mukaddes Kalyoncu,

Antenatal Bartter syndrome (BS) is an autosomal recessive hereditary renal tubular disorder caused by mutation in the solute carrier family 12 member 1 (SLC12A1) gene on chromosome 15q21.1. This syndrome is characterized by polyuria, hyponatremia, hypokalemic hypochloremic metabolic alkalosis, and hypercalciuria associated with increased urinary loss of electrolytes. Herein, we ... Read more >>

Indian J Nephrol (Indian journal of nephrology)
[2019, 29(5):360-363]

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Hyponatremia in infants with community-acquired infections on hospital admission.

Marta B Mazzoni, Gregorio P Milani, Silvia Bernardi, Ludovica Odone, Alessia Rocchi, Emanuela A D'Angelo, Marco Alberzoni, Carlo Agostoni, Mario G Bianchetti, Emilio F Fossali,

Acute moderate to severe gastroenteritis is traditionally associated with hypernatremia but recent observations suggest that hypernatremia is currently less common than hyponatremia. The latter has sometimes been documented also in children with acute community-acquired diseases, such as bronchiolitis and pyelonephritis. We investigated the prevalence of dysnatremia in children with acute ... Read more >>

PLoS ONE (PloS one)
[2019, 14(7):e0219299]

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Gitelman syndrome combined with growth hormone deficiency: Three cases report.

Ke Huang, Yang-Li Dai, Jian-Wei Zhang, Li Zhang, Wei Wu, Guan-Ping Dong, Rahim Ullah, Yue Fei, Jun-Fen Fu,

RATIONALE:Gitelman syndrome (GS) is a rare autosomal recessive hereditary salt-losing tubulopathy caused by loss-of-function mutations in the SLC12A3 gene. It is usually characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria. There are only a few reports on GS combined with growth hormone deficiency (GHD). PATIENT CONCERNS:Three patients presented with weakness, ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(40):e17244]

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A rare cause of hypertension in childhood: Questions.

Nuran Kucuk, Zehra Yavas Abali, Saygın Abali, Nur Canpolat, Gozde Yesil, Serap Turan, Abdullah Bereket, Tulay Guran,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(1):77-78]

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The utility of next generation sequencing in the correct diagnosis of congenital hypochloremic hypokalemic metabolic alkalosis.

Yael Ben-David, Rephael Halevy, Waheeb Sakran, Yoav Zehavi, Ronen Spiegel,

Persistent hypokalemic hypochloremic metabolic alkalosis represents a heterogeneous group of genetic disorders of which the most common is Bartter syndrome (BS). BS is an inherited renal tubulopathy caused by defective salt reabsorption in the thick ascending loop of Henle, which results in persistent hypokalemic hypochloremic metabolic alkalosis. Here we report ... Read more >>

Eur J Med Genet (European journal of medical genetics)
[2019, 62(10):103728]

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Acute Kidney Injury Following High-Dose Methotrexate Administration in a Day Care Hospital.

Srimanta Chandra Misra, Alberto Santagostino, Gerard Dine, Larence Bonhomme Faivre,

Day care is a potential alternative to inpatient care of cancer patients. Using day care reduces medical costs substantially compared to inpatient care, which is driving the transfer of many inpatient chemotherapy protocols to day care hospitals (DCHs). However, in contrast to inpatient management, day care provides limited observation time, ... Read more >>

Drug Saf Case Rep (Drug safety - case reports)
[2019, 6(1):12]

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Comparison of laparoscopic and open pyloromyotomy: Concerns for omental herniation at port sites after the laparoscopic approach.

Fenne A I M van den Bunder, Ernest van Heurn, Joep P M Derikx,

Pyloromyotomy is a common surgical procedure in infants with hypertrophic pyloric stenosis and can be performed with a small laparotomy or laparoscopically. No specific complications have been documented about one of the approaches. We aim to study (severity of) complications of pyloromyotomy and to compare complications of both approaches. Children ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):363]

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Adequacy of Preoperative Resuscitation in Laparoscopic Pyloromyotomy and Anesthetic Emergence.

Laura E Gilbertson, Christopher S Fiedorek, Michael C Fiedorek, Humphrey Lam, Thomas M Austin,

BACKGROUND:Pyloromyotomy is one of the most common surgical procedures performed on otherwise healthy infants. Pyloric stenosis results in a hypochloremic, hypokalemic metabolic alkalosis that is considered a medical emergency. This alkalotic state is believed to be associated with an increased incidence of apneic episodes. Because apnea tends to occur during ... Read more >>

Anesth. Analg. (Anesthesia and analgesia)
[2019, :]

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Recommendations for Therapeutic Apheresis by the Section "Preparative and Therapeutic Hemapheresis" of the German Society for Transfusion Medicine and Immunohematology.

Nina Worel, Behrouz Mansouri Taleghani, Erwin Strasser,

The section "Preparative and Therapeutic Hemapheresis" of the German Society for Transfusion Medicine and Immunohematology (DGTI) has reviewed the actual literature and updated techniques and indications for evidence-based use of therapeutic apheresis in human disease. The recommendations are mostly in line with the "Guidelines on the Use of Therapeutic Apheresis ... Read more >>

Transfus Med Hemother (Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie)
[2019, 46(6):394-406]

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Should isolated Pseudo-Bartter syndrome be considered a CFTR-related disorder of infancy?

Piercarlo Poli, Domenico Umberto De Rose, Silviana Timpano, Gianfranco Savoldi, Rita Padoan,

BACKGROUND:Infants that are negative to cystic fibrosis (CF) newborn screening (NBS) programs, or in countries without NBS, may present with metabolic alkalosis and severe salt depletion, a well-known clinical manifestation of CF termed Pseudo-Bartter syndrome (PBS). Here, we report the cases of three CF-negative children, who carry rare mutations in ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2019, 54(10):1578-1583]

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