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Pediatric Hypernatremia

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Assessment of a Day Hospital Management Program for Children With Type 1 Diabetes.

Sarah Lawson, Jacob M Redel, Allison Smego, Melanie Gulla, Pamela J Schoettker, Mary Jolly, Farida Mostajabi, Lindsey Hornung,

Importance:A shift in the setting of care delivery for children with a new diagnosis of type 1 diabetes led to a reorganization of treatment. Objective:To determine whether a new diagnosis of pediatric diabetes can be successfully managed in a day hospital model. Design, Setting, and Participants:This quality improvement study used ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(3):e200347]

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Vecuronium- and Esmolol-Induced Pseudohypernatremia Due to Drug Interference With Ion-Selective Electrodes.

Tracey G Polsky, Eloise Salmon, Sarah S Welsh, Derick Lim, Sheng Feng, Lance Ballester, Abdulla M Ehlayel, Jennifer L Hewlett, Michelle R Denburg, Donald L Boyer, Ulf H Beier,

Objectives:We observed that patients treated with continuous vecuronium or esmolol infusions showed elevated plasma sodium measurements when measured by the routine chemistry analyzer as part of the basic metabolic panel (Vitros 5600; Ortho Clinical Diagnostics, Raritan, NJ), but not by blood gas analyzers (RAPIDLab 1265; Siemens, Tarrytown, NY). Both instruments ... Read more >>

Crit Care Explor (Critical Care Explorations)
[2020, 2(1):e0073]

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A Case of Congenital Nephrogenic Diabetes Insipidus Caused by Thr108Met Variant of Aquaporin 2.

Lina Ma, Dengyan Wu, Xingmin Wang, Yonghong Yang,

Congenital nephrogenic diabetes insipidus (CNDI) is a rare renal disorder caused by mutations in arginine vasopressin receptor 2 (AVPR2) or aquaporin 2 (AQP2). The clinical signs of CNDI include polyuria, compensatory polydipsia, dehydration, electrolyte disorder, and developmental retardation without prompt treatment. In this study we report a rare case of ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:15]

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Panhypopituitarism from neurosarcoidosis in an adolescent: case report and literature review.

Anju Sukumaran,

Background Neurosarcoidosis is not a common entity from an endocrinology standpoint. Prompt diagnosis is essential in order to determine appropriate treatment and to establish prognosis. Case presentation Our case illustrates the difficulties encountered in making a diagnosis of sarcoidosis in an adolescent who presented with polyuria, polydipsia and hypernatremia. She ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(9):1039-1042]

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Salty diabetes: a case series of hypernatremia presenting with diabetic ketoacidosis.

Elias Estifan, Sushant M Nanavati, Vinod Kumar, Sandra Gibiezaite, Patrick Michael,

Hyponatremia is an expected electrolyte resultant in diabetic ketoacidosis (DKA) that presents secondary to the dilutional effect of hyperglycemia. However, hypernatremia in DKA is a rare presentation, more common in the pediatric population, that rides poor morbidity and mortality. We describe three cases of patients presenting with DKA and hypernatremia ... Read more >>

AME Case Rep (AME case reports)
[2019, 3:27]

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Clinical Characteristics of Pediatric Patients With Sellar and Suprasellar Lesions Who Initially Present With Central Diabetes Insipidus: A Retrospective Study of 55 Cases From a Large Pituitary Center in China.

Xin Ji, Zihao Wang, Wenze Wang, Lu Gao, Xiaopeng Guo, Chenzhe Feng, Wei Lian, Kan Deng, Bing Xing,

Purpose: To increase knowledge for the early differential diagnosis and accurate therapeutic strategies for pediatric patients with sellar or suprasellar region (SSR) lesions who initially present with central diabetes insipidus (CDI). Methods: This is a retrospective review of 55 pediatric patients (≤14 years old) with identified lesions in the SSR ... Read more >>

Front Endocrinol (Lausanne) (Frontiers in Endocrinology)
[2020, 11:76]

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Prevalence and Risk Factors for Hyponatremia in Preterm Infants.

Tran Kiem Hao,

BACKGROUND:Hyponatremia is the result of a negative sodium balance caused by inadequate salt intake or excessive salt loss due to immature renal or intestinal function in preterm infants. AIM:The aim of our study was to define the incidence of and factors affecting its development in preterm newborns. METHODS:This was a ... Read more >>

Open Access Maced J Med Sci (Open access Macedonian journal of medical sciences)
[2019, 7(19):3201-3204]

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Serum Steroid Profiling by Liquid Chromatography-Tandem Mass Spectrometry for the Rapid Confirmation and Early Treatment of Congenital Adrenal Hyperplasia: A Neonatal Case Report.

Ilaria Cicalini, Stefano Tumini, Paola Irma Guidone, Damiana Pieragostino, Mirco Zucchelli, Sara Franchi, Gabriele Lisi, Pierluigi Lelli Chiesa, Liborio Stuppia, Vincenzo De Laurenzi, Claudia Rossi,

Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders of steroid biosynthesis, in 95% of cases due to 21-hydroxylase deficiency. The resulting hormonal imbalances lead to increased 17-hydroxyprogesterone and androgens levels, at the expense of decreased concentrations of glucocorticoids and, in some cases, of mineralocorticoids. A variety of ... Read more >>

Metabolites (Metabolites)
[2019, 9(12):]

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IMPACT OF MELD SODIUM ON LIVER TRANSPLANTATION WAITING LIST.

Alexandre Coutinho Teixeira de Freitas, Aline Tatiane Rampim, Carolline Popovicz Nunes, Júlio Cezar Uili Coelho,

BACKGROUND:Serum sodium was incorporated to MELD score for the allocation of liver transplantation In the USA in 2016. Hyponatremia significantly increased the efficacy of the score to predict mortality on the waiting list. Such modification was not adopted in Brazil. AIM:To carry out a simulation using MELD-Na as waiting list ... Read more >>

Arq Bras Cir Dig (Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery)
[2019, 32(3):e1460]

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Hyponatremia in infants with community-acquired infections on hospital admission.

Marta B Mazzoni, Gregorio P Milani, Silvia Bernardi, Ludovica Odone, Alessia Rocchi, Emanuela A D'Angelo, Marco Alberzoni, Carlo Agostoni, Mario G Bianchetti, Emilio F Fossali,

Acute moderate to severe gastroenteritis is traditionally associated with hypernatremia but recent observations suggest that hypernatremia is currently less common than hyponatremia. The latter has sometimes been documented also in children with acute community-acquired diseases, such as bronchiolitis and pyelonephritis. We investigated the prevalence of dysnatremia in children with acute ... Read more >>

PLoS ONE (PloS one)
[2019, 14(7):e0219299]

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Failure to thrive: the importance of measuring the electrolytes.

, A Sallemi, G Stroscio, D Impollonia, T Arrigo, V Di Benedetto, V Salvo, L Marseglia, M G Scuderi, M P Calabrò, C Fede, C Cuppari, C Salpietro, R Chimenz,

Diabetes insipidus (DI) is characterized by hypoosmotic polyuria related to deficiency of arginine-vasopressin (AVP) secretion (centraldiabetesinsipidus, CDI) or renalinsensitivity to AVP (nephrogenicdiabetesinsipidus, NDI). We report a case of a child with congenital NDI. ... Read more >>

J. Biol. Regul. Homeost. Agents (Journal of biological regulators and homeostatic agents)
[2019, 33(5 Suppl. 1):3-5]

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N-acetylcysteine for Management of Distal Intestinal Obstruction Syndrome.

Abigail L Schauble, Elizabeth K Bisaccia, Grace Lee, Samya Z Nasr,

With the improving life expectancy of cystic fibrosis patients, new manifestations of the disease are emerging. Distal intestinal obstruction syndrome is one of the increasingly noted complications. Traditionally this syndrome was treated surgically. N-acetylcysteine is sometimes used as a non-surgical treatment option despite lack of definitive evidence for its efficacy ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(5):390-397]

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Management of the Pediatric Organ Donor.

Elizabeth J Beckman,

Management of the pediatric organ donor necessitates understanding the physiologic changes that occur preceding and after death determination. Recognizing these changes allows application of the therapeutic strategies designed to optimize hemodynamics and metabolic state to allow for preservation of end-organ function for maximal organ recovery and minimal damage to the ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(4):276-289]

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Transient water-electrolyte disturbance after hemispherotomy in young infants with epileptic encephalopathy.

Takashi Saito, Kenji Sugai, Akio Takahashi, Naoki Ikegaya, Eiji Nakagawa, Masayuki Sasaki, Masaki Iwasaki, Taisuke Otsuki,

PURPOSE:This study aimed to elucidate the clinical features of water-electrolyte disturbance (WED) as a sequela of hemispherotomy. METHODS:We performed a retrospective chart review to identify the clinical features of diabetes insipidus (DI) as a complication in < 12-month-old patients who underwent hemispherectomy or hemispherotomy for severe epilepsy between 2007 and 2018. ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2019, :]

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Administration of gamma-hydroxybutyrate instead of beta-hydroxybutyrate to a liver transplant recipient suffering from propionic acidemia and cardiomyopathy: A case report on a medication prescribing error.

Caroline Tuchmann-Durand, Eloise Thevenet, Florence Moulin, Fabrice Lesage, Juliette Bouchereau, Mehdi Oualha, Diala Khraiche, Anaïs Brassier, Camille Wicker, Stéphanie Gobin-Limballe, Jean-Baptiste Arnoux, Florence Lacaille, Clotilde Wicart, Bruno Coat, Joel Schlattler, Salvatore Cisternino, Sylvain Renolleau, Philippe-Henri Secretan, Pascale De Lonlay,

Beta-hydroxybutyrate (BHB) is a synthetic ketone body used as an adjuvant energy substrate in the treatment of patients with metabolic cardiomyopathy. A medication prescribing error led to the administration of the general anesthetic sodium gamma-hydroxybutyrate (GHB) instead of sodium BHB in a liver transplant recipient with propionic acidemia and cardiomyopathy, ... Read more >>

JIMD Rep (JIMD reports)
[2020, 51(1):25-29]

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154 compared to 54 mmol per liter of sodium in intravenous maintenance fluid therapy for adult patients undergoing major thoracic surgery (TOPMAST): a single-center randomized controlled double-blind trial.

Niels Van Regenmortel, Steven Hendrickx, Ella Roelant, Ingrid Baar, Karolien Dams, Karen Van Vlimmeren, Bart Embrecht, Anouk Wittock, Jeroen M Hendriks, Patrick Lauwers, Paul E Van Schil, Amaryllis H Van Craenenbroeck, Walter Verbrugghe, Manu L N G Malbrain, Tim Van den Wyngaert, Philippe G Jorens,

PURPOSE:To determine the effects of the sodium content of maintenance fluid therapy on cumulative fluid balance and electrolyte disorders. METHODS:We performed a randomized controlled trial of adults undergoing major thoracic surgery, randomly assigned (1:1) to receive maintenance fluids containing 154 mmol/L (Na154) or 54 mmol/L (Na54) of sodium from the start of ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(10):1422-1432]

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Hidden health IT hazards: a qualitative analysis of clinically meaningful documentation discrepancies at transfer out of the pediatric intensive care unit.

Evan W Orenstein, Daria F Ferro, Christopher P Bonafide, Christopher P Landrigan, Scott Gillespie, Naveen Muthu,

Objective:The risk of medical errors increases upon transfer out of the intensive care unit (ICU). Discrepancies in the documented care plan between notes at the time of transfer may contribute to communication errors. We sought to determine the frequency of clinically meaningful discrepancies in the documented care plan for patients ... Read more >>

JAMIA Open (JAMIA open)
[2019, 2(3):392-398]

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Clinical Approach to Sodium Homeostasis Disorders in Children with Pituitary-Suprasellar Tumors.

Gerdi Tuli, Patrizia Matarazzo, Luisa de Sanctis,

Children with pituitary-suprasellar tumors are at high risk of developing sodium metabolism disorders since the tumoral mass itself or surgical and medical treatment can damage AVP release circuits. Additional risk factors are represented by the use of hypotonic fluids, the young age, total parenteral nutrition, and obstructive hydrocephalus secondary to ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2020, 110(3-4):161-171]

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First line in psychiatric emergency: pre-hospital emergency protocol for mental disorders in Iran.

Fatemeh Shirzad, Fatemeh Hadi, Seyede Salehe Mortazavi, Maryam Biglari, Hassan Noori Sari, Zeinab Mohammadi, Mehrdad Kazemzade Atoofi, Seyed Vahid Shariat,

INTRODUCTION:This article is a report of designing a rapid and effective guide for paramedics who take care of patients in a pre-hospital setting to answer developing demands. METHODS:The relevant literature was reviewed, and the topics were extracted. Then, the extracted items were discussed in an expert panel. Finally, items were ... Read more >>

BMC Emerg Med (BMC emergency medicine)
[2020, 20(1):19]

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SUN-277 Severe Hyperglycemia in the Setting of Hypernatremic Dehydration.

Meenal Gupta, Fida Bacha,

Abstract Hypernatremic dehydration associated with hyperglycemia in non-diabetic infants has a potential to cause serious metabolic derangement. Review of limited literature available on this condition reveals pathogenesis of hyperglycemia is likely multi-factorial. We present a case of extreme hyperglycemia in a 10 months old infant with severe hypernatremic dehydration ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2019, 3(Suppl 1):]

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Etiology, Clinical Features, And Short-Term Outcome Of Seizures In Newborns Admitted To The University Of Gondar Hospital, Ethiopia.

Hailu Tazebew Amare, Ashenafi Tazebew Amare,

Background:Neonatal seizures are the most common neurological dysfunction in the neonatal period. Neonatal seizure patterns and short-term neurologic outcomes, particularly in the Ethiopian context, have not been adequately studied. Objective:The main aim of this study is to assess the pattern, probable etiology, short-term outcomes, and determinants of neonatal seizures in ... Read more >>

Pediatric Health Med Ther (Pediatric health, medicine and therapeutics)
[2019, 10:107-113]

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Factors associated with cerebral edema in children under 5 years of age admitted in an intensive care unit and their outcome.

Shamin Islam, Monira Sarmin, Tahmeed Ahmed, Farzana Afroze, Mohammod Jobayer Chisti,

Objective:We aimed to evaluate risk factors and outcome of cerebral edema in children with diarrhea. Methods:In this retrospective chart analysis, data of all diarrheal children under 5 years of age having convulsion and admitted in intensive care unit were retrieved from an electronic medical record system of Dhaka Hospital of ... Read more >>

SAGE Open Med (SAGE Open Medicine)
[2019, 7:2050312119874622]

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Hyperosmolar Therapy for Severe Traumatic Brain Injury in Pediatrics: A Review of the Literature.

Norman E Fenn, Caroline M Sierra,

Traumatic brain injury remains a leading cause of morbidity and mortality in children. The use of hyperosmolar therapy to offset increased intracranial pressure (ICP) is described in pediatric guidelines, yet some controversy remains regarding which option to select. A search was conducted using the PubMed, MEDLINE, Cumulative Index of Nursing ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(6):465-472]

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[Sodium balance impairment in a child with severe traumatic brain injury].

Y S Aleksandrovich, K V Pshenisnov, A S Ustinova, V V Kopylov, I V Aleksandrovich, V I Gordeev,

We report a case of cerebral salt-wasting syndrome in a 12-year-old boy with severe traumatic brain injury. The child developed refractory intracranial hypertension at the time of injury, which required decompressive craniectomy on the 7th day after injury. Infusion of hypertonic sodium chloride solutions performed at the intensive care unit ... Read more >>

Probl Endokrinol (Mosk) (Problemy endokrinologii)
[2019, 65(1):39-45]

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Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study.

Henrik Arnell, Frederic V Valla, Geneviève Malfilâtre, Patrick Pladys, Thibault Senterre, Alessandro Pontes-Arruda,

OBJECTIVES:Hypermagnesemia has been reported in preterm neonates treated with commercial pediatric triple-chamber bag (3CB) parenteral nutrition (PN). This postmarketing study was requested by the European Medicines Agency to assess the safety of a 3CB PN product in full-term neonates and children up to 24 months of age. METHODS:This prospective, multicenter, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2019, 69(6):e151-e157]

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