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Pediatric Guillain Barre Syndrome

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Clinical Characteristics and Electrodiagnostic Features of Guillain-Barré Syndrome Among the Pediatric Population.

Mahmoud Reza Ashrafi, Ariadokht Mohammadalipoor, Alireza Ranjbar Naeini, Man Amanat, Ali Reza Tavasoli, Morteza Heidari, Reza Shervin Badv, Mahmoud Mohammadi, Gholam Reza Zamani, Shahram Rahimi-Dehgolan, Rosa Rahimi, Masood Ghahvechi Akbari,

INTRODUCTION:Guillain-Barré syndrome is an immune-mediated peripheral neuropathy characterized by different clinical manifestations. We aimed to describe the clinical features, seasonal distribution, subtypes, and electrodiagnostic characteristics of Iranian children with Guillain-Barré syndrome. METHODS:In this prospective study, a total of 30 children with Guillain-Barré syndrome were evaluated. All demographic features were collected ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820905157]

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Superimposed Guillain-Barré Syndrome (GBS) in pediatric hypoxic brain injury.

Enoch Leung, Simra Javaid, Erika Erlandson, Charles B Pelshaw,

BACKGROUND:Hypoxic brain injury results in severe disabilities that require extensive acute inpatient and outpatient rehabilitation to promote maximal functional and cognitive recovery. Brain hypoxemia can result from a multitude of causes, including but not limited to cardiac arrest, drug overdose, and/or shock. While recovery from a hypoxic brain injury alone ... Read more >>

J Pediatr Rehabil Med (Journal of pediatric rehabilitation medicine)
[2020, :]

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Pediatric Guillain-Barré Syndrome in a 30-Year Nationwide Cohort.

Lotte Sahin Levison, Reimar Wernich Thomsen, Lars Kjøbsted Markvardsen, Diana Hedevang Christensen, Søren Hein Sindrup, Henning Andersen,

BACKGROUND:Guillain-Barré syndrome is the most common cause of acute flaccid paresis in childhood. Few validated large-scale population-based data are available concerning pediatric Guillain-Barré syndrome, including incidence, risk factors, and initial clinical characteristics. METHODS:In the Danish National Patient Registry, we identified all children aged below 16 years (N = 212) diagnosed ... Read more >>

Pediatr. Neurol. (Pediatric neurology)
[2020, :]

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Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline.

R Korinthenberg, R Trollmann, U Felderhoff-Müser, G Bernert, A Hackenberg, M Hufnagel, M Pohl, G Hahn, H J Mentzel, C Sommer, J Lambeck, F Mecher, M Hessenauer, C Winterholler, U Kempf, B C Jacobs, K Rostasy, W Müller-Felber,

This evidence- and consensus-based practical guideline for the diagnosis and treatment of Guillain-Barré Syndrome (GBS) in childhood and adolescence has been developed by a group of delegates from relevant specialist societies and organisations; it is the result of an initiative by the German-Speaking Society of Neuropediatrics (GNP), and is supported ... Read more >>

Eur. J. Paediatr. Neurol. (European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society)
[2020, :]

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Nitrous oxide recreational abuse presenting with myeloneuropathy and mimicking Guillain-Barre syndrome.

Hussein Algahtani, Bader Shirah, Nawal Abdelghaffar, Osamah Abuhawi, Abdulrahman Alqahtani,

The recreational use of nitrous oxide (N2O) is increasing in festivals, university parties, clubs, private residences, and parks. The abuse of N2O has serious complications of the central and peripheral nervous system. In this article, we report a case of a 28-year-old previously healthy man who presented with a three-day ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):54-57]

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Seizure in a Child with Guillain-Barré Syndrome: Association or coincidence!

Prateek Kumar Panda, Indar Kumar Sharawat,

Indian Pediatr (Indian pediatrics)
[2020, 57(1):79]

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Case Report: An Adolescent Girl with Isolated Neuropsychiatric Features and Apparent Post-Malaria Neurological Syndrome.

Prateek Kumar Panda, Indar Kumar Sharawat, Pramod Kumar Panda,

The post-malaria neurological syndrome (PMNS) is an unusual and relatively underreported complication of malaria, which usually occurs after the resolution of acute febrile illness and the patient is free from parasitemia. The clinical spectrum of the PMNS varies from acute-onset cerebellar ataxia to significant encephalopathy with focal deficits resembling acute ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2020, :]

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Measuring parent proxy-reported quality of life of 11 rare diseases in children in Zhejiang, China

Qisheng Gao, Shanshan Wang, Jianping Ren, Xin Wen,

<title>Abstract</title> <p> Background It is increasingly important to measure the health-related quality of life (HRQoL) of rare disease in children and adolescents in recent decades. Much attention has been paid to investigate the HROoL of one specific rare disease by self-report in previous studies. This study aimed to ... Read more >>

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Incidence rates of health outcomes of interest among Chinese children exposed to selected vaccines in Yinzhou Electronic Health Records: A population-based retrospective cohort study.

Kui Huang, Sha Tao, Xiaofeng Zhou, Jingping Mo, Bowen Zhu, Peng Shen, Hongbo Lin, Patrick J Arena, Na He,

INTRODUCTION:Oral poliovirus vaccine (OPV) and diphtheria-tetanus-acellular pertussis vaccine (DTaP) are widely used in China while Haemophilus influenzae type b vaccines (Hib) and a DTaP, inactivated poliovirus (IPV) andHib polysaccharide conjugated to tetanus protein (PRP ~ T) combined vaccine (DTaP-IPV//PRP ~ T) have lower coverage. There are limited safety data on these vaccines in Chinese ... Read more >>

Vaccine (Vaccine)
[2020, :]

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Predictive factors of first dosage intravenous immunoglobulin-related adverse effects in children.

Jun Kubota, Shin-Ichiro Hamano, Atsuro Daida, Erika Hiwatari, Satoru Ikemoto, Yuko Hirata, Ryuki Matsuura, Daishi Hirano,

BACKGROUND:Intravenous immunoglobulin (IVIG) therapy is used in the treatment of various diseases, and IVIG-related adverse effects (IVIG-AEs) vary from mild to severe. However, the mechanisms underlying IVIG-AEs and the potential predictive factors are not clear. This study investigated whether certain IVIG-AEs can be predicted before IVIG administration. STUDY DESIGN AND ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227796]

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Maxillary sinus floor augmentation and simultaneous dental implant placement in a patient with Guillain-Barre syndrome: A case report.

Fardin Faraji, Mojtaba Bayani, Maryam Jafarpour, Fateme Abdolalian,

Dental implant placement in patients with Guillain-Barre syndrome could be accomplished, and it may turn into a successful treatment for edentulous sites and functionally stabilized for long life. However, a proper patient selection, accurate medical consultation with physician, atraumatic surgery, and other important cautions should be considered. ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(12):2331-2335]

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Prognostic factors for the sequelae and severity of Guillain-Barré syndrome in children.

Sophie Estrade, Clara Guiomard, Vincent Fabry, Eloise Baudou, Claude Cances, Yves Chaix, Pascal Cintas, Pierre Meyer, Emmanuel Cheuret,

INTRODUCTION:Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuritis. Our aim in this study was to describe the clinical characteristics and the long-term sequelae of GBS in a French pediatric population. METHODS:In this multicenter, retrospective study we evaluated clinical signs, radiological examinations, laboratory tests, treatments, and outcomes. RESULTS:One hundred ten children were ... Read more >>

Muscle Nerve (Muscle & nerve)
[2019, 60(6):716-723]

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IV Immunoglobulin in Guillain-Barré Syndrome: Is It Still Justifiable?

Suresh Kumar Angurana, Renu Suthar, Karthi Nallasamy,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(10):1002]

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Respiratory illness and acute flaccid myelitis in the Tokai district in 2018.

Akihisa Okumura, Shingo Numoto, Hideyuki Iwayama, Hirokazu Kurahashi, Jun Natsume, Shinji Saitoh, Tetsushi Yoshikawa, Toshiyuki Fukao, Masahiro Hirayama, Yoshiyuki Takahashi, ,

BACKGROUND:An outbreak of acute flaccid myelitis was chronologically correlated with that of severe respiratory illness in Japan in 2015. We hypothesized that increases in children hospitalized with severe respiratory illnesses might be associated with increase in acute flaccid myelitis also in autumn 2018. METHODS:We explored the temporal correlations between respiratory ... Read more >>

Pediatr Int (Pediatrics international : official journal of the Japan Pediatric Society)
[2019, :]

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Successful treatment of a 12-year-old boy with Guillain-Barré syndrome requiring tracheostomy due to respiratory muscle paralysis: A case report.

Manabu Miyamoto, George Imataka, Go Ichikawa, Yutaka Saito, Takashi Kashiwagi, Yoshiyuki Kaji, Koji Wake, Kei Funakoshi, Takahide Nagashima, Norito Kokubun, Shigemi Yoshihara,

Childhood Guillain-Barré syndrome (GBS) occasionally leads to respiratory failure early after onset, requiring long-term ventilation management after tracheal intubation. However, patients requiring tracheostomy management are rare. In the present study, a case of a 12-year-old boy with GBS who required artificial respiration management due to rapid progression of respiratory muscle ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(2):1091-1094]

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Recurrent Demyelinating Episodes as Sole Manifestation of Inherited CD59 Deficiency.

Ismail Solmaz, Elif Soyak Aytekin, Deniz Çağdaş, Cagman Tan, Ilhan Tezcan, Rahsan Gocmen, Goknur Haliloglu, Banu Anlar,

Defects in the regulatory components of the complement system can lead to inflammatory diseases. We present a patient who had four episodes of demyelination in the central nervous system as the only manifestation of inherited CD59 deficiency. Relapsing encephalopathy partially responsive to intravenous immunoglobulin and steroid treatments on the background ... Read more >>

Neuropediatrics (Neuropediatrics)
[2019, :]

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Genetic Diversity of Collaborative Cross Mice Controls Viral Replication, Clinical Severity, and Brain Pathology Induced by Zika Virus Infection, Independently of Oas1b.

Caroline Manet, Etienne Simon-Lorière, Grégory Jouvion, David Hardy, Matthieu Prot, Laurine Conquet, Marie Flamand, Jean-Jacques Panthier, Anavaj Sakuntabhai, Xavier Montagutelli,

The explosive spread of Zika virus (ZIKV) has been associated with major variations in severe disease and congenital afflictions among infected populations, suggesting an influence of host genes. We investigated how genome-wide variants could impact susceptibility to ZIKV infection in mice. We first describe that the susceptibility of Ifnar1-knockout mice ... Read more >>

J. Virol. (Journal of virology)
[2020, 94(3):]

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Acute Neuromuscular Disorders in the Pediatric Intensive Care Unit.

Dana B Harrar, Basil T Darras, Partha S Ghosh,

BACKGROUND:The neuromuscular disorders encountered in the pediatric intensive care unit (PICU) encompass a broad spectrum of pathologies. These include acute disorders (eg, Guillain-Barre syndrome), acute-on-chronic disorders (eg, myasthenia gravis), progressive disorders (eg, muscular dystrophy), and disorders that develop in the PICU (eg, critical illness myopathy/polyneuropathy). Familiarity with the presenting features ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(1):17-24]

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Diagnosis and treatment of Guillain-Barré syndrome during the Zika virus epidemic in Brazil: A national survey study.

Sonja E Leonhard, Rodrigo M Conde, Francisco de Assis Aquino Gondim, Bart C Jacobs,

The Zika virus (ZIKV) epidemic in Brazil in 2015-2016 was followed by an increase in the incidence of patients with Guillain-Barré syndrome (GBS). With this national survey study, we aimed to gain a better understanding of how neurologists in Brazil are currently diagnosing and treating patients with GBS, and how ... Read more >>

J. Peripher. Nerv. Syst. (Journal of the peripheral nervous system : JPNS)
[2019, 24(4):340-347]

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Role of IV Immunoglobulin in Indian Children With Guillain-Barré Syndrome.

Jayantee Kalita, Mritunjai Kumar, Usha K Misra,

OBJECTIVES:To evaluate the outcome of Indian children with Guillain-Barré syndrome who received IV immunoglobulin compared with those who did not receive any specific therapy. DESIGN:Single center, prospective cross-sectional study. SETTING:Tertiary care neurology teaching hospital. PATIENTS:Children (≤ 18 yr old) with Guillain-Barré syndrome were included from a prospectively maintained Guillain-Barré syndrome ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(7):652-659]

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Changing trends in IVIG use in pediatric patients: A retrospective review of practices in a network of major USA pediatric hospitals.

Alfred Balch, Jacob Wilkes, Emily Thorell, Andrew Pavia, Catherine M T Sherwin, Elena Y Enioutina,

The use of immunoglobulins is gradually increasing. Intravenous immunoglobulins (IVIG) are used as replacement therapy for primary and secondary immune deficiencies, and as an anti-inflammatory and immunomodulatory medication for the treatment of neurologic, dermatologic, and rheumatologic diseases. The objective of this study was to analyze trends in the IVIG use ... Read more >>

Int. Immunopharmacol. (International immunopharmacology)
[2019, 76:105868]

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Intravenous Immunoglobulin Treatment Did Not Improve Tics in a Patient With Gilles de la Tourette Syndrome and Intrathecal Antibody Synthesis.

Natalia Szejko, Carolin Fremer, Kurt-Wolfram Sühs, Pedro Macul Ferreira de Barros, Kirsten R Müller-Vahl,

Gilles de la Tourette syndrome (GTS) is a neuropsychiatric disorder characterized by motor and vocal tics. There are several hypotheses as to the cause of the disease. One of which suggests that the immune system is involved in the pathophysiology of GTS. Here, we present a 40-year-old female patient with ... Read more >>

Front Neurol (Frontiers in Neurology)
[2020, 11:110]

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Initial Response and Outcome of Critically Ill Children With Guillain Barre' Syndrome.

Hafez M Bazaraa, Hanaa I Rady, Shereen A Mohamed, Walaa A Rabie, Noha H ElAnwar,

Background: Guillain-Barre syndrome is the most common cause of acute flaccid paralysis worldwide since the eradication of poliomyelitis. Severe cases may require intensive care and mechanical ventilation. Purpose: was to study pediatric patients with severe GBS requiring intensive care unit (ICU) admission, to assess their course and response to initial ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:378]

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Is It Possible That IV Immunoglobulin Does Not Improve Outcome in Children With Guillain-Barré Syndrome? Answer: Yes.

John W Kuluz,

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2019, 20(7):681-682]

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Antecedent infections in Guillain-Barré syndrome: a single-center, prospective study.

Yanlei Hao, Weifang Wang, Bart C Jacobs, Baojun Qiao, Mengshi Chen, Daiqiang Liu, Xungang Feng, Yuzhong Wang,

OBJECTIVE:To investigate the spectrum of antecedent infections in Chinese patients with Guillain-Barré syndrome (GBS) and analyze the infections-related clinical phenotypes locally. METHODS:A prospective case-control study of 150 patients diagnosed with GBS and age- and sex-matched neurological and healthy controls was performed to investigate recent infections of 14 pathogens serologically and ... Read more >>

Ann Clin Transl Neurol (Annals of clinical and translational neurology)
[2019, 6(12):2510-2517]

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