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Pediatric Lead Toxicity

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A long journey for acute kidney injury biomarkers.

Dong-Jin Oh,

Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. However, it has only marginally declined over the past 25 years. Previous authoritative publications have been pointed out that the ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):154-165]

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Unilateral temporary diaphragmatic paralysis secondary to bronchial artery embolization in a girl with cystic fibrosis and massive hemoptysis: a case report.

V Terlizzi, M Botti, G Gabbani, F Fanelli, M De Martino, G Taccetti,

BACKGROUND:Massive hemoptysis is a serious complication in Cystic Fibrosis (CF), occurring commonly in older patients. Bronchial artery embolization (BAE) can be performed to stop the bleeding. BAE is generally safe and effective, but can sometimes lead to serious complications. We report the first case of temporary unilateral diaphragmatic paralysis associated ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2020, 20(1):38]

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Doc, can you test me for "toxic metals"? Challenges of testing for toxicants in patients with environmental concerns.

Lauren Zajac, Sarah A Johnson, Marissa Hauptman,

Laboratory testing is an important tool to assist clinicians in evaluation of patients with potential environmentally-related illness, however, it can be challenging to select or interpret the appropriate toxicological tests. Recent advances in analytical techniques and expanded consumer access to environmental laboratories led to a rise in laboratory testing for ... Read more >>

Curr Probl Pediatr Adolesc Health Care (Current problems in pediatric and adolescent health care)
[2020, :100762]

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Technology and precision therapy delivery in childhood cancer.

Caitlin Tydings, AeRang Kim,

PURPOSE OF REVIEW:The purpose of this review is to describe current advances in pediatric precision therapy through innovations in technology and engineering. A multimodal approach of chemotherapy, surgery and/or radiation therapy has improved survival outcomes for pediatric cancer but with significant early and late toxicities. The pediatric population is particularly ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2020, 32(1):1-6]

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Pediatric Pyomyositis: A Rare but Important Complication of Varicella.

Luísa Vital, Luís Vieira, Bernardo Nunes, Frederico Raposo, Vitorino Veludo, André Pinho,

Varicella is a common viral infection in children and most of them recover without sequelae, but serious complications can follow this infection and 6% have been reported to be musculoskeletal. A previously healthy 3-year-old Caucasian male presented with odynophagia, anorexy, fever, refusal to bear weight, and vesicular exanthema. Varicella was ... Read more >>

Case Rep Orthop (Case reports in orthopedics)
[2020, 2020:3896264]

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Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study.

Dan Sun, Hui Li, Xiao-Xia Lu, Han Xiao, Jie Ren, Fu-Rong Zhang, Zhi-Sheng Liu,

BackgroundAn outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan, Hubei, China. People of all ages are susceptible to SARS-CoV-2 infection. No information on severe pediatric patients with COVID-19 has been reported. We aimed to describe the clinical features of severe pediatric patients with COVID-19.MethodsWe ... Read more >>

World J Pediatr (World journal of pediatrics : WJP)
[0, :1-9]

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Severe sepsis caused by serious gastrointestinal infection in sJIA patients treated with IL-6 receptor antagonist: a case report.

Meng Xu, Congcong Liu, Lishuang Guo, Sirui Yang,

BACKGROUND:Interleukin (IL)-6 plays an essential role in the pathogenesis of systemic juvenile idiopathic arthritis (sJIA). Tocilizumab (TCZ), a kind of biological agent against both membrane and soluble IL-6 receptor, is the only biological agent approved for the treatment of sJIA in China. Infections are the most common adverse events during ... Read more >>

BMC Pediatr (BMC pediatrics)
[2020, 20(1):126]

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How I Treat the Toxicities of Pegasparaginase in Adults with Acute Lymphoblastic Leukemia.

Ibrahim Aldoss, Dan Douer,

Administering asparaginase has always been problematic in adults since most general oncologists who treat adults are not familiar with its usage and toxicity. The toxicity profile of the drug is unique and not observed with any other chemotherapy agent. Furthermore, asparaginase is almost exclusively used in acute lymphoblastic leukemia (ALL) ... Read more >>

Blood (Blood)
[2020, :]

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Characteristics of Pediatric Patients With Retained Bullet Fragments and Need for Follow-Up Blood Lead Monitoring.

Todd Fleenor, Joshua Haupt, Kathleen Richard, Michele Nichols, Nipam Shah,

OBJECTIVES:Multiple case reports of lead toxicity related to retained bullet fragments in pediatric patients sustaining gunshot wound have been published. The purpose of the present study was to determine whether the demographic and clinical characteristics of gunshot wounds (GSWs) could be classified high/low risk and whether routine blood lead monitoring ... Read more >>

South. Med. J. (Southern medical journal)
[2020, 113(1):23-28]

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Intussusception in an Immunocompromised Patient: A Case Report and Review of the Literature.

Charles-Henri Wassmer, Ziad Abbassi, Frédéric Ris, Thierry Berney,

BACKGROUND Intussusception in adults (AI) accounts for 1% of all cases of bowel obstruction. While pediatric intussusception is well known and almost always idiopathic, an underlying cause is usually found in adults. Indication for surgical treatment and intussusception reduction before resection remain controversial in AI. Here, we present an uncommon ... Read more >>

Am J Case Rep (The American journal of case reports)
[2020, 21:e919974]

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Bundle Adherence of Intravenous Antibiotic Fluid Resuscitation and Vasopressor in Children with Severe Sepsis or Septic Shock.

Clarice L Barboza, Cristina Os Valete, André Ra da Silva,

Objective:The aim of this study was to measure the effects of a bundle of interventions in children admitted with severe sepsis or septic shock in the first hour after diagnosis on mortality. Materials and methods:A retrospective study was conducted at a pediatric intensive care unit (PICU) between January 2014 and ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(2):128-132]

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Evaluation of hair cotinine and toxic metal levels in children who were exposed to tobacco smoke.

Fatih Gunay, Nisa Eda Cullas Ilarslan, Filiz Bakar-Ates, Kiymet Deniz, Yusuf Kagan Kadioglu, Sibel Kiran, Batuhan Bakirarar, Nazan Cobanoglu,

Tobacco or tobacco products (TTP) are harmful because they contain nicotine and some heavy metals. In this study, it was aimed to evaluate whether the responses of parents to questionnaires were compatible with the hair cotinine levels of their children, and to investigate whether exposure to environmental tobacco smoke (ETS) ... Read more >>

Pediatr. Pulmonol. (Pediatric pulmonology)
[2020, 55(4):1012-1019]

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IVIG and under Burn Unit Care Yield Favorable Outcomes in Pediatric Patients with Toxic Epidermal Necrolysis: A Case Report and Literature Review.

Tareq Z Alzughayyar, Wasim Noureddin Ibrahim Hamad, Eman A S Abuqweider, Bilal Nabeel Mohammad Alqam, Sadi A Abukhalaf, Rami A Misk, Fawzy M Abunejma, Jihad Samer Zalloum, Mohanad Saleh, Ali A Abumunshar, Yousef I M Zatari,

Body reactions to drugs can manifest as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). TEN is the most severe form of cutaneous reactions with an incidence rate of 1-2 per million cases per year. Despite TEN being a critical and life-threatening condition, there is little to no evidence of ... Read more >>

Case Rep Dermatol Med (Case reports in dermatological medicine)
[2020, 2020:6274053]

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New and Emerging Targeted Therapies for Pediatric Acute Myeloid Leukemia (AML).

Jing Chen, Chana L Glasser,

The relapse rate for children with acute myeloid leukemia (AML) remains high despite advancements in risk classification, multi-agent chemotherapy intensification, stem cell transplantation, and supportive care guidelines. Prognosis for this subgroup of children with relapsed/refractory AML remains poor. It is well known that the ceiling of chemotherapy intensification has been ... Read more >>

Children (Basel) (Children)
[2020, 7(2):]

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ECMO for Neonatal Sepsis in 2019.

Warwick Wolf Butt, Roberto Chiletti,

Sepsis and septic shock in newborns causes mortality and morbidity depending on the organism and primary site. ECMO provides cardiorespiratory support to allow adequate organ perfusion during the time for antibiotics and source control surgery (if needed) to occur. ECMO mode and cannulation site vary depending on support required and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:50]

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CD19 CAR T Cells for the Treatment of Pediatric Pre-B Cell Acute Lymphoblastic Leukemia.

Holly L Pacenta, Theodore W Laetsch, Samuel John,

The development of cluster of differentiation (CD)-19-targeted chimeric antigen receptor (CAR) T cells for the treatment of pre-B-cell acute lymphoblastic leukemia (B-ALL) is an exciting new advancement in the field of pediatric oncology. Tisagenlecleucel and axicabtagene ciloleucel are the first US FDA-approved CD19-targeted CAR T cells. While various different CD19 ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(1):1-11]

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Kerosene, Camphor, and Naphthalene Poisoning in Children.

Surjeet Kumar, T K Kavitha, Suresh K Angurana,

Kerosene poisoning is one of the most common accidental poisoning in children in developing countries due common use of kerosene in house-hold and unsafe storage practices. Aspiration pneumonitis is the most common manifestation of kerosene ingestion due to its low viscosity, high volatility, and low surface tension. The treatment of ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2019, 23(Suppl 4):S278-S281]

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Adverse drug event rates in pediatric pulmonary hypertension: a comparison of real-world data sources.

Alon Geva, Steven H Abman, Shannon F Manzi, Dunbar D Ivy, Mary P Mullen, John Griffin, Chen Lin, Guergana K Savova, Kenneth D Mandl,

OBJECTIVE:Real-world data (RWD) are increasingly used for pharmacoepidemiology and regulatory innovation. Our objective was to compare adverse drug event (ADE) rates determined from two RWD sources, electronic health records and administrative claims data, among children treated with drugs for pulmonary hypertension. MATERIALS AND METHODS:Textual mentions of medications and signs/symptoms that ... Read more >>

J Am Med Inform Assoc (Journal of the American Medical Informatics Association : JAMIA)
[2020, 27(2):294-300]

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Prevalence and molecular characterizations of Staphylococcus aureus nasal colonization among patients in pediatric intensive care units in Taiwan.

Yu-Hsin Chen, Kuan-Ying A Huang, Yi-Chuan Huang, Hsin Chi, Chun-Yi Lu, Luan-Yin Chang, Yu-Huai Ho, Chia-Yu Chi, Ching-Chuan Liu, Li-Min Huang, Tien Yu Owen Yang, Yhu-Chering Huang,

BACKGROUND:Nasal colonization of Staphylococcus aureus is a risk factor for the pathogen transmission and the development of infections. Limited information is available on the prevalence and molecular characteristics of S. aureus colonization in pediatric intensive care unit (ICU) patients. METHODS:A cross-sectional, island-wide study was conducted in 2011. Nasal swabs were ... Read more >>

Antimicrob Resist Infect Control (Antimicrobial resistance and infection control)
[2020, 9(1):41]

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Alterations in the Nervous System and Gut Microbiota after β-Hemolytic Streptococcus Group A Infection-Characteristics and Diagnostic Criteria of PANDAS Recognition.

Jacek Baj, Elżbieta Sitarz, Alicja Forma, Katarzyna Wróblewska, Hanna Karakuła-Juchnowicz,

The objective of this paper is to review and summarize conclusions from the available literature regarding Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). The authors have independently reviewed articles from 1977 onwards, primarily focusing on the etiopathology, symptoms, differentiation between similar psychiatric conditions, immunological reactions, alterations in the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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Harnessing T Cells to Target Pediatric Acute Myeloid Leukemia: CARs, BiTEs, and Beyond.

Rebecca Epperly, Stephen Gottschalk, Mireya Paulina Velasquez,

Outcomes for pediatric patients with acute myeloid leukemia (AML) remain poor, highlighting the need for improved targeted therapies. Building on the success of CD19-directed immune therapy for acute lymphocytic leukemia (ALL), efforts are ongoing to develop similar strategies for AML. Identifying target antigens for AML is challenging because of the ... Read more >>

Children (Basel) (Children)
[2020, 7(2):]

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A Quality Improvement Project Focused on Improving First Dose Antibiotic Timeliness for Pediatric Intensive Care Unit Patients with Severe Sepsis.

Ryan Keul, Jordan Rodriguez, Ariel Coleman, Prerna Yadav,

Recommended time to start administration of first dose antibiotics for sepsis patients is 60 minutes from time 0. Institution-specific data revealed that only one-quarter of severe sepsis patients were meeting this goal when measured from the time of provider order entry. Reliance on a pneumatic tube system for first-dose antibiotic ... Read more >>

Pediatr Qual Saf (Pediatric quality & safety)
[2020, 5(1):e250]

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Acute Cannabis Toxicity.

Kei U Wong, Carl R Baum,

The change in legal status of cannabis (the botanical species Cannabis sativa, commonly known as marijuana) in the United States has had significant impact on pediatric drug exposures. In states with decriminalization of recreational and medicinal use of cannabis, emergency department visits and poison control center calls for unintentional pediatric ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2019, 35(11):799-804]

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The Effect of Smartphone-Based Application Learning on the Nursing Students' Performance in Preventing Medication Errors in the Pediatric Units.

Sima Pourteimour, Masumeh Hemmati MalsakPak, Madineh Jasemi, Samereh Eghtedar, Naser Parizad,

Medication errors (MEs) are potentially harmful patient safety events in all age groups. MEs are particularly hazardous in the pediatric population, especially with patients who require special attention due to the high incidence and severity of disease. This study aimed to determine the effect of a smartphone messenger application on ... Read more >>

Pediatr Qual Saf (Pediatric quality & safety)
[2019, 4(6):e226]

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Beat pediatric ALL MRD: CD28 CAR T and transplant.

Marco Ruella, Frederick L Locke,

Blood (Blood)
[2019, 134(26):2333-2335]

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