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Pediatric Hepatorenal Syndrome

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A long journey for acute kidney injury biomarkers.

Dong-Jin Oh,

Acute kidney injury (AKI) is a life-threatening illness that continues to have an in-hospital mortality rate of patients with AKI ranges from 20% to 50% or greater, depending on underlying conditions. However, it has only marginally declined over the past 25 years. Previous authoritative publications have been pointed out that the ... Read more >>

Ren Fail (Renal failure)
[2020, 42(1):154-165]

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Long-Term Outcomes and Health Perceptions in Pediatric-Onset Portal Hypertension Complicated by Varices.

Topi Luoto, Antti Koivusalo, Mikko Pakarinen,

OBJECTIVES:Outcomes of pediatric-onset portal hypertension are poorly defined. We aimed assess population-based long-term outcomes of pediatric-onset portal hypertension complicated by varices. METHODS:All children with esophageal varices (n = 126) were identified from 14144 single nationwide referral center endoscopy reports during 1987-2013, and followed up through national health care and death registers. A ... Read more >>

J. Pediatr. Gastroenterol. Nutr. (Journal of pediatric gastroenterology and nutrition)
[2020, :]

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Is renal replacement therapy necessary in deceased donor liver transplantation candidates with hepatorenal syndrome?: a 2-year experience at a high-volume center.

Gil-Chun Park, Shin Hwang, Dong-Hwan Jung, Gi-Won Song, Chul-Soo Ahn, Ki-Hun Kim, Deok-Bog Moon, Tae-Yong Ha, Young-In Yoon, Hui-Dong Cho, Jae-Hyun Kwon, Yong-Kyu Chung, Sang-Hyun Kang, I-Ji Jung, Jin Uk Choi, Sung-Gyu Lee,

Purpose:Hepatorenal syndrome (HRS) is a fatal complication in patients with end-stage liver disease awaiting liver transplantation (LT). HRS often develops in patients with high model for end-stage liver disease (MELD) score. This study investigated the outcomes of peritransplant management of HRS in a high-volume LT center in Korea for 2 ... Read more >>

Ann Surg Treat Res (Annals of surgical treatment and research)
[2020, 98(2):102-109]

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Mushroom intoxication, a fatal condition in Romanian children: Two case reports.

Cristina Oana Mărginean, Lorena Elena Meliţ, Maria Oana Mărginean,

RATIONALE:Approximately 5000 species of wild mushroom are reported worldwide, of which 100 are documented as poisonous and <10 are fatal. The clinical picture of patients with wild mushroom intoxication depends mostly on the type of ingested mushroom, ranging from mild gastrointestinal symptoms to organ failure and death. PATIENT CONCERNS:We report ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(41):e17574]

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The postoperative hepatic artery resistance index after living donor liver transplantation can predict early allograft dysfunction.

Tao Lv, LingXiang Kong, Jiayin Yang, Hong Wu, Tianfu Wen, Li Jiang, Jian Yang,

To investigate whether postoperative hepatic hemodynamics have an impact on graft function.Using a retrospective cohort with 262 adult living donor liver transplantation (LDLT) recipients, we discussed the relationship between postoperative hepatic hemodynamics and patient outcomes.According to the definition of early allograft dysfunction (EAD), the patients were classified into the EAD ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(4):e18677]

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Segmental intrahepatic cholestasis as a technical complication of the transjugular intrahepatic porto-systemic shunt.

Julian Nikolaus Bucher, Marcus Hollenbach, Steffen Strocka, Gereon Gaebelein, Michael Moche, Thorsten Kaiser, Michael Bartels, Albrecht Hoffmeister,

BACKGROUND:Segmental intrahepatic cholestasis caused by transjugular intrahepatic portosystemic shunt (TIPS) (SIC-T), is a rare complication of this technique and only referred by case reports. Thus, we conducted a systematic, retrospective analysis to provide evidence regarding prevalence and consequences of this TIPS-induced bile duct compression. AIM:To assess prevalence and outcome of ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2019, 25(43):6430-6439]

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Antibiotic use in cirrhotic children with acute upper gastrointestinal bleeding: A retrospective study using the pediatric health information system (PHIS) database.

Lina Castillo, Sittichoke Prachuapthunyachart, Mel Hall, Shaija Shelby, Ruben E Quiros-Tejeira, Hanh D Vo,

Prior studies have demonstrated positive impacts of antibiotic use on reducing mortality, rebleeding events, and length of hospitalization in adult cirrhotic patients with acute upper gastrointestinal bleeding (UGIB). We aimed to investigate the use of antibiotics in cirrhotic children with acute UGIB and its impact on patient outcomes.This was a ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(29):e16505]

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Oxalate retinopathy is irreversible despite early combined liver-kidney transplantation in primary hyperoxaluria type 1.

Yevgeniya Atiskova, Simon Dulz, Kaja Schmäschke, Jun Oh, Enke Grabhorn, Markus J Kemper, Florian Brinkert,

In primary hyperoxaluria type 1 (PH1), systemic oxalate deposition (oxalosis) in end-stage renal disease (ESRD) is associated with high morbidity and mortality, particularly in children with infantile oxalosis (IO). Combined liver and kidney transplantation (CLKT) is the only curative treatment option in these patients. After CLKT, systemic oxalosis decreases continuously, ... Read more >>

Am. J. Transplant. (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2019, 19(12):3328-3334]

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Including Fibroblast Growth Factor-21 in Combined Biomarker Panels Improves Predictions of Liver Steatosis Severity in Children.

Man-Chin Hua, Jing-Long Huang, Ching-Chih Hu, Tsung-Chieh Yao, Ming-Wei Lai,

Background: Previous studies reported conflicting results regarding the association between fibroblast growth factor-21 (FGF-21) and non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the feasibility of combining FGF-21, obesity indices, and biochemical tests for predicting high-grade liver steatosis in children. Methods: A total of 203 children and adolescents ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:420]

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Childhood adrenocortical tumor: A clinical and immunohistochemical study of 13 cases.

Xiaohui Wu, Jun Xu, Jinhu Wang, Weizhong Gu, Chaochun Zou,

The aim of the study was to investigate the molecular mechanisms in childhood adrenocortical tumors (ACTs), which is still unclear.A total of 9 girls and 4 boys with ACTs were enrolled. Relevant clinical features were obtained from records. Immunohistochemistry of vimentin, chromogranin A, S100, synaptophysin, cytokeratin (CK), type 2 3β-hydroxysteroid ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(46):e17921]

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IMPACT OF MELD SODIUM ON LIVER TRANSPLANTATION WAITING LIST.

Alexandre Coutinho Teixeira de Freitas, Aline Tatiane Rampim, Carolline Popovicz Nunes, Júlio Cezar Uili Coelho,

BACKGROUND:Serum sodium was incorporated to MELD score for the allocation of liver transplantation In the USA in 2016. Hyponatremia significantly increased the efficacy of the score to predict mortality on the waiting list. Such modification was not adopted in Brazil. AIM:To carry out a simulation using MELD-Na as waiting list ... Read more >>

Arq Bras Cir Dig (Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery)
[2019, 32(3):e1460]

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Eplet mismatch analysis and allograft outcome across racially diverse groups in a pediatric transplant cohort: a single-center analysis.

Mary Carmelle Philogene, Anita Amin, Sheng Zhou, Olga Charnaya, Renato Vega, Niraj Desai, Alicia M Neu, Cozumel S Pruette,

HLA eplet mismatch load has been suggested as an improvement to HLA antigen mismatch determination for organ selection. Given that eplet mismatches are determined based on amino acid sequence difference among HLA alleles, and that the frequency of HLA alleles varies between racial groups, we investigated the correlation between eplet ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2020, 35(1):83-94]

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Ultrasound-based techniques for the diagnosis of liver steatosis.

Giovanna Ferraioli, Livia Beatriz Soares Monteiro,

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of diffuse liver disease. An accurate estimate of the fat in the liver is important in the diagnostic work-up of patients with NAFLD because the degree of liver steatosis is linked to the metabolic syndrome and the cardiovascular risk. Ultrasound (US) ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2019, 25(40):6053-6062]

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Clinical courses and complications of young adults with Autosomal Recessive Polycystic Kidney Disease (ARPKD).

Kathrin Burgmaier, Samuel Kilian, Bert Bammens, Thomas Benzing, Heiko Billing, Anja Büscher, Matthias Galiano, Franziska Grundmann, Günter Klaus, Djalila Mekahli, Laurence Michel-Calemard, Gordana Milosevski-Lomic, Bruno Ranchin, Katja Sauerstein, Susanne Schaefer, Rukshana Shroff, Rosalie Sterenborg, Sarah Verbeeck, Lutz T Weber, Dorota Wicher, Elke Wühl, Jörg Dötsch, Franz Schaefer, Max C Liebau,

Autosomal recessive polycystic kidney disease (ARPKD) is a severe pediatric hepatorenal disorder with pronounced phenotypic variability. A substantial number of patients with early diagnosis reaches adulthood and some patients are not diagnosed until adulthood. Yet, clinical knowledge about adult ARPKD patients is scarce. Here, we describe forty-nine patients with longitudinal ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):7919]

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Acute-on-chronic liver failure in children with biliary atresia awaiting liver transplantation.

Rashmi D'Souza, Tassos Grammatikopoulos, Akhilesh Pradhan, Harry Sutton, Abdel Douiri, Mark Davenport, Anita Verma, Anil Dhawan,

OBJECTIVES:Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ... Read more >>

Pediatr Transplant (Pediatric transplantation)
[2019, 23(2):e13339]

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Extracorporeal treatment in children with acute severe poisoning.

Xiaomei Sun, Xiuying Chen, Jing Lu, Yuhong Tao, Lijuan Zhang, Liqun Dong,

Acute poisoning in children is a clinical emergency. Prompt and effective treatment is critical for life-threatening poisoning. Extracorporeal treatment (ECTR) is a practical option for enhancing the elimination of poisons.We conducted a retrospective observational study on 338 children with severe acute poisoning who received ECTR during hospitalization from January 2010 ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(47):e18086]

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Liver-Kidney: Indications, Patient Selection, and Allocation Policy.

Pratima Sharma,

Clin Liver Dis (Hoboken) (Clinical liver disease)
[2019, 13(6):165-169]

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Cardiovascular and Metabolic Consequences of Liver Transplantation: A Review.

Oana Plotogea, Madalina Ilie, Vasile Sandru, Alexandru Chiotoroiu, Ovidiu Bratu, Camelia Diaconu,

Liver transplantation (LT) is considered the curative treatment option for selected patients who suffer from end-stage or acute liver disease or hepatic malignancy (primary). After LT, patients should be carefully monitored for complications that may appear, partially due to immunosuppressive therapy, but not entirely. Cardiovascular diseases are frequently encountered in ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(8):]

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Propofol vs desflurane on the cytokine, matrix metalloproteinase-9, and heme oxygenase-1 response during living donor liver transplantation: A pilot study.

Zhi-Fu Wu, Wei-Lin Lin, Meei-Shyuan Lee, Nan-Kai Hung, Yuan-Shiou Huang, Teng-Wei Chen, Chueng-He Lu,

BACKGROUND:We investigated the effects of propofol vs desflurane on ischemia and reperfusion injury (IRI)-induced inflammatory responses, especially in matrix metalloproteinase-9 (MMP-9) downregulation and heme oxygenase-1 (HO-1) upregulation, which may result in different clinical outcomes in liver transplant recipients. METHODS:Fifty liver transplant recipients were randomized to receive propofol-based total intravenous anesthesia ... Read more >>

Medicine (Baltimore) (Medicine)
[2019, 98(48):e18244]

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Cholangitis Lenta Causing Bile Cast Nephropathy: A Unique Model of Hepatorenal Failure in Sepsis.

Christopher Antonio Febres Febres Aldana, Robert J Poppiti,

INTRODUCTION:Inadequate perfusion and abnormal cellular metabolism are among the mechanisms of organ dysfunction in sepsis. Concomitant hepatorenal failure during the late phase of sepsis is poorly understood. CASE REPORT:The autopsy of a child who developed sepsis-induced hepatorenal failure revealed bile cast nephropathy, hepatic centrilobular necrosis and cholangitis lenta, a type ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2018, 37(6):424-432]

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Clinical manifestations of Wilson disease in organs other than the liver and brain.

Karolina Dzieżyc-Jaworska, Tomasz Litwin, Anna Członkowska,

Wilson disease (WD) is an inherited genetic disorder that is caused by copper metabolism disturbances with main hepatic, neurological, and psychiatric presentation. Deposits of copper accumulate in different organs and may cause a broad range of clinical manifestations. Patients with WD may present with ophthalmological symptoms, or renal, cardiac and ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(Suppl 2):S62]

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Superior Outcomes and Reduced Wait Times in Pediatric Recipients of Living Donor Liver Transplantation.

Mohit Kehar, Rulan S Parekh, Jennifer Stunguris, Maria De Angelis, Krista Van Roestel, Anand Ghanekar, Mark Cattral, Annie Fecteau, Simon Ling, Binita M Kamath, Nicola Jones, Yaron Avitzur, David Grant, Vicky Lee Ng,

Background:Living donor liver transplantation (LDLT) is increasingly used to bridge the gap between the current supply and demand imbalance for deceased donor organs to provide lifesaving liver transplantation. Methods:Outcomes of 135 children who underwent LDLT were compared with 158 recipients of deceased donor liver transplantation (DDLT) at the largest pediatric ... Read more >>

Transplant Direct (Transplantation direct)
[2019, 5(3):e430]

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Single-center experience of hemodialysis in patients after Fontan palliation.

Brian Young, Wayne Franklin, Wilson Lam, Peter Ermis,

Int J Cardiol Heart Vasc (International journal of cardiology. Heart & vasculature)
[2018, 21:94-95]

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Cirrhosis and Portal Hypertension in the Pediatric Population.

Catherine A Chapin, Lee M Bass,

Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, ... Read more >>

Clin Liver Dis (Clinics in liver disease)
[2018, 22(4):735-752]

Cited: 2 times

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GASTRO-HEP News.

Samantha Alleman,

Gastroenterol Hepatol (N Y) (Gastroenterology & hepatology)
[2018, 14(8):494]

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