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Pediatric Hyponatremia

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Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.

Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana,

Background: Lesch-Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.Case report: A 15-year-old male who had been diagnosed with cerebral palsy was referred to our hospital due to renal failure ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):113-121]

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Hyponatremia As A Predictor Of Adverse Outcome In Children With Severe Lower Respiratory Tract Infection In Tribhuvan University Teaching Hospital (Tuth), Nepal

Machhindra Lamichhane, Laxman Shrestha, Luna Bajracharya, Archana Bagale,

<title>Abstract</title> <p> Background Lower respiratory tract infection (LRTI) is one of the major causes of mortality in children with estimated 1 million deaths every year. Hyponatremia is the most common electrolyte abnormality seen in LRTI. Objective To find association of hyponatremia (serum sodium<135meq/l) with severe LRTI. Design Prospective ... Read more >>

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Effect of intraoperative Hartmann's versus hypotonic solution administration on FLACC pain scale scores in children: A prospective randomized controlled trial.

Mihyun Kim, Jiyoung Lee, Sungwon Yang, Minsoo Lee, Min Suk Chae, Hyungmook Lee,

BACKGROUND:In healthy children, an isotonic solution containing no glucose or a small amount of glucose (1-2%) has been recommended as an intraoperative maintenance fluid due to the potential risk of hyponatremia associated with hypotonic solutions. However, a hypotonic solution with glucose is still widely used as a maintenance fluid for ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230556]

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Hypervolemic hyponatremia and transplant-free survival in children with cirrhosis due to biliary atresia.

Renata Silva Duarte Dos Santos, Carlos Oscar Kieling, Marina Rossato Adami, Renata Rostirola Guedes, Sandra Maria Gonçalves Vieira,

BACKGROUND:Biliary atresia is the number one cause of cirrhosis and liver transplantation in children. Hyponatremia is the most important electrolytic disturbance observed in decompensated cirrhosis. Studies of hyponatremia in cirrhotic children are scarce and those that exist have defined hyponatremia as serum sodium < 130 mEq/L lasting for at least 7 days. METHODS:We evaluated ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2020, :e13687]

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Risk factors for hyponatremia after hypotonic fluid infusion.

Yoko Shirai, Kenichiro Miura, Satoru Shimizu, Motoshi Hattori, Norikazu Shimizu,

BACKGROUND:Hypotonic maintenance i.v. fluids (IVF) pose a higher risk of hyponatremia than isotonic maintenance IVF, but isotonic maintenance IVF can result in excess sodium (Na) load in children. This study analyzed the incidence and risk factors for hyponatremia in children given hypotonic fluids with different Na concentrations and different maintenance ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, 61(12):1239-1243]

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Improvement Of Congenital Chloride Diarrhea With Corticosteroids: An Incidental Finding.

Ehsan Valavi, Hazhir Javaherizadeh, Mehran Hakimzadeh, Parisa Amoori,

Congenital chloride diarrhea of infancy is a life threatening disease. We discuss two boys with congenital chloride diarrhea over a long time period before and after kidney transplantation. In the first case, prenatal sonography revealed polyhydramnios and generalized bowel loop distention. The genetic study confirmed congenital chloride diarrhea of infancy. ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2019, 10:153-156]

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A Case of Hyponatremia-induced Seizures in an Infant Secondary to Water Intoxication from the Use of Almond Milk.

Jessica Houck, Latha Ganti, Ariel E Vera,

Pediatric seizures are a common presentation to the emergency department. It is important to separate non-febrile seizures from febrile seizures, as non-febrile seizures have a much broader differential diagnosis. For infants less than six months of age with a normal exam, hyponatremia is the leading cause of new onset non-febrile ... Read more >>

Cureus (Cureus)
[2019, 11(10):e5899]

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Autoimmune polyglandular syndrome type II with co-manifestation of Addison's and Graves' disease in a 15-year-old boy: case report and literature review.

Lena Schulz, Elke Hammer,

Background Autoimmune polyglandular syndrome type II (APS II) is defined as the combination of autoimmune adrenal insufficiency and autoimmune thyroid disease (AITD) and/or type I diabetes mellitus (T1DM) in the same patient. Case presentation A 15-year-old boy had a history of weight loss, nausea and vomiting, headache, restlessness, and tanned ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, :]

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Nonosmotic secretion of arginine vasopressin and salt loss in hyponatremia in Kawasaki disease.

Kenichiro Miura, Yutaka Harita, Naoto Takahashi, Haruko Tsurumi, Hiroki Yasudo, Tsuyoshi Isojima, Yoichiro Hirata, Ryo Inuzuka, Keiichi Takizawa, Etsushi Toyofuku, Hajime Nishimoto, Masaru Takamizawa, Taro Ando, Masahiro Sugawa, Atsuhiro Yanagisawa, Jun Inatomi, Yoshitsugu Nogimori, Akiko Kinumaki, Yoshiyuki Namai, Motoshi Hattori, Akira Oka,

BACKGROUND:The precise mechanism of hyponatremia in Kawasaki disease (KD) remains elusive because assessment of volume status based on serial changes in body weight is lacking in previous reports. METHODS:Seventeen patients who were diagnosed with KD and hyponatremia (serum sodium levels <135 mmol/L) were analyzed. Volume status was assessed based on serial ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, :]

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Efficacy of Antihypertensive Therapy in a Child with Unilateral Focal Fibromuscular Dysplasia of the Renal Artery: A Case Study and Review of Literature.

Ratna Acharya, Savannah Ellenwood, Kiran Upadhyay,

Background: Fibromuscular dysplasia (FMD) is one of the important etiologies of renovascular hypertension in children. It is usually resistant to multiple antihypertensive agents and can cause extreme elevation in blood pressures, which can lead to end organ damage if not promptly diagnosed and treated. Treatment options include medical management with ... Read more >>

Medicines (Basel) (Medicines (Basel, Switzerland))
[2020, 7(2):]

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Case report on a misleading case of appendiceal perforation presented with severe generalized convulsion.

Abu Taiub Mohammed Mohiuddin Chowdhury, Yonglin Liu, Juan Liu, Fuyong Jiao, Guo Dan, Shuixiang He,

Appendicitis and convulsions are two common pathologies among children. Though appendicitis has some certain symptoms, they might present with atypical symptoms in young ages. Here we present a misleading case of a perforated appendix that presented with severe generalized convulsion, no significant abdominal symptoms and had a recent history of ... Read more >>

Transl Pediatr (Translational pediatrics)
[2020, 9(1):81-85]

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Prevalence and Risk Factors for Hyponatremia in Preterm Infants.

Tran Kiem Hao,

BACKGROUND:Hyponatremia is the result of a negative sodium balance caused by inadequate salt intake or excessive salt loss due to immature renal or intestinal function in preterm infants. AIM:The aim of our study was to define the incidence of and factors affecting its development in preterm newborns. METHODS:This was a ... Read more >>

Open Access Maced J Med Sci (Open access Macedonian journal of medical sciences)
[2019, 7(19):3201-3204]

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Osmoregulation in children with cystic fibrosis.

Yury V Natochin, Alla A Kuznetsova, Anastasia V Prokopenko, Gregorio P Milani, Sebastiano A G Lava, Anna S Marina,

Hyponatremia is not rare in cystic fibrosis and might be due to several mechanisms. An endocrine and renal imbalance in water and salt homeostasis was suggested. To address this hypothesis, we assessed the urinary concentrating and diluting ability in 12 cystic fibrosis patients (6 females, 6 males) and in two ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2020, :]

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Idiopathic SIADH in the premature newborn, a case report.

D van der Lee, C de Bruin, S J Steggerda, H Vlaardingerbroek,

BACKGROUND:Hyponatremia is a common laboratory finding in premature and ill neonates. When the degree of hyponatremia is more severe, the likelihood of a pathologic entity increases. In this case report we describe a premature neonate with severe hyponatremia due to the idiopathic syndrome of inappropriate antidiuretic hormone secretion (SIADH). CASE ... Read more >>

J Neonatal Perinatal Med (Journal of neonatal-perinatal medicine)
[2019, :]

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Sodium monitoring in infants < 100 days of life.

Sebastiano A G Lava, Mario G Bianchetti, Carlo Agostoni, Gregorio P Milani,

Eur. J. Pediatr. (European journal of pediatrics)
[2019, :]

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A rare cause of chronic hyponatremia in an infant: Questions.

Gül Yeşiltepe Mutlu, Mehmet Taşdemir, Nuray Uslu Kızılkan, Tülay Güran, Şükrü Hatun, Hülya Kayserili, Ilmay Bilge,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):241-242]

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A rare cause of chronic hyponatremia in an infant: Answers.

Gül Yeşiltepe Mutlu, Mehmet Taşdemir, Nuray Uslu Kızılkan, Tülay Güran, Şükrü Hatun, Hülya Kayserili, Ilmay Bilge,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(2):243-245]

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Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study.

Henrik Arnell, Frederic V Valla, Geneviève Malfilâtre, Patrick Pladys, Thibault Senterre, Alessandro Pontes-Arruda,

OBJECTIVES:Hypermagnesemia has been reported in preterm neonates treated with commercial pediatric triple-chamber bag (3CB) parenteral nutrition (PN). This postmarketing study was requested by the European Medicines Agency to assess the safety of a 3CB PN product in full-term neonates and children up to 24 months of age. METHODS:This prospective, multicenter, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2019, 69(6):e151-e157]

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Clinical Implications of Ketosis in Children with Benign Convulsions with Mild Gastroenteritis.

Jeong Yong Lee, Jeong Min Ryu, Jong Seung Lee, Tae Sung Ko, Mi Sun Yum,

BACKGROUND AND PURPOSE:The pathophysiologic mechanisms underlying benign convulsions with mild gastroenteritis (CwG) in children remain unclear. We investigated the incidence of ketosis in CwG and whether this is related to seizures. METHODS:This retrospective study included children aged from 6 months to 6 years who visited our emergency department and were ... Read more >>

J Clin Neurol (Journal of clinical neurology (Seoul, Korea))
[2020, 16(1):96-101]

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Safety and Tolerability of Adjunctive Eslicarbazepine Acetate in Pediatric Patients (Aged 4-17 Years) With Focal Seizures.

Mark Mintz, Jesus E Pina-Garza, Steven M Wolf, Patricia E McGoldrick, Sergiusz Józwiak, Todd Grinnell, David Cantu, Raquel Costa, Joana Moreira, Yan Li, David Blum,

OBJECTIVE:To evaluate the safety and tolerability of adjunctive eslicarbazepine acetate (ESL) in pediatric patients (aged 4-17 years) with refractory focal seizures. METHODS:Pooled safety data from patients aged 4-17 years in Study 208 (NCT01527513) and Study 305 (NCT00988156) were analyzed. Both were randomized, double-blind, placebo-controlled studies of ESL as adjunctive treatment ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(4):265-273]

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Necrotizing enterocolitis following diazoxide therapy for persistent neonatal hypoglycemia.

Christina M Theodorou, Shinjiro Hirose,

Recalcitrant neonatal hypoglycemia poses a treatment challenge for clinicians. When a patient's hypoglycemia does not respond to dextrose infusion, several medication options are available, including diazoxide(1,2). Several side effects of diazoxide are described in the literature, including fluid retention with the risk of development of congestive heart failure(3,4). We describe ... Read more >>

J Pediatr Surg Case Rep (Journal of pediatric surgery case reports)
[2020, 52:]

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IMPACT OF MELD SODIUM ON LIVER TRANSPLANTATION WAITING LIST.

Alexandre Coutinho Teixeira de Freitas, Aline Tatiane Rampim, Carolline Popovicz Nunes, Júlio Cezar Uili Coelho,

BACKGROUND:Serum sodium was incorporated to MELD score for the allocation of liver transplantation In the USA in 2016. Hyponatremia significantly increased the efficacy of the score to predict mortality on the waiting list. Such modification was not adopted in Brazil. AIM:To carry out a simulation using MELD-Na as waiting list ... Read more >>

Arq Bras Cir Dig (Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery)
[2019, 32(3):e1460]

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Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosis.

Min-Hua Tseng, Jing-Long Huang, Shih-Ming Huang, Jeng-Daw Tsai, Tai-Wei Wu, Wen-Lang Fan, Jhao-Jhuang Ding, Shih-Hua Lin,

BACKGROUND:Type IV renal tubular acidosis (RTA) is a severe complication of urinary tract infection (UTI) in infants. A detailed clinical and molecular analysis is still lacking. METHODS:Infants with UTI who exhibited features of type IV RTA were prospectively enrolled. Clinical, laboratory, and image characteristics and sequencing of genes responsible for ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, :]

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Higher incidence of syndrome of inappropriate antidiuretic hormone secretion during induction chemotherapy of acute lymphoblastic leukemia in indian children.

Shwetha Seetharam, Priyakumari Thankamony, Kaduveettil Gopinathan Gopakumar, K M Jagathnath Krishna,

BACKGROUND:Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a well-known adverse effect of vincristine (VCR). Literature suggests that Asians are predisposed to develop SIADH following VCR administration. However, data regarding the occurrence of SIADH in children with malignancy are limited. This study aims to analyze the incidence, clinical picture, risk ... Read more >>

Indian J Cancer (Indian journal of cancer)
[2019, 56(4):320-324]

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Persistent Hiccups Because of Water Intoxication by Colonic Irrigation With Tap Water.

Marlon van Weelden, Esther Edelenbos, Tim de Meij,

Hyponatremia by colonic irrigation with water is a rare complication, especially in children. We describe a child with chronic constipation who was admitted because of persistent hiccups provoked by severe hyponatremia by water intoxication due to colonic irrigation with tap water. Awareness of complications of colonic irrigation may be crucial ... Read more >>

ACG Case Rep J (ACG case reports journal)
[2019, 6(8):]

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