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Pediatric Metabolic Acidosis

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Timing of initiation of renal replacement therapy in acute kidney injury: an updated meta-analysis of randomized controlled trials.

Ling Zhang, Dezheng Chen, Xin Tang, Peiyun Li, Yong Zhang, Ye Tao,

Purpose: The results from randomized controlled trials (RCTs) concerning the timing of initiation of renal replacement therapy (RRT) for patients with acute kidney injury (AKI) are still inconsistent.Materials and methods: We searched for RCTs, as well as relevant references, focusing on the timing of RRT for AKI patients in the ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):77-88]

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Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.

Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana,

Background: Lesch-Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.Case report: A 15-year-old male who had been diagnosed with cerebral palsy was referred to our hospital due to renal failure ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):113-121]

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Incomplete distal renal tubular acidosis in children.

Marta Alonso-Varela, Helena Gil-Peña, Fernando Santos,

AIM:To describe incomplete distal renal tubular acidosis (iDRTA) in pediatric patients, a term used for the diagnosis of patients who do not develop spontaneous overt metabolic acidosis but are unable to acidify the urine in response to an ammonium chloride load. METHODS:Tests used to explore urinary acidification were revised. In ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, :]

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Extracorporeal Membrane Oxygenation in Pediatric Pulmonary Hypertension.

Emily Morell, Satish K Rajagopal, Peter Oishi, Ravi R Thiagarajan, Jeffrey R Fineman, Martina A Steurer,

OBJECTIVE:To describe the epidemiology, critical care interventions, and mortality of children with pulmonary hypertension receiving extracorporeal membrane oxygenation. DESIGN:Retrospective analysis of prospectively collected multicenter data. SETTING:Data entered into the Extracorporeal Life Support Organization database between January 2007 and November 2018. PATIENTS:Pediatric patients between 28 days and 18 years old with ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, 21(3):256-266]

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Thoracoscopic Repair of Congenital Diaphragmatic Hernia.

Richard Wagner, Steffi Mayer, Xiaoyan Feng, Jan-Hendrik Gosemann, Peter Zimmermann, Martin Lacher,

The surgical management of patients with congenital diaphragmatic hernia (CDH) is challenging and ever changing. It requires the highest expertise not only on the surgical level but also of neonatologists and anesthesiologists. In selected patients traditional open surgery is increasingly replaced by thoracoscopic CDH repair in many centers worldwide. Despite ... Read more >>

Eur J Pediatr Surg (European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie)
[2020, :]

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Difference in the Duration of Pediatric Diabetic Ketoacidosis: Comparison of New-onset to Known Type 1 Diabetes.

Leonardo Valero-Guzmán, Pablo Vásquez-Hoyos, Jhon Camacho-Cruz, Luis Carlos Maya-Hijuelos, Susan Martínez-Lozada, Ana María Rubiano-Acevedo, Marleny Lara-Bernal, Tomas Diaz-Angarita,

OBJECTIVE:To compare the duration (hours until HCO3 -  ≥ 15 mmol/L) of diabetic ketoacidosis (DKA) episodes that are the first manifestation of new type 1 diabetes (NT1D) and those that are a complication in patients with known type 1 diabetes (PT1D). METHODS:A multicenter retrospective cohort study was designed. The duration of DKA ... Read more >>

Pediatr Diabetes (Pediatric diabetes)
[2020, :]

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Ketoacidosis in type 1 diabetics: we should return to pediatric guidelines.

Sébastien Redant, David De Bels, Jacques Massaut, Jacques Devriendt, Xavier Beretta-Piccoli, Rachid Attou, Patrick M Honore,

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):19]

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Genetic Testing in Pediatric Kidney Disease.

Veronica Arora, Kanav Anand, Ishwar Chander Verma,

The advent of next gene sequencing technology has led to the publication of a profusion of papers on monogenic contributions to pediatric kidney disorders. It started with the discovery of mutations in the podocin gene in steroid resistant nephrotic syndrome (SRNS). It is realized now that genetic disorders contribute to ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2020, :]

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Factors Associated With Cerebral Edema at Admission in Indian Children with Diabetic Ketoacidosis.

N Agarwal, C Dave, R Patel, R Shukla, R Kapoor, A Bajpai,

OBJECTIVE:To evaluate the time course and predictors of cerebral edema in diabetic ketoacidosis (DKA). METHODS:Review of hospital records of 107 episodes of DKA between January 2013 to March 2019. RESULTS:Cerebral edema was identified in 26 (24.3%; 22 at presentation and 4 during treatment). Cerebral edema at presentation was associated with ... Read more >>

Indian Pediatr (Indian pediatrics)
[2020, :]

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Suspected propofol infusion syndrome during normal targeted propofol concentration.

Taku Ichikawa, Keiko Okuyama, Kotoe Kamata, Kenichi Masui, Makoto Ozaki,

To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown. Moreover, there is no widely accepted definition of PRIS, even though it is a potentially fatal condition. While many suspected cases of PRIS have been reported in both pediatric and adult populations, the actual propofol ... Read more >>

J Anesth (Journal of anesthesia)
[2020, :]

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Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement.

Kunling Shen, Yonghong Yang, Tianyou Wang, Dongchi Zhao, Yi Jiang, Runming Jin, Yuejie Zheng, Baoping Xu, Zhengde Xie, Likai Lin, Yunxiao Shang, Xiaoxia Lu, Sainan Shu, Yan Bai, Jikui Deng, Min Lu, Leping Ye, Xuefeng Wang, Yongyan Wang, Liwei Gao,

Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City, China, by January 30, 2020, a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China. Among the confirmed cases, 1527 were severe cases, 171 had recovered and been ... Read more >>

World J Pediatr (World Journal of Pediatrics)
[0, :1-9]

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Prevalence and clinical profile of glycogen storage diseases in children from Western India.

Ira Shah, Drishti Tolani, Naman S Shetty, Vishrutha Karkare,

Aim of the study:To determine the prevalence and clinical profile of glycogen storage diseases (GSD) in children in western India. Material and methods:This retrospective analysis was conducted over a period of 7 years from 2006 to 2012. All children diagnosed with GSD on liver biopsy were included in the study. ... Read more >>

Clin Exp Hepatol (Clinical and experimental hepatology)
[2020, 6(1):9-12]

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Early Recognition and Treatment of Malignant Hyperthermia in Pediatric Patient during Bronchoscopy.

Warangkana Lapisatepun, Supawan Arkarattanakul,

Malignant hyperthermia is a rare pharmacogenetic disorder triggered by depolarizing muscle relaxant and potent volatile anesthetic agents. An MH crisis is an emergency and life-threatening event requiring early recognition and prompt management. Dantrolene is the specific antagonist of MH. The authors report the case of a 9-year-old boy who underwent ... Read more >>

Case Rep Anesthesiol (Case reports in anesthesiology)
[2020, 2020:6562896]

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Critical Care Education Day: A Novel, Multidisciplinary, and Interactive Critical Care Education Session for Emergency Medicine Residents.

Natalie N Htet, Alexandra June Gordon, Tsuyoshi Mitarai,

Critical care medicine (CCM) is central to emergency medicine (EM) resident education. We feel that the traditional lecture format is not the ideal way to teach EM critical care, which requires integration and prioritization of diagnostic workup and team-based resuscitation under time pressure. We describe a novel critical care education day where ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6785]

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Iron Packaging Regulations in the United States and Pediatric Morbidity: A Retrospective Cohort Study.

James B Leonard, Elizabeth Quaal Hines, Wendy Klein-Schwartz,

Iron poisoning was a leading cause of pediatric morbidity and mortality. We sought to assess whether the removal of strict iron packaging requirements in 2003 resulted in an increase in iron-related morbidity and mortality in pediatric exposures. We performed a retrospective cohort study utilizing the National Poison Data System from ... Read more >>

Clin Pediatr (Phila) (Clinical pediatrics)
[2020, :9922819901010]

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Challenges in the management of an ignored cause of hyperammonemic encephalopathy: pyruvate carboxylase deficiency.

Melis Demir Köse, Ruya Colak, Ezgi Yangin Ergon, Ferit Kulali, Meral Yildiz, Senem Alkan, Taner Atilgan, Fatma Aslan, Ruth Brown, Garry Brown, Erkin Serdaroğlu, Sebnem Çalkavur,

Pyruvate carboxylase (PC) deficiency is a rare autosomal recessive disease and provides clinics in three essential phenotypes. Type B PC deficiency is characterized by lactic acidosis and hyperammonemia. We report a Turkish patient who was diagnosed with type B PC deficiency. Despite the application of anaplerotic treatment with biotin, citrate ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, :]

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MALIGNANT HYPERTHERMIA IN A CHILD AFTER MAGNETIC RESONANCE IMAGING: A CASE REPORT.

Carlos Gustavo de Almeida, José Colleti Junior,

OBJECTIVE:To report on a case of malignant hyperthermia in a child after a magnetic resonance imaging of the skull was performed using sevoflurane anesthesia. CASE DESCRIPTION:A 3-year-old boy admitted to the pediatric intensive care unit after presenting clinical and laboratory findings consistent with unspecified viral meningoencephalitis. While the patient was ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018267]

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Milrinone Use in Persistent Pulmonary Hypertension of the Newborn.

Amna Qasim, Sunil K Jain,

Failure of the normal transition from in utero to ex utero physiology leads to "persistent" pulmonary hypertension of the newborn (PPHN). PPHN is frequently associated with low systemic blood pressure and low cardiac output because of increased right ventricular afterload and myocardial dysfunction. The general management of newborns with PPHN ... Read more >>

Neoreviews (NeoReviews)
[2020, 21(3):e165-e178]

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The factors relevant to partial remission in children with type 1 diabetes mellitus after measles vaccination: A retrospective study.

Gonca Bektaş, Hasan Önal, Erdal Adal,

We aimed to identify the determinants of partial remission in patients with type 1 diabetes mellitus (DM), and whether there is an influence of vaccination against measles on partial remission. This was a retrospective study consisting of consecutive patients diagnosed with type 1 DM followed-up from 1 September 2010, through ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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First definition of burned choroid plexus in acidic cerebrospinal fluid-filled brain ventricles during subarachnoid hemorrhage: Experimental study.

Tuba Demirci, Mehmet D Aydin, Ozgur Caglar, Nazan Aydin, Sevilay Ozmen, Kemal A Nalci, Ali Ahiskalioglu, Mehmet N Kocak, Sait Keles,

Blood and cerebrospinal fluid (CSF) acidosis is the most troubling complication in subarachnoid hemorrhage (SAH) if carotid body (CB) networks are disrupted. However, histopathological examination of the choroid plexus (CP) in acidic CSF has not been evaluated so far. In this study, we aimed to investigate the CP in acidic ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2020, :]

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The Influence of Chloride for the Interpretation of Plasma Bicarbonate During the Treatment of Diabetic Ketoacidosis.

Juan Pablo Ferreira, Magali Hamui, Milagros Torrents, Romina Carrano, Mabel Ferraro, Ismael Toledo,

INTRODUCTION:Hyperchloremic metabolic acidosis can occur in diabetic ketoacidosis (DKA) and may affect the acid-base interpretation during treatment. OBJECTIVES:This study aims to describe the prevalence of hyperchloremia during the treatment of DKA and its effect on the interpretation of bicarbonate value. METHODS:A cross-sectional study, including all cases of DKA in patients ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, 36(3):e143-e145]

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Evaluation of continuous renal replacement therapy and risk factors in the pediatric intensive care unit.

Fatih Aygun,

Acute kidney injury (AKI) is one of the most common causes of increased mortality and morbidity in the pediatric intensive care unit (PICU). Continuous renal replacement therapy (CRRT) is the mainstay treatment for AKI in children as it allows continuous and programmed removal of fluids, which is tolerated better hemodynamically. ... Read more >>

Saudi J Kidney Dis Transpl (Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia)
[2020, 31(1):53-61]

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Assessment of a Day Hospital Management Program for Children With Type 1 Diabetes.

Sarah Lawson, Jacob M Redel, Allison Smego, Melanie Gulla, Pamela J Schoettker, Mary Jolly, Farida Mostajabi, Lindsey Hornung,

Importance:A shift in the setting of care delivery for children with a new diagnosis of type 1 diabetes led to a reorganization of treatment. Objective:To determine whether a new diagnosis of pediatric diabetes can be successfully managed in a day hospital model. Design, Setting, and Participants:This quality improvement study used ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e200347]

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Air occlusion in insulin pumps of children and adolescents with type 1 diabetes.

Michelle M Knoll, Turaj Vazifedan, Eric Gyuricsko,

Background Insulin pumps are a frequently used technology among youth with type 1 diabetes. Air bubbles within insulin pump tubing are common, preventing insulin delivery and increasing the risk of large glycemic excursions and diabetic ketoacidosis (DKA). We sought to determine the prevalence of air bubbles in insulin pump tubing ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(2):179-184]

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