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Pediatric Carbon Monoxide Toxicity

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Multi-Omic integration after carbon monoxide toxicity in a child reveals gene transcripts related to Parkinson and Multiple Sclerosis

Mara Leimanis, Jeremy Prokop, Derek Nedveck, Christina Darin, Todd Lydic, Caleb Bupp, Steven DeRoos, Surender Rajasekaran,

<title>Abstract</title> <p> Background This report highlights the unique transcriptomic and lipidomic changes noted in a 4-year-old African American female patient exposed to a house fire. She required admission to the pediatric Intensive care unit due to organ failure that resulted from CO and cyanide toxicity. Patient was neurologically ... Read more >>

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MANAGEMENT OF ACUTE RESPIRATORY DISTRESS SYNDROME IN A CHILD WITH ADENOVIRUS PNEUMONIA: CASE REPORT AND LITERATURE REVIEW.

Felipe Rezende Caino de Oliveira, Krisna de Medeiros Macias, Patricia Andrea Rolli, José Colleti Junior, Werther Brunow de Carvalho,

OBJECTIVE:To report the case of a child who developed acute respiratory distress syndrome (ARDS) from a pulmonary infection by adenovirus. CASE DESCRIPTION:A female patient aged 2 years and 6 months, weighting 10,295 grams developed fever, productive cough and vomiting, later on progressing to ARDS despite initial therapy in accordance with ... Read more >>

Rev Paul Pediatr (Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo)
[2020, 38:e2018280]

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What is the Significance of Elevated Troponin I in Children and Adolescents? A Diagnostic Approach.

Tamer Yoldaş, Utku Arman Örün,

Troponin is a marker that displays cardiac injury quickly and accurately. In adults, troponin elevation is usually associated with coronary artery disease and requires urgent cardiac catheterization. In healthy children, myocardial injury is rare and may develop due to many different causes. Therefore, troponin elevation in children and adolescents does ... Read more >>

Pediatr Cardiol (Pediatric cardiology)
[2019, 40(8):1638-1644]

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What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?

Rajalakshmi Iyer, Arun Bansal,

Nutrition in pediatric acute respiratory distress syndrome (PARDS) is an essential aspect of therapy, with potential to modify outcomes. The gut is slowly establishing its place as the motor of critical illness, and the 'gut-lung' axis has been shown to be in play in the systemic inflammatory response. Thus, utilizing ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(19):510]

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The Good Side of Carbon Monoxide.

Alla Katsnelson,

ACS Cent Sci (ACS central science)
[2019, 5(10):1632-1635]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[0, :1-53]

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Busulfan-Induced Lung Injury in Pediatric Oncology Patients-Review of the Literature with an Illustrative Case.

Nusa Matijasic, Aleksandra Bonevski, Visnja Tokic Pivac, Ivan Pavic,

Background: Impaired lung function has been detected in up to 65% of all childhood cancer survivors. It is often caused by exposure to radiation therapy and various chemotherapeutics. The first cytotoxic drug ever identified as a causative agent of lung injury was busulfan, reported in the early 1960s. Signs and ... Read more >>

Pediatr Allergy Immunol Pulmonol (Pediatric allergy, immunology, and pulmonology)
[2019, 32(3):86-91]

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Bleomycin in Hodgkin's Lymphoma - A Boon or a Bane? - A Retrospective Study of Bleomycin Pulmonary Toxicity in Hodgkin's Lymphoma.

Chethana Babu K Udupa, Prakashini Koteshwar, Karthik S Udupa,

Introduction:Hodgkin's lymphoma (HL) is one of the most curable malignancies with cure rates of above 85% across all stages. Bleomycin containing regimen is routinely employed in the treatment of HL. Pulmonary toxicity due to this drug is the most feared side effect in these regimens where the mortality rate is ... Read more >>

Indian J Palliat Care (Indian journal of palliative care)
[2019, 25(4):523-526]

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ECMO for Neonatal Sepsis in 2019.

Warwick Wolf Butt, Roberto Chiletti,

Sepsis and septic shock in newborns causes mortality and morbidity depending on the organism and primary site. ECMO provides cardiorespiratory support to allow adequate organ perfusion during the time for antibiotics and source control surgery (if needed) to occur. ECMO mode and cannulation site vary depending on support required and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:50]

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Homocysteine: Its Possible Emerging Role in At-Risk Population Groups.

Elena Azzini, Stefania Ruggeri, Angela Polito,

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(4):]

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A shared protocol for porcine surfactant use in pediatric acute respiratory distress syndrome: a feasibility study.

Andrea Wolfler, Marco Piastra, Angela Amigoni, Pierantonio Santuz, Eloisa Gitto, Emanuele Rossetti, Carmine Tinelli, Cinzia Montani, Fabio Savron, Simone Pizzi, Luigia D'amato, Maria Cristina Mondardini, Giorgio Conti, Annalisa De Silvestri,

BACKGROUND:Pediatric ARDS still represents a difficult challenge in Pediatric Intensive Care Units (PICU). Among different treatments proposed, exogenous surfactant showed conflicting results. Aim of this multicenter retrospective observational study was to evaluate whether poractant alfa use in pediatric ARDS might improve gas exchange in children less than 2 years old, according ... Read more >>

BMC Pediatr (BMC Pediatrics)
[2019, 19(1):203]

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Nitrous oxide recreational abuse presenting with myeloneuropathy and mimicking Guillain-Barre syndrome.

Hussein Algahtani, Bader Shirah, Nawal Abdelghaffar, Osamah Abuhawi, Abdulrahman Alqahtani,

The recreational use of nitrous oxide (N2O) is increasing in festivals, university parties, clubs, private residences, and parks. The abuse of N2O has serious complications of the central and peripheral nervous system. In this article, we report a case of a 28-year-old previously healthy man who presented with a three-day ... Read more >>

Intractable Rare Dis Res (Intractable & rare diseases research)
[2020, 9(1):54-57]

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E-Cigarette, or Vaping, Product Use Associated Lung Injury (EVALI) with Acute Respiratory Failure in Three Adolescent Patients: a Clinical Timeline, Treatment, and Product Analysis.

Ramya Billa, Cody Tigges, Niranjan Vijayakumar, Joshua Radke, Caitlin Pedati, Rebecca Weiner, Daniel McCabe,

IntroductionE-cigarette, or vaping, product use associated lung injury (EVALI) has become a recent concern among public health officials. Factors that contribute to the concern include an increasing number of cases over time, the severity of the illness, and an unknown understanding of the pathophysiology and etiology of the illness.Case SeriesWe ... Read more >>

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[0, :1-7]

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Prognostic value of the delta neutrophil index in pediatric cardiac arrest.

Seo Hee Yoon, Eun Ju Lee, Jinae Lee, Moon Kyu Kim, Jong Gyun Ahn,

The delta neutrophil index (DNI), which reflects the ratio of circulating immature neutrophils, has been reported to be highly predictive of mortality in systemic inflammation. We investigated the prognostic significance of DNI value for early mortality and neurologic outcomes after pediatric cardiac arrest (CA). We retrospectively analyzed the data of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3497]

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Assessing the Microcirculation With Handheld Vital Microscopy in Critically Ill Neonates and Children: Evolution of the Technique and Its Potential for Critical Care.

Özge Erdem, Can Ince, Dick Tibboel, Jan Willem Kuiper,

Assuring adequate tissue oxygenation in the critically ill, but still developing child is challenging. Conventional hemodynamic monitoring techniques fall short in assessing tissue oxygenation as these are directed at the macrocirculation and indirect surrogates of tissue oxygenation. The introduction of handheld vital microscopy (HVM) has allowed for the direct visualization ... Read more >>

Front Pediatr (Frontiers in Pediatrics)
[2019, 7:273]

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New insights into microvascular injury to inform enhanced diagnostics and therapeutics for severe malaria.

Clara Erice, Kevin C Kain,

Severe malaria (SM) has high mortality and morbidity rates despite treatment with potent antimalarials. Disease onset and outcome is dependent upon both parasite and host factors. Infected erythrocytes bind to host endothelium contributing to microvascular occlusion and dysregulated inflammatory and immune host responses, resulting in endothelial activation and microvascular damage. ... Read more >>

Virulence (Virulence)
[2019, 10(1):1034-1046]

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Assessment of pulmonary outcomes, exercise capacity, and longitudinal changes in lung function in pediatric survivors of high-risk neuroblastoma.

Anne Stone, Danielle Novetsky Friedman, Brian H Kushner, Suzanne Wolden, Shakeel Modak, Michael P LaQuaglia, Jessica Costello, Xian Wu, Nai-Kong Cheung, Charles A Sklar,

BACKGROUND/OBJECTIVES:Survivors of high-risk neuroblastoma (NB) are exposed to multimodality therapies early in life and confront late therapy-related toxicities. This study assessed respiratory symptoms, exercise capacity, and longitudinal changes in pulmonary function tests (PFTs) among survivors. DESIGN/METHODS:Survivors of high-risk NB followed in the long-term follow-up clinic at Memorial Sloan Kettering Cancer ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2019, 66(11):e27960]

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Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Azka Shahid Zergham, Amanpreet Kaur Sekhon, Amal Mebasher, Gantuya Tserenpil, Bilal Haider Malik,

Inflammatory bowel diseases (IBD) is an umbrella term that covers both ulcerative colitis (UC) and Crohn's disease (CD), which are chronic inflammatory conditions of the gastrointestinal system. Airway diseases are one of the most commonly studied manifestations of IBD. It is observed that populations with pre-existing obstructive pulmonary conditions are at higher ... Read more >>

Cureus (Cureus)
[2020, 12(1):e6836]

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Extra-corporeal membrane oxygenation in paediatric acute respiratory distress syndrome: overrated or underutilized?

Simon Erickson,

Extracorporeal membrane oxygenation (ECMO) is a modified form of cardiopulmonary bypass which may provide support for severe cardiorespiratory failure including paediatric acute respiratory distress syndrome (PARDS). While ECMO was initially demonstrated to successfully support neonates with severe respiratory failure, the use of ECMO has expanded rapidly to support both paediatric ... Read more >>

Ann Transl Med (Annals of translational medicine)
[2019, 7(19):512]

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Turning The Tables On Tradition: Flipped High-Fidelity Simulation To Potentiate Learning.

Leslie A Bilello,

Innovative teaching modalities are more popular than ever within medical education. Examples include the flipped classroom model, incorporation of digital media and use of high-fidelity simulation technology. Our novel flipped simulation curriculum proposes the use of the flipped teaching method within the simulation lab for undergraduate and graduate medical education. ... Read more >>

Adv Med Educ Pract (Advances in medical education and practice)
[2019, 10:959-961]

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Epidemiological and sociocultural assessment of childhood poisonings.

Halil Kazanasmaz, Özlem Kazanasmaz, Mustafa Çalık,

Objectives:Poisoning occurring in childhood still continues to be an important public health issue. The aim of the study is to socio-demographically and clinically examine poisoning cases consulted to emergency department. Methods:The findings of 121 patients between the ages of 1 month and 17 years consulting to the pediatric emergency department ... Read more >>

Turk J Emerg Med (Turkish journal of emergency medicine)
[2019, 19(4):127-131]

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The SNP rs2298383 Reduces ADORA2A Gene Transcription and Positively Associates with Cytokine Production by Peripheral Blood Mononuclear Cells in Patients with Multiple Chemical Sensitivity.

Attilio Cannata, Chiara De Luca, Liudmila G Korkina, Nadia Ferlazzo, Riccardo Ientile, Monica Currò, Giulia Andolina, Daniela Caccamo,

Systemic inflammation and immune activation are striking features of multiple chemical sensitivity (MCS). The rs2298383 SNP of ADORA2A gene, coding for adenosine receptor type 2A (A2AR), has been involved in aberrant immune activation. Here we aimed to assess the prevalence of this SNP in 279 MCS patients and 238 healthy ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(5):]

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An epidemiological snapshot of toxicological exposure in children 12 years of age and younger in Riyadh.

Nahar Dakeel Alruwaili, Bachar Halimeh, Mohammed Al-Omar, Badria Alhatali, Ismail Ibrahim Sabie, Mohammed Alsaqoub,

BACKGROUND:Poisoning among the pediatric population is an important public health concern that is responsible for frequent pediatric emergency department visits and hospital admissions. Surveillance of poisoning cases is essential for designing and implementing effective preventive strategies. OBJECTIVE:Describe the characteristics of acute poison exposure and related therapeutic interventions in children aged ... Read more >>

Ann Saudi Med (Annals of Saudi medicine)
[2019, 39(4):229-235]

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The Evolving Role of Brentuximab Vedotin in Classical Hodgkin Lymphoma.

Catherine Lai, Adrese Michael Kandahari, Chaitra Ujjani,

The arrival of the CD30 directed antibody-drug conjugate, brentuximab vedotin (BV), has altered the approach to patients with classical Hodgkin lymphoma. Since initial approval in 2011, BV has been extensively studied in previously untreated and relapsed/refractory patients. Treatment indications for the antibody-drug conjugate have been expanded from the previously treated ... Read more >>

Blood Lymphat Cancer (Blood and lymphatic cancer : targets and therapy)
[2019, 9:63-71]

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Cerebellar Hippocampal and Basal Nuclei Transient Edema with Restricted diffusion (CHANTER) Syndrome.

Adam S Jasne, Khalid H Alsherbini, Matthew S Smith, Abhi Pandhi, Achala Vagal, Daniel Kanter,

BACKGROUND:Abnormal restricted diffusion on magnetic resonance imaging is often associated with ischemic stroke or anoxic injury, but other conditions can present similarly. We present six cases of an unusual but consistent pattern of restricted diffusion in bilateral hippocampi and cerebellar cortices. This pattern of injury is distinct from typical imaging ... Read more >>

Neurocrit Care (Neurocritical care)
[2019, 31(2):288-296]

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