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Pediatric Hypokalemia

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Potassium disorders in pediatric emergency department: Clinical spectrum and management.

O Barbance, D De Bels, P M Honoré, D Bargalzan, A Tolwani, K Ismaili, D Biarent, S Redant,

INTRODUCTION:Potassium abnormalities are frequent in intensive care but their incidence in the emergency department is unknown. AIM:We describe the spectrum of potassium abnormalities in our tertiary-level pediatric emergency department. METHODS:Retrospective case-control study of all the patients admitted to a single-center tertiary emergency department over a 2.5-year period. We compared patients ... Read more >>

Arch Pediatr (Archives de pediatrie : organe officiel de la Societe francaise de pediatrie)
[2020, :]

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Ketoacidosis in type 1 diabetics: we should return to pediatric guidelines.

Sébastien Redant, David De Bels, Jacques Massaut, Jacques Devriendt, Xavier Beretta-Piccoli, Rachid Attou, Patrick M Honore,

Ann Intensive Care (Annals of intensive care)
[2020, 10(1):19]

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Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-onset Hypertension.

Peng Fan, Xiao-Cheng Pan, Di Zhang, Kun-Qi Yang, Ying Zhang, Tao Tian, Fang Luo, Wen-Jun Ma, Ya-Xin Liu, Lin-Ping Wang, Hui-Min Zhang, Lei Song, Jun Cai, Xian-Liang Zhou,

BACKGROUND:Liddle syndrome (LS), an autosomal dominant disorder, is a common monogenic hypertension in pediatrics. In this study, we reported a novel SCNN1G variant in a Chinese family with pediatric LS, and conduct a systematic review of ENaC-gene-positive LS cases to conclude the clinical genetic features of LS in childhood. METHODS:Next-generation ... Read more >>

Am. J. Hypertens. (American journal of hypertension)
[2020, :]

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EMA Recommendation for the Pediatric Indications of Plerixafor (Mozobil) to Enhance Mobilization of Hematopoietic Stem Cells for Collection and Subsequent Autologous Transplantation in Children with Lymphoma or Malignant Solid Tumors.

Dominik Karres, Sahra Ali, Paula B van Hennik, Sabine Straus, Filip Josephson, Geanne Thole, Pieter J Glerum, Carla Herberts, Negar Babae, Ralf Herold, Irene Papadouli, Francesco Pignatti,

On March 28, 2019, the Committee for Medicinal Products for Human Use adopted a positive opinion recommending the marketing authorization for the medicinal product plerixafor. The marketing authorization holder for this medicinal product is Genzyme Europe B.Th. The adoption was for an extension of the existing adult indication in combination ... Read more >>

Oncologist (The oncologist)
[2020, :]

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Hypokalemia in a pediatric patient on continuous renal replacement therapy: Answers.

Alexandra Idrovo, Ayse Akcan-Arikan, Rossana Malatesta-Muncher, Leyat Tal,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(12):2553-2555]

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[Evaluation of Micafungin Use in Children].

Edanur Yeşil, Solmaz Çelebi, Melike Sezgin Evim, Arife Özer, Cansu Turan, Demet Timur, Salih Çağrı Çakır, Beyhan Bülbül, Beyza Ener, Adalet Meral Güneş, Nilgün Köksal, Hilal Özkan, Betül Sevinir, Duygu Düzcan Kilimci, Mustafa Hacımustafaoğlu,

Micafungin is recommended especially in patients with liver and kidney failure and in the presence of other side effects due to antifungals apart from its known priority indications such as invasive candidiasis. The aim of this study was to evaluate the children who have received micafungin treatment. In the study, ... Read more >>

Mikrobiyol Bul (Mikrobiyoloji bulteni)
[2020, 54(1):120-134]

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Improvement Of Congenital Chloride Diarrhea With Corticosteroids: An Incidental Finding.

Ehsan Valavi, Hazhir Javaherizadeh, Mehran Hakimzadeh, Parisa Amoori,

Congenital chloride diarrhea of infancy is a life threatening disease. We discuss two boys with congenital chloride diarrhea over a long time period before and after kidney transplantation. In the first case, prenatal sonography revealed polyhydramnios and generalized bowel loop distention. The genetic study confirmed congenital chloride diarrhea of infancy. ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2019, 10:153-156]

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Hypokalemia and hearing loss in a 3-year-old boy: Questions.

Ozlem Yuksel Aksoy, Fatma Semsa Cayci, Serdar Ceylaner, Sibel Alicura Tokgoz, Gunay Kaplan, Umut Selda Bayrakci,

Bartter syndrome with sensorineural deafness (Bartter syndrome type 4) is an autosomal recessive disorder characterized with polyhydramniosis, premature birth, massive polyuria, renal salt-wasting, hypokalemic metabolic alkalosis, normotensive hyperreninemic hyperaldosteronism, and hearing loss. Homozygous mutations in BSND, CLCNKA, and CLCNKB mutations cause the disorder. Here we report a 3-year-old boy who ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):615]

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A dilemma of proximal tubule in an infant: hypophosphatemia and hypouricemia without hypokalemia and acidosis: Answers.

Eren Soyaltın, Belde Kasap Demir, Gökçen Erfidan, Seçil Arslansoyu Çamlar, Demet Alaygut, Fatma Mutlubaş,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):611-613]

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A Dilemma of Proximal Tubule in An Infant: Hypophosphatemia and Hypourisemia Without Hypokalemia and Acidosis: Questions.

Eren Soyaltın, Belde Kasap Demir, Gökçen Erfidan, Seçil Arslansoyu Çamlar, Demet Alaygut, Fatma Mutlubaş,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):609]

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Hypokalemia and hearing loss in a 3-year-old boy: Answers.

Ozlem Yuksel Aksoy, Fatma Semsa Cayci, Serdar Ceylaner, Sibel Alicura Tokgoz, Gunay Kaplan, Umut Selda Bayrakci,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):617-618]

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Efficacy of Antihypertensive Therapy in a Child with Unilateral Focal Fibromuscular Dysplasia of the Renal Artery: A Case Study and Review of Literature.

Ratna Acharya, Savannah Ellenwood, Kiran Upadhyay,

Background: Fibromuscular dysplasia (FMD) is one of the important etiologies of renovascular hypertension in children. It is usually resistant to multiple antihypertensive agents and can cause extreme elevation in blood pressures, which can lead to end organ damage if not promptly diagnosed and treated. Treatment options include medical management with ... Read more >>

Medicines (Basel) (Medicines (Basel, Switzerland))
[2020, 7(2):]

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Inherited salt-losing tubulopathy: an old condition but a new category of tubulopathy.

Kandai Nozu, Tomohiko Yamamura, Tomoko Horinouchi, China Nagano, Nana Sakakibara, Kenji Ishikura, Riku Hamada, Naoya Morisada, Kazumoto Iijima,

Bartter syndrome (BS) and Gitelman syndrome (GS) are syndromes associated with congenital tubular dysfunction characterized by hypokalemia and metabolic alkalosis. Clinically, BS is classified into two types: the severe antenatal/neonatal type, which develops during the fetal period with polyhydramnios and preterm delivery; and the relatively mild classical type, which is ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, :]

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Systemic lupus erythematosus complicated by a Gitelman-like syndrome in an 8-year-old girl.

Gowri Shankar Barathidasan, Sriram Krishnamurthy, Pediredla Karunakar, Ranjitha Rajendran, Kagnur Ramya, Gunasekaran Dhandapany, Jaikumar Govindaswamy Ramamoorthy, Rajesh Nachiappa Ganesh,

An 8-year-old girl with recently diagnosed Systemic Lupus Erythematosus (SLE) (class 4 lupus nephritis with autoimmune hemolytic anemia) presented to the pediatric nephrology clinic with polyuria, tiredness and cramps; laboratory investigations revealed refractory hypokalemia, hypomagnesemia, metabolic alkalosis, hypocalciuria and hyperchloriuria. There was no history of diuretic administration. These features were ... Read more >>

CEN Case Rep (CEN case reports)
[2019, :]

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Fluid Therapy For Pediatric Patients With Diabetic Ketoacidosis: Current Perspectives.

Muralidharan Jayashree, Vijai Williams, Rajalakshmi Iyer,

Diabetic ketoacidosis (DKA) is a preventable life-threatening complication of type 1 diabetes. Fluids form a crucial component of DKA therapy, goals being the restoration of intravascular, interstitial and intracellular compartments. Hydration reduces hyperglycemia by decreased counter-regulatory hormones, enhanced renal glucose clearance and augmented insulin sensitivity. However, for the last several ... Read more >>

Diabetes Metab Syndr Obes (Diabetes, metabolic syndrome and obesity : targets and therapy)
[2019, 12:2355-2361]

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Decitabine and Vorinostat with Chemotherapy in Relapsed Pediatric Acute Lymphoblastic Leukemia: A TACL Pilot Study.

Michael J Burke, Rumen Kostadinov, Richard Sposto, Lia Gore, Shannon M Kelley, Cara Rabik, Jane B Trepel, Min-Jung Lee, Akira Yuno, Sunmin Lee, Deepa Bhojwani, Sima Jeha, Bill H Chang, Maria Luisa Sulis, Michelle L Hermiston, Paul Gaynon, Van Huynh, Anupam Verma, Rebecca Gardner, Kenneth M Heym, Robyn M Dennis, David S Ziegler, Theodore W Laetsch, Javier E Oesterheld, Steven G Dubois, Jessica A Pollard, Julia Glade-Bender, Todd M Cooper, Joel A Kaplan, Midhat S Farooqi, Byunggil Yoo, Erin Guest, Alan S Wayne, Patrick A Brown,

PURPOSE:Treatment failure from drug resistance is the primary reason for relapse in acute lymphoblastic leukemia. Improving outcomes by targeting mechanisms of drug resistance is a potential solution. EXPERIMENTAL DESIGN:We report results investigating the epigenetic modulators decitabine and vorinostat with vincristine, dexamethasone, mitoxantrone and PEG-asparaginase for pediatric patients with relapsed or ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, :]

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A rare cause of delayed puberty in two cases with 46,XX and 46,XY karyotype: 17 α-hydroxylase deficiency due to a novel variant in CYP17A1 gene.

Edip Unal, Ruken Yıldırım, Funda Feryal Taş, Suat Tekin, Serdar Ceylaner, Yusuf Kenan Haspolat,

Aims: 17α-hydroxylase deficiency is a rare form of congenital adrenal hyperplasia (CAH) which is inherited autosomal recessive. It occurs result of a mutations in gene cytochrome (CYP)17A1, which encodes both 17α-hydroxylase and 17,20-lyase enzymes. The main clinical findings of the disease are delayed puberty, primary amenorrhea in females, and disorders ... Read more >>

Gynecol. Endocrinol. (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2019, :1-4]

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Combination of furosemide and fludrocortisone as a loading test for diagnosis of distal renal tubular acidosis in a pediatric case.

Yuki Kyono, Kandai Nozu, Taku Nakagawa, Yuichi Takami, Hideki Fujita, Tomoaki Ioroi, Masaaki Kugo, Kazumoto Iijima, Naohiro Kamiyoshi,

Renal tubular acidosis (RTA) is a rare disease caused by a defect of urinary acidification. The ammonium chloride loading test is the gold standard method for determining the type of RTA. However, because this test has some side effects (e.g., nausea, vomiting, and stomach discomfort), applying this test for pediatric ... Read more >>

CEN Case Rep (CEN case reports)
[2020, 9(1):81-86]

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Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study.

Henrik Arnell, Frederic V Valla, Geneviève Malfilâtre, Patrick Pladys, Thibault Senterre, Alessandro Pontes-Arruda,

OBJECTIVES:Hypermagnesemia has been reported in preterm neonates treated with commercial pediatric triple-chamber bag (3CB) parenteral nutrition (PN). This postmarketing study was requested by the European Medicines Agency to assess the safety of a 3CB PN product in full-term neonates and children up to 24 months of age. METHODS:This prospective, multicenter, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2019, 69(6):e151-e157]

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Hypokalemia in a pediatric patient on continuous renal replacement therapy: Questions.

Alexandra Idrovo, Ayse Akcan-Arikan, Rossana Malatesta-Muncher, Leyat Tal,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(12):2551-2552]

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Combination Antifungal Therapy for Invasive Mold Infections Among Pediatric Patients with Hematological Malignancies: Data from A Real-Life Case-Series.

Anna Maria Peri, Marta Verna, Stefano Biffi, Laura Alagna, Benedetta Longhi, Guglielmo Marco Migliorino, Sergio Foresti, Alessandra Bandera, Attilio Rovelli, Carmelo Rizzari, Andrea Gori, Antonella Colombini,

Background:Invasive mold infections in children with hematological malignancies are associated with high mortality rates. The use of combination antifungal therapy in cases with a severe clinical course is increasing, although information on the efficacy and safety of this approach is limited. Methods:We present a case series of 13 children affected ... Read more >>

Pathog Immun (Pathogens & immunity)
[2019, 4(2):180-194]

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Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity.

Xin He, Zubin Modi, Tobias Else,

Secondary hypertension is a common condition with a broad differential diagnosis. Identification of the true cause of hypertension can be critical for guiding appropriate management. Here, we review hereditary conditions underlying the most common cause of secondary hypertension, primary aldosteronism, as well as other disorders impacting various levels of mineralocorticoid ... Read more >>

Gland Surg (Gland surgery)
[2020, 9(1):150-158]

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Incidence, clinical profile, and risk factors for serious bacterial infections in children hospitalized with fever in Ujjain, India.

Ashish Pathak, Radika Upadhayay, Aditya Mathur, Sunil Rathi, Cecilia Stålsby Lundborg,

BACKGROUND:Fever is a cause for concern for both parents and the treating pediatrician and a common reason for antibiotic overuse. However, the proportion of children hospitalized for fever with serious bacterial infection (SBI) is uncertain. We aimed to evaluate the epidemiological, clinical, hematological, and biochemical risks for SBI among the ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):162]

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Adrenal neuroblastoma in an elderly adult: a case report and review of the literature.

Haibin Zhang, Ziwei Feng,

BACKGROUND:Neuroblastoma is an embryonal malignancy of the autonomic nervous system and is the most common extracranial tumor of early childhood. However, neuroblastoma in adults is rare with an overall incidence of 1 in 10 million adults/year. Adults with neuroblastoma have a significantly worse prognosis than children with neuroblastoma. CASE PRESENTATION:In ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):284]

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Comparison of admission serum albumin and hemoglobin as predictors of outcome in children with moderate to severe traumatic brain injury: A retrospective study.

Hong-Chun Luo, Yue-Qiang Fu, Cheng-Yan You, Cheng-Jun Liu, Feng Xu,

Hypoalbuminemia and anemia are frequent among in patients with traumatic brain injury (TBI). We assess whether serum albumin and hemoglobin at admission can predict outcome in children with moderate to severe TBI.This retrospective study was conducted in a tertiary pediatric hospital between May 2012 and Jun 2018 included children with ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(44):e17806]

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