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Parkinson Disease

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Expression of Concern: Long noncoding RNA HAGLROS regulates apoptosis and autophagy in Parkinson's disease via regulating miR-100/ATG10 axis and PI3K/Akt/mTOR pathway activation.

Artif Cells Nanomed Biotechnol (Artificial cells, nanomedicine, and biotechnology)
[2020, 48(1):708]

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Carbonic anhydrase IX as a novel candidate in liquid biopsy.

Ozen Ozensoy Guler, Claudiu T Supuran, Clemente Capasso,

Among the diagnostic techniques for the identification of tumour biomarkers, the liquid biopsy is considered one that offers future research on precision diagnosis and treatment of tumours in a non-invasive manner. The approach consists of isolating tumor-derived components, such as circulating tumour cells (CTC), tumour cell-free DNA (ctDNA), and extracellular ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):255-260]

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New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

Carlos Gonzalez-Fernandez, Pau González, Francisco Javier Rodríguez,

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2-5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1580-1589]

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Non-pharmacological interventions for Parkinson's disease mild cognitive impairment: future directions for research.

Davide Maria Cammisuli, Roberto Ceravolo, Ubaldo Bonuccelli,

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1650-1651]

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Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?

Scott P Allen,

Neural Regen Res (Neural regeneration research)
[2020, 15(9):1654-1655]

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The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease.

Susan R Goulding, Aideen M Sullivan, Gerard W O'Keeffe, Louise M Collins,

Parkinson's disease is the second most common neurodegenerative disorder; it affects 1% of the population over the age of 65. The number of people with Parkinson's disease is set to rapidly increase due to changing demographics and there is an unmet clinical need for disease-modifying therapies. The pathological hallmarks of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1432-1436]

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The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?

Dennis Dik-Long Chau, Kwok-Fai Lau,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1475-1476]

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Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson's disease.

Luisa Seguella, Giovanni Sarnelli, Giuseppe Esposito,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1037-1038]

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Novel small molecule TRVA242 targets neuromuscular junction in amyotrophic lateral sclerosis.

Poulomee Bose,

Neural Regen Res (Neural regeneration research)
[2020, 15(6):1041-1042]

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Type XIX collagen: a promising biomarker from the basement membranes.

Ana C Calvo, Laura Moreno, Leticia Moreno, Janne M Toivonen, Raquel Manzano, Nora Molina, Miriam de la Torre, Tresa López, Francisco J Miana-Mena, María J Muñoz, Pilar Zaragoza, Pilar Larrodé, Alberto García-Redondo, Rosario Osta,

Among collagen members in the collagen superfamily, type XIX collagen has raised increasing interest in relation to its structural and biological roles. Type XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member, one main subclass of collagens in this superfamily. This collagen contains a triple helix composed of ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):988-995]

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Quantitative MRI markers in Parkinson's disease and parkinsonian syndromes.

Germain Arribarat, Patrice Péran,

PURPOSE OF REVIEW:In Parkinson's disease and parkinsonian disorders, the differential diagnosis is still challenging. We aim to review current developments in MRI quantitative markers and their potential in a clinical and neuroscientific setting. RECENT FINDINGS:There have been efforts to improve MRI acquisition methods and to explore new promising biomarkers. In ... Read more >>

Curr. Opin. Neurol. (Current opinion in neurology)
[2020, 33(2):222-229]

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Modulation of Nigrofugal and Pallidofugal Pathways in Deep Brain Stimulation for Parkinson Disease.

Josue M Avecillas-Chasin, Christopher R Honey,

BACKGROUND:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical therapy for patients with Parkinson disease (PD). OBJECTIVE:To define the role of adjacent white matter stimulation in the effectiveness of STN-DBS. METHODS:We retrospectively evaluated 43 patients with PD who received bilateral STN-DBS. The volumes of activated tissue ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):E387-E397]

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The Study of Subthalamic Deep Brain Stimulation for Parkinson Disease-Associated Camptocormia.

Siquan Liang, Yang Yu, Haitao Li, Yue Wang, Yuanyuan Cheng, Hechao Yang,

BACKGROUND Camptocormia is an axis symptom of Parkinson disease. It remains uncertain whether treatment with medications and surgery are effective. In this study, we assessed the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson disease-associated camptocormia and explored some of its mechanisms. MATERIAL AND METHODS Parkinson disease-associated ... Read more >>

Med. Sci. Monit. (Medical science monitor : international medical journal of experimental and clinical research)
[2020, 26:e919682]

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Factors Associated With Postoperative Confusion and Prolonged Hospital Stay Following Deep Brain Stimulation Surgery for Parkinson Disease.

Hesham Abboud, Gencer Genc, Saira Saad, Nicolas Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Xin Xin Yu, Darlene Floden, Michal Gostkowski, Anwar Ahmed, Ayman Ezzeldin, Hazem M Marouf, Ossama Y Mansour, Hubert H Fernandez,

BACKGROUND:Several patient and disease characteristics are thought to influence DBS outcomes; however, most previous studies have focused on long-term outcomes with only a few addressing immediate postoperative course. OBJECTIVE:To evaluate predictors of immediate outcomes (postoperative confusion and length of postoperative hospitalization) following deep brain stimulation surgery (DBS) in Parkinson disease ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):524-529]

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Profile of social self-management practices in daily life with Parkinson's disease is associated with symptom severity and health quality of life.

Linda Tickle-Degnen, Michael T Stevenson, Sarah D Gunnery, Marie Saint-Hilaire, Cathi A Thomas, Linda Sprague Martinez, Barbara Habermann, Elena N Naumova,

Purpose: Social participation is a key determinant of healthy aging, yet little is known about how people with Parkinson's disease manage social living. This study describes individual differences in social self-management practices and their association with symptom severity and health quality of life.Methods: People with Parkinson's disease (N = 90) completed measures ... Read more >>

Disabil Rehabil (Disability and rehabilitation)
[2020, :1-13]

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Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series.

H Geut, D H Hepp, E Foncke, H W Berendse, J M Rozemuller, I Huitinga, W D J van de Berg,

The clinical diagnosis in patients with parkinsonian disorders can be challenging, and a definite diagnosis requires neuropathological confirmation. The aim of this study was to examine whether a clinical diagnosis of Parkinson's disease (PD) and atypical parkinsonian disorders predict the presence of Lewy pathology (LP) and concomitant neuropathological lesions.We included ... Read more >>

Acta Neuropathol Commun (Acta neuropathologica communications)
[2020, 8(1):39]

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Pharmacokinetics and pharmacodynamics of levodopa/carbidopa cotherapies for Parkinson's disease.

Thomas Müller,

Introduction: Parkinson's disease is a chronic, neurodegenerative disease entity with heterogeneous features and course. Levodopa is the most efficacious dopamine substituting drug. Particularly, long term application of oral levodopa/decarboxylase inhibitor formulations sooner or later supports onset of fluctuations of movement. It also shifts levodopa turnover to O-methylation, which impairs human ... Read more >>

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2020, :]

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Parkinson Disease-Related Pattern of Glucose Metabolism Associated With the Potential for Motor Improvement After Deep Brain Stimulation.

Eun Jung Lee, Jungsu S Oh, Hyojeong Moon, Min-Ju Kim, Mi Sun Kim, Sun Ju Chung, Jae Seung Kim, Sang Ryong Jeon,

BACKGROUND:Motor dysfunctions in Parkinson disease (PD) patients are not completely normalized by deep brain stimulation (DBS), and there is an obvious difference in the degree of symptom improvement after DBS for each patient. OBJECTIVE:To test our hypothesis that each patient has their own restoration capacity for motor improvement after DBS, ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 86(4):492-499]

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Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial.

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Background:Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD). Objective:To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD. Design:Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial. (ClinicalTrials.gov: NCT02168842). Setting:57 Parkinson Study Group sites in North America. ... Read more >>

Ann. Intern. Med. (Annals of internal medicine)
[2020, :]

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Challenges in ICU Care: The Patient With Parkinson's Disease.

Jeffrey Mucksavage, Keri S Kim,

Patients with Parkinson's disease (PD) face unique challenges when admitted to the hospital. The nature of the disease, complexity of the pharmacotherapeutic home regimens, and the medication-related policies of institutionalized care all contribute to the challenges patients and providers face. In addition, medication errors are common in this population. Incorrectly ... Read more >>

Crit Care Nurs Q (Critical care nursing quarterly)
[2020, 43(2):205-215]

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Prefrontal Cortical Activation With Open and Closed-Loop Tactile Cueing When Walking and Turning in Parkinson Disease: A Pilot Study.

Samuel Stuart, Martina Mancini,

BACKGROUND AND PURPOSE:Gait and turning impairments are common in people with Parkinson disease (PwPD). Tactile cues delivered in open- or closed-loop modalities may improve gait and turning in PwPD, but underlying mechanisms are unclear. Attention stemming from the prefrontal cortex (PFC) may play a role in cue response, but PFC ... Read more >>

J Neurol Phys Ther (Journal of neurologic physical therapy : JNPT)
[2020, 44(2):121-131]

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Post-traumatic stress disorder is associated with further increased Parkinson's disease risk in veterans with traumatic brain injury.

Donna L White, Mark E Kunik, Hong Yu, Helen L Lin, Peter A Richardson, Suzanne Moore, Aliya I Sarwar, Laura Marsh, Ricardo E Jorge,

OBJECTIVE:Determining if traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) are risk factors for Parkinson's disease (PD). This constitutes a research priority for the Veterans Administration (VA) with implications for screening policy and prevention. METHODS:Population-based, matched case-control study among veterans using VA healthcare facilities from 10/1/1999 to 09/30/2013. We ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, :]

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Detailed visual assessment of striatal dopaminergic depletion in patients with idiopathic normal pressure hydrocephalus: Unremarkable or not?

Kyum-Yil Kwon, Jeong-Yoon Lee, Soo Park, Mina Lee, Hyunjin Ju, Kayeong Im,

<title>Abstract</title> <p> Background Dopamine transporter (DAT) imaging may enable clinicians to discriminate idiopathic normal pressure hydrocephalus (iNPH) from other parkinsonian disorders. However, a specific pattern of dopaminergic loss in DAT imaging of iNPH patients remains to be further elucidated. Methods In this preliminary study, 11 patients with iNPH ... Read more >>

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Orofacial Strength and Voice Quality as Outcome of Levodopa Challenge Test in Parkinson Disease.

Jérôme R Lechien, Bertil Delsaut, Anissa Abderrakib, Kathy Huet, Veronique Delvaux, Myriam Piccaluga, Mohamad Khalife, Bernard Harmegnies, Sven Saussez, Serge Blecic,

OBJECTIVE:To assess the usefulness of orofacial strength and voice quality as assessment of response to levodopa challenge test (LCT) used in the diagnosis of early idiopathic Parkinson disease (IPD). STUDY DESIGN:Controlled Prospective Study. METHODS:From January 2014 to April 2019, patients with early IPD and healthy individuals were recruited and evaluated ... Read more >>

Laryngoscope (The Laryngoscope)
[2020, :]

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Determination of Parkinson Disease Laterality After Deep Brain Stimulation Using 123I FP-CIT SPECT.

Hye Ran Park, Seunggyun Ha, Dong Soo Lee, Hyung-Jun Im, Sun Ha Paek,

INTRODUCTION:Symptom laterality is one of the main characteristics of Parkinson disease (PD) and reported to be associated with motor and nonmotor symptom severity and prognosis. This study aimed to evaluate the changes of laterality after deep brain stimulation (DBS) and the association between dopamine transporter SPECT using I FP-CIT (DAT ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2020, 45(4):e178-e184]

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