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Partial Epilepsies

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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LIM kinases in synaptic plasticity and their potential as therapeutic targets.

Eva Halasz, Ellen Townes-Anderson, Weiwei Wang,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1471-1472]

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Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus.

Dong-Qi Lin, Xin-Ying Cai, Chun-Hua Wang, Bin Yang, Ri-Sheng Liang,

Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we investigated the effects of necrostatin-1 on ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):936-943]

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Astrocytic modulation of potassium under seizures.

Fushun Wang, Xiaoming Qi, Jun Zhang, Jason H Huang,

The contribution of an impaired astrocytic K+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade. A defective K+ regulation leads to an elevated extracellular K+ concentration ([K+]o). When [K+]o reaches peaks of 10-12 mM, it is strongly associated with seizure initiation during hypersynchronous neuronal ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):980-987]

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Seizures following surgery for supratentorial extratemporal low-grade tumors in children: a multicenter retrospective study.

Jonathan Roth, Or Bercovich, Ashton Roach, Francesco T Mangano, Arvind C Mohan, Guillermo Aldave, Howard L Weiner, Ulrich-Wilhelm Thomale, Andreas Schaumann, Shimrit Uliel-Sibony, Shlomi Constantini,

OBJECTIVE:Resection of brain tumors may lead to new-onset seizures but may also reduce seizure rates in patients presenting with seizures. Seizures are seen at presentation in about 24% of patients with brain tumors. For lesional epilepsy in general, early resection is associated with improved seizure control. However, the literature is ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2020, :1-7]

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Anxiety as the only manifestation of focal non-convulsive status epilepticus: case report and review of the literature.

Mariarita Albini, Alessandra Morano, Jinane Fattouch, Martina Fanella, Federica Avorio, Luca Manfredi Basili, Emanuele Cerulli Irelli, Mario Manfredi, Anna Teresa Giallonardo, Carlo Di Bonaventura,

Psychiatric disorders represent common comorbidities in epileptic patients. Sometimes anxiety is part of the ictal semiology, especially during seizures arising from/involving frontal or temporal lobes. We describe a patient with focal epilepsy and recurrent hyperkinetic seizures who also presented prolonged episodes characterized by massive anxiety, alarm and fear. A Video-Electroencephalographic ... Read more >>

Neurocase (Neurocase)
[2020, :1-5]

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Altered integrity of corpus callosum in generalized epilepsy in relation to seizure lateralization after corpus callosotomy.

Po Ching Chen, Steven A Messina, Eduardo Castillo, James Baumgartner, Joo Hee Seo, Holly Skinner, Elakkat D Gireesh, Ki Hyeong Lee,

OBJECTIVE:Generalized-onset seizures are usually conceptualized as engaging bilaterally distributed networks with no clear focus. However, the authors previously reported a case series demonstrating that in some patients with generalized-onset seizures, focal seizure onset could be discovered after corpus callosotomy. The corpus callosum is considered to be a major pathway for ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E15]

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The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States.

Sarah N Gibbs, Jiyoon Choi, Ibrahim Khilfeh, K Hamzah Ahmed, Irina Yermilov, Eric Segal,

OBJECTIVE:To better understand the humanistic and economic burden of focal seizures in children 2-12 years old. METHODS:We conducted a targeted literature review by searching MEDLINE for English-language publications reporting on children 2-12 years old with focal seizures published in the United States since 2008. RESULTS:Thirty-five publications were included. Incidence of ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820911785]

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Pediatric functional hemispherectomy: operative techniques and complication avoidance.

Christopher C Young, John R Williams, Abdullah H Feroze, Margaret McGrath, Ali C Ravanpay, Richard G Ellenbogen, Jeffrey G Ojemann, Jason S Hauptman,

Functional hemispherectomy/hemispherotomy is a disconnection procedure for severe medically refractory epilepsy where the seizure foci diffusely localize to one hemisphere. It is an improvement on anatomical hemispherectomy and was first performed by Rasmussen in 1974. Less invasive surgical approaches and refinements have been made to improve seizure freedom and minimize ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E9]

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Efficacy, Tolerability, and Safety of Concentrated Intranasal Midazolam Spray as Emergency Medication in Epilepsy Patients During Video-EEG Monitoring.

Anemone von Blomberg, Lara Kay, Susanne Knake, Sven Fuest, Johann Philipp Zöllner, Philipp S Reif, Eva Herrmann, Ümniye Balaban, Susanne Schubert-Bast, Felix Rosenow, Adam Strzelczyk,

BACKGROUND:An efficient, well tolerated, and safe emergency treatment with a rapid onset of action is needed to prevent seizure clusters and to terminate prolonged seizures and status epilepticus. OBJECTIVES:This study aimed to examine the efficacy, tolerability, and safety of intranasal midazolam (in-MDZ) spray in clinical practice. METHODS:In this retrospective, multicenter ... Read more >>

CNS Drugs (CNS drugs)
[2020, :]

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Electrical status epilepticus in sleep affects intrinsically connected networks in patients with benign childhood epilepsy with centrotemporal spikes.

Wen He, Hongsheng Liu, Zhenqing Liu, Qianqian Wu,

BACKGROUND:Although outcomes of benign childhood epilepsy with centrotemporal spikes (BECTS) are frequently excellent, some atypical forms of BECTS, especially electrical status epilepticus in sleep (ESES), are characterized by worse outcomes and negative impacts on cognitive development. METHODS:To explore specific ESES-related brain networks in patients with BECTS, we used resting-state functional ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107032]

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Anti-Epileptogenic Effects of Antiepileptic Drugs.

Barbara Miziak, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, Stanisław J Czuczwar,

Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(7):]

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Single umbilical artery and risk of congenital malformation: population-based study in Norway.

C Ebbing, J Kessler, D Moster, S Rasmussen,

OBJECTIVES:Single umbilical artery (SUA) is associated with congenital malformations in most organ systems, but reported findings have not been consistent. While it has been suggested that genetic and persisting environmental factors influence the development of SUA, it is not known whether there is an increased risk of recurrence in a ... Read more >>

Ultrasound Obstet Gynecol (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology)
[2020, 55(4):510-515]

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Characterization of Pediatric Seizures in the Commonwealth of the Northern Mariana Islands.

Ahana Yogesh, Michael Taylor, And Mary P Chang,

Saipan is a United States (US) territory Western Pacific island where little recent data exists regarding epidemiology, clinical presentation, and standard of care for pediatric seizures. This paper characterizes these features in Saipan's pediatric population with comparisons to mainland US. This is a retrospective chart review of all pediatric patients ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(4):]

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Electrographic seizures and ictal-interictal continuum (IIC) patterns in critically ill patients.

Sahar F Zafar, Thanujaa Subramaniam, Gamaleldin Osman, Aline Herlopian, Aaron F Struck,

Critical care long-term continuous electroencephalogram (cEEG) monitoring has expanded dramatically in the last several decades spurned by technological advances in EEG digitalization and several key clinical findings: 1-Seizures are relatively common in the critically ill-large recent observational studies suggest that around 20% of critically ill patients placed on cEEG have ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107037]

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Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP).

Melissa J Maguire, Cerian F Jackson, Anthony G Marson, Sarah J Nevitt,

BACKGROUND:This is an updated version of the original Cochrane Review, published in 2016, Issue 7. Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in ... Read more >>

Cochrane Database Syst Rev (The Cochrane database of systematic reviews)
[2020, 4:CD011792]

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Constitutive deletion of astrocytic connexins aggravates kainate-induced epilepsy.

Tushar Deshpande, Tingsong Li, Lukas Henning, Zhou Wu, Julia Müller, Gerald Seifert, Christian Steinhäuser, Peter Bedner,

The astroglial gap junctional network formed by connexin (Cx) channels plays a central role in regulating neuronal activity and network synchronization. However, its involvement in the development and progression of epilepsy is not yet understood. Loss of interastrocytic gap junction (GJ) coupling has been observed in the sclerotic hippocampus of ... Read more >>

Glia (Glia)
[2020, :]

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Rescuing Kv10.2 protein changes cognitive and emotional function in kainic acid-induced status epilepticus rats.

Yamei Liu, Yanhong Duan, Dongshu Du, Fuxue Chen,

Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral nervous system and are crucial mediators of neuronal excitability. Importantly, these channels also actively participate in cellular and molecular signaling pathways that regulate the life and death processes of neurons. The current study used a kainic acid (KA)-induced ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:106894]

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Electro-clinical and neurodevelopmental outcome in six children with early diagnosis of tuberous sclerosis complex and role of the genetic background.

M N Savini, A Mingarelli, A Peron, F La Briola, F Cervi, R M Alfano, M P Canevini, A Vignoli,

BACKGROUND:Seizures in individuals affected by tuberous sclerosis complex (TSC) commonly develop in the first year of life, are often preceded by a progressive deterioration of the electroencephalogram (EEG), and likely influence developmental outcome. Although early diagnosis of TSC has offered a tremendous opportunity to monitor affected patients before seizure onset, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2020, 46(1):36]

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Drug Treatment of Progressive Myoclonic Epilepsy.

Gregory L Holmes,

The progressive myoclonic epilepsies (PMEs) represent a rare but devastating group of syndromes characterized by epileptic myoclonus, typically action-induced seizures, neurological regression, medically refractory epilepsy, and a variety of other signs and symptoms depending on the specific syndrome. Most of the PMEs begin in children who are developing as expected, ... Read more >>

Paediatr Drugs (Paediatric drugs)
[2020, 22(2):149-164]

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Long-term safety, efficacy, and quality of life outcomes with adjunctive brivaracetam treatment at individualized doses in patients with epilepsy: An up to 11-year, open-label, follow-up trial.

Terence J O'Brien, Simon Borghs, Qin Jane He, Anne-Liv Schulz, Stephen Yates, Victor Biton,

OBJECTIVE:To evaluate long-term safety/tolerability of brivaracetam at individualized doses ≤200 mg/d (primary) and maintenance of efficacy over time (secondary) in adults with focal seizures or primary generalized seizures (PGS) enrolled in phase 3, open-label, long-term follow-up trial N01199 (NCT00150800). METHODS:Patients ≥16 years of age who had completed double-blind, placebo-controlled adjunctive brivaracetam trials ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Epilepsy surgery reduced seizure frequency for patients with severe motor and intellectual disorders.

Ayataka Fujimoto, Tohru Okanishi, Naoki Ichikawa, Kazuki Sakakura, Shimpei Baba, Keishiro Sato, Mitsuyo Nishimura, Hideo Enoki,

INTRODUCTION:Little is known about epilepsy surgery for patients with severe motor and intellectual disorders (SMIDs). We hypothesized that epilepsy surgery could reduce epileptic seizure frequency in these patients. The purpose of this study was to compare pre- and postoperative seizure frequency in patients with SMIDs. METHODS:A total of 288 surgeries ... Read more >>

Epilepsy Behav (Epilepsy & behavior : E&B)
[2020, 106:107031]

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Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.

Lucy Deng, Alan Ma, Nicholas Wood, Simone Ardern-Holmes,

PURPOSE:SCN1A variants cause a spectrum of epilepsy syndromes from Dravet Syndrome, a severe epileptic encephalopathy of early infancy to the milder disorder of genetic epilepsy with febrile seizures plus (GEFS+). These genetic epilepsies are associated with increased risk of poor outcome including complications of status epilepticus and early mortality. Individualised ... Read more >>

Seizure (Seizure)
[2020, 78:49-52]

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Analyzing clinical and genetic characteristics of a cohort with multiple congenital anomalies-hypotonia-seizures syndrome (MCAHS).

Xianru Jiao, Jiao Xue, Pan Gong, Xinhua Bao, Ye Wu, Yuehua Zhang, Yuwu Jiang, Zhixian Yang,

OBJECTIVE:To summarize and extend the phenotypic characterization of Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome, and to discuss genotype-phenotype correlations. METHODS:Collecting clinical information of 17 patients with pathogenic variants in PIGN, PIGA, and PIGT. Genetic studies were performed on all patients. RESULTS:There were 7 patients with 15 PIGN mutations (one patient carrying 3 ... Read more >>

Orphanet J Rare Dis (Orphanet journal of rare diseases)
[2020, 15(1):78]

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Forecasting cycles of seizure likelihood.

Philippa J Karoly, Mark J Cook, Matias Maturana, Ewan S Nurse, Daniel Payne, Benjamin H Brinkmann, David B Grayden, Sonya B Dumanis, Mark P Richardson, Greg A Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean R Freestone,

OBJECTIVE:Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood can be influenced by a range of environmental and physiological factors that are difficult to measure and quantify. However, some generalizable patterns have been demonstrated in seizure onset. A majority of people with ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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