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Pediatric Carbamazepine Toxicity

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Toxicological screening reveals toxic epidermal necrolysis likely carbamazepine-induced rather than idiopathic.

Clementine Toussaint, Paola Sanchez-Pena, Karine Titier, Nadege Castaing, Mathieu Molimard, Brigitte Milpied,

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2020, :]

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ACMT 2020 Annual Scientific Meeting Abstracts – New York, NY.

J Med Toxicol (Journal of medical toxicology : official journal of the American College of Medical Toxicology)
[0, :1-53]

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Sutureless Amniotic Membrane Transplantation in a Pediatric Patient with Acute Toxic Epidermal Necrolysis

Zeynep Baş, Ömür Uçakhan Gündüz,

The purpose of this case report is to describe a new surgical method for sutureless placement of the amniotic membrane with a symblepharon ring in a pediatric patient with acute toxic epidermal necrolysis (TEN). A 1-year-old girl developed severe ocular surface inflammation with large corneal and conjunctival epithelial defects secondary ... Read more >>

Turk J Ophthalmol (Turkish journal of ophthalmology)
[2019, 49(6):356-360]

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Severe cutaneous adverse drug reactions manifesting as Stevens-Johnson syndrome and toxic epidermal necrolysis reported to the national pharmacovigilance center in Nigeria: a database review from 2004 to 2017.

Kazeem Adeola Oshikoya, Ibrahim Abayomi Ogunyinka, Comfort Kunak Ogar, Abiodun Abiola, Ali Ibrahim, Ibrahim Adekunle Oreagba,

Background:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions (SCARs). There is scant literature on the characteristics and causes of these conditions among the Nigerian population. Here, we describe the epidemiology, associated morbidity and mortality, and culpable drugs in SJS and TEN cases using the National ... Read more >>

Ther Adv Drug Saf (Therapeutic advances in drug safety)
[2020, 11:2042098620905998]

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Pediatric drug reaction with eosinophilia and systemic symptoms: A systematic review of the literature.

Lauren Metterle, Leigh Hatch, Lucia Seminario-Vidal,

BACKGROUND:Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction including integumentary and internal organs. An extensive literature review of DRESS in the pediatric population has not been performed. METHODS:A literature search was performed to find reports of pediatric DRESS published between 1997 and March 2019. ... Read more >>

Pediatr Dermatol (Pediatric dermatology)
[2020, 37(1):124-129]

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Prediction of Clearance in Children from Adults Following Drug-Drug Interaction Studies: Application of Age-Dependent Exponent Model.

Iftekhar Mahmood,

BACKGROUND AND OBJECTIVE:Pharmacokinetic drug-drug interaction (DDI) studies are conducted in adult subjects during drug development but there are limited studies that have characterized pharmacokinetic DDI studies in children. The objective of this study was to evaluate if the DDI clearance values from adults can be allometrically extrapolated from adults to ... Read more >>

Drugs R D (Drugs in R&D)
[2020, 20(1):47-54]

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Genetic variations associated with pharmacoresistant epilepsy.

Noemí Cárdenas-Rodríguez, Liliana Carmona-Aparicio, Diana L. Pérez-Lozano, Daniel Ortega-Cuellar, Saúl Gómez-Manzo, Iván Ignacio-Mejía,

Epilepsy is a common, serious neurological disorder worldwide. Although this disease can be successfully treated in most cases, not all patients respond favorably to medical treatments, which can lead to pharmacoresistant epilepsy. Drug-resistant epilepsy can be caused by a number of mechanisms that may involve environmental and genetic factors, as ... Read more >>

Mol Med Rep (Molecular Medicine Reports)
[2020, 21(4):1685-1701]

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An electronic medical records-based approach to identify idiosyncratic drug-induced liver injury in children.

Tracy L Sandritter, Jennifer L Goldman, Clayton J Habiger, James F Daniel, Jennifer Lowry, Ryan T Fischer,

Drug-induced liver injury (DILI) is the leading cause of liver failure in the United States and the most common cause of drug recall. As opposed to the recognized direct toxicity of super-therapeutic acetaminophen or chemotherapeutic agents in children, limited data exists for pediatric populations on the incidence of idiosyncratic DILI ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):18090]

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Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse events.

Elena Genova, Federica Cavion, Marianna Lucafò, Luigina De Leo, Marco Pelin, Gabriele Stocco, Giuliana Decorti,

Adverse drug reactions (ADRs) are major clinical problems, particularly in special populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of different drugs leading, in some cases, to hospitalization, disability or even death. In addition, pediatric patients may respond differently to drugs with respect to adults ... Read more >>

World J Stem Cells (World journal of stem cells)
[2019, 11(12):1020-1044]

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Pediatric SJS/TEN Subdued by a Combination of Dexamethasone, Cyclosporine, and Etanercept.

Jérôme Coulombe, Eugénie Belzile, Amélie Duhamel, Pauline Rault, Chantal Buteau, Jean-Jacques DeBruycker, Jean-François Bussières,

We report a case of an 17-year-old male with a drug reaction in the spectrum of Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN), triggered by carbamazepine, who was succesfully treated with the combination of dexamethasone, cyclosporine, and etanercept. This triple therapy halted and prevented skin epidermolysis without immediate or late onset ... Read more >>

J Cutan Med Surg (Journal of cutaneous medicine and surgery)
[2019, 23(5):547-550]

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Prevalence of potential drug-drug interactions in Swedish pediatric outpatients.

Johan Holm, Birgit Eiermann, Elin Kimland, Buster Mannheimer,

PURPOSE:To describe the occurrence of potential drug-drug interactions (DDIs) in prescribed drugs, dispensed to pediatric outpatients in Sweden. METHODS:A cross sectional study was conducted based on data from a national register of prescribed drugs, dispensed at pharmacies, to children 0-17 years old. The study period was January 1 to April ... Read more >>

PLoS ONE (PloS one)
[2019, 14(8):e0220685]

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Unmet Quality Needs in Oral Drug Delivery: Contrasts of Drug Content and Uniformity on Distinct Approaches for Achieving Individual Dosing.

Jaqueline Kalleian Eserian, Márcia Lombardo, Jair Ribeiro Chagas, José Carlos Fernandes Galduróz,

Individualized dosing is often required in pharmacotherapy, particularly for pediatric and geriatric patients and adjustment of drugs that demand dose adaptation. This study aimed to evaluate critical quality attributes (CQAs) of doses obtained by distinct approaches for achieving individual dosing. Approaches were evaluated as follows: subdivision of tablets by splitter ... Read more >>

AAPS PharmSciTech (AAPS PharmSciTech)
[2019, 20(8):332]

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Association of Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs in pediatric patients: Subgroup analysis based on a Japanese spontaneous database.

Ayaka Inada, Saki Oyama, Iku Niinomi, Tomohito Wakabayashi, Kazunori Iwanaga, Keiko Hosohata,

WHAT IS KNOWN AND OBJECTIVE:Antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are severe cutaneous disorders; however, real-world data remain limited, especially on pediatric patients. The objective of this study was to investigate the association of AEDs with SJS and TEN in ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2019, 44(5):775-779]

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Safety and Tolerability of Adjunctive Eslicarbazepine Acetate in Pediatric Patients (Aged 4-17 Years) With Focal Seizures.

Mark Mintz, Jesus E Pina-Garza, Steven M Wolf, Patricia E McGoldrick, Sergiusz Józwiak, Todd Grinnell, David Cantu, Raquel Costa, Joana Moreira, Yan Li, David Blum,

OBJECTIVE:To evaluate the safety and tolerability of adjunctive eslicarbazepine acetate (ESL) in pediatric patients (aged 4-17 years) with refractory focal seizures. METHODS:Pooled safety data from patients aged 4-17 years in Study 208 (NCT01527513) and Study 305 (NCT00988156) were analyzed. Both were randomized, double-blind, placebo-controlled studies of ESL as adjunctive treatment ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, 35(4):265-273]

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Chemotherapy-Related Encephalopathy With Super-Refractory Status Epilepticus in a Child With Osteosarcoma: A Case Report With a Review of Literature.

Lorenza Di Genova, Katia Perruccio, Maria Grazia Celani, Elena Mastrodicasa, Teresa Anna Cantisani, Susanna Esposito, Maurizio Caniglia,

Osteosarcoma is the most frequent primary cancer of the bones, and a combination of primary chemotherapy, surgery, and adjuvant chemotherapy is its current treatment. In adults, some authors have reported problems with memory and concentration following chemotherapy, but in children, severe neurologic dysfunction has been rarely reported. This report describes ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2019, 10:963]

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Peripheral Opioid Receptor Antagonists for Opioid-Induced Constipation: A Primer on Pharmacokinetic Variabilities with a Focus on Drug Interactions.

Jeffrey Gudin, Jeffrey Fudin,

Opioid analgesics remain a treatment option for refractory acute and chronic pain, despite their potential risk for abuse and adverse events (AEs). Opioids are associated with several common AEs, but the most bothersome is opioid-induced constipation (OIC). OIC is often overlooked but has the potential to affect patient quality of ... Read more >>

J Pain Res (Journal of Pain Research)
[2020, 13:447-456]

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Renal replacement therapy in the management of intoxications in children: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) workgroup.

Rupesh Raina, Manpreet K Grewal, Martha Blackford, Jordan M Symons, Michael J G Somers, Christoph Licht, Rajit K Basu, Sidharth Kumar Sethi, Deepa Chand, Gaurav Kapur, Mignon McCulloch, Arvind Bagga, Vinod Krishnappa, Hui-Kim Yap, Marcelo de Sousa Tavares, Timothy E Bunchman, Michelle Bestic, Bradley A Warady, Maria Díaz-González de Ferris,

BACKGROUND:Intentional or unintentional ingestions among children and adolescents are common. There are a number of ingestions amenable to renal replacement therapy (RRT). METHODS:We systematically searched PubMed/Medline, Embase, and Cochrane databases for literature regarding drugs/intoxicants and treatment with RRT in pediatric populations. Two experts from the PCRRT (Pediatric Continuous Renal Replacement ... Read more >>

Pediatr. Nephrol. (Pediatric nephrology (Berlin, Germany))
[2019, 34(11):2427-2448]

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Rare Conduction Abnormality in a Four-year-old Child with Carbamazepine Acute Poisoning.

Cristina Iolanda Vivisenco, Coriolan Emil Ulmeanu,

Background:Cardiac conduction abnormalities are reported after ingestion of a toxic dose of carbamazepine. Case presentation:We describe the case of a four-year-old child with carbamazepine acute poisoning who developed reversible synoatrial block along with neurological toxic signs, despite a serum level of carbamazepine close to the upper limit of the therapeutic ... Read more >>

Maedica (Buchar) (Maedica)
[2019, 14(2):165-168]

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Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy.

Abdelnaby Khalyfa, David Sanz-Rubio,

Sleep remains one of the least understood phenomena in biology, and sleep disturbances are one of the most common behavioral problems in childhood. The etiology of sleep disorders is complex and involves both genetic and environmental factors. Epilepsy is the most popular childhood neurological condition and is characterized by an ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(21):]

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Adverse drug reactions in primary care: a scoping review.

H Khalil, C Huang,

BACKGROUND:Medication-related adverse events, or adverse drug reactions (ADRs) are harmful events caused by medication. ADRs could have profound effects on the patients' quality of life, as well as creating an increased burden on the healthcare system. ADRs are one of the rising causes of morbidity and mortality internationally, and will ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):5]

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Drug-Induced Liver Injury: Clinical and Etiologic Features at a Large Tertiary Teaching Hospital in China.

Yao Liu, Shi-Peng Zhan, Lin Song, Yonggang Chen, Yun-Tao Jia, Fang Liu, Feng-Jun Sun, Qian Wang, Pei-Yuan Xia,

BACKGROUND Since the epidemiological profile of drug-induced liver injury (DILI) in China, especially the western of China, it has rarely been studied. The aim of this study was to analyze the characteristics of DILI patients in a large tertiary teaching hospital at Chongqing, a municipality in western China. MATERIAL AND ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919435]

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Parental non-hereditary teratogenic exposure factors on the occurrence of congenital heart disease in the offspring in the northeastern Sichuan, China.

Yun Liang, Xingsheng Hu, Xiaoqin Li, Bing Wen, Liang Wang, Cheng Wang,

Nonhereditary factors play an important role in the occurrence of congenital heart disease (CHD). This study was to explore the possible parental nonhereditary exposure factors relevant to the occurrence of CHD in the northeastern Sichuan area. A total of 367 children with CHD and 367 children without congenital malformations aged ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):3905]

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Pharmacotherapy for Pediatric Convulsive Status Epilepticus.

Avantika Singh, Coral M Stredny, Tobias Loddenkemper,

Convulsive status epilepticus (CSE) is one of the most common pediatric neurological emergencies. Ongoing seizure activity is a dynamic process and may be associated with progressive impairment of gamma-aminobutyric acid (GABA)-mediated inhibition due to rapid internalization of GABAA receptors. Further hyperexcitability may be caused by AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA ... Read more >>

CNS Drugs (CNS drugs)
[2020, 34(1):47-63]

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Why should we monitor for hematologic adverse drug reactions to oxcarbazepine?

Gwang Cheon Jang,

Korean J Pediatr (Korean journal of pediatrics)
[2019, 62(8):299-300]

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Pharmacovigilance of Cutaneous Adverse Drug Reactions among Patients Attending Dermatology Department at a Tertiary Care Hospital.

Shweta Sharma, Dhanya Jayakumar, Dhanya S Palappallil,

Context:Cutaneous adverse drug reactions (CADRs) are the most frequent of all manifestations of drug sensitivity that present with varied and diverse morphology and therefore, awareness about them is essential for diagnosis and prevention. Aims: To evaluate the clinical spectrum, morphology, causality, severity and preventability of cutaneous adverse drug reactions in ... Read more >>

Indian Dermatol Online J (Indian Dermatology Online Journal)
[2019, 10(5):547-554]

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