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Pediatric Hyperkalemia

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Timing of initiation of renal replacement therapy in acute kidney injury: an updated meta-analysis of randomized controlled trials.

Ling Zhang, Dezheng Chen, Xin Tang, Peiyun Li, Yong Zhang, Ye Tao,

Purpose: The results from randomized controlled trials (RCTs) concerning the timing of initiation of renal replacement therapy (RRT) for patients with acute kidney injury (AKI) are still inconsistent.Materials and methods: We searched for RCTs, as well as relevant references, focusing on the timing of RRT for AKI patients in the ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):77-88]

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Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.

Cahyani Gita Ambarsari, Daffodilone Cahyadi, Lenny Sari, Oryza Satria, Felly Sahli, Thyrza Laudamy Darmadi, Agustina Kadaristiana,

Background: Lesch-Nyhan disease (LND) is a rare X-linked recessive inborn error of purine metabolism. Late diagnosis of LND may cause significant morbidity. LND cases have never been reported in Indonesia.Case report: A 15-year-old male who had been diagnosed with cerebral palsy was referred to our hospital due to renal failure ... Read more >>

Ren Fail (Renal Failure)
[2020, 42(1):113-121]

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Potassium disorders in pediatric emergency department: Clinical spectrum and management.

O Barbance, D De Bels, P M Honoré, D Bargalzan, A Tolwani, K Ismaili, D Biarent, S Redant,

INTRODUCTION:Potassium abnormalities are frequent in intensive care but their incidence in the emergency department is unknown. AIM:We describe the spectrum of potassium abnormalities in our tertiary-level pediatric emergency department. METHODS:Retrospective case-control study of all the patients admitted to a single-center tertiary emergency department over a 2.5-year period. We compared patients ... Read more >>

Arch Pediatr (Archives de pediatrie : organe officiel de la Societe francaise de pediatrie)
[2020, :]

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Prevalence, diagnosis, and management of secondary pseudohypoaldosteronism.

Erica Memoli, Sebastiano A G Lava, Mario G Bianchetti, Federica Vianello, Carlo Agostoni, Gregorio P Milani,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(4):713-714]

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Tumor lysis syndrome in childhood malignancies.

Wing Lum Cheung, Kam Lun Hon, Cheuk Man Fung, Alexander Kc Leung,

Background:Tumor lysis syndrome (TLS) is the most common life-threatening oncological emergency encountered by physicians treating children with lymphoproliferative malignancies. Healthcare providers should be aware of the condition in order to prevent occurrence and prompt timely management to avoid severe consequences. Objective:To provide an update on the current understanding, evaluation, and ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Tuberculosis and Tumor Lysis Syndrome-Coincidence or Coexistent: A Case Report.

Viresh Swami, A V Lalitha, T K Anjan Kumar,

Extrapulmonary tuberculosis (TB) involving bone marrow can present with various manifestations, including pancytopenia, maturation arrest, hemophagocytic lymphohistiocytosis (HLH), or infiltration of the bone marrow by caseating or noncaseating granulomas causing reversible or irreversible fibrosis. Tumor lysis syndrome (TLS) is an oncologic emergency resulting from massive tumor cell lysis. Children with ... Read more >>

Indian J Crit Care Med (Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine)
[2020, 24(2):145-147]

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Characteristics of nonoliguric hyperkalemia in preterm infants: a case-control study in a single center.

Kuraaki Aoki, Kazuhiro Akaba,

BACKGROUND:Preterm infants often present with hyperkalemia during the first days after birth without showing oliguria, which is known as nonoliguric hyperkalemia (NOHK). As its clinical features have not been completely understood to date, we aimed to elucidate the characteristics of NOHK, including its risk factors in preterm infants. METHODS:For this ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, :]

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Clinical features, genetic background, and outcome in infants with urinary tract infection and type IV renal tubular acidosis.

Min-Hua Tseng, Jing-Long Huang, Shih-Ming Huang, Jeng-Daw Tsai, Tai-Wei Wu, Wen-Lang Fan, Jhao-Jhuang Ding, Shih-Hua Lin,

BACKGROUND:Type IV renal tubular acidosis (RTA) is a severe complication of urinary tract infection (UTI) in infants. A detailed clinical and molecular analysis is still lacking. METHODS:Infants with UTI who exhibited features of type IV RTA were prospectively enrolled. Clinical, laboratory, and image characteristics and sequencing of genes responsible for ... Read more >>

Pediatr. Res. (Pediatric research)
[2019, :]

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MALIGNANT HYPERTHERMIA IN A CHILD AFTER MAGNETIC RESONANCE IMAGING: A CASE REPORT.

Carlos Gustavo de Almeida, José Colleti Junior,

OBJECTIVE:To report on a case of malignant hyperthermia in a child after a magnetic resonance imaging of the skull was performed using sevoflurane anesthesia. CASE DESCRIPTION:A 3-year-old boy admitted to the pediatric intensive care unit after presenting clinical and laboratory findings consistent with unspecified viral meningoencephalitis. While the patient was ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018267]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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One-month-old girl presenting with pseudohypoaldosteronism leading to the diagnosis of CDK13-related disorder: a case report and review of the literature.

Renata Yakubov, Asaly Ayman, Adi Klein Kremer, Machiel van den Akker,

BACKGROUND:It is not uncommon that an infant with a disease of unknown etiology is presented to a physician. Facial dysmorphic features lead to a different diagnosis. It is a challenge to link the presentation to the newfound diagnosis. CASE PRESENTATION:A 37-day-old Yemenite Jewish girl was presented to our institution with ... Read more >>

J Med Case Rep (Journal of medical case reports)
[2019, 13(1):386]

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A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy.

Li-Ping Yin, Huan Zhu, Ru-Yuan Zhu, Li Huang,

Systematic form of pseudohypoaldosteronism Type I (PHA I) is a rare recessive homozygous inherited syndrome characterized by severe salt loss, hyperkalemia, hyponatremia, metabolic acidosis, hyperaldosteronism and hyperreninemia. It is caused by mutations in one of the genes encoding the α, β and γ subunits of epithelial sodium channels (ENaC). In ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2019, 519(2):415-421]

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Should ACE inhibitors or calcium channel blockers be used for post-transplant hypertension?

Tomáš Seeman, Janusz Feber,

Arterial hypertension in renal transplant recipients warrants antihypertensive treatment. The preferable choice of antihypertensives that should be used in patients after kidney transplantation remains a matter of debate; however, calcium channel blockers (CCB) and angiotensin-converting enzyme inhibitors (ACEI) are currently the most commonly used antihypertensives. This educational review summarizes the ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, :]

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Rare cause of severe hypertension in an adolescent boy presenting with short stature: Answers.

Zehra Yavas Abali, Gozde Yesil, Tarık Kirkgoz, Neslihan Cicek, Harika Alpay, Serap Turan, Abdullah Bereket, Tulay Guran,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):405-407]

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Severe Hyperkalemia Immediately After Birth.

Alja Kavčič, Simona Avčin, Štefan Grosek,

BACKGROUND Hyperkalemia is an important cause of arrhythmias and a medical emergency that requires urgent treatment. The etiology is usually multifactorial. It is most frequently caused by impaired potassium secretion, followed by transcellular potassium shifts and an increased potassium load. CASE REPORT A male newborn developed monomorphic ventricular tachycardia 2 ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1471-1475]

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Hereditary causes of primary aldosteronism and other disorders of apparent excess mineralocorticoid activity.

Xin He, Zubin Modi, Tobias Else,

Secondary hypertension is a common condition with a broad differential diagnosis. Identification of the true cause of hypertension can be critical for guiding appropriate management. Here, we review hereditary conditions underlying the most common cause of secondary hypertension, primary aldosteronism, as well as other disorders impacting various levels of mineralocorticoid ... Read more >>

Gland Surg (Gland surgery)
[2020, 9(1):150-158]

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Safety of a Triple-chamber Bag Parenteral Nutrition in Children Ages up to 24 Months: An Observational Study.

Henrik Arnell, Frederic V Valla, Geneviève Malfilâtre, Patrick Pladys, Thibault Senterre, Alessandro Pontes-Arruda,

OBJECTIVES:Hypermagnesemia has been reported in preterm neonates treated with commercial pediatric triple-chamber bag (3CB) parenteral nutrition (PN). This postmarketing study was requested by the European Medicines Agency to assess the safety of a 3CB PN product in full-term neonates and children up to 24 months of age. METHODS:This prospective, multicenter, ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2019, 69(6):e151-e157]

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Selective ß2-Adrenoceptor Agonists and Relevant Hyperlactatemia: Systematic Review and Meta-Analysis.

Alina G Liedtke, Sebastiano A G Lava, Gregorio P Milani, Carlo Agostoni, Viola Gilardi, Mario G Bianchetti, Giorgio Treglia, Pietro B Faré,

Selective ß2-agonists have been imputed as potential cause of l-hyperlactatemia since the 1970s. To document the prevalence of hyperlactatemia associated with selective ß2-agonists and to investigate the predisposing factors, we searched for published articles until April 2019 pertaining to the interplay of administration of selective ß2-agonists and circulating l-lactic acid ... Read more >>

J Clin Med (Journal of clinical medicine)
[2019, 9(1):]

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Phenotypic diversity and correlation with the genotypes of pseudohypoaldosteronism type 1.

Jaya Sujatha Gopal-Kothandapani, Arpan B Doshi, Kath Smith, Martin Christian, Talat Mushtaq, I Banerjee, Raja Padidela, Renuka Ramakrishnan, Catherine Owen, Timothy Cheetham, Paul Dimitri,

Background Type I pseudohypoaldosteronism (PHA1) is a rare condition characterised by profound salt wasting, hyperkalaemia and metabolic acidosis due to renal tubular resistance to aldosterone (PHA1a) or defective sodium epithelial channels (PHA1b or systemic PHA). Our aim was to review the clinical presentation related to the genotype in patients with ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2019, 32(9):959-967]

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Hyponatremia in children under 100 days old: incidence and etiologies.

Caroline Storey, Stéphane Dauger, Georges Deschenes, Alice Heneau, Olivier Baud, Jean Claude Carel, Laetitia Martinerie,

Hyponatremia is one of the most common electrolyte disorders in hospitalized children. The underlying mechanisms are poorly understood and potentially multifactorial, making management difficult, particularly in neonates. This retrospective study aimed to determine the incidence and etiologies of hyponatremia in hospitalized children under the age of 100 days, in our pediatric ... Read more >>

Eur. J. Pediatr. (European journal of pediatrics)
[2019, 178(9):1353-1361]

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Rare cause of severe hypertension in an adolescent boy presenting with short stature: Questions.

Zehra Yavas Abali, Gozde Yesil, Tarık Kirkgoz, Neslihan Cicek, Harika Alpay, Serap Turan, Abdullah Bereket, Tulay Guran,

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(3):403-404]

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Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction.

Michelle Bernshteyn, Alexandria Smith-Hannah, Amit S Dhamoon,

A 66-year-old woman presented to the hospital with a one-month history of shortness of breath, fatigue, and postmenopausal vaginal bleeding and a one-week history of chest pain. This case report discusses the rare synchronous occurrence of two different malignancies in the setting of non-ST segment elevation myocardial infarction and the ... Read more >>

Case Rep Oncol Med (Case reports in oncological medicine)
[2020, 2020:6192754]

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Tumor lysis syndrome in pediatric acute lymphoblastic leukemia at tertiary care center.

Bilqis Naeem, Khemchand N Moorani, Misbah Anjum, Uzma Imam,

Objectives:Tumor lysis syndrome (TLS) is common complication of acute lymphoblastic leukemia (ALL). It is characterized by presence of two or more of hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. TLS may cause acute kidney injury (AKI), arrhythmias and seizures. Our objective was to determine the frequency of TLS and its biochemical abnormalities ... Read more >>

Pak J Med Sci (Pakistan journal of medical sciences)
[2019, 35(4):899-904]

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Post Circumcision Intraperitoneal Rupture of the Urinary Bladder: A Rare Complication.

Sherif Abdelmaksoud, Mohammed Albishbishy, Mostafa Elayyouti, Mohamed Zohiri, Adham Elsaied,

Circumcision is one of the most common pediatric surgical procedures performed all over the world and especially in Arab and Islamic countries. Many complications have been documented following this maneuver. We report on a rare case of intraperitoneal bladder rupture in a 7-day-old baby who was circumcised on his second ... Read more >>

European J Pediatr Surg Rep (European journal of pediatric surgery reports)
[2020, 8(1):e14-e17]

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Spotlight on Spironolactone Oral Suspension for the Treatment of Heart Failure: Focus on Patient Selection and Perspectives.

Antonis A Manolis, Theodora A Manolis, Helen Melita, Antonis S Manolis,

Spironolactone, an antagonist of aldosterone, initially used as a potassium-sparing diuretic, was subsequently shown to be a very effective adjunctive agent in the treatment of patients with heart failure with reduced ejection fraction, by halting the disease progression, with significant beneficial effects on both morbidity and mortality. Other uses comprise ... Read more >>

Vasc Health Risk Manag (Vascular health and risk management)
[2019, 15:571-579]

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