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Pediatric Fungal Endocarditis

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Clinical Significance of Aerococcus-Related Infections: An Emerging Threat.

Kamal Kant Sahu, Ajay Kumar Mishra, Amos Lal,

J Pediatric Infect Dis Soc (Journal of the Pediatric Infectious Diseases Society)
[2019, 8(6):578]

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Intravenous and Oral Posaconazole Pharmacokinetics in a Five-Year-Old With Mucor: A Case Report and Review of the Literature.

Matthew O Ruland, Tosha A Egelund, John S Ng, Scott M Bradfield, Eric F Egelund,

Posaconazole is a lipophilic triazole antifungal that exhibits variable absorption when administered orally. It possesses a broad spectrum of activity against various fungi, such as Aspergillus and traditionally resistant molds such as Rhizopus and Mucor, which carry a poor prognosis. Unfortunately, the tablet and suspension formulations of posaconazole are Food ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2019, 24(6):528-533]

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Candida Parapsilosis Endocarditis Following Transcatheter Pulmonary Valve Implantation.

Weiyi Tan, Amy Dora, Gentian Lluri, Jamil Aboulhosn,

Fungal prosthetic valve endocarditis (PVE) is rare and carries a high mortality rate. While uncommon, fungal endocarditis in transcatheter aortic valves has been reported. We present a unique case of Candida parapsilosis fungal PVE in a patient with a transcatheter pulmonary valve replacement. ... Read more >>

World J Pediatr Congenit Heart Surg (World journal for pediatric & congenital heart surgery)
[2020, 11(1):112-113]

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High Direct Bilirubin Associated With Levoffoxacin Use in a Neonate.

Amy P Holmes, Charles E Hartis, Laurie J Rollins,

Limited data exist regarding the use of fluoroquinolones in the neonatal population. Levofloxacin has some utility in this population because it is one of a very limited number of antibiotics with activity against Stenotrophomonas maltophilia. We describe the successful treatment of S maltophilia tracheitis in a premature neonate using levofloxacin ... Read more >>

J Pediatr Pharmacol Ther (The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG)
[2020, 25(1):64-67]

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Pediatric Blood Cultures and Antibiotic Resistance: An Overview.

Chand Wattal, Neeraj Goel,

Bloodstream infections (BSI) due to multidrug-resistant organisms, especially from pediatric intensive care units (PICU), are being increasingly reported across the world. Since BSI is associated with high mortality, it is essential to treat these infections early with appropriate antibiotics. Surveillance of etiology and emerging antimicrobial resistance (AMR) is considered an ... Read more >>

Indian J Pediatr (Indian journal of pediatrics)
[2020, 87(2):125-131]

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Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.

Scott L Weiss, Mark J Peters, Waleed Alhazzani, Michael S D Agus, Heidi R Flori, David P Inwald, Simon Nadel, Luregn J Schlapbach, Robert C Tasker, Andrew C Argent, Joe Brierley, Joseph Carcillo, Enitan D Carrol, Christopher L Carroll, Ira M Cheifetz, Karen Choong, Jeffry J Cies, Andrea T Cruz, Daniele De Luca, Akash Deep, Saul N Faust, Claudio Flauzino De Oliveira, Mark W Hall, Paul Ishimine, Etienne Javouhey, Koen F M Joosten, Poonam Joshi, Oliver Karam, Martin C J Kneyber, Joris Lemson, Graeme MacLaren, Nilesh M Mehta, Morten Hylander Møller, Christopher J L Newth, Trung C Nguyen, Akira Nishisaki, Mark E Nunnally, Margaret M Parker, Raina M Paul, Adrienne G Randolph, Suchitra Ranjit, Lewis H Romer, Halden F Scott, Lyvonne N Tume, Judy T Verger, Eric A Williams, Joshua Wolf, Hector R Wong, Jerry J Zimmerman, Niranjan Kissoon, Pierre Tissieres,

OBJECTIVES:To develop evidence-based recommendations for clinicians caring for children (including infants, school-aged children, and adolescents) with septic shock and other sepsis-associated organ dysfunction. DESIGN:A panel of 49 international experts, representing 12 international organizations, as well as three methodologists and three public members was convened. Panel members assembled at key international ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(Suppl 1):10-67]

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Pulmonary artery aneurysm: a review.

Mridul Gupta, Abhinav Agrawal, Annamaria Iakovou, Stuart Cohen, Rakesh Shah, Arunabh Talwar,

Pulmonary artery aneurysm is a rare but important entity in the spectrum of pulmonary vascular diseases. The etiologies can be varied and patients can present with non-specific symptoms with the diagnosis being incidental. There is limited consensus regarding the diagnostic criteria and follow-up imaging for patients diagnosed with this entity. ... Read more >>

Pulm Circ (Pulmonary Circulation)
[2020, 10(1):2045894020908780]

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Infection-related Glomerulonephritis and C3 Glomerulonephritis - Similar Yet Dissimilar: A Case Report and Brief Review of Current Literature.

Gajapathiraju Chamarthi, William L Clapp, Harini Bejjanki, Jena Auerbach, Abhilash Koratala,

Infection-related glomerulonephritis (IRGN) is an immune complex-mediated glomerulonephritis (GN), often preceded by infection with subsequent recovery of renal function after the resolution of the infection. C3 deposition in the absence of immune complex deposits can be seen in patients with IRGN, but with the emergence of C3 glomerulonephritis (C3GN), the ... Read more >>

Cureus (Cureus)
[2020, 12(2):e7127]

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Consensus Report on Diagnosis, Treatment and Prevention of Infective Endocarditis by Turkish Society of Cardiovascular Surgery (TSCVS), Turkish Society of Clinical Microbiology and Infectious Diseases (KLIMIK), Turkish Society of Cardiology (TSC), Turkish Society of Nuclear Medicine (TSNM), Turkish Society of Radiology (TSR), Turkish Dental Association (TDA) and Federation of Turkish Pathology Societies (TURKPATH) Cardiovascular System Study Group.

Serap Şimşek-Yavuz, Ahmet Rüçhan Akar, Sinan Aydoğdu, Denef Berzeg-Deniz, Hakan Demir, Tuncay Hazırolan, Mehmet Ali Özatik, Necla Özer, Murat Sargın, Emine Nursen Topcuoğlu, Nesrin Turhan, Mehmet Birhan Yılmaz, Özlem Azap, Seniha Başaran, Yasemin Çağ, Atahan Çağatay, Güle Çınar, Sibel Doğan-Kaya, Lokman Hızmalı, Mehmet Emirhan Işık, Nirgül Kılıçaslan, Şirin Menekşe, Meliha Meriç-Koç, Serpil Öztürk, Ayfer Şensoy, Yasemin Tezer-Tekçe, Elif Tükenmez-Tigen, Yeşim Uygun-Kızmaz, Mutlu Şeyda Velioğlu-Öcalmaz, Ayşegül Yeşilkaya, Emel Yılmaz, Neziha Yılmaz, Fatma Yılmaz-Karadağ,

Infective endocarditis (IE) is rare, but associated with significant morbidity and mortality rates. Estimates of the incidence of IE in Turkey are compromised by the absence of population-based prospective studies. Due to the frequent presence of predisposing cardiac conditions and higher rates of nosocomial bacteremia in highrisk groups, the incidence ... Read more >>

Turk Gogus Kalp Damar Cerrahisi Derg (Turk gogus kalp damar cerrahisi dergisi)
[2020, 28(1):2-42]

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Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: A nationwide study.

Eric H Chou, Shaynna Mann, Tzu-Chun Hsu, Wan-Ting Hsu, Carolyn Chia-Yu Liu, Toral Bhakta, Dahlia M Hassani, Chien-Chang Lee,

PURPOSE:To determine the trends of infection sites and outcome of sepsis using a national population-based database. MATERIALS AND METHODS:Using the Nationwide Inpatient Sample database of the US, adult sepsis hospitalizations and infection sites were identified using a validated approach that selects admissions with explicit ICD-9-CM codes for sepsis and diagnosis/procedure ... Read more >>

PLoS ONE (PloS one)
[2020, 15(1):e0227752]

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Treatment-resistant eosinophilic oesophagitis successfully managed with tofacitinib.

Lybil Briscia Mendoza Alvarez, Xiuli Liu, Sarah Glover,

We present a case of a 34-year-old man with long-term diagnosis of eosinophilic oesophagitis (EoE) who did not achieve control of disease after multiple therapies including topical and systemic steroids, immune modulators and biologics. Initial endoscopic findings showed signs of active eosinophilic oesophagitis and biopsies were significant for up to ... Read more >>

BMJ Case Rep (BMJ case reports)
[2019, 12(12):]

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The first report of Streptococcus pluranimalium infection from Iran: A case report and literature review.

Kiarash Ghazvini, Mohsen Karbalaei, Hamidreza Kianifar, Masoud Keikha,

The Streptococcus pluranimalium was isolated from both of animals and human infection. There is limited information about pathogenicity of S pluranimalium. As fastidious bacteria, S pluranimalium is not isolated in the routinely culture media and easily misidentified with other streptococci species with conventional microbiology test. According to review of the literatures, the ... Read more >>

Clin Case Rep (Clinical case reports)
[2019, 7(10):1858-1862]

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Veillonella parvula periorbital cellulitis: an unusual pathogen causing a common clinical sign.

Liesbeth Wellens, Ingele Casteels, Marc Huygens,

We describe the case of a one-year-old boy who presented at the emergency department with a sudden onset of fulminant edema of the right eyelid. He had been suffering from a varicella zoster virus (VZV) infection for 5 days. A secondary bacterial infection of varicella skin lesions was suspected. Computed ... Read more >>

GMS Ophthalmol Cases (GMS ophthalmology cases)
[2019, 9:Doc17]

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Invasive Candidiasis in Infants and Children: Recent Advances in Epidemiology, Diagnosis, and Treatment.

Thomas J Walsh, Aspasia Katragkou, Tempe Chen, Christine M Salvatore, Emmanuel Roilides,

This paper reviews recent advances in three selected areas of pediatric invasive candidiasis: epidemiology, diagnosis, and treatment. Although the epidemiological trends of pediatric invasive candidiasis illustrate a declining incidence, this infection still carries a heavy burden of mortality and morbidity that warrants a high index of clinical suspicion, the need ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2019, 5(1):]

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Infective endocarditis in children with normal heart: Indication for surgical intervention.

Bana Agha Nasser, Abdullah Al Qwaee, Abdul Rahman Almesned, Ali Akhfash, Tagelden Mohamad, Farah Chaikhouni, Fahad Alhabshan, Mohamed S Kabbani,

Although infective endocarditis is an uncommon condition, it can be fatal if not treated. The new era of infective endocarditis in children with structurally normal heart has become apparent entity. Duke criteria has been established for a long time and gives clear guidelines for diagnosis; however, surgical indication in pediatric ... Read more >>

J Saudi Heart Assoc (Journal of the Saudi Heart Association)
[2019, 31(2):51-56]

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Rare cytogenetic abnormalities and their clinical relevance in pediatric acute leukemia of Saudi Arabian population.

Nawaf Alkhayat, Ghaleb Elyamany, Yasser Elborai, Qanita Sedick, Mohammad Alshahrani, Omar Al Sharif, Abdulmalik Alenezy, Amjad Hammdan, Hatem Elghezal, Omar Alsuhaibani, Mansour S Aljabry, May AlMoshary, Eman Al Mussaed,

Background:Childhood Acute Leukemia (AL) is characterized by recurrent genetic aberrations in 60% of AML cases and 90% of ALL cases. Insufficient data exists of rare cytogenetic abnormalities in AL. Therefore, we tested rare cytogenetic abnormalities occurring in childhood AL and its effect on clinical prognosis in patients diagnosed at our ... Read more >>

Mol Cytogenet (Molecular cytogenetics)
[2019, 12:42]

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Peritonitis by Exophiala dermatitidis in a pediatric patient.

Rosângela L Pinheiro, Regielly C R Cognialli, Rodolfo C Barros, Tyane de A Pinto, Mariana F M Cunha, Tony T Tahan, Morgana F Voidaleski, Renata R Gomes, Guilherme N Becker, Lucas V Andrade, Flavio Queiroz-Telles, G Sybren de Hoog, Renata R Sakiyama, Vânia A Vicente,

Fungal peritonitis is frequent on peritoneal dialysis, with rare cases by Exophiala dermatitidis. A 25-month-old female admitted to the pediatric ICU with acute renal failure was submitted to peritoneal dialysis. After 10 days patient presented fever. Peritoneal fluid culture showed yeast colonies molecularly identified as E. dermatitidis. Patient was treated ... Read more >>

Med Mycol Case Rep (Medical mycology case reports)
[2019, 24:18-22]

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A Unique Pathogen Causing Infective Endocarditis in a Three-year-old Girl.

Apoorva Ravindranath Waikar, Omosede Uzamere, Kaneisha Bailey, Louisdon Pierre, Adebayo Adeyinka,

The overall incidence of infective endocarditis (IE) in adults has been reported to be 1.5 to 6.0 per 100,000 patient-years. In children, the incidence of IE in the general population is approximately three times lower. The presence of cyanotic congenital heart disease is considered to be the most strongly associated ... Read more >>

Cureus (Cureus)
[2019, 11(3):e4249]

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Infectious Diseases Consultation Is Associated With Decreased Mortality in Enterococcal Bloodstream Infections.

Rachael A Lee, Daniel T Vo, Joanna C Zurko, Russell L Griffin, J Martin Rodriguez, Bernard C Camins,

Background:Enterococcus species frequently cause health care-associated bacteremia, with high attributable mortality. The benefit of consultation with infectious disease (ID) specialists has been previously illustrated with Staphylococcus aureus bacteremia. Whether ID consultation (IDC) improves mortality in enterococcal bacteremia is unknown. Methods:This is a retrospective cohort single-center study from January 1, 2015, ... Read more >>

Open Forum Infect Dis (Open Forum Infectious Diseases)
[2020, 7(3):ofaa064]

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Incidence, clinical profile, and risk factors for serious bacterial infections in children hospitalized with fever in Ujjain, India.

Ashish Pathak, Radika Upadhayay, Aditya Mathur, Sunil Rathi, Cecilia Stålsby Lundborg,

BACKGROUND:Fever is a cause for concern for both parents and the treating pediatrician and a common reason for antibiotic overuse. However, the proportion of children hospitalized for fever with serious bacterial infection (SBI) is uncertain. We aimed to evaluate the epidemiological, clinical, hematological, and biochemical risks for SBI among the ... Read more >>

BMC Infect. Dis. (BMC infectious diseases)
[2020, 20(1):162]

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Chronic Cavitary Pulmonary Aspergillosis: A Case Report and Review of the Literature.

Kathryn G Graham, Asad Nasir,

BACKGROUND Aspergillus spores have the ability to affect patients with or without intact immune systems; because of this disease's wide patient involvement it deserves a place on the differential diagnosis list, with endocarditis and tuberculosis, for those presenting with new pulmonary nodules or cavitation. CASE REPORT This case report involves ... Read more >>

Am J Case Rep (The American journal of case reports)
[2019, 20:1220-1224]

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Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis-a binational multicenter cohort study.

Luregn J Schlapbach, Roberto Chiletti, Lahn Straney, Marino Festa, Daniel Alexander, Warwick Butt, Graeme MacLaren, ,

BACKGROUND:The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock. METHODS:Retrospective binational multicenter cohort study of all ICUs contributing to the Australian and New Zealand Paediatric Intensive Care Registry. We included patients ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):429]

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Risk factors for refractory septic shock treated with VA ECMO.

Lei Han, Yan Zhang, Yonghui Zhang, Wei Wu, Ping He,

Background:Refractory septic shock is a serious disorder with high mortality. There is currently limited evidence to support the use of extracorporeal membrane oxygenation (ECMO) in adult septic shock. We describe the outcome of patients with refractory septic shock in our hospital and try to identify prognostic factors. Methods:We studied a ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(18):476]

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1014. Microbiology and Outcome of Bloodstream Infections in Children With Intestinal Failure.

Talal Seddik, Yvonne Maldonado, Colleen Nespor, John Kerner, Hayley Gans,

AbstractBackgroundChildren with intestinal failure (IF) represent 20% of bloodstream infection (BSI) pediatric hospitalizations. We studied the microbiology and associated outcomes of this population.MethodsRetrospective cohort study of children ≤18 years with IF dependent on parenteral nutrition (PN), with ≥1 BSI from January 2007 to December 2016. Organisms causing BSI were divided ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2018, 5(Suppl 1):S302-S302]

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Identification of a Phenylthiazole Small Molecule with Dual Antifungal and Antibiofilm Activity Against Candida albicans and Candida auris.

Haroon Mohammad, Hassan E Eldesouky, Tony Hazbun, Abdelrahman S Mayhoub, Mohamed N Seleem,

Candida species are a leading source of healthcare infections globally. The limited number of antifungal drugs combined with the isolation of Candida species, namely C. albicans and C. auris, exhibiting resistance to current antifungals necessitates the development of new therapeutics. The present study tested 85 synthetic phenylthiazole small molecules for ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18941]

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