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Pediatric First Seizure

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Characterization of Pediatric Seizures in the Commonwealth of the Northern Mariana Islands.

Ahana Yogesh, Michael Taylor, And Mary P Chang,

Saipan is a United States (US) territory Western Pacific island where little recent data exists regarding epidemiology, clinical presentation, and standard of care for pediatric seizures. This paper characterizes these features in Saipan's pediatric population with comparisons to mainland US. This is a retrospective chart review of all pediatric patients ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(4):]

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Psychosocial assessment of families caring for a child with acute lymphoblastic leukemia, epilepsy or asthma: Psychosocial risk as network of interacting symptoms.

Chiara Colliva, Monica Cellini, Francesca Dalla Porta, Martina Ferrari, Barbara Maria Bergamini, Azzurra Guerra, Silvia Di Giuseppe, Annamaria Pinto, Roberto Capasso, Daniela Caprino, Marta Ferrari, Cristina Benatti, Fabio Tascedda, Johanna M C Blom,

The purpose of this study is to assess psychosocial risk across several pediatric medical conditions and test the hypothesis that different severe or chronic pediatric illnesses are characterized by disease specific enhanced psychosocial risk and that risk is driven by disease specific connectivity and interdependencies among various domains of psychosocial ... Read more >>

PLoS ONE (PloS one)
[2020, 15(3):e0230194]

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Identification of PCDH19 Gene Mutations/Deletions in Patients with Early Onset Epilepsy.

Semra Gursoy, Esra Ataman, Bahar Toklu Baysal, Berk Özyılmaz, Pınar Gençpınar, Ayşe Semra Hız, Uluç Yiş, Aycan Ünalp, Nihal Olgaç Dündar, Ayfer Ülgenalp, Derya Erçal,

Background and Aims:PCDH19 gene, which encodes protocadherin 19, is associated with epilepsy and intellectual disability, mainly in affected females. The clinical manifestations are heterogeneous and the main features include early onset seizure, generalized or focal seizures sensitive to fever, and brief seizures occurring in clusters. The disorders exhibit a unique ... Read more >>

Ann Indian Acad Neurol (Annals of Indian Academy of Neurology)
[2020, 23(2):206-210]

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Social isolation and exclusion: the parents' experience of caring for children with rare neurodevelopmental disorders.

Genevieve Currie, Joanna Szabo,

Purpose: The experiences of parents caring for the complex care needs of children with rare neurodevelopmental disorders are not well understood. Parents struggle to meet their children's medical, behavioural, and social needs within and across health, social, and family systems. The purpose of this study was to explore the parents' ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1725362]

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The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States.

Sarah N Gibbs, Jiyoon Choi, Ibrahim Khilfeh, K Hamzah Ahmed, Irina Yermilov, Eric Segal,

OBJECTIVE:To better understand the humanistic and economic burden of focal seizures in children 2-12 years old. METHODS:We conducted a targeted literature review by searching MEDLINE for English-language publications reporting on children 2-12 years old with focal seizures published in the United States since 2008. RESULTS:Thirty-five publications were included. Incidence of ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820911785]

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Early Electroencephalogram Background Could Guide Tailored Duration of Monitoring for Neonatal Encephalopathy Treated with Therapeutic Hypothermia.

Giulia M Benedetti, Rebecca J Vartanian, Harlan McCaffery, Renée A Shellhaas,

OBJECTIVE:To evaluate whether features of the early electroencephalographic (EEG) background could guide the optimal duration of continuous video EEG monitoring for seizure detection in newborn infants treated with therapeutic hypothermia for hypoxic ischemic encephalopathy (HIE). STUDY DESIGN:Retrospective cohort study of 114 consecutive infants treated with therapeutic hypothermia for moderate to ... Read more >>

J. Pediatr. (The Journal of pediatrics)
[2020, :]

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Midazolam use in pediatric dentistry: a review.

Shreyans Aditya Jain, Nilesh Rathi, Nilima Thosar, Sudhindra Baliga,

Behaviour management and dental procedures performed in very young, pre-cooperative, highly anxious, or medically disabled children are challenging tasks. Various drugs and methods have, however, been introduced to facilitate treatment for this patient population. Midazolam is a benzodiazepine used as an adjunct to behavior management techniques in the dental treatment ... Read more >>

J Dent Anesth Pain Med (Journal of dental anesthesia and pain medicine)
[2020, 20(1):1-8]

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Filamin A-negative hyaline astrocytic inclusions in pediatric patients with intractable epilepsy: report of 2 cases.

Grant M Fischer, Elmira Vaziri Fard, Manish N Shah, Rajan P Patel, Gretchen Von Allmen, Leomar Y Ballester, Meenakshi B Bhattacharjee,

Although rare, hyaline cytoplasmic inclusions isolated to astrocytes of the cerebral cortex have been identified in a spectrum of diseases ranging from intractable epilepsy in pediatric patients with only mild to moderate developmental delays to Aicardi syndrome. These inclusions classically stain positive for filamin A, giving rise to the term ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2020, :1-7]

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The role of targeted gene panel in pediatric drug-resistant epilepsy.

Chang-Chun Wu, Meng-Han Tsai, Yen-Ju Chu, Wen-Chin Weng, Pi-Chuan Fan, Wang-Tso Lee,

About 10-30% of pediatric patients with epilepsy have drug-resistant epilepsy. Genetic panels may be useful in identifying etiology and guiding treatment in pediatric patients with drug-resistant epilepsy. In our tertiary center, we used two epilepsy panels, an initial 24-genes panel followed by a more comprehensive 122-genes panel to screen for ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107003]

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Clinical Implementation of a Parent Questionnaire to Identify Seizures in High-Risk Children.

Celia Greenlaw, Sarah Nuss, Cristina Camayd-Muñoz, Rinat Jonas, Julie Vanier Rollins, Howard Cabral, Laurie M Douglass,

BACKGROUND:This study evaluated the effectiveness of a parent-completed questionnaire for detecting seizures in high-risk children. METHODS:A 2-part seizure screen for children up to 12 years of age with suspected autism spectrum disorder, developmental delay, or seizure, was implemented in 12 Massachusetts clinics serving populations with high health disparities. Primary care ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820911505]

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Different experiences of two PRRT2-associated self-limited familial infantile epilepsy.

Qianlei Zhao, Zhenwei Liu, Ying Hu, Shiyu Fang, Feixia Zheng, Xiucui Li, Feng Li, Zhongdong Lin,

To analyze the clinical characteristics and PRRT2 gene mutation of self-limited familial infantile epilepsy and evaluate the treatment responses of different antiepileptic drugs in self-limited familial infantile epilepsy. We reviewed the clinical feature and genetic mutation results and treatment responses of two sibling sisters. They were detected with the PRRT2 ... Read more >>

Acta Neurol Belg (Acta neurologica Belgica)
[2020, :]

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Guideline for advanced neuroimaging in pediatric epilepsy.

Yun Jung Hur,

Clin Exp Pediatr (Clinical and experimental pediatrics)
[2020, 63(3):100-101]

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Pediatric functional hemispherectomy: operative techniques and complication avoidance.

Christopher C Young, John R Williams, Abdullah H Feroze, Margaret McGrath, Ali C Ravanpay, Richard G Ellenbogen, Jeffrey G Ojemann, Jason S Hauptman,

Functional hemispherectomy/hemispherotomy is a disconnection procedure for severe medically refractory epilepsy where the seizure foci diffusely localize to one hemisphere. It is an improvement on anatomical hemispherectomy and was first performed by Rasmussen in 1974. Less invasive surgical approaches and refinements have been made to improve seizure freedom and minimize ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E9]

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Medical Cannabis for Intractable Epilepsy in Childhood: A Review.

Bruria Ben-Zeev,

In recent years, cannabis has been gaining increasing interest in both the medical research and clinical fields, with regard to its therapeutic effects in various disorders. One of the major fields of interest is its role as an anticonvulsant for refractory epilepsy, especially in the pediatric population. This paper presents ... Read more >>

Rambam Maimonides Med J (Rambam Maimonides medical journal)
[2020, 11(1):]

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Assessing Frequency of Respiratory Complications in Children Undergoing Adenotonsillectomy.

Alyson K Baker, Christopher L Carroll, Christopher R Grindle, Kathleen A Sala, Allison S Cowl,

OBJECTIVES:To determine the frequency of respiratory complications in children admitted to the ICU after adenotonsillectomy and to identify factors associated with the risk of respiratory complications in this cohort. DESIGN:Retrospective observational study. SETTING:PICU. PATIENT POPULATION:All children admitted to the ICU following adenotonsillectomy from September 30, 2009, to March 30, 2014. ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.

Katrien Stouffs, Patrick Verloo, Stefanie Brock, Luc Régal, Diane Beysen, Berten Ceulemans, Anna C Jansen, Marije E C Meuwissen,

NEDD4L encodes an ubiquitin ligase which is expressed in the cortex and ventricular zone of the fetal brain. Missense variants in NEDD4L have been reported in nine patients with periventricular nodular heterotopia (PNH), polymicrogyria, cleft palate, and syndactyly. All reported variants are located in the HECT domain, causing deregulation of ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:26]

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Epilepsia Open- March 2020 - Announcements.

Epilepsia Open (Epilepsia open)
[2020, 5(1):127-130]

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Stereo-EEG in Tuberous Sclerosis Complex.

Jun T Park, Guadalupe Fernandez-Baca Vaca,

A collaborative research team lead by an investigator from the Lyon Neuroscience Research Center and Lyon University Hospital and Lyon 1 University studied epileptogenicity of tuber and its surrounding cortex using stereoelectroencephalography (SEEG) in patients diagnosed with tuberous sclerosis complex (TSC) (genetic or clinical). ... Read more >>

Pediatr Neurol Briefs (Pediatric Neurology Briefs)
[2020, 34:6]

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Editorial: Pediatric Inflammatory Bowel Diseases: Looking to the Future.

Eytan Wine, Wael El-Matary, Jeff Critch, Víctor Manuel Navas-López, Seamus Hussey,

Front Pediatr (Frontiers in pediatrics)
[2020, 8:56]

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Two different missense mutations of PEX genes in two similar patients with severe Zellweger syndrome: an argument on the genotype-phenotype correlation.

Cengiz Havali, Sevil Dorum, Yılmaz Akbaş, Orhan Görükmez, Tugba Hirfanoglu,

Background Peroxisomal biogenesis disorders (PBDs) include a miscellaneous group of diseases which cause serious multisystem disease. Mutations of 13 different PEX genes lead to PBDs including Zellweger syndrome (ZS). Different types of mutations of PEX1 and PEX10 genes are correlated with broad-range phenotypes of PBDs. Case presentation Patient 1 is ... Read more >>

J. Pediatr. Endocrinol. Metab. (Journal of pediatric endocrinology & metabolism : JPEM)
[2020, 33(3):437-441]

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Pediatric autoimmune encephalitis: Recognition and diagnosis.

Marienke A A M de Bruijn, Arlette L Bruijstens, Anna E M Bastiaansen, Agnes van Sonderen, Marco W J Schreurs, Peter A E Sillevis Smitt, Rogier Q Hintzen, Rinze F Neuteboom, Maarten J Titulaer, ,

OBJECTIVE:The aims of this study were (1) to describe the incidence of autoimmune encephalitis (AIE) and acute disseminated encephalomyelitis (ADEM) in children, (2) to validate the currently used clinical criteria to diagnose AIE, and (3) to describe pitfalls in the diagnosis of pediatric autoimmune (AI) and inflammatory neurologic disorders. METHODS:This ... Read more >>

Neurol Neuroimmunol Neuroinflamm (Neurology(R) neuroimmunology & neuroinflammation)
[2020, 7(3):]

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IDDCA syndrome in a Chinese infant due to GNB5 biallelic mutations.

Mingxing Tang, Yajian Wang, Yuanyuan Xu, Wenjia Tong, Danqun Jin, Xiu-An Yang,

Herein, we present a Chinese infant with an early-onset intellectual developmental disorder with cardiac arrhythmia syndrome. A 6-month-old boy visited our hospital because of convulsions and paroxysmal cyanosis for 1 day. Mental development analysis showed that the patient had a neurodevelopmental delay. Frequent seizures occurred, and ECG monitoring demonstrated severe ... Read more >>

J. Hum. Genet. (Journal of human genetics)
[2020, :]

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Clinical value of a set of neuropeptides in term and preterm neonates with seizures: Brain derived neurotrophic factor, galanin and neuropeptide Y.

Mahir Tanrıverdi, Nilgun Kultursay, Hasan Tekgul, Eser Sozmen, Ozge Altun Koroglu, Gul Aktan, Mehmet Yalaz,

The aim of our study to investigate clinical value of a set of neuropeptides (brain derived neurotrophic factor-BDNF, galanin and neuropeptide Y-NPY) in critically ill neonates. A total of 53 neonates (preterm: 26, term: 27) evaluated with lumbar pucture for etiologic evaluation were consequtively included into the study. Serum and ... Read more >>

J Clin Neurosci (Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia)
[2020, :]

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Minimizing blood loss in hemispherectomy for hemimegalencephaly in low-weight infants: technical note.

Sandeep Sood, Eishi Asano, Aimee Luat,

INTRODUCTION:Drug-resistant seizures due to hemimegalencephaly in neonates and infants are a unique surgical and anesthesia challenge. While early surgery in these patients may predict a better seizure control, a lower body weight, limited blood volume, and surgical blood loss may make hemispherectomy prohibitive. METHODS:Two infants (weight, 8.7 kg and 3.7 ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, 36(4):841-845]

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