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Pediatric Malignant Pericardial Effusion

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Cardiac point-of-care ultrasound reveals unexpected, life-threatening findings in two children.

Stephanie J Doniger, Nicholas Ng,

BACKGROUND:The diagnosis of pericardial effusion with cardiac tamponade can at times be elusive in pediatric patients since it is relatively uncommon. Point-of-care ultrasound (POCUS) can readily be performed at the bedside to assess for the presence of a pericardial effusion, tamponade, and can occasionally yield unexpected results. CASE PRESENTATION:Two cases ... Read more >>

Ultrasound J (The ultrasound journal)
[2020, 12(1):4]

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Prenatal Diagnosis and Management of a Rare Central Tendon Defect Type of Congenital Diaphragmatic Hernia with a Massive Pericardial Effusion.

Inas Babic, Haifa Al-Jobair, Osama Al Towaijri, Huda Al-Shammary, Merna Atiyah, Jamal Al Hudhaif, Amer Ammari,

The central tendon defect type of congenital diaphragmatic hernia (CDH) is extremely rare and usually associated with a significant pericardial effusion. Prenatal diagnostic ultrasound features of this quite rare entity remain often overlooked or misdiagnosed. There is a dearth of literature about the role of prenatal intervention, often through an ... Read more >>

Case Rep Obstet Gynecol (Case reports in obstetrics and gynecology)
[2020, 2020:6798253]

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Everolimus for cardiac rhabdomyomas in children with tuberous sclerosis. The ORACLE study protocol (everOlimus for caRdiac rhAbdomyomas in tuberous sCLErosis): a randomised, multicentre, placebo-controlled, double-blind phase II trial.

Erica V Stelmaszewski, Daniella B Parente, Alberto Farina, Anna Stein, Anthony Gutierrez, Antonio F Raquelo-Menegassio, Carla Manterola, Carolina F de Sousa, Carolina Victor, Dina Maki, Elias M Morón, Fabiano F de Abrantes, Fatima Iqbal, Jazmin Camacho-Vilchez, Joanna Jimenez-Pavón, Juan P Polania, Lorenzo Thompson, Lygia Bonanato, Matthias Diebold, Maria V C P Da Silva, Mariam W J Nashwan, Marianna A G Galvani, Osama E A Idris, Pierina Danos, Rocio Ortiz-Lopez, Rofida A A Mahmoud, Sergio Gresse, Karla L Loss,

INTRODUCTION:Tuberous sclerosis complex is a rare genetic disorder leading to the growth of hamartomas in multiple organs, including cardiac rhabdomyomas. Children with symptomatic cardiac rhabdomyoma require frequent admissions to intensive care units, have major complications, namely, arrhythmias, cardiac outflow tract obstruction and heart failure, affecting the quality of life and ... Read more >>

Cardiol Young (Cardiology in the young)
[2020, 30(3):337-345]

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Juvenile Polyposis Syndrome in a Young Girl from Northern Tanzania.

Jay Lodhia, David Msuya, Abdallah Msemo, Huda Akrabi, Patrick Amsi, Deborah Mchaile, Kondo Chilonga,

Introduction. Juvenile polyposis syndrome is a rare autosomal dominant disorder in children characterized by multiple polyps in the gastrointestinal tract. A variety of clinical features manifest, including prolapse of a polyp or entire rectum, gastrointestinal bleeding, anaemia, and intussusception. This condition if left unmanaged promptly leads to fatal complications including ... Read more >>

Case Rep Surg (Case reports in surgery)
[2020, 2020:1536090]

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A Rare Case of Intracardiac Extension of Hepatocellular Carcinoma in a Child.

Abdulrahman Al Jassmi, Hani Humad, Said Abou Eida,

Hepatocellular carcinoma (HCC) is the fifth most common malignancy found in men and ninth most common in women, out of which 72.5% reported cases are from Asia. In children, it accounts for <2% cases worldwide with even rarer incidence of 1.2% involving intracardial extension. However, it presents with a high ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2019, 2019:4783595]

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Imaging for diagnosis, staging and response assessment of Hodgkin lymphoma and non-Hodgkin lymphoma.

Kathleen M McCarten, Helen R Nadel, Barry L Shulkin, Steve Y Cho,

Hodgkin lymphoma and non-Hodgkin lymphoma are common malignancies in children and are now highly treatable. Imaging plays a major role in diagnosis, staging and response using conventional CT and MRI and metabolic imaging with positron emission tomography (PET)/CT and PET/MRI. Cross-sectional imaging has replaced staging laparotomy and splenectomy by demonstrating ... Read more >>

Pediatr Radiol (Pediatric radiology)
[2019, 49(11):1545-1564]

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Recurrent Pericarditis in Children and Adolescents.

Enrico Tombetti, Teresa Giani, Antonio Brucato, Rolando Cimaz,

Recurrent pericarditis (RP) is a clinical syndrome characterized by recurrent attacks of acute pericardial inflammation. Prognosis quoad vitam is good, although morbidity might be significant, especially in children and adolescents. Multiple potential etiologies result in RP, in the vast majority of cases through autoimmune or autoinflammatory mechanisms. Idiopathic RP is ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:419]

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Recurrent lymphoma presenting as painless, chronic intussusception: A case report.

Parker Giroux, Anderson Collier, Michael Nowicki,

BACKGROUND:The clinical presentation of acute lymphoblastic lymphoma is highly varied. While prognosis is good, recurrence of disease can occur. Gastrointestinal relapse, including intussusception, is well-described but the absence of abdominal pain in this setting is rare. CASE SUMMARY:We report a 13-year-old male with B-cell precursor acute lymphoblastic leukemia in remission ... Read more >>

World J Clin Cases (World journal of clinical cases)
[2020, 8(2):306-312]

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Clinical manifestation of pediatric mediastinal tumors, a single center experience.

Chieh-Ho Chen, Kang-Hsi Wu, Yu-Hua Chao, De-Fu Weng, Jeng-Sheng Chang, Chien-Heng Lin,

Medical decisions should be well-planned to improve prognosis and reduce complications of mediastinal tumors. In this study, we analyzed the clinical presentations of pediatric mediastinal tumors and their correlation with long-term clinical outcome.Forty patients under 18 years of age diagnosed with mediastinal tumors at China Medical University Children's Hospital between ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(32):e16732]

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Hemophagocytic lymphohistiocytosis complicating invasive pneumococcal disease: a pediatric case report.

Mitsuru Tsuge, Machiko Miyamoto, Reiji Miyawaki, Yoichi Kondo, Hirokazu Tsukahara,

BACKGROUND:Hemophagocytic lymphohistiocytosis (HLH) is an infrequent but life-threatening disease due to excessive immune activation. Secondary HLH can be triggered by infections, autoimmune diseases, and malignant diseases. Streptococcus pneumoniae is a pathogenic bacterium responsible for invasive pneumococcal disease (IPD) such as meningitis and bacteremia. Although the pneumococcal conjugate vaccine (PCV) has ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):15]

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Anesthetic Management of a Patient With an Anterior Mediastinal Mass Undergoing Endoscopic Retrograde Cholangiopancreatography in the Prone Position: A Case Report.

Alfredo Armas, Aaron N Primm,

Patients with anterior mediastinal masses pose a significant challenge to anesthesiologists. Catastrophic outcomes have been described in patients with mediastinal masses undergoing anesthesia. However, despite an abundance of literature discussing anesthetic management of these patients, there is a lack of reports detailing the management of this population undergoing advanced endoscopic ... Read more >>

A A Pract (A&A practice)
[2020, 14(1):25-27]

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Alectinib, an anaplastic lymphoma kinase (ALK) inhibitor, as a bridge to allogeneic stem cell transplantation in a patient with ALK-positive anaplastic large-cell lymphoma refractory to chemotherapy and brentuximab vedotin.

Ritsuko Nakai, Suguru Fukuhara, Akiko Miyagi Maeshima, Sung-Won Kim, Yuta Ito, Shunsuke Hatta, Tomotaka Suzuki, Sayako Yuda, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai Maruyama, Koji Izutsu,

This is the first case report of alectinib as a bridge to allo-SCT in a patient with ALK-positive ALCL refractory to both conventional chemotherapies and BV. This report offers a ray of hope for a condition with poor prognosis. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(12):2500-2504]

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Anomalous Left Coronary Artery From The Pulmonary Artery (ALCAPA) as a Cause of Heart Failure.

Daniel Sadoma, Christopher Valente, Adam Sigal,

BACKGROUND Anomalous left coronary artery from the pulmonary artery (ALCAPA) is a rare anomaly. When present it can result in failure to thrive and congestive heart failure. CASE REPORT We present the case of a 6-month old female whose presentation was one of failure to thrive. Point of care ultrasound ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1797-1800]

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Rib Exostoses Presenting as Mediastinal Masses: A Rare Presentation and Minireview of the Literature.

Doina Butcovan, Veronica Mocanu, Raluca Ecaterina Haliga, Dana Baran, Carmen Ungureanu, Ştefana Carp, Grigore Tinică,

Costal osteocartilaginous exostoses, also known as osteochondromas, are the most common neoplasms of the long bones but are rare tumors of the ribs. Osteochondroma is often asymptomatic and incidentally observed. Tumors typically begin to grow before puberty and continue until bone maturation is reached. Our paper presents the case of ... Read more >>

Case Rep Med (Case Reports in Medicine)
[2020, 2020:8283565]

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Pediatric Sarcoidosis: A Review with Emphasis on Early Onset and High-Risk Sarcoidosis and Diagnostic Challenges.

Brian Chiu, Jackie Chan, Sumit Das, Zainab Alshamma, Consolato Sergi,

Sarcoidosis is a non-necrotizing granulomatous inflammatory syndrome with multisystemic manifestations. We performed a systematic review of sarcoidosis in the pediatric population with particular emphases on early onset sarcoidosis, high-risk sarcoidosis, and newly reported or unusual sarcoid-related diseases. Blau Syndrome and early onset sarcoidosis/ BS-EOS are seen in children younger than ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2019, 9(4):]

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Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study.

Mulubirhan Tirfe, Teshome Nedi, Desalew Mekonnen, Alemseged Beyene Berha,

BACKGROUND:Acute heart failure is a rapid onset of new or worsening of signs and symptoms of heart failure that requires hospitalization or a visit to the emergency department. The aim of this study was to evaluate treatment outcome and determine factors that predict a poor treatment outcome in acute heart ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2020, 20(1):16]

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Clinical features and outcomes of patients with hemophagocytic lymphohistiocytosis at onset of systemic autoinflammatory disorder and compare with Epstein-Barr virus (EBV)-related hemophagocytic lymphohistiocytosis.

Yunze Zhao, Zhigang Li, Li Zhang, Hongyun Lian, Honghao Ma, Dong Wang, Xiaoxi Zhao, Qing Zhang, Tianyou Wang, Rui Zhang,

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease. In clinical practice, we have observed that some HLH patients who have features of systemic autoinflammatory diseases (SAIDs) exhibit unique clinical manifestations and outcomes different from other HLH patients.We analyzed data from 25 HLH patients who were considered to have SAIDs; data were ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(1):e18503]

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The use of intracardiac echocardiography catheters in endocardial ablation of cardiac arrhythmia: Meta-analysis of efficiency, effectiveness, and safety outcomes.

Masahiko Goya, Diana Frame, Larry Gache, Yoko Ichishima, Daiane Oliveira Tayar, Laura Goldstein, Stephanie Hsiao Yu Lee,

AIMS:The optimal use of intracardiac echocardiography (ICE) may reduce fluoroscopy time and procedural complications during endocardial ablation of cardiac arrhythmias. Due to limited evidence in this area, we conducted the first systematic literature review and meta-analysis to evaluate outcomes associated with the use of ICE. METHODS AND RESULTS:Studies reporting the ... Read more >>

J. Cardiovasc. Electrophysiol. (Journal of cardiovascular electrophysiology)
[2020, 31(3):664-673]

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Transcatheter and intraoperative device closure of atrial septal defect in infants under three years of age.

Yangyang Han, Xiquan Zhang, Fengwei Zhang,

BACKGROUND:Transcatheter and intraoperative device closures have been widely used in the treatment of secundum atrial septal defect (ASD). However, for young infants with ASD, device closure remains controversial, and such treatment features limited data. We compared the clinical data and follow-up results of percutaneous and intraoperative device closure for ASD ... Read more >>

J Cardiothorac Surg (Journal of cardiothoracic surgery)
[2020, 15(1):9]

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Zero Fluoroscopy During Ablation of Right-Sided Supraventricular Tachycardia Substrates in a Pediatric Population - Initial Experience in Taiwan.

Wei-Chieh Tseng, Mei-Hwan Wu, Chun-Wei Lu, Kun-Lang Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-An Chen, Shuenn-Nan Chiu,

Background:Zero fluoroscopy during ablation of arrhythmias has been introduced to reduce radiation exposure. However, the safety, feasibility and efficacy of the technique in pediatric populations have yet to be delineated. Objectives:To investigate the safety, feasibility and effectiveness of zero fluoroscopic-guided transcatheter ablation of right-sided supraventricular tachycardia substrates in a pediatric ... Read more >>

Acta Cardiol Sin (Acta Cardiologica Sinica)
[2019, 35(5):476-483]

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An Isolated Testicular Relapse of Burkitt's Lymphoma.

Young Suk Kwon, Faizanahmed Munshi, Neeket R Patel, Virian Serei, Nupam Patel, Richard A Drachtman, Joseph G Barone,

Glob Pediatr Health (Global Pediatric Health)
[2019, 6:2333794X19872427]

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Primary pleural lymphoma of T cell origin in a paediatric patient with a focus on radiological findings - a case report and review of literature.

Amirreza Jahanshahi, Amirataollah Hiradfar, Armin Zarrintan, Mohammad Mirza-Aghazadeh-Attari,

Purpose:Pleural lymphoma is a medical condition characterised by shortness of breath and obscure chest pain, which may be a diagnostic challenge, especially when it occurs in children. Plain chest X-rays and computed tomography (CT) scan are the main imaging techniques and are the initial diagnostic methods utilised. Case report:A four-year-old ... Read more >>

Pol J Radiol (Polish journal of radiology)
[2019, 84:e353-e359]

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Cardiac ultrasound in resource-limited settings (CURLS): towards a wider use of basic echo applications in Africa.

Michaëla A M Huson, Dan Kaminstein, Daniel Kahn, Sabine Belard, Prakash Ganesh, Vanessa Kandoole-Kabwere, Claudia Wallrauch, Sam Phiri, Benno Kreuels, Tom Heller,

BACKGROUND:Point-of-care ultrasound is increasingly being used as a diagnostic tool in resource-limited settings. The majority of existing ultrasound protocols have been developed and implemented in high-resource settings. In sub-Saharan Africa (SSA), patients with heart failure of various etiologies commonly present late in the disease process, with a similar syndrome of ... Read more >>

Ultrasound J (The ultrasound journal)
[2019, 11(1):34]

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Efficacy of the NCCV Cocktail-1 vaccine for refractory pediatric solid tumors: A phase I clinical trial.

Yu Akazawa, Ako Hosono, Toshiaki Yoshikawa, Hide Kaneda, Chika Nitani, Junichi Hara, Yoshiaki Kinoshita, Kenichi Kohashi, Atsushi Manabe, Miki Fukutani, Masashi Wakabayashi, Akihiro Sato, Kayoko Shoda, Manami Shimomura, Shoichi Mizuno, Yasunari Nakamoto, Tetsuya Nakatsura,

Pediatric refractory solid tumors are aggressive malignant diseases, resulting in an extremely poor prognosis. KOC1, FOXM1, and KIF20A are cancer antigens that could be ideal targets for anticancer immunotherapy against pediatric refractory solid tumors with positive expression for these antigens. This nonrandomized, open-label, phase I clinical trial evaluated the safety ... Read more >>

Cancer Sci. (Cancer science)
[2019, 110(12):3650-3662]

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Anterior mediastinal teratoma with pericardial effusion. Rare presentation.

Moaath Al Smady, Nurul Nadia Binti Zahari, Noor Syahirah Binti Mohd Sahid, Nurul Syuhada Binti Saparudin,

Mediastinal teratoma is an uncommon finding in the pediatric age group, accounting for only 7-11% of extragonadal teratomas. Rarely, the tumor can rupture and erode into the pericardium or pleural space. However, pericardial effusion due to rupture is infrequent. We report a case of such a rare presentation in a ... Read more >>

J Surg Case Rep (Journal of Surgical Case Reports)
[2019, 2019(5):rjz136]

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