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Pediatric Iron Toxicity

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A long journey for acute kidney injury biomarkers.

Dong-Jin Oh,

Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. However, it has only marginally declined over the past 25 years. Previous authoritative publications have been pointed out that the ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):154-165]

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Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury.

Juan Zhen, Haitao Yu, Honglei Ji, Lu Cai, Jiyan Leng, Bradley B Keller,

Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies and limited clinical trials is the iron ... Read more >>

Life Sci. (Life sciences)
[2019, 239:117070]

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A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease.

Robert Siblerud, Joachim Mutter, Elaine Moore, Johannes Naumann, Harald Walach,

Mercury is one of the most toxic elements and causes a multitude of health problems. It is ten times more toxic to neurons than lead. This study was created to determine if mercury could be causing Alzheimer's disease (AD) by cross referencing the effects of mercury with 70 factors associated ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2019, 16(24):]

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Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).

Tiago Nava, Marc Ansari, Jean-Hugues Dalle, Christina Diaz de Heredia, Tayfun Güngör, Eugenia Trigoso, Ulrike Falkenberg, Alice Bertaina, Brenda Gibson, Andrea Jarisch, Adriana Balduzzi, Halvard Boenig, Gergely Krivan, Kim Vettenranta, Toni Matic, Jochen Buechner, Krzysztof Kalwak, Anita Lawitschka, Akif Yesilipek, Giovanna Lucchini, Christina Peters, Dominik Turkiewicz, Riitta Niinimäki, Tamara Diesch, Thomas Lehrnbecher, Petr Sedlacek, Daphna Hutt, Arnaud Dalissier, Jacek Wachowiak, Isaac Yaniv, Jerry Stein, Koray Yalçin, Luisa Sisinni, Marco Deiana, Marianne Ifversen, Michaela Kuhlen, Roland Meisel, Shahrzad Bakhtiar, Simone Cesaro, Andre Willasch, Selim Corbacioglu, Peter Bader,

Hematopoietic stem cell transplantation (HSCT) is currently the standard of care for many malignant and nonmalignant blood diseases. As several treatment-emerging acute toxicities are expected, optimal supportive measurements critically affect HSCT outcomes. The paucity of good clinical studies in supportive practices gives rise to the establishment of heterogeneous guidelines across ... Read more >>

Bone Marrow Transplant. (Bone marrow transplantation)
[2020, :]

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Hydroxyurea-induced Tooth Discoloration

Muhammed Okuyucu, Memiş Hilmi Atay,

Turk J Haematol (Turkish journal of haematology : official journal of Turkish Society of Haematology)
[2020, 37(1):74-75]

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Fragile X syndrome and associated disorders: Clinical aspects and pathology.

Maria Jimena Salcedo-Arellano, Brett Dufour, Yingratana McLennan, Veronica Martinez-Cerdeno, Randi Hagerman,

This review aims to assemble many years of research and clinical experience in the fields of neurodevelopment and neuroscience to present an up-to-date understanding of the clinical presentation, molecular and brain pathology associated with Fragile X syndrome, a neurodevelopmental condition that develops with the full mutation of the FMR1 gene, ... Read more >>

Neurobiol. Dis. (Neurobiology of disease)
[2020, 136:104740]

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Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree?

Balaraman Kalyanaraman,

Doxorubicin (DOX), or Adriamycin, an anthracycline antibiotic discovered serendipitously as a chemotherapeutic drug several decades ago, is still one of the most effective drugs for treating various adult and pediatric cancers (breast cancer, Hodgkin's disease, lymphoblastic leukemia). However, one of the major side effects of the continuous use of DOX ... Read more >>

Redox Biol (Redox biology)
[2020, 29:101394]

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Blood product administration during high risk neuroblastoma therapy.

Allison Silverstein, Kiranmye Reddy, Valeria Smith, Jennifer H Foster, Heidi V Russell, Sarah B Whittle,

The increasing intensity of high-risk neuroblastoma (HR NB) treatment over the last decades has resulted in improved survival at the expense of prolonging therapy and exposure to additional potentially toxic agents. Anemia and thrombocytopenia requiring transfusion are common during therapy for HR NB. Risks of cumulative red blood cell and ... Read more >>

Pediatr Hematol Oncol (Pediatric hematology and oncology)
[2020, 37(1):5-14]

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Cetirizine as a Causative Agent for Drug Induced Methemoglobinemia: A Case Report and Review.

Matthew Grillo, Joseph Hong, Sujatha Kosuri, Rita Verma,

A case of methemoglobinemia (MHb) in a teenage woman, triggered by an acute ingestion of approximately 120 to 180 mg of cetirizine, allegedly, with no suicidal intent is described. The patient presented with anxiety and tremors and rapidly developed central cyanosis unresponsive to oxygen supplementation. There was a history of ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(6):538-541]

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Anemia and Related Factors Among Highly Active Antiretroviral Therapy Experienced Children in Hawassa Comprehensive Specialized Hospital, Southern Ethiopia: Emphasis on Patient Management.

Demissie Assegu Fenta, Metsihet Mohammed Nuru, Tilahun Yemane, Yaregal Asres, Temesgen Bizuayehu Wube,

BackgroundHuman Immunodeficiency Virus (HIV) and its therapy cause a variety of hematological abnormalities that have been known to be one of the most common causes of morbidity and mortality in HIV-positive children. One of the commonly observed hematologic manifestations in HIV-positive children is anemia and it has a multifactorial source. ... Read more >>

Drug Healthc Patient Saf (Drug, healthcare and patient safety)
[2020, 12:49-56]

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Heart Failure in Relation to Anthracyclines and Other Chemotherapies.

Tolulope A Agunbiade, Raja Y Zaghlol, Ana Barac,

Anthracyclines are the cornerstone of therapy for a wide range of solid and hematologic malignancies; however, their use is limited by the risk of chemotherapy-induced cardiotoxicity leading to cardiomyopathy and heart failure. The incidence of cardiotoxicity in the literature depends on the definition being used, anthracycline dose, duration of follow-up, ... Read more >>

Methodist Debakey Cardiovasc J (Methodist DeBakey cardiovascular journal)
[2019, 15(4):243-249]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of Medical Toxicology)
[0, :1-53]

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Oral submucous fibrosis: a contemporary narrative review with a proposed inter-professional approach for an early diagnosis and clinical management.

Naman R Rao, Alessandro Villa, Chandramani B More, Ruwan D Jayasinghe, Alexander Ross Kerr, Newell W Johnson,

Oral Submucous fibrosis (OSMF) has traditionally been described as "a chronic, insidious, scarring disease of the oral cavity, often with involvement of the pharynx and the upper esophagus". Millions of individuals are affected, especially in South and South East Asian countries. The main risk factor is areca nut chewing. Due ... Read more >>

J Otolaryngol Head Neck Surg (Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale)
[2020, 49(1):3]

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End points for sickle cell disease clinical trials: renal and cardiopulmonary, cure, and low-resource settings.

Ann T Farrell, Julie Panepinto, Ankit A Desai, Adetola A Kassim, Jeffrey Lebensburger, Mark C Walters, Daniel E Bauer, Rae M Blaylark, Donna M DiMichele, Mark T Gladwin, Nancy S Green, Kathryn Hassell, Gregory J Kato, Elizabeth S Klings, Donald B Kohn, Lakshmanan Krishnamurti, Jane Little, Julie Makani, Punam Malik, Patrick T McGann, Caterina Minniti, Claudia R Morris, Isaac Odame, Patricia Ann Oneal, Rosanna Setse, Poornima Sharma, Shalini Shenoy,

To address the global burden of sickle cell disease and the need for novel therapies, the American Society of Hematology partnered with the US Food and Drug Administration to engage the work of 7 panels of clinicians, investigators, and patients to develop consensus recommendations for clinical trial end points. The ... Read more >>

Blood Adv (Blood advances)
[2019, 3(23):4002-4020]

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Lead Exposure in Newly Resettled Pediatric Refugees in Syracuse, NY.

Christina D Lupone, Danielle Daniels, Dawn Lammert, Robyn Borsuk, Travis Hobart, Sandra Lane, Andrea Shaw,

Lead is a major environmental toxin that presents numerous health consequences for children. Refugee children are at a risk of lead poisoning post-resettlement due to urban housing and environmental inequalities stemming from lack of funding, legislation, and advocacy. This article addresses lead exposure upon arrival and post-resettlement in 705 refugee ... Read more >>

J Immigr Minor Health (Journal of immigrant and minority health)
[2020, 22(1):34-43]

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Comparative Evaluation of Physical and Mechanical Properties of Different Brands of Primary Molar Stainless-Steel Crowns: An In Vitro Study.

Zhaleh Bamdadian, Nilgoon Pasdar, Abdolhamid Alhavaz, Shahram Ghasemi, Ali Bijani,

BACKGROUND:There is some cases of perforation and undesirable properties of some primary molars stainless steel crowns. AIM:The aim of this study was to compare the physical and mechanical properties of different commercial brands of these crowns. METHODS:In an in vitro study, 10 stainless steel tooth crowns of the second primary ... Read more >>

Open Access Maced J Med Sci (Open Access Macedonian Journal of Medical Sciences)
[2019, 7(23):4120-4126]

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Intravenous and Oral Posaconazole Pharmacokinetics in a Five-Year-Old With Mucor: A Case Report and Review of the Literature.

Matthew O Ruland, Tosha A Egelund, John S Ng, Scott M Bradfield, Eric F Egelund,

Posaconazole is a lipophilic triazole antifungal that exhibits variable absorption when administered orally. It possesses a broad spectrum of activity against various fungi, such as Aspergillus and traditionally resistant molds such as Rhizopus and Mucor, which carry a poor prognosis. Unfortunately, the tablet and suspension formulations of posaconazole are Food ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(6):528-533]

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Conservative Management of Hyperferritinemia in Hemolytic Disease of the Fetus and Newborn: A Case Report and Review of the Literature.

Danielle L Adam, Lynette Bowes, Lisa Goodyear, Paul C Moorehead,

We report a newborn with hemolytic disease of the fetus and newborn (HDFN) with rapid resolution of extreme hyperferritinemia without chelation. An infant born at 35+3 weeks with HDFN and a history of 3 intrauterine transfusions developed severe hyperferritinemia (maximum, 8258 mcg/L) without evidence of toxic iron deposition on liver biopsy. ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2019, :]

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Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review.

Dominik Ochocinski, Mansi Dalal, L Vandy Black, Silvana Carr, Judy Lew, Kevin Sullivan, Niranjan Kissoon,

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion, insidious vital organ deterioration, early mortality, and diminished quality of life. Life-threatening acute physiologic crises may occur on a background of progressive diminishing vital organ function. Sickle hemoglobin polymerizes in the deoxygenated state, resulting in erythrocyte membrane deformation, ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:38]

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Sepsis Immunometabolism: From Defining Sepsis to Understanding How Energy Production Affects Immune Response.

Ioannis Koutroulis, Rachael Batabyal, Brittany McNamara, Matthew Ledda, Claire Hoptay, Robert J Freishtat,

Objectives:This review will examine current definitions and trends in sepsis management as well pathophysiologic mechanisms in animal and ex vivo studies that correlate decreased energy production with deranged inflammatory response during the septic process. Data Sources:The latest articles in the literature that focus on the role of immunometabolism and associated ... Read more >>

Crit Care Explor (Critical Care Explorations)
[2019, 1(11):e0061]

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Busulfan-Induced Lung Injury in Pediatric Oncology Patients-Review of the Literature with an Illustrative Case.

Nusa Matijasic, Aleksandra Bonevski, Visnja Tokic Pivac, Ivan Pavic,

Background: Impaired lung function has been detected in up to 65% of all childhood cancer survivors. It is often caused by exposure to radiation therapy and various chemotherapeutics. The first cytotoxic drug ever identified as a causative agent of lung injury was busulfan, reported in the early 1960s. Signs and ... Read more >>

Pediatr Allergy Immunol Pulmonol (Pediatric allergy, immunology, and pulmonology)
[2019, 32(3):86-91]

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Blood Lead Levels in Children Living Near an Informal Lead Battery Recycling Workshop in Patna, Bihar.

Jamal Akhtar Ansari, Abbas Ali Mahdi, Promila Sharma Malik, Tabrez Jafar,

Background:Lead can cause significant biological and neurologic damage, even at small concentrations, and young children are at higher risk. Informal recycling of lead batteries and lead-based workshops/industries have increased the burden of lead toxicity in developing countries, including India. Many informal recycling lead battery workshops have been established by the ... Read more >>

J Health Pollut (Journal of health & pollution)
[2020, 10(25):200308]

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Prevalence of potential drug-drug interactions in Swedish pediatric outpatients.

Johan Holm, Birgit Eiermann, Elin Kimland, Buster Mannheimer,

PURPOSE:To describe the occurrence of potential drug-drug interactions (DDIs) in prescribed drugs, dispensed to pediatric outpatients in Sweden. METHODS:A cross sectional study was conducted based on data from a national register of prescribed drugs, dispensed at pharmacies, to children 0-17 years old. The study period was January 1 to April ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220685]

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Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group.

Mohamad Mohty, Florent Malard, Manuel Abecasis, Erik Aerts, Ahmed S Alaskar, Mahmoud Aljurf, Mutlu Arat, Peter Bader, Frederic Baron, Grzegorz Basak, Ali Bazarbachi, Didier Blaise, Fabio Ciceri, Selim Corbacioglu, Jean-Hugues Dalle, Fiona Dignan, Takahiro Fukuda, Anne Huynh, Jurgen Kuball, Silvy Lachance, Hillard Lazarus, Tamas Masszi, Mauricette Michallet, Arnon Nagler, Mairead NiChonghaile, Shinichiro Okamoto, Antonio Pagliuca, Christina Peters, Finn B Petersen, Paul G Richardson, Tapani Ruutu, Wael Saber, Bipin N Savani, Robert Soiffer, Jan Styczynski, Elisabeth Wallhult, Ibrahim Yakoub-Agha, Rafael F Duarte, Enric Carreras,

Bone Marrow Transplant. (Bone marrow transplantation)
[2020, 55(3):485-495]

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Red Cell Distribution Width as a Novel Prognostic Marker in Multiple Clinical Studies.

Bahman Yousefi, Sarvin Sanaie, Ali A Ghamari, Hassan Soleimanpour, Ansar Karimian, Ata Mahmoodpoor,

Red cell distribution width (RDW), which is a quantitative method applied for the measurement of anisocytosis, is the most reliable and inexpensive method for differentiation of iron deficiency anemia and thalassemia trait. An increase in its rate reflects a great heterogeneity in the size of red blood cells (RBCs). Recent ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(1):49-54]

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