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Pediatric Cardiac Tumors

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Pneumonectomy for Pediatric Tumors-a Pediatric Surgical Oncology Research Collaborative Study.

Stephanie F Polites, Todd E Heaton, Michael P LaQuaglia, Eugene S Kim, Wesley E Barry, Catherine J Goodhue, Andrew J Murphy, Andrew M Davidoff, Max R Langham, Rebecka L Meyers, Scott S Short, Timothy B Lautz, Richard D Glick, Sanjeev A Vasudevan, Christina M Bence, Dave R Lal, Reto M Baertschiger, Bryanna Emr, Marcus M Malek, Roshni Dasgupta,

OBJECTIVE:To describe utilization and long-term outcomes of pneumonectomy in children and adolescents with cancer. SUMMARY BACKGROUND DATA:Pneumonectomy in adults is associated with significant morbidity and mortality. Little is known about the indications and outcomes of pneumonectomy for pediatric tumors. METHODS:The Pediatric Surgical Oncology Research Collaborative (PSORC) identified pediatric patients <21 ... Read more >>

Ann. Surg. (Annals of surgery)
[2020, :]

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Association of childhood obesity with risk of early all-cause and cause-specific mortality: A Swedish prospective cohort study.

Louise Lindberg, Pernilla Danielsson, Martina Persson, Claude Marcus, Emilia Hagman,

BACKGROUND:Pediatric obesity is associated with increased risk of premature death from middle age onward, but whether the risk is already increased in young adulthood is unclear. The aim was to investigate whether individuals who had obesity in childhood have an increased mortality risk in young adulthood, compared with a population-based ... Read more >>

PLoS Med. (PLoS medicine)
[2020, 17(3):e1003078]

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Clinical and Prognostic Role of 18F-FDG PET/CT in Pediatric Ewing Sarcoma.

Domenico Albano, Francesco Dondi, Richard Fabian Schumacher, Carmelita D'Ippolito, Fulvio Porta, Raffaele Giubbini, Francesco Bertagna,

Ewing sarcoma (ES) is one of the most common pediatric solid tumors with aggressive behavior and unfavorable survival. In this study, we evaluated the diagnostic accuracy of baseline and restaging fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) scans and their possible prognostic role in pediatric ES. We evaluated 17 patients who ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, 42(2):e79-e86]

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Age-Dependent Presentation and Clinical Course of 1465 Patients Aged 0 to Less than 18 Years with Ovarian or Testicular Germ Cell Tumors; Data of the MAKEI 96 Protocol Revisited in the Light of Prenatal Germ Cell Biology.

Gabriele Calaminus, Dominik T Schneider, Dietrich von Schweinitz, Heribert Jürgens, Nacera Infed, Stefan Schönberger, Thomas A Olson, Peter Albers, Christian Vokuhl, Raimund Stein, Leendert Looijenga, Jalid Sehouli, Martin Metzelder, Alexander Claviez, Michael Dworzak, Angelika Eggert, Birgit Fröhlich, Nicolas U Gerber, Christian P Kratz, Jörg Faber, Thomas Klingebiel, Dieter Harms, Ulrich Göbel,

OBJECTIVE:To evaluate prognostic factors in pediatric patients with gonadal germ cell tumors (GCT). METHODS:Patients <18 years with ovarian and testicular GCT (respectively OGCT and TGCT) were prospectively registered according to the guidelines of MAKEI 96. After resection of the primary tumor, patients staged ≥II received risk-stratified cisplatin-based combination chemotherapy. Patients ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(3):]

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Health disparities among Tennessee pediatric renal tumor patients.

Kevin Neuzil, Annie Apple, Amelia Sybenga, Heidi Chen, Shilin Zhao, Martin Whiteside, Hernan Correa, Hannah M Phelps, Harold N Lovvorn,

BACKGROUND/PURPOSE:Wilms tumor (WT) poses a cancer health disparity to black children globally, which has not been evaluated thoroughly for other pediatric renal cancers. We aimed to characterize health disparities among Tennessee children treated for any renal cancer. METHODS:The Tennessee Cancer Registry (TCR) was queried for patients ≤18 years having any renal ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2020, :]

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Cardiac Tumor Presenting as Acute Right Hemiparesis in a 13-Year-Old Boy.

Chun-Yu Chen, Yu-Chieh Chen, Kuang-Jen Chien, Chu-Chuan Lin, Kai-Sheng Hsieh, Ken-Pen Weng,

Acta Cardiol Sin (Acta Cardiologica Sinica)
[2020, 36(2):168-170]

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Thirty-Day Outcomes following Pediatric Bone and Soft Tissue Sarcoma Surgery: A NSQIP Pediatrics Analysis.

Kathryn E Gallaway, Junho Ahn, Alexandra K Callan,

Background:Pediatric bone and soft tissue sarcomas are rare; therefore, national registries are essential tools for orthopedic oncology research. Past studies provide excellent data on long-term prognosis and survival trends but fail to examine treatment-specific morbidity. The aim of this study is to use a national registry to describe patient demographics, ... Read more >>

Sarcoma (Sarcoma)
[2020, 2020:1283080]

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Pediatric Right Ventricular Cardiac Steatosis following Immunosuppressive Treatment.

Diana Kozman, Carlos R Abramowsky, Janet Poulik, Pheven Dereje, Larisa Bondarenko, Jasmine Vickery, Stephen Dzul, Abdul Hanan, Bahig M Shehata,

Background: Right ventricular myocardial fatty infiltration has been observed in pediatric cardiac allografts with an associated decrease in graft life expectancy. A possible explanation included an immunosuppressant drug effect which prompted us to examine common factors between non-cardiac transplanted immunosuppressed patients and postmortem hearts of pediatric patients who died of ... Read more >>

Fetal Pediatr Pathol (Fetal and pediatric pathology)
[2020, :1-6]

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The Application of Next-generation Sequencing Tumor Molecular Profiling in the Diagnosis and Management of a Case of Acute Myelogenous Leukemia With MLL-PTD (Partial Tandem Duplication) in a Pediatric Heart Transplant Recipient.

William C Woolbright, Victor Wong, Eric Severson, Dennis J Kuo,

A 6-year-old girl with a history of heart transplantation was diagnosed with myelodysplastic syndrome, which progressed to acute myelogenous leukemia. Comprehensive genomic profiling of her tumor discovered an MLL-PTD (partial tandem duplication) and she received chemotherapy and a hematopoietic stem cell transplant (HSCT). She subsequently relapsed and tumor molecular profiling ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, :]

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Molecularly Targeted Agents in the Therapy of Pediatric Brain Tumors.

Miriam Bornhorst, Eugene I Hwang,

Pediatric brain tumors are the leading cause of cancer-related death in children. Recent advances in sequencing techniques, and collaborative efforts to encode the mutational landscape of various tumor subtypes, have resulted in the identification of recurrent mutations that may present as actionable targets in these tumors. A number of molecularly ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(1):45-54]

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The Role of a Good Quality Autopsy in Pediatric Malpractice Claim: A Case Report of an Unexpected Death in an Undiagnosed Thymoma.

Nunzio Di Nunno, Federico Giuseppe Patanè, Francesco Amico, Alessio Asmundo, Cristoforo Pomara,

Thymomas are extremely rare in the first 20 years of life, with different clinical presentations: from asymptomatic mediastinal masses to compressive and paraneoplastic syndromes. In pediatric population, the respiratory disorders have a higher incidence. The overall thymoma mortality rate is described as 40% and metastasized tumors are more aggressive. This ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:31]

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Passive Peritoneal Drainage Impact on Fluid Balance and Inflammatory Mediators: A Randomized Pilot Study.

Kamal K Pourmoghadam, Stacey Kubovec, William M DeCampli, Bertha Ben Khallouq, Kurt Piggott, Carlos Blanco, Harun Fakioglu, Alicia Kube, Sukumar Suguna Narasimhulu,

BACKGROUND:Infants after cardiopulmonary bypass are exposed to increasing inflammatory mediator release and are at risk of developing fluid overload. The aim of this pilot study was to evaluate the impact of passive peritoneal drainage on achieving negative fluid balance and its ability to dispose of inflammatory cytokines. METHODS:From September 2014 ... Read more >>

World J Pediatr Congenit Heart Surg (World journal for pediatric & congenital heart surgery)
[2020, 11(2):150-158]

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Rapid Advancement in Enteral Nutrition Does Not Affect Systemic Inflammation and Insulin Homeostasis Following Pediatric Cardiopulmonary Bypass Surgery.

Alejandro A Floh, Joann Herridge, Chun-Po S Fan, Cedric Manlhiot, Brian W McCrindle, Glen Van Arsdell, Diana Balmer-Minnes, Steven M Schwartz,

OBJECTIVES:To determine impact of enteral nutrition delivery on the relationship among inflammation, insulin resistance, and outcomes following pediatric cardiopulmonary bypass surgery. DESIGN:Pilot, randomized study analyzed according to intention-to-treat analysis. SETTING:Pediatric cardiac ICU. PATIENTS:Infants (≤ 6 mo) undergoing cardiopulmonary bypass. INTERVENTIONS:Patients randomly assigned to receive rapid escalation to enteral nutrition reaching ... Read more >>

Pediatr Crit Care Med (Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies)
[2020, :]

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Optimization of percutaneous biopsy for diagnosis and pretreatment risk assessment of neuroblastoma.

Richard E Overman, Tanvi T Kartal, Aaron J Cunningham, Elizabeth A Fialkowski, Bindi J Naik-Mathuria, Sanjeev A Vasudevan, Marcus M Malek, Ranjeet Kalsi, Hau D Le, Linda Cherney Stafford, Timothy B Lautz, Benjamin T Many, Rachel E Jones, Andreana Bütter, Jacob Davidson, Andrew Williams, Roshni Dasgupta, Jana Lewis, Misty Troutt, Jennifer H Aldrink, Sara A Mansfield, Dave R Lal, Jerry Xiao, Rebecka L Meyers, Scott S Short, Erika A Newman,

BACKGROUND:Image-guided percutaneous core needle biopsy (PCNB) is increasingly utilized to diagnose solid tumors. The objective of this study is to determine whether PCNB is adequate for modern biologic characterization of neuroblastoma. PROCEDURE:A multi-institutional retrospective study was performed by the Pediatric Surgical Oncology Research Collaborative on children with neuroblastoma at 12 ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2020, 67(5):e28153]

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Targeting RAS in pediatric cancer: is it becoming a reality?

Angelina V Vaseva, Marielle E Yohe,

PURPOSE OF REVIEW:The current review aims to highlight the frequency of RAS mutations in pediatric leukemias and solid tumors and to propose strategies for targeting oncogenic RAS in pediatric cancers. RECENT FINDINGS:The three RAS genes (HRAS, NRAS, and KRAS) comprise the most frequently mutated oncogene family in human cancer. RAS ... Read more >>

Curr. Opin. Pediatr. (Current opinion in pediatrics)
[2020, 32(1):48-56]

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Salvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol.

Ashley A Adile, Michelle M Kameda-Smith, David Bakhshinyan, Laura Banfield, Sabra K Salim, Forough Farrokhyar, Adam J Fleming,

BACKGROUND:Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy ... Read more >>

Syst Rev (Systematic reviews)
[2020, 9(1):47]

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Minimally invasive surgery for abdominal and thoracic neuroblastic tumors: A systematic review by the APSA Cancer committee.

Juan P Gurria, Marcus M Malek, Todd E Heaton, Alison Gehred, Timothy B Lautz, Daniel S Rhee, Elisabeth T Tracy, Christa N Grant, Reto M Baertshiger, Jennifer Bruny, Emily R Christison-Lagay, David A Rodeberg, Peter F Ehrlich, Roshni Dasgupta, Jennifer H Aldrink,

BACKGROUND:Minimally invasive surgery has broad applicability to pediatric diseases, including pediatric cancer resection. Neuroblastic tumors of childhood are highly variable in presentation, and so careful selection of appropriate candidates for minimally invasive resection is paramount to achieving safe and durable surgical and oncological outcomes. METHODS:The American Pediatric Surgical Association Cancer ... Read more >>

J. Pediatr. Surg. (Journal of pediatric surgery)
[2020, :]

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ACE2/Angiotensin-(1-7)/Mas receptor axis in human cancer: Potential role for pediatric tumors.

Ana Luiza Ataide Carneiro de Paula Gonzaga, Vitória Andrade Palmeira, Thomas Felipe Silva Ribeiro, Larissa Braga Costa, Karla Emília de Sá Rodrigues, Ana Cristina Simões-E-Silva,

BACKGROUND:Pediatric tumors remain the highest cause of death in developed countries. Research on novel therapeutic strategies with lesser side effects is of utmost importance. In this scenario, the role of Renin Angiotensin System (RAS) axes, the classical one formed by angiotensin converting enzyme (ACE), Angiotensin II and AT1 receptor and ... Read more >>

Curr Drug Targets (Current drug targets)
[2020, :]

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An Integrative Review of Factors Associated With Symptom Burden at the End of Life in Children With Cancer.

Ijeoma Julie Eche, Ifeoma Mary Eche, Teri Aronowitz,

Children with cancer experience multiple symptoms at end of life (EOL) that impair their health-related quality of life. Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, this integrative literature review comprehensively summarized symptom experiences of children with cancer at EOL. The Cumulative Index to Nursing and Allied ... Read more >>

J Pediatr Oncol Nurs (Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses)
[2020, :1043454220909805]

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Tumor lysis syndrome in childhood malignancies.

Wing Lum Cheung, Kam Lun Hon, Cheuk Man Fung, Alexander Kc Leung,

Background:Tumor lysis syndrome (TLS) is the most common life-threatening oncological emergency encountered by physicians treating children with lymphoproliferative malignancies. Healthcare providers should be aware of the condition in order to prevent occurrence and prompt timely management to avoid severe consequences. Objective:To provide an update on the current understanding, evaluation, and ... Read more >>

Drugs Context (Drugs in context)
[2020, 9:]

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Population-Based Analysis of Demographic and Socioeconomic Disparities in Pediatric CNS Cancer Survival in the United States.

Robert Fineberg, Shadi Zahedi, Megan Eguchi, Muriel Hart, Myles Cockburn, Adam L Green,

Previous studies have demonstrated effects of racial and socioeconomic factors on survival of adults with cancer. While less studied in the pediatric population, data exist demonstrating disparities of care and survival in pediatric oncology patients based on socioeconomic and racial/ethnic factors. Brain cancers recently overtook leukemia as the number one ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):4588]

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Assessment of traditional and non-traditional risk factors for premature atherosclerosis in children with juvenile dermatomyositis and pediatric controls.

Dawn M Wahezi, Emily J Liebling, Jaeun Choi, Marija Dionizovik-Dimanovski, Qi Gao, Jillian Parekh,

BACKGROUND:Children with juvenile dermatomyositis (JDM), the most common inflammatory myopathy of childhood, may be at increased risk of premature atherosclerosis given a host of traditional and non-traditional risk factors. The primary aim of this study was to determine the underlying frequency of premature atherosclerosis in children with JDM compared to ... Read more >>

Pediatr Rheumatol Online J (Pediatric Rheumatology Online Journal)
[2020, 18(1):25]

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Low expression of ANT1 confers oncogenic properties to rhabdomyosarcoma tumor cells via modulating metabolism and death pathways

Vial, Huchedé, Fagault, Basset, Rossi, Geoffray, Bisaccia, Creveaux, Neves, Fauvelle, Castets, Carré, Weber, Castets,

ABSTRACT Rhabdomyosarcoma (RMS) is the most frequent form of pediatric soft-tissue sarcoma. It is divided into 2 main subtypes: ERMS (embryonal) and ARMS (alveolar). Current treatments are based on chemotherapy, surgery and radiotherapy. 5-year survival rate remains of 70% since 2000, despite several clinical trials. RMS cells are thought to ... Read more >>

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Treatment patterns and outcomes for pancreatic tumors in children: an analysis of the National Cancer Database.

Omar Picado, Anthony Ferrantella, Celisse Zabalo, Krishnamurti Rao, Chad M Thorson, Juan E Sola, Eduardo A Perez,

PURPOSE:Pancreatic tumors are rare in children and limited data are available regarding incidence, treatment, and outcomes. We aim to describe patient and tumor characteristics and to report on survival of these diseases. METHODS:Children with pancreatic tumors were queried from the National Cancer Database (2004-2014). The association between treatment and hazard ... Read more >>

Pediatr. Surg. Int. (Pediatric surgery international)
[2020, 36(3):357-363]

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